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Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain.

Klass SH, Smith MJ, Fiala TA, Lee JP, Omole AO, Han BG, Downing KH, Kumar S, Francis MB.

J Am Chem Soc. 2019 Mar 13;141(10):4291-4299. doi: 10.1021/jacs.8b10688. Epub 2019 Feb 26.


Resolving the Morphology of Peptoid Vesicles at the 1 nm Length Scale Using Cryogenic Electron Microscopy.

Jiang X, Spencer RK, Sun J, Ophus C, Zuckermann RN, Downing KH, Balsara NP.

J Phys Chem B. 2019 Feb 7;123(5):1195-1205. doi: 10.1021/acs.jpcb.8b11752. Epub 2019 Jan 25.


Architectural Dynamics of CaMKII-Actin Networks.

Khan S, Downing KH, Molloy JE.

Biophys J. 2019 Jan 8;116(1):104-119. doi: 10.1016/j.bpj.2018.11.006. Epub 2018 Nov 10.


Near-atomic model of microtubule-tau interactions.

Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E.

Science. 2018 Jun 15;360(6394):1242-1246. doi: 10.1126/science.aat1780. Epub 2018 May 10.


Reentrant phase behavior and coexistence in asymmetric block copolymer electrolytes.

Loo WS, Jiang X, Maslyn JA, Oh HJ, Zhu C, Downing KH, Balsara NP.

Soft Matter. 2018 Apr 18;14(15):2789-2795. doi: 10.1039/c8sm00175h.


Estimating the effect of finite depth of field in single-particle cryo-EM.

Downing KH, Glaeser RM.

Ultramicroscopy. 2018 Jan;184(Pt A):94-99. doi: 10.1016/j.ultramic.2017.08.007. Epub 2017 Aug 19.


Editorial overview: Cryo Electron Microscopy: Exciting advances in CryoEM Herald a new era in structural biology.

Chiu W, Downing KH.

Curr Opin Struct Biol. 2017 Oct;46:iv-viii. doi: 10.1016/ Epub 2017 Aug 8. No abstract available.


Cytoskeletal organization in microtentacles.

Killilea AN, Csencsits R, Le EBNT, Patel AM, Kenny SJ, Xu K, Downing KH.

Exp Cell Res. 2017 Aug 15;357(2):291-298. doi: 10.1016/j.yexcr.2017.05.024. Epub 2017 May 25.


Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.

Kellogg EH, Hejab NMA, Howes S, Northcote P, Miller JH, Díaz JF, Downing KH, Nogales E.

J Mol Biol. 2017 Mar 10;429(5):633-646. doi: 10.1016/j.jmb.2017.01.001. Epub 2017 Jan 17.


Stable Disk Assemblies of a Tobacco Mosaic Virus Mutant as Nanoscale Scaffolds for Applications in Drug Delivery.

Finbloom JA, Han K, Aanei IL, Hartman EC, Finley DT, Dedeo MT, Fishman M, Downing KH, Francis MB.

Bioconjug Chem. 2016 Oct 19;27(10):2480-2485. doi: 10.1021/acs.bioconjchem.6b00424. Epub 2016 Oct 7.


Long shelf-life streptavidin support-films suitable for electron microscopy of biological macromolecules.

Han BG, Watson Z, Kang H, Pulk A, Downing KH, Cate J, Glaeser RM.

J Struct Biol. 2016 Aug;195(2):238-244. doi: 10.1016/j.jsb.2016.06.009. Epub 2016 Jun 15.


Morphology and Proton Transport in Humidified Phosphonated Peptoid Block Copolymers.

Sun J, Jiang X, Siegmund A, Connolly MD, Downing KH, Balsara NP, Zuckermann RN.

Macromolecules. 2016 Apr 26;49(8):3083-3090. Epub 2016 Apr 4.


Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles.

Sun J, Jiang X, Lund R, Downing KH, Balsara NP, Zuckermann RN.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):3954-9. doi: 10.1073/pnas.1517169113. Epub 2016 Mar 28.


The linac coherent light source single particle imaging road map.

Aquila A, Barty A, Bostedt C, Boutet S, Carini G, dePonte D, Drell P, Doniach S, Downing KH, Earnest T, Elmlund H, Elser V, Gühr M, Hajdu J, Hastings J, Hau-Riege SP, Huang Z, Lattman EE, Maia FR, Marchesini S, Ourmazd A, Pellegrini C, Santra R, Schlichting I, Schroer C, Spence JC, Vartanyants IA, Wakatsuki S, Weis WI, Williams GJ.

Struct Dyn. 2015 Apr 21;2(4):041701. doi: 10.1063/1.4918726. eCollection 2015 Jul.


CTF Challenge: Result summary.

Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, Quintana A, Sorzano CO, Stahlberg H, Vargas J, Voss NR, Chiu W, Carazo JM.

J Struct Biol. 2015 Jun;190(3):348-59. doi: 10.1016/j.jsb.2015.04.003. Epub 2015 Apr 23.


Diverse uncultivated ultra-small bacterial cells in groundwater.

Luef B, Frischkorn KR, Wrighton KC, Holman HY, Birarda G, Thomas BC, Singh A, Williams KH, Siegerist CE, Tringe SG, Downing KH, Comolli LR, Banfield JF.

Nat Commun. 2015 Feb 27;6:6372. doi: 10.1038/ncomms7372.


Electron tomography of cryo-immobilized plant tissue: a novel approach to studying 3D macromolecular architecture of mature plant cell walls in situ.

Sarkar P, Bosneaga E, Yap EG Jr, Das J, Tsai WT, Cabal A, Neuhaus E, Maji D, Kumar S, Joo M, Yakovlev S, Csencsits R, Yu Z, Bajaj C, Downing KH, Auer M.

PLoS One. 2014 Sep 10;9(9):e106928. doi: 10.1371/journal.pone.0106928. eCollection 2014.


Effect of morphology of nanoscale hydrated channels on proton conductivity in block copolymer electrolyte membranes.

Chen XC, Wong DT, Yakovlev S, Beers KM, Downing KH, Balsara NP.

Nano Lett. 2014 Jul 9;14(7):4058-64. doi: 10.1021/nl501537p. Epub 2014 Jun 3.


Absence of Schroeder's paradox in a nanostructured block copolymer electrolyte membrane.

Beers KM, Yakovlev S, Jackson A, Wang X, Hexemer A, Downing KH, Balsara NP.

J Phys Chem B. 2014 Jun 19;118(24):6785-91. doi: 10.1021/jp501374r. Epub 2014 Jun 5.


Minimizing electrostatic charging of an aperture used to produce in-focus phase contrast in the TEM.

Glaeser RM, Sassolini S, Cambie R, Jin J, Cabrini S, Schmid AK, Danev R, Buijsse B, Csencsits R, Downing KH, Larson DM, Typke D, Han BG.

Ultramicroscopy. 2013 Dec;135:6-15. doi: 10.1016/j.ultramic.2013.05.023. Epub 2013 Jun 8.


Architectural insights into a ciliary partition.

Ounjai P, Kim KD, Liu H, Dong M, Tauscher AN, Witkowska HE, Downing KH.

Curr Biol. 2013 Feb 18;23(4):339-44. doi: 10.1016/j.cub.2013.01.029. Epub 2013 Jan 31.


Insights on the study of nafion nanoscale morphology by transmission electron microscopy.

Yakovlev S, Balsara NP, Downing KH.

Membranes (Basel). 2013 Dec 16;3(4):424-39. doi: 10.3390/membranes3040424.


Visualization of clusters in polymer electrolyte membranes by electron microscopy.

Yakovlev S, Downing KH.

Phys Chem Chem Phys. 2013 Jan 28;15(4):1052-64. doi: 10.1039/c2cp42969a.


Future developments in instrumentation for electron crystallography.

Downing KH.

Methods Mol Biol. 2013;955:353-79. doi: 10.1007/978-1-62703-176-9_20.


Iron-reducing bacteria accumulate ferric oxyhydroxide nanoparticle aggregates that may support planktonic growth.

Luef B, Fakra SC, Csencsits R, Wrighton KC, Williams KH, Wilkins MJ, Downing KH, Long PE, Comolli LR, Banfield JF.

ISME J. 2013 Feb;7(2):338-50. doi: 10.1038/ismej.2012.103. Epub 2012 Oct 4.


Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in vivo.

Watkins BY, Joshi SA, Ball DA, Leggett H, Park S, Kim J, Austin CD, Paler-Martinez A, Xu M, Downing KH, Brown EJ.

Infect Immun. 2012 Oct;80(10):3512-20. doi: 10.1128/IAI.00686-12. Epub 2012 Jul 30.


Three-dimensional structure of the bovine sperm connecting piece revealed by electron cryotomography.

Ounjai P, Kim KD, Lishko PV, Downing KH.

Biol Reprod. 2012 Sep 28;87(3):73. Print 2012 Sep.


3-Helix micelles stabilized by polymer springs.

Dong H, Shu JY, Dube N, Ma Y, Tirrell MV, Downing KH, Xu T.

J Am Chem Soc. 2012 Jul 18;134(28):11807-14. doi: 10.1021/ja3048128. Epub 2012 Jul 9.


Outcome of the first electron microscopy validation task force meeting.

Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL.

Structure. 2012 Feb 8;20(2):205-14. doi: 10.1016/j.str.2011.12.014.


A portable cryo-plunger for on-site intact cryogenic microscopy sample preparation in natural environments.

Comolli LR, Duarte R, Baum D, Luef B, Downing KH, Larson DM, Csencsits R, Banfield JF.

Microsc Res Tech. 2012 Jun;75(6):829-36. doi: 10.1002/jemt.22001. Epub 2011 Dec 30.


Direct imaging of nanoscale acidic clusters in a polymer electrolyte membrane.

Yakovlev S, Wang X, Ercius P, Balsara NP, Downing KH.

J Am Chem Soc. 2011 Dec 28;133(51):20700-3. doi: 10.1021/ja209240d. Epub 2011 Dec 6.


Freezing in sealed capillaries for preparation of frozen hydratedsections.

Yakovlev S, Downing KH.

J Microsc. 2011 Dec;244(3):235-47. doi: 10.1111/j.1365-2818.2011.03530.x. No abstract available.


Crystalline ice as a cryoprotectant: theoretical calculation of cooling speed in capillary tubes.

Yakovlev S, Downing KH.

J Microsc. 2011 Jul;243(1):8-14. doi: 10.1111/j.1365-2818.2011.03498.x. Epub 2011 Apr 28.


The surface of evaporated carbon films is an insulating, high-bandgap material.

Larson DM, Downing KH, Glaeser RM.

J Struct Biol. 2011 May;174(2):420-3. doi: 10.1016/j.jsb.2011.02.005. Epub 2011 Feb 19.


Commentary on "Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography" by Y. Miyazaki et al.

Downing KH.

J Mol Biol. 2010 Dec 17;404(5):749-50. doi: 10.1016/j.jmb.2010.10.021. Epub 2010 Oct 19. No abstract available.


Analysis of the intact surface layer of Caulobacter crescentus by cryo-electron tomography.

Amat F, Comolli LR, Nomellini JF, Moussavi F, Downing KH, Smit J, Horowitz M.

J Bacteriol. 2010 Nov;192(22):5855-65. doi: 10.1128/JB.00747-10. Epub 2010 Sep 10.


Structural basis of interprotofilament interaction and lateral deformation of microtubules.

Sui H, Downing KH.

Structure. 2010 Aug 11;18(8):1022-31. doi: 10.1016/j.str.2010.05.010.


The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor.

Yeh YC, Comolli LR, Downing KH, Shapiro L, McAdams HH.

J Bacteriol. 2010 Oct;192(19):4847-58. doi: 10.1128/JB.00607-10. Epub 2010 Aug 6.


Subtomogram alignment by adaptive Fourier coefficient thresholding.

Amat F, Comolli LR, Moussavi F, Smit J, Downing KH, Horowitz M.

J Struct Biol. 2010 Sep;171(3):332-44. doi: 10.1016/j.jsb.2010.05.013. Epub 2010 Jun 1.


Desulfovibrio magneticus RS-1 contains an iron- and phosphorus-rich organelle distinct from its bullet-shaped magnetosomes.

Byrne ME, Ball DA, Guerquin-Kern JL, Rouiller I, Wu TD, Downing KH, Vali H, Komeili A.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12263-8. doi: 10.1073/pnas.1001290107. Epub 2010 Jun 21.


Specimen preparation for electron diffraction of thin crystals.

Wang H, Downing KH.

Micron. 2011 Feb;42(2):132-40. doi: 10.1016/j.micron.2010.05.003. Epub 2010 May 19. Review.


DipM links peptidoglycan remodelling to outer membrane organization in Caulobacter.

Goley ED, Comolli LR, Fero KE, Downing KH, Shapiro L.

Mol Microbiol. 2010 Jul 1;77(1):56-73. doi: 10.1111/j.1365-2958.2010.07222.x. Epub 2010 May 24.


An atomic-level mechanism for activation of the kinesin molecular motors.

Sindelar CV, Downing KH.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4111-6. doi: 10.1073/pnas.0911208107. Epub 2010 Feb 16.


Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function.

Bowman GR, Comolli LR, Gaietta GM, Fero M, Hong SH, Jones Y, Lee JH, Downing KH, Ellisman MH, McAdams HH, Shapiro L.

Mol Microbiol. 2010 Apr;76(1):173-89. doi: 10.1111/j.1365-2958.2010.07088.x. Epub 2010 Feb 10.


Survey of large protein complexes in D. vulgaris reveals great structural diversity.

Han BG, Dong M, Liu H, Camp L, Geller J, Singer M, Hazen TC, Choi M, Witkowska HE, Ball DA, Typke D, Downing KH, Shatsky M, Brenner SE, Chandonia JM, Biggin MD, Glaeser RM.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16580-5. doi: 10.1073/pnas.0813068106. Epub 2009 Sep 11.


Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response.

Holman HY, Wozei E, Lin Z, Comolli LR, Ball DA, Borglin S, Fields MW, Hazen TC, Downing KH.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12599-604. doi: 10.1073/pnas.0902070106. Epub 2009 Jun 16.


Effect of ion distribution on conductivity of block copolymer electrolytes.

Gomez ED, Panday A, Feng EH, Chen V, Stone GM, Minor AM, Kisielowski C, Downing KH, Borodin O, Smith GD, Balsara NP.

Nano Lett. 2009 Mar;9(3):1212-6. doi: 10.1021/nl900091n.


The tubulin binding mode of microtubule stabilizing agents studied by electron crystallography.

Nettles JH, Downing KH.

Top Curr Chem. 2009;286:209-57. doi: 10.1007/128_2008_24.


Three-dimensional analysis of the structure and ecology of a novel, ultra-small archaeon.

Comolli LR, Baker BJ, Downing KH, Siegerist CE, Banfield JF.

ISME J. 2009 Feb;3(2):159-67. doi: 10.1038/ismej.2008.99. Epub 2008 Oct 23.


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