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Assessing emotional and social health using photographs: An innovative research method for rural studies and its applicability in a care-farming program for youth.

Norwood MF, Lakhani A, Maujean A, Downes M, Fullagar S, McIntyre M, Byrne J, Stewart A, Barber BL, Kendall E.

Eval Program Plann. 2019 Sep 6;77:101707. doi: 10.1016/j.evalprogplan.2019.101707. [Epub ahead of print]


Developing a cerebral palsy-specific preference-based measure for a six-dimensional classification system (CP-6D): protocol for a valuation study.

Bahrampour M, Norman R, Byrnes J, Downes M, Scuffham PA.

BMJ Open. 2019 Sep 12;9(9):e029325. doi: 10.1136/bmjopen-2019-029325.


Evaluation of cancer testis antigen (CT10, PRAME) and MHC I expression in high-grade urothelial carcinoma of the bladder.

Hodgson A, Jungbluth AA, Katabi N, Xu B, Downes MR.

Virchows Arch. 2019 Sep 2. doi: 10.1007/s00428-019-02661-2. [Epub ahead of print]


The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.

Chang C, Loo CS, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18528-18536. doi: 10.1073/pnas.1907563116. Epub 2019 Aug 27.


The Role of Family Functioning in the Development of Executive Functions in Preschool Children with Sickle Cell Anemia.

Downes M, de Haan M, Telfer PT, Kirkham FJ.

Dev Neuropsychol. 2019 Aug 26:1-16. doi: 10.1080/87565641.2019.1660779. [Epub ahead of print]


Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells.

Saleeb RM, Farag M, Ding Q, Downes M, Bjarnason G, Brimo F, Plant P, Rotondo F, Lichner Z, Finelli A, Yousef GM.

Am J Pathol. 2019 Aug 2. pii: S0002-9440(19)30655-8. doi: 10.1016/j.ajpath.2019.07.002. [Epub ahead of print]


MicroRNA‑198 suppresses prostate tumorigenesis by targeting MIB1.

Ray J, Hoey C, Huang X, Jeon J, Taeb S, Downes MR, Boutros PC, Liu SK.

Oncol Rep. 2019 Sep;42(3):1047-1056. doi: 10.3892/or.2019.7234. Epub 2019 Jul 15.


Preschool children's preferences for sedentary activity relates to parent's restrictive rules around active outdoor play.

Wiseman N, Harris N, Downes M.

BMC Public Health. 2019 Jul 15;19(1):946. doi: 10.1186/s12889-019-7235-x.


YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.

Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15184-15193. doi: 10.1073/pnas.1904360116. Epub 2019 Jul 9.


Low-dose ketamine provides poor analgesia for pain in redback spider envenoming.

Ryan NM, James R, Downes MA, Isbister GK.

Br J Clin Pharmacol. 2019 Jul 3. doi: 10.1111/bcp.14052. [Epub ahead of print]


Response Time Distribution Analysis of Semantic and Response Interference in a Manual Response Stroop Task.

Hasshim N, Downes M, Bate S, Parris BA.

Exp Psychol. 2019 May;66(3):231-238. doi: 10.1027/1618-3169/a000445.


Inter- and intraobserver agreement of programmed death ligand 1 scoring in head and neck squamous cell carcinoma, urothelial carcinoma and breast carcinoma.

Downes MR, Slodkowska E, Katabi N, Jungbluth AA, Xu B.

Histopathology. 2019 Jun 27. doi: 10.1111/his.13946. [Epub ahead of print]


A systematic review of the validity and reliability of patient-reported experience measures.

Bull C, Byrnes J, Hettiarachchi R, Downes M.

Health Serv Res. 2019 Oct;54(5):1023-1035. doi: 10.1111/1475-6773.13187. Epub 2019 Jun 19.


Monetary Cost of the MyPlate Diet in Young Adults: Higher Expenses Associated with Increased Fruit and Vegetable Consumption.

Clark RL, Famodu OA, Barr ML, Hagedorn RL, Ruseski J, White JA, Warner CM, Morrell AM, Murray PJ, Olfert IM, McFadden JW, Downes MT, Colby SE, Olfert MD.

J Nutr Metab. 2019 May 2;2019:2790963. doi: 10.1155/2019/2790963. eCollection 2019.


Gleason grade patterns in nodal metastasis and corresponding prostatectomy specimens: impact on patient outcome.

Downes MR, Xu B, van der Kwast TH.

Histopathology. 2019 Jun 8. doi: 10.1111/his.13938. [Epub ahead of print]


Temporal stability and prognostic biomarker potential of the prostate cancer urine transcriptome.

Jeon J, Olkhov-Mitsel E, Xie H, Yao CQ, Zhao F, Jahangiri S, Cuizon C, Scarcello S, Jeyapala R, Watson JD, Fraser M, Ray J, Commisso K, Loblaw A, Fleshner NE, Bristow RG, Downes M, Vesprini D, Liu S, Bapat B, Boutros PC.

J Natl Cancer Inst. 2019 Jun 4. pii: djz112. doi: 10.1093/jnci/djz112. [Epub ahead of print]


A Canadian guideline on the use of next-generation sequencing in oncology.

Yip S, Christofides A, Banerji S, Downes MR, Izevbaye I, Lo B, MacMillan A, McCuaig J, Stockley T, Yousef GM, Spatz A.

Curr Oncol. 2019 Apr;26(2):e241-e254. doi: 10.3747/co.26.4731. Epub 2019 Apr 1.


Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T.

Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. Epub 2019 Apr 17.


Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.

Downes MA, Sadler CW, Vidler S, Lovett CJ.

Emerg Med Australas. 2019 Jun;31(3):493-494. doi: 10.1111/1742-6723.13289. Epub 2019 Apr 8. No abstract available.


A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease.

Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu ZZ, Downes MR, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R.

Nat Commun. 2019 Mar 29;10(1):1406. doi: 10.1038/s41467-019-09455-9.


Educational intervention improves fruit and vegetable intake in young adults with metabolic syndrome components.

Clark RL, Famodu OA, Holásková I, Infante AM, Murray PJ, Olfert IM, McFadden JW, Downes MT, Chantler PD, Duespohl MW, Cuff CF, Olfert MD.

Nutr Res. 2019 Feb;62:89-100. doi: 10.1016/j.nutres.2018.11.010. Epub 2018 Nov 22.


FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM.

Cell. 2019 Feb 21;176(5):1098-1112.e18. doi: 10.1016/j.cell.2019.01.036.


Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol .

Egan H, Isbister GK, Robinson J, Downes M, Chan BS, Vecellio E, Chiew AL.

Clin Toxicol (Phila). 2019 Aug;57(8):703-711. doi: 10.1080/15563650.2018.1547829. Epub 2019 Feb 21.


Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy.

Zhang M, Milot L, Khalvati F, Sugar L, Downes M, Baig SM, Klotz L, Haider MA.

Radiology. 2019 Apr;291(1):83-89. doi: 10.1148/radiol.2019180712. Epub 2019 Jan 29.


β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.

Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R.

Development. 2019 Mar 19;146(6). pii: dev167080. doi: 10.1242/dev.167080.


E47 modulates hepatic glucocorticoid action.

Hemmer MC, Wierer M, Schachtrup K, Downes M, Hübner N, Evans RM, Uhlenhaut NH.

Nat Commun. 2019 Jan 18;10(1):306. doi: 10.1038/s41467-018-08196-5.


Temperament in preschool children with sickle cell anaemia.

Downes M, de Haan M, O'Leary T, Telfer PT, Kirkham FJ.

Arch Dis Child. 2018 Dec 21. doi: 10.1136/archdischild-2018-315054. [Epub ahead of print]


Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease.

Elbel EE, Lavine JE, Downes M, Van Natta M, Yu R, Schwimmer JB, Behling C, Brunt EM, Tonascia J, Evans R.

Hepatol Commun. 2018 Sep 27;2(10):1213-1226. doi: 10.1002/hep4.1232. eCollection 2018 Oct.


Immune infiltrates and PD-L1 expression in treatment-naïve acinar prostatic adenocarcinoma: an exploratory analysis.

Hahn E, Liu SK, Vesprini D, Xu B, Downes MR.

J Clin Pathol. 2018 Nov;71(11):1023-1027. doi: 10.1136/jclinpath-2018-205404. Epub 2018 Sep 26.


Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisúa Belmonte JC, Shilatifard A, Evans RM.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386. doi: 10.1073/pnas.1809480115. Epub 2018 Sep 25.


Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set.

Masoomian M, Downes MR, Sweet J, Cheung C, Evans AJ, Fleshner N, Maganti M, Van der Kwast T.

Histopathology. 2019 Feb;74(3):474-482. doi: 10.1111/his.13747. Epub 2018 Nov 4.


Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types.

Wang C, Hahn E, Slodkowska E, Eskander A, Enepekides D, Higgins K, Vesprini D, Liu SK, Downes MR, Xu B.

Hum Pathol. 2018 Dec;82:131-139. doi: 10.1016/j.humpath.2018.07.024. Epub 2018 Aug 1.


Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2018 Sep;561(7721):E1. doi: 10.1038/s41586-018-0304-y.


Harmonization of PD-L1 testing in oncology: a Canadian pathology perspective.

Ionescu DN, Downes MR, Christofides A, Tsao MS.

Curr Oncol. 2018 Jun;25(3):e209-e216. doi: 10.3747/co.25.4031. Epub 2018 Jun 28. Review.


Executive performance on the preschool executive task assessment in children with sickle cell anemia and matched controls.

Downes M, Kirkham FJ, Berg C, Telfer P, de Haan M.

Child Neuropsychol. 2019 Feb;25(2):278-285. doi: 10.1080/09297049.2018.1491962. Epub 2018 Jun 28.


Basal-subtype bladder tumours show a 'hot' immunophenotype.

Hodgson A, Liu SK, Vesprini D, Xu B, Downes MR.

Histopathology. 2018 Nov;73(5):748-757. doi: 10.1111/his.13696. Epub 2018 Aug 14.


Modulating ATP binding cassette transporters in papillary renal cell carcinoma type 2 enhances its response to targeted molecular therapy.

Saleeb RM, Farag M, Lichner Z, Brimo F, Bartlett J, Bjarnason G, Finelli A, Rontondo F, Downes MR, Yousef GM.

Mol Oncol. 2018 Oct;12(10):1673-1688. doi: 10.1002/1878-0261.12346. Epub 2018 Aug 23.


Assessment of Executive Functions in Preschool Children With Sickle Cell Anemia.

Downes M, Kirkham FJ, Telfer PT, de Haan M.

J Int Neuropsychol Soc. 2018 Oct;24(9):949-954. doi: 10.1017/S1355617718000255. Epub 2018 May 30.


Metabolic Regulation by Nuclear Receptors.

Liu S, Downes M, Evans RM.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.


Prognostic pathological factors in radical cystectomy after neoadjuvant chemotherapy.

Brimo F, Downes MR, Jamaspishvili T, Berman D, Barkan GA, Athanazio D, Abro S, Visram K, Yilmaz A, Solanki S, Hahn E, Siemens R, Kassouf W, Trpkov K.

Histopathology. 2018 Nov;73(5):732-740. doi: 10.1111/his.13654. Epub 2018 Aug 6.


Vitamin D Switches BAF Complexes to Protect β Cells.

Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM.

Cell. 2018 May 17;173(5):1135-1149.e15. doi: 10.1016/j.cell.2018.04.013. Epub 2018 May 10.


PD-L1 Immunohistochemistry Assay Concordance in Urothelial Carcinoma of the Bladder and Hypopharyngeal Squamous Cell Carcinoma.

Hodgson A, Slodkowska E, Jungbluth A, Liu SK, Vesprini D, Enepekides D, Higgins K, Katabi N, Xu B, Downes MR.

Am J Surg Pathol. 2018 Aug;42(8):1059-1066. doi: 10.1097/PAS.0000000000001084.


Multilevel Regression and Poststratification: A Modeling Approach to Estimating Population Quantities From Highly Selected Survey Samples.

Downes M, Gurrin LC, English DR, Pirkis J, Currier D, Spittal MJ, Carlin JB.

Am J Epidemiol. 2018 Aug 1;187(8):1780-1790. doi: 10.1093/aje/kwy070.


ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.


ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle.

Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He MX, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 6;22(10):2521-2529. doi: 10.1016/j.celrep.2018.02.047.


Visual attention control differences in 12-month-old preterm infants.

Downes M, Kelly D, Day K, Marlow N, de Haan M.

Infant Behav Dev. 2018 Feb;50:180-188. doi: 10.1016/j.infbeh.2018.01.002. Epub 2018 Feb 3.


Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.

Howard J, Slee AE, Skene S, Inusa B, Kawadler J, Downes M, Gavlak J, Koelbel M, Stotesbury H, Chorozoglou M, Tebbs S, Chakravorty S, Awogbade M, Rees DC, Gupta A, Murphy PB, Hart N, Sahota S, Nwosu C, Gwam M, Saunders D, Muthurangu V, Barber N, Ako E, Thein SL, Marshall M, Reading IC, Cheng MYE, Kirkham FJ, Liossi C.

Trials. 2018 Jan 22;19(1):55. doi: 10.1186/s13063-017-2419-0.


Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs.

White CN, Downes MJ, Jones G, Wigfall C, Dean RS, Brennan ML.

Vet Rec. 2018 Jan 6;182(1):21. doi: 10.1136/vr.104390. Epub 2017 Dec 23.


Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.

Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM.

PLoS One. 2017 Dec 6;12(12):e0189051. doi: 10.1371/journal.pone.0189051. eCollection 2017.

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