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Decision regret in men living with and beyond non-metastatic prostate cancer in the UK: a population-based patient-reported outcome study.

Wilding S, Downing A, Selby P, Cross W, Wright P, Watson EK, Wagland R, Kind P, Donnelly DW, Hounsome L, Mottram R, Allen M, Kearney T, Butcher H, Gavin A, Glaser A.

Psychooncology. 2020 Feb 17. doi: 10.1002/pon.5362. [Epub ahead of print]


Evidence from big data in obesity research: international case studies.

Wilkins E, Aravani A, Downing A, Drewnowski A, Griffiths C, Zwolinsky S, Birkin M, Alvanides S, Morris MA.

Int J Obes (Lond). 2020 Jan 27. doi: 10.1038/s41366-020-0532-8. [Epub ahead of print]


Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials.

Wessels AM, Tariot PN, Zimmer JA, Selzler KJ, Bragg SM, Andersen SW, Landry J, Krull JH, Downing AM, Willis BA, Shcherbinin S, Mullen J, Barker P, Schumi J, Shering C, Matthews BR, Stern RA, Vellas B, Cohen S, MacSweeney E, Boada M, Sims JR.

JAMA Neurol. 2019 Nov 25. doi: 10.1001/jamaneurol.2019.3988. [Epub ahead of print]


Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma.

Shakir R, Adams R, Cooper R, Downing A, Geh I, Gilbert D, Jacobs C, Jones C, Lorimer C, Namelo WC, Sebag-Montefiore D, Shaw P, Muirhead R.

Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):329-339. doi: 10.1016/j.ijrobp.2019.10.016. Epub 2019 Oct 17.


Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes.

Sandercock DA, Barnett MW, Coe JE, Downing AC, Nirmal AJ, Di Giminiani P, Edwards SA, Freeman TC.

Front Vet Sci. 2019 Sep 18;6:314. doi: 10.3389/fvets.2019.00314. eCollection 2019.


Quality of life among symptomatic compared to PSA-detected prostate cancer survivors - results from a UK wide patient-reported outcomes study.

Donnelly DW, Vis LC, Kearney T, Sharp L, Bennett D, Wilding S, Downing A, Wright P, Watson E, Wagland R, Cross WR, Mason MD, Siesling S, van Manen JG, Glaser AW, Gavin A.

BMC Cancer. 2019 Oct 15;19(1):947. doi: 10.1186/s12885-019-6164-5.


Time to Surgery Following Short-Course Radiotherapy in Rectal Cancer and its Impact on Postoperative Outcomes. A Population-Based Study Across the English National Health Service, 2009-2014.

Levick BA, Gilbert AJ, Spencer KL, Downing A, Taylor JC, Finan PJ, Sebag-Montefiore DJ, Morris EJA.

Clin Oncol (R Coll Radiol). 2020 Feb;32(2):e46-e52. doi: 10.1016/j.clon.2019.08.008. Epub 2019 Aug 30.


Validation of an algorithm using inpatient electronic health records to determine the presence and severity of cirrhosis in patients with hepatocellular carcinoma in England: an observational study.

Driver RJ, Balachandrakumar V, Burton A, Shearer J, Downing A, Cross T, Morris E, Rowe IA.

BMJ Open. 2019 Jul 9;9(7):e028571. doi: 10.1136/bmjopen-2018-028571.


Extensive necrotizing fasciitis from Fournier's gangrene.

Joury A, Mahendra A, Alshehri M, Downing A.

Urol Case Rep. 2019 Jun 9;26:100943. doi: 10.1016/j.eucr.2019.100943. eCollection 2019 Sep.


Adenomatoid odontogenic tumour: A rare threat to orthodontic treatment planning.

Han L, Downing A, Farr D, Dasgupta K, Stewart D.

J Orthod. 2019 Sep;46(3):259-266. doi: 10.1177/1465312519856357. Epub 2019 Jun 24.


Growth environment and organ specific variation in in-vitro cytoprotective activities of Picea mariana in PC12 cells exposed to glucose toxicity: a plant used for treatment of diabetes symptoms by the Cree of Eeyou Istchee (Quebec, Canada).

Downing AD, Eid HM, Tang A, Ahmed F, Harris CS, Haddad PS, Johns T, Arnason JT, Bennett SAL, Cuerrier A.

BMC Complement Altern Med. 2019 Jun 18;19(1):137. doi: 10.1186/s12906-019-2550-4.


Life and bladder cancer: protocol for a longitudinal and cross-sectional patient-reported outcomes study of Yorkshire (UK) patients.

Mason SJ, Downing A, Wright P, Bottomley SE, Winterbottom A, Glaser AW, Catto JWF.

BMJ Open. 2019 Jun 17;9(6):e030850. doi: 10.1136/bmjopen-2019-030850. Erratum in: BMJ Open. 2019 Jul 9;9(7):e030850corr1.


Hidden treasures: Human-made aquatic ecosystems harbour unexplored opportunities.

Koschorreck M, Downing AS, Hejzlar J, Marcé R, Laas A, Arndt WG, Keller PS, Smolders AJP, van Dijk G, Kosten S.

Ambio. 2020 Feb;49(2):531-540. doi: 10.1007/s13280-019-01199-6. Epub 2019 May 28.


The psychological impact of being on a monitoring pathway for localised prostate cancer: A UK-wide mixed methods study.

Matheson L, Wilding S, Wagland R, Nayoan J, Rivas C, Downing A, Wright P, Brett J, Kearney T, Cross W, Glaser A, Gavin A, Watson E.

Psychooncology. 2019 Jul;28(7):1567-1575. doi: 10.1002/pon.5133. Epub 2019 Jun 10.


Cancer-related symptoms, mental well-being, and psychological distress in men diagnosed with prostate cancer treated with androgen deprivation therapy.

Wilding S, Downing A, Wright P, Selby P, Watson E, Wagland R, Donnelly DW, Hounsome L, Butcher H, Mason M, Henry A, Gavin A, Glaser AW.

Qual Life Res. 2019 Oct;28(10):2741-2751. doi: 10.1007/s11136-019-02212-x. Epub 2019 May 21.


Key factors associated with social distress after prostate cancer: Results from the United Kingdom Life after Prostate Cancer diagnosis study.

Wright P, Wilding S, Watson E, Downing A, Selby P, Hounsome L, Wagland R, Brewster DH, Huws D, Butcher H, Mottram R, Kearney T, Allen M, Gavin A, Glaser A.

Cancer Epidemiol. 2019 Jun;60:201-207. doi: 10.1016/j.canep.2019.04.006. Epub 2019 May 6.


Regional Variations in Quality of Survival Among Men with Prostate Cancer Across the United Kingdom.

Donnelly DW, Gavin A, Downing A, Hounsome L, Kearney T, McNair E, Allan D, Huws DW, Wright P, Selby PJ, Kind P, Watson E, Wagland R, Wilding S, Butcher H, Mottram R, Allen M, McSorley O, Sharp L, Mason MD, Cross WR, Catto JWF, Glaser AW.

Eur Urol. 2019 Aug;76(2):228-237. doi: 10.1016/j.eururo.2019.04.018. Epub 2019 May 4.


Quality of life in men living with advanced and localised prostate cancer in the UK: a population-based study.

Downing A, Wright P, Hounsome L, Selby P, Wilding S, Watson E, Wagland R, Kind P, Donnelly DW, Butcher H, Catto JWF, Cross W, Mason M, Sharp L, Weller D, Velikova G, McCaughan E, Mottram R, Allen M, Kearney T, McSorley O, Huws DW, Brewster DH, McNair E, Gavin A, Glaser AW.

Lancet Oncol. 2019 Mar;20(3):436-447. doi: 10.1016/S1470-2045(18)30780-0. Epub 2019 Jan 31.


Rectal cancer in old age -is it appropriately managed? Evidence from population-based analysis of routine data across the English national health service.

Birch RJ, Taylor JC, Downing A, Spencer K, Finan PJ, Audisio RA, Carrigan CM, Selby PJ, Morris EJA.

Eur J Surg Oncol. 2019 Jul;45(7):1196-1204. doi: 10.1016/j.ejso.2019.01.005. Epub 2019 Jan 7.


Designing Trials of Disease Modifying Agents for Early and Preclinical Alzheimer's Disease Intervention: What Evidence is Meaningful to Patients, Providers, and Payers?

Messner DA, Rabins P, Downing AC, Irizarry M, Foster NL, Al Naber J, Dabbous O, Fillit H, Gabler S, Krakauer R, Lotz D, Payzant E, Schneider L, Tyrone J, Van Amerongen D, Wuest D.

J Prev Alzheimers Dis. 2019;6(1):20-26. doi: 10.14283/jpad.2018.42.


Functional Outcomes and Health-Related Quality of Life After Curative Treatment for Rectal Cancer: A Population-Level Study in England.

Downing A, Glaser AW, Finan PJ, Wright P, Thomas JD, Gilbert A, Corner J, Richards M, Morris EJA, Sebag-Montefiore D.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1132-1142. doi: 10.1016/j.ijrobp.2018.12.005. Epub 2018 Dec 13.


'Very difficult for an ordinary guy': Factors influencing the quality of treatment decision-making amongst men diagnosed with localised and locally advanced prostate cancer: Findings from a UK-wide mixed methods study.

Wagland R, Nayoan J, Matheson L, Rivas C, Brett J, Downing A, Wilding S, Butcher H, Gavin A, Glaser AW, Watson E.

Patient Educ Couns. 2019 Apr;102(4):797-803. doi: 10.1016/j.pec.2018.12.004. Epub 2018 Dec 3.


Retrospective assessment of patient characteristics and healthcare costs prior to a diagnosis of Alzheimer's disease in an administrative claims database.

Nair R, Haynes VS, Siadaty M, Patel NC, Fleisher AS, Van Amerongen D, Witte MM, Downing AM, Fernandez LAH, Saundankar V, Ball DE.

BMC Geriatr. 2018 Oct 16;18(1):243. doi: 10.1186/s12877-018-0920-2.


Treatment for erectile dysfunction among older men in Northern Ireland.

Donnelly DW, Kearney T, McCaughan E, Downing A, Weller D, Glaser AW, Gavin A.

Int J Clin Pract. 2019 Jan;73(1):e13259. doi: 10.1111/ijcp.13259. Epub 2018 Sep 17.


Factors influencing job loss and early retirement in working men with prostate cancer-findings from the population-based Life After Prostate Cancer Diagnosis (LAPCD) study.

Bennett D, Kearney T, Donnelly DW, Downing A, Wright P, Wilding S, Wagland R, Watson E, Glaser A, Gavin A.

J Cancer Surviv. 2018 Oct;12(5):669-678. doi: 10.1007/s11764-018-0704-x. Epub 2018 Jul 30.


Toxicity, Tolerability, and Compliance of Concurrent Capecitabine or 5-Fluorouracil in Radical Management of Anal Cancer With Single-dose Mitomycin-C and Intensity Modulated Radiation Therapy: Evaluation of a National Cohort.

Jones CM, Adams R, Downing A, Glynne-Jones R, Harrison M, Hawkins M, Sebag-Montefiore D, Gilbert DC, Muirhead R.

Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1202-1211. doi: 10.1016/j.ijrobp.2018.04.033. Epub 2018 Apr 19.


Health-related quality of life after treatment for bladder cancer in England.

Mason SJ, Downing A, Wright P, Hounsome L, Bottomley SE, Corner J, Richards M, Catto JW, Glaser AW.

Br J Cancer. 2018 May;118(11):1518-1528. doi: 10.1038/s41416-018-0084-z. Epub 2018 May 14.


Evaluating patient-reported outcome measures (PROMs) for bladder cancer: a systematic review using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist.

Mason SJ, Catto JWF, Downing A, Bottomley SE, Glaser AW, Wright P.

BJU Int. 2018 Nov;122(5):760-773. doi: 10.1111/bju.14368. Epub 2018 Jun 8.


Urinary, bowel and sexual health in older men from Northern Ireland.

Donnelly DW, Donnelly C, Kearney T, Weller D, Sharp L, Downing A, Wilding S, Wright P, Kind P, Catto JWF, Cross WR, Mason MD, McCaughan E, Wagland R, Watson E, Mottram R, Allen M, Butcher H, Hounsome L, Selby P, Huws D, Brewster DH, McNair E, Rivas C, Nayoan J, Horton M, Matheson L, Glaser AW, Gavin A.

BJU Int. 2018 Nov;122(5):845-857. doi: 10.1111/bju.14182. Epub 2018 Mar 25.


Obesity surgery and risk of colorectal and other obesity-related cancers: An English population-based cohort study.

Aravani A, Downing A, Thomas JD, Lagergren J, Morris EJA, Hull MA.

Cancer Epidemiol. 2018 Apr;53:99-104. doi: 10.1016/j.canep.2018.01.002. Epub 2018 Feb 3.


Development Review of the BACE1 Inhibitor Lanabecestat (AZD3293/LY3314814).

Sims JR, Selzler KJ, Downing AM, Willis BA, Aluise CD, Zimmer J, Bragg S, Andersen S, Ayan-Oshodi M, Liffick E, Eads J, Wessels AM, Monk S, Schumi J, Mullen J.

J Prev Alzheimers Dis. 2017;4(4):247-254. doi: 10.14283/jpad.2017.38. Review.


FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule.

Thomsen LN, Thomsen PD, Downing A, Talbot R, Berg LC.

BMC Vet Res. 2017 Apr 14;13(1):106. doi: 10.1186/s12917-017-1003-x.


Health-related quality of life in cancer survivorship: Predictive power of the Social Difficulties Inventory.

Ashley L, Velikova G, Downing A, Morris E, Wright P.

Psychooncology. 2017 Nov;26(11):1994-1997. doi: 10.1002/pon.4368. Epub 2017 Feb 27. No abstract available.


Life after prostate cancer diagnosis: protocol for a UK-wide patient-reported outcomes study.

Downing A, Wright P, Wagland R, Watson E, Kearney T, Mottram R, Allen M, Cairnduff V, McSorley O, Butcher H, Hounsome L, Donnelly C, Selby P, Kind P, Cross W, Catto JW, Huws D, Brewster DH, McNair E, Matheson L, Rivas C, Nayoan J, Horton M, Corner J, Verne J, Gavin A, Glaser AW.

BMJ Open. 2016 Dec 7;6(12):e013555. doi: 10.1136/bmjopen-2016-013555.


The effect of Liver Transplantation on the quality of life of the recipient's main caregiver - a systematic review.

Young AL, Rowe IA, Absolom K, Jones RL, Downing A, Meader N, Glaser A, Toogood GJ.

Liver Int. 2017 Jun;37(6):794-801. doi: 10.1111/liv.13333. Epub 2016 Dec 31. Review.


Compensatory dynamics stabilize aggregate community properties in response to multiple types of perturbations.

Brown BL, Downing AL, Leibold MA.

Ecology. 2016 Aug;97(8):2021-2033. doi: 10.1890/15-1951.1.


High hospital research participation and improved colorectal cancer survival outcomes: a population-based study.

Downing A, Morris EJ, Corrigan N, Sebag-Montefiore D, Finan PJ, Thomas JD, Chapman M, Hamilton R, Campbell H, Cameron D, Kaplan R, Parmar M, Stephens R, Seymour M, Gregory W, Selby P.

Gut. 2017 Jan;66(1):89-96. doi: 10.1136/gutjnl-2015-311308. Epub 2016 Oct 19.


Missed Opportunities for HIV Diagnosis.

Downing A, Garcia-Diaz JB.

J Int Assoc Provid AIDS Care. 2017 Jan/Feb;16(1):14-17. doi: 10.1177/2325957416661423. Epub 2016 Aug 19.


Neonatal Resuscitation Training: Implications of Course Construct and Discipline Compartmentalization on Role Confusion and Role Ambiguity.

Jnah AJ, Newberry DM, Trembath AN, Robertson T, Downing A, Greene M, Sewell K.

Adv Neonatal Care. 2016 Jun;16(3):201-10. doi: 10.1097/ANC.0000000000000294. Review.


Sensitivity of the xerophytic moss Syntrichia caninervis to prolonged simulated nitrogen deposition.

Zhang Y, Zhou X, Yin B, Downing A.

Ann Bot. 2016 Jun;117(7):1153-61. doi: 10.1093/aob/mcw058. Epub 2016 Apr 16.


Impact of a pharmacist-driven warfarin management protocol on achieving therapeutic International Normalized Ratios.

Downing A, Mortimer M, Hiers J.

Am J Health Syst Pharm. 2016 Mar 1;73(5 Suppl 1):S69-73. doi: 10.2146/sp150039.


Serotonin 2A Receptor SNP rs7330461 Association with Treatment Response to Pomaglumetad Methionil in Patients with Schizophrenia.

Nisenbaum LK, Downing AM, Zhao F, Millen BA, Munsie L, Kinon BJ, Adams DH, Gomez JC, Penny MA.

J Pers Med. 2016 Feb 5;6(1). pii: E9. doi: 10.3390/jpm6010009.


Bridging the Gap between Research and Clinical Practice in Asymptomatic Alzheimer's Disease.

Downing AM, Yaari R, Ball DE, Selzler KJ, Devous MD Sr.

J Prev Alzheimers Dis. 2016;3(1):30-42. doi: 10.14283/jpad.2015.86.


The perspectives of obese women receiving antenatal care: A qualitative study of women's experiences.

Knight-Agarwal CR, Williams LT, Davis D, Davey R, Shepherd R, Downing A, Lawson K.

Women Birth. 2016 Apr;29(2):189-95. doi: 10.1016/j.wombi.2015.10.008. Epub 2015 Nov 10.


Which Frail Older People Are Dehydrated? The UK DRIE Study.

Hooper L, Bunn DK, Downing A, Jimoh FO, Groves J, Free C, Cowap V, Potter JF, Hunter PR, Shepstone L.

J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1341-7. doi: 10.1093/gerona/glv205. Epub 2015 Nov 9.


Development and testing of a text-mining approach to analyse patients' comments on their experiences of colorectal cancer care.

Wagland R, Recio-Saucedo A, Simon M, Bracher M, Hunt K, Foster C, Downing A, Glaser A, Corner J.

BMJ Qual Saf. 2016 Aug;25(8):604-14. doi: 10.1136/bmjqs-2015-004063. Epub 2015 Oct 28.


Identifying Social Distress: A Cross-Sectional Survey of Social Outcomes 12 to 36 Months After Colorectal Cancer Diagnosis.

Wright P, Downing A, Morris EJ, Corner JL, Richards MA, Sebag-Montefiore D, Finan P, Glaser AW.

J Clin Oncol. 2015 Oct 20;33(30):3423-30. doi: 10.1200/JCO.2014.60.6129. Epub 2015 Aug 17.


The Effect of the UK Coordinating Centre for Cancer Research Anal Cancer Trial (ACT1) on Population-based Treatment and Survival for Squamous Cell Cancer of the Anus.

Downing A, Morris EJ, Aravani A, Finan PJ, Lawton S, Thomas JD, Sebag-Montefiore D.

Clin Oncol (R Coll Radiol). 2015 Dec;27(12):708-12. doi: 10.1016/j.clon.2015.06.019. Epub 2015 Jul 15.


Health-related quality of life after colorectal cancer in England: a patient-reported outcomes study of individuals 12 to 36 months after diagnosis.

Downing A, Morris EJ, Richards M, Corner J, Wright P, Sebag-Montefiore D, Finan P, Kind P, Wood C, Lawton S, Feltbower R, Wagland R, Vernon S, Thomas J, Glaser AW.

J Clin Oncol. 2015 Feb 20;33(6):616-24. doi: 10.1200/JCO.2014.56.6539. Epub 2015 Jan 5.


A Double-Blind, Placebo-Controlled Comparator Study of LY2140023 monohydrate in patients with schizophrenia.

Downing AM, Kinon BJ, Millen BA, Zhang L, Liu L, Morozova MA, Brenner R, Rayle TJ, Nisenbaum L, Zhao F, Gomez JC.

BMC Psychiatry. 2014 Dec 10;14:351. doi: 10.1186/s12888-014-0351-3.

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