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Items: 29


Novel method for the depletion of cariogenic bacteria using dextranomer microspheres.

Mashburn-Warren L, Downey JS, Goodman SD.

Mol Oral Microbiol. 2017 Dec;32(6):475-489. doi: 10.1111/omi.12186. Epub 2017 Jun 26.


A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein.

Freire MO, Devaraj A, Young A, Navarro JB, Downey JS, Chen C, Bakaletz LO, Zadeh HH, Goodman SD.

Mol Oral Microbiol. 2017 Feb;32(1):74-88. doi: 10.1111/omi.12155. Epub 2016 Apr 5.


In vitro manganese-dependent cross-talk between Streptococcus mutans VicK and GcrR: implications for overlapping stress response pathways.

Downey JS, Mashburn-Warren L, Ayala EA, Senadheera DB, Hendrickson WK, McCall LW, Sweet JG, Cvitkovitch DG, Spatafora GA, Goodman SD.

PLoS One. 2014 Dec 23;9(12):e115975. doi: 10.1371/journal.pone.0115975. eCollection 2014.


Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.

Thaventhiran T, Alhumeed N, Yeang HX, Sethu S, Downey JS, Alghanem AF, Olayanju A, Smith EL, Cross MJ, Webb SD, Williams DP, Bristow A, Ball C, Stebbings R, Sathish JG.

MAbs. 2014;6(5):1290-9. doi: 10.4161/mabs.29758. Epub 2014 Oct 30.


A biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutans.

Ayala E, Downey JS, Mashburn-Warren L, Senadheera DB, Cvitkovitch DG, Goodman SD.

PLoS One. 2014 Sep 17;9(9):e108027. doi: 10.1371/journal.pone.0108027. eCollection 2014.


Dimeric structure of p300/CBP associated factor.

Shi S, Lin J, Cai Y, Yu J, Hong H, Ji K, Downey JS, Lu X, Chen R, Han J, Han A.

BMC Struct Biol. 2014 Jan 14;14:2. doi: 10.1186/1472-6807-14-2.


Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.

Wang C, Sang J, Wang J, Su M, Downey JS, Wu Q, Wang S, Cai Y, Xu X, Wu J, Senadheera DB, Cvitkovitch DG, Chen L, Goodman SD, Han A.

PLoS Biol. 2013;11(2):e1001493. doi: 10.1371/journal.pbio.1001493. Epub 2013 Feb 26.


Aberrant community architecture and attenuated persistence of uropathogenic Escherichia coli in the absence of individual IHF subunits.

Justice SS, Li B, Downey JS, Dabdoub SM, Brockson ME, Probst GD, Ray WC, Goodman SD.

PLoS One. 2012;7(10):e48349. doi: 10.1371/journal.pone.0048349. Epub 2012 Oct 25.


Genome sequence of a serotype b non-JP2 aggregatibacter actinomycetemcomitans strain, ANH9381, from a periodontally healthy individual.

Chen C, Kittichotirat W, Chen W, Downey JS, Bumgarner R.

J Bacteriol. 2012 Apr;194(7):1837. doi: 10.1128/JB.06770-11.


Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans.

Senadheera DB, Cordova M, Ayala EA, Chávez de Paz LE, Singh K, Downey JS, Svensäter G, Goodman SD, Cvitkovitch DG.

J Bacteriol. 2012 Mar;194(6):1307-16. doi: 10.1128/JB.06071-11. Epub 2012 Jan 6.


Oligomerization of the response regulator ComE from Streptococcus mutans is affected by phosphorylation.

Hung DC, Downey JS, Kreth J, Qi F, Shi W, Cvitkovitch DG, Goodman SD.

J Bacteriol. 2012 Mar;194(5):1127-35. doi: 10.1128/JB.06565-11. Epub 2011 Dec 30.


T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness.

Downey JS, Attaf M, Moyle G, Gazzard B, Gotch F, Imami N.

AIDS. 2011 Oct 23;25(16):1981-6. doi: 10.1097/QAD.0b013e32834b35a9.


Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.

Goodman SD, Obergfell KP, Jurcisek JA, Novotny LA, Downey JS, Ayala EA, Tjokro N, Li B, Justice SS, Bakaletz LO.

Mucosal Immunol. 2011 Nov;4(6):625-37. doi: 10.1038/mi.2011.27. Epub 2011 Jun 29.


Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans.

Hung DC, Downey JS, Ayala EA, Kreth J, Mair R, Senadheera DB, Qi F, Cvitkovitch DG, Shi W, Goodman SD.

J Bacteriol. 2011 Jul;193(14):3642-52. doi: 10.1128/JB.00155-11. Epub 2011 May 20.


Quikgene: a gene synthesis method integrated with ligation-free cloning.

Mao Y, Lin J, Zhou A, Ji K, Downey JS, Chen R, Han A.

Anal Biochem. 2011 Aug 1;415(1):21-6. doi: 10.1016/j.ab.2011.04.004. Epub 2011 Apr 15.


Development of an animal model for Aggregatibacter actinomycetemcomitans biofilm-mediated oral osteolytic infection: a preliminary study.

Freire MO, Sedghizadeh PP, Schaudinn C, Gorur A, Downey JS, Choi JH, Chen W, Kook JK, Chen C, Goodman SD, Zadeh HH.

J Periodontol. 2011 May;82(5):778-89. doi: 10.1902/jop.2010.100263. Epub 2011 Jan 11.


Regulation of ciaXRH operon expression and identification of the CiaR regulon in Streptococcus mutans.

Wu C, Ayala EA, Downey JS, Merritt J, Goodman SD, Qi F.

J Bacteriol. 2010 Sep;192(18):4669-79. doi: 10.1128/JB.00556-10. Epub 2010 Jul 16.


Genome sequence of naturally competent Aggregatibacter actinomycetemcomitans serotype a strain D7S-1.

Chen C, Kittichotirat W, Chen W, Downey JS, Si Y, Bumgarner R.

J Bacteriol. 2010 May;192(10):2643-4. doi: 10.1128/JB.00157-10. Epub 2010 Mar 26.


Characterization of a glutamate transporter operon, glnQHMP, in Streptococcus mutans and its role in acid tolerance.

Krastel K, Senadheera DB, Mair R, Downey JS, Goodman SD, Cvitkovitch DG.

J Bacteriol. 2010 Feb;192(4):984-93. doi: 10.1128/JB.01169-09. Epub 2009 Dec 18.


Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up.

Herasimtschuk AA, Westrop SJ, Moyle GJ, Downey JS, Imami N.

J Immune Based Ther Vaccines. 2008 Oct 31;6:7. doi: 10.1186/1476-8518-6-7.


Borrelia burgdorferi membranes are the primary targets of reactive oxygen species.

Boylan JA, Lawrence KA, Downey JS, Gherardini FC.

Mol Microbiol. 2008 May;68(3):786-99. doi: 10.1111/j.1365-2958.2008.06204.x. Epub 2008 Mar 25.


Insights into the complex regulation of rpoS in Borrelia burgdorferi.

Burtnick MN, Downey JS, Brett PJ, Boylan JA, Frye JG, Hoover TR, Gherardini FC.

Mol Microbiol. 2007 Jul;65(2):277-93. Epub 2007 Jun 21.


T-cell signalling and immune system disorders.

Wilkinson B, Downey JS, Rudd CE.

Expert Rev Mol Med. 2005 Dec 19;7(29):1-29. Review.


Frequency and distribution of AP-1 sites in the human genome.

Zhou H, Zarubin T, Ji Z, Min Z, Zhu W, Downey JS, Lin S, Han J.

DNA Res. 2005;12(2):139-50.


Gene suppression by tristetraprolin and release by the p38 pathway.

Zhu W, Brauchle MA, Di Padova F, Gram H, New L, Ono K, Downey JS, Han J.

Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508.


Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.

Wang X, McGowan CH, Zhao M, He L, Downey JS, Fearns C, Wang Y, Huang S, Han J.

Mol Cell Biol. 2000 Jul;20(13):4543-52.


Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.

Zhu W, Downey JS, Gu J, Di Padova F, Gram H, Han J.

J Immunol. 2000 Jun 15;164(12):6349-58.


Cellular activation mechanisms in septic shock.

Downey JS, Han J.

Front Biosci. 1998 Apr 30;3:d468-76. Review.


The LEC rat possesses reduced hepatic selenium, contributing to the severity of spontaneous hepatitis and sensitivity to carcinogenesis.

Downey JS, Bingle CD, Cottrell S, Ward N, Churchman D, Dobrota M, Powell CJ.

Biochem Biophys Res Commun. 1998 Mar 17;244(2):463-7.


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