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Items: 1 to 50 of 210

1.

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition.

Raeeszadeh-Sarmazdeh M, Greene KA, Sankaran B, Downey GP, Radisky DC, Radisky ES.

J Biol Chem. 2019 Jun 14;294(24):9476-9488. doi: 10.1074/jbc.RA119.008321. Epub 2019 Apr 30.

PMID:
31040180
2.

Update in Cystic Fibrosis 2018.

Ramsey BW, Downey GP, Goss CH.

Am J Respir Crit Care Med. 2019 May 15;199(10):1188-1194. doi: 10.1164/rccm.201902-0310UP. No abstract available.

PMID:
30917288
3.

Isolated Cystic Lung Disease: An Algorithmic Approach to Distinguishing Birt-Hogg-Dubé Syndrome, Lymphangioleiomyomatosis, and Lymphocytic Interstitial Pneumonia.

Escalon JG, Richards JC, Koelsch T, Downey GP, Lynch DA.

AJR Am J Roentgenol. 2019 Mar 19:1-5. doi: 10.2214/AJR.18.20920. [Epub ahead of print]

PMID:
30888864
4.

Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis.

Gupta N, Lee HS, Young LR, Strange C, Moss J, Singer LG, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Downey GP, Taveira-DaSilva AM, Krischer JP, Setchell K, Trapnell BC, Inoue Y, McCormack FX; NIH Rare Lung Disease Consortium.

Eur Respir J. 2019 Apr 4;53(4). pii: 1802066. doi: 10.1183/13993003.02066-2018. Print 2019 Apr.

PMID:
30846465
5.

Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration.

Reinhard J, Wiemann S, Joachim SC, Palmhof M, Woestmann J, Denecke B, Wang Y, Downey GP, Faissner A.

Mol Neurobiol. 2019 Jun;56(6):4322-4345. doi: 10.1007/s12035-018-1376-2. Epub 2018 Oct 12.

PMID:
30315478
6.

Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling.

Berman R, Downey GP, Dakhama A, Day BJ, Chu HW.

Toxicol Sci. 2018 Dec 1;166(2):345-353. doi: 10.1093/toxsci/kfy217.

PMID:
30169750
7.

The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.

Aschner Y, Downey GP.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):535-547. doi: 10.1165/rcmb.2018-0049TR. Review.

PMID:
29812954
8.

Regulation of IL-1 signaling through control of focal adhesion assembly.

Wang Q, Delcorde J, Tang T, Downey GP, McCulloch CA.

FASEB J. 2018 Jun;32(6):3119-3132. doi: 10.1096/fj.201700966R. Epub 2018 Jan 22.

9.

Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline.

Gupta N, Finlay GA, Kotloff RM, Strange C, Wilson KC, Young LR, Taveira-DaSilva AM, Johnson SR, Cottin V, Sahn SA, Ryu JH, Seyama K, Inoue Y, Downey GP, Han MK, Colby TV, Wikenheiser-Brokamp KA, Meyer CA, Smith K, Moss J, McCormack FX; ATS Assembly on Clinical Problems.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1337-1348. doi: 10.1164/rccm.201709-1965ST.

10.

Emerging Roles of Inflammasomes in Acute Pneumonia.

Ravi Kumar S, Paudel S, Ghimire L, Bergeron S, Cai S, Zemans RL, Downey GP, Jeyaseelan S.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):160-171. doi: 10.1164/rccm.201707-1391PP. Review. No abstract available.

11.

Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis.

Downey GP, Aschner Y.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):418-420. doi: 10.1164/rccm.201609-1921ED. No abstract available.

12.

Chasing the Lymph: New Clues for the Management of Idiopathic Plastic Bronchitis.

Downey GP, Aschner Y.

Ann Am Thorac Soc. 2016 Oct;13(10):1671-1673. No abstract available.

13.

Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.

McCormack FX, Gupta N, Finlay GR, Young LR, Taveira-DaSilva AM, Glasgow CG, Steagall WK, Johnson SR, Sahn SA, Ryu JH, Strange C, Seyama K, Sullivan EJ, Kotloff RM, Downey GP, Chapman JT, Han MK, D'Armiento JM, Inoue Y, Henske EP, Bissler JJ, Colby TV, Kinder BW, Wikenheiser-Brokamp KA, Brown KK, Cordier JF, Meyer C, Cottin V, Brozek JL, Smith K, Wilson KC, Moss J; ATS/JRS Committee on Lymphangioleiomyomatosis.

Am J Respir Crit Care Med. 2016 Sep 15;194(6):748-61. doi: 10.1164/rccm.201607-1384ST.

14.

Adhesion Molecules: Master Controllers of the Circulatory System.

Schmidt EP, Kuebler WM, Lee WL, Downey GP.

Compr Physiol. 2016 Mar 15;6(2):945-73. doi: 10.1002/cphy.c150020. Review.

PMID:
27065171
15.

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease.

Aschner Y, Downey GP.

Am J Respir Cell Mol Biol. 2016 May;54(5):647-55. doi: 10.1165/rcmb.2015-0391TR. Review.

16.

A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.

Wang Q, Wang Y, Downey GP, Plotnikov S, McCulloch CA.

Biochem J. 2016 Feb 15;473(4):397-410. doi: 10.1042/BJ20150907. Epub 2015 Nov 26.

PMID:
26611753
17.

Vestibulitis: a medic's struggle with vulval pain from the other side of the curtain.

Black A, Singh A, Downey GP.

Br J Gen Pract. 2015 Sep;65(638):474. doi: 10.3399/bjgp15X686581. No abstract available.

18.

Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung.

Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S1-2. doi: 10.1513/AnnalsATS.201411-536MG. No abstract available.

19.

Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS.

Aschner Y, Zemans RL, Yamashita CM, Downey GP.

Chest. 2014 Oct;146(4):1081-1091. doi: 10.1378/chest.14-0397. Review.

20.

Divergent functions of Toll-like receptors during bacterial lung infections.

Baral P, Batra S, Zemans RL, Downey GP, Jeyaseelan S.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):722-32. doi: 10.1164/rccm.201406-1101PP. Review.

21.

The importance of matrix metalloproteinase-3 in respiratory disorders.

Yamashita CM, Radisky DC, Aschner Y, Downey GP.

Expert Rev Respir Med. 2014 Aug;8(4):411-21. doi: 10.1586/17476348.2014.909288. Epub 2014 May 29. Review.

PMID:
24869454
22.

Interactions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.

Wang Q, Wang Y, Fritz D, Rajshankar D, Downey GP, McCulloch CA.

J Biol Chem. 2014 Jun 27;289(26):18427-41. doi: 10.1074/jbc.M113.540294. Epub 2014 May 12.

23.

Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection.

Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S.

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1461-8. doi: 10.1164/rccm.201311-2103PP. Review.

24.

Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.

Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP.

Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17.

25.

Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.

Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):825-37. doi: 10.1165/rcmb.2013-0386OC.

26.

Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial.

Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX; MILES Trial Group.

Lancet Respir Med. 2013 Aug;1(6):445-52.

27.

Role of PTPα in the destruction of periodontal connective tissues.

Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M, Downey GP, McCulloch CA.

PLoS One. 2013 Aug 5;8(8):e70659. doi: 10.1371/journal.pone.0070659. Print 2013.

28.

Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions.

Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP.

Am J Respir Cell Mol Biol. 2013 Jul;49(1):1-5. doi: 10.1165/rcmb.2012-0472TR. Review.

29.

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance.

Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP.

Eur Respir J. 2014 Jan;43(1):276-85. doi: 10.1183/09031936.00196412. Epub 2013 Mar 21. Review.

30.

Reply: defining lung injury in animals.

Matute-Bello G, Downey GP.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):267-8. No abstract available.

PMID:
23487848
31.

The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease.

Vij N, Downey GP.

Am J Respir Crit Care Med. 2013 Jan 15;187(2):120-2. doi: 10.1164/rccm.201211-2011ED. No abstract available.

32.

Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.

Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L415-27. doi: 10.1152/ajplung.00180.2012. Epub 2013 Jan 11.

33.

Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury.

Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK.

Mucosal Immunol. 2013 Jul;6(4):762-75. doi: 10.1038/mi.2012.114. Epub 2012 Nov 28.

34.

Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.

Wang Q, Siminovitch KA, Downey GP, McCulloch CA.

Biochem J. 2013 Feb 1;449(3):771-82. doi: 10.1042/BJ20121170.

PMID:
23145787
35.

IL-1β enhances cell adhesion to degraded fibronectin.

Rajshankar D, Downey GP, McCulloch CA.

FASEB J. 2012 Nov;26(11):4429-44. doi: 10.1096/fj.12-207381. Epub 2012 Jul 24.

36.

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.

Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC.

Sci Transl Med. 2012 Jul 11;4(142):142ra95. doi: 10.1126/scitranslmed.3004062.

37.

Human epidermal growth factor receptor signaling in acute lung injury.

Finigan JH, Downey GP, Kern JA.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):395-404. doi: 10.1165/rcmb.2012-0100TR. Epub 2012 May 31. Review.

38.

Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42.

Flannagan RS, Jaumouillé V, Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S.

Cell Microbiol. 2012 Feb;14(2):239-54. doi: 10.1111/j.1462-5822.2011.01715.x. Epub 2011 Nov 15.

PMID:
22023324
39.

On, around, and through: neutrophil-endothelial interactions in innate immunity.

Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP.

Physiology (Bethesda). 2011 Oct;26(5):334-47. doi: 10.1152/physiol.00011.2011. Review.

40.

Resolving the scar of pulmonary fibrosis.

Downey GP.

N Engl J Med. 2011 Sep 22;365(12):1140-1. doi: 10.1056/NEJMe1108558. No abstract available.

PMID:
21992127
41.

Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling.

Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15990-5. doi: 10.1073/pnas.1110144108. Epub 2011 Aug 31.

42.

Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.

Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP.

Am J Pathol. 2011 Oct;179(4):1733-45. doi: 10.1016/j.ajpath.2011.06.041. Epub 2011 Aug 24.

43.

Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.

Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L510-8. doi: 10.1152/ajplung.00122.2011. Epub 2011 Jul 8.

44.

Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK.

Wang Q, Downey GP, McCulloch CA.

FASEB J. 2011 Oct;25(10):3448-64. doi: 10.1096/fj.11-183459. Epub 2011 Jun 30.

45.

Efficacy and safety of sirolimus in lymphangioleiomyomatosis.

McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC; National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group.

N Engl J Med. 2011 Apr 28;364(17):1595-606. doi: 10.1056/NEJMoa1100391. Epub 2011 Mar 16.

46.

Inactivation of macrophage Rab7 by Burkholderia cenocepacia.

Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S.

J Innate Immun. 2010;2(6):522-33. doi: 10.1159/000319864. Epub 2010 Sep 10.

47.

Rare lung diseases III: pulmonary Langerhans' cell histiocytosis.

Juvet SC, Hwang D, Downey GP.

Can Respir J. 2010 May-Jun;17(3):e55-62. Review.

48.

Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression.

Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey GP, McCulloch CA.

J Biol Chem. 2010 Jul 16;285(29):22308-17. doi: 10.1074/jbc.M110.102426. Epub 2010 May 14.

49.

It's much more than just pretty pictures.

Henson PM, Downey GP, Irvin CG.

Am J Respir Cell Mol Biol. 2010 May;42(5):515-6. doi: 10.1165/rcmb.2010-0085ED. No abstract available.

PMID:
20393072
50.

Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences.

Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L677-86. doi: 10.1152/ajplung.00030.2009. Epub 2009 Jul 24.

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