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Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection.

Downes KJ, Boge CLK, Baro E, Wharton GT, Liston KM, Haltzman BL, Emerson HM, Doe E, Fulchiero R, Tran V, Yen L, Lieu P, Van Driest SL, Grisso AG, Aka IT, Hale J, Gillon J, Pingel JS, Coffin SE, McMahon AW.

J Pediatr. 2020 Feb 6. pii: S0022-3476(19)31735-4. doi: 10.1016/j.jpeds.2019.12.056. [Epub ahead of print]


Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model.

Pais GM, Liu J, Avedissian SN, Hiner D, Xanthos T, Chalkias A, d'Aloja E, Locci E, Gilchrist A, Prozialeck WC, Rhodes NJ, Lodise TP, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

J Antimicrob Chemother. 2020 Feb 3. pii: dkz563. doi: 10.1093/jac/dkz563. [Epub ahead of print]


Administration and Dosing of Systemic Antifungal Agents in Pediatric Patients.

Downes KJ, Fisher BT, Zane NR.

Paediatr Drugs. 2020 Jan 23. doi: 10.1007/s40272-020-00379-2. [Epub ahead of print] Review.


Defining the younger patient: age as a predictive factor for outcomes in shoulder arthroplasty.

Brewley EE Jr, Christmas KN, Gorman RA 2nd, Downes KL, Mighell MA, Frankle MA.

J Shoulder Elbow Surg. 2020 Jan 3. pii: S1058-2746(19)30643-3. doi: 10.1016/j.jse.2019.09.016. [Epub ahead of print]


Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: Application to pediatric pharmacokinetic study.

Moorthy GS, Vedar C, Zane NR, Downes KJ, Prodell JL, DiLiberto MA, Zuppa AF.

J Pharm Biomed Anal. 2020 Feb 5;179:113002. doi: 10.1016/j.jpba.2019.113002. Epub 2019 Nov 20.


Characterization of a large cohort of patients with unclassified bleeding disorder; clinical features, management of haemostatic challenges and use of global haemostatic assessment with proposed recommendations for diagnosis and treatment.

MacDonald S, Wright A, Beuche F, Downes K, Besser M, Symington E, Kelly A, Thomas W.

Int J Lab Hematol. 2019 Nov 20. doi: 10.1111/ijlh.13124. [Epub ahead of print]


How common are single gene mutations as a cause for lacunar stroke? A targeted gene panel study.

Tan RYY, Traylor M, Megy K, Duarte D, Deevi SVV, Shamardina O, Mapeta RP; NIHR BioResource: Rare Diseases Consortium, Ouwehand WH, Gräf S, Downes K, Markus HS.

Neurology. 2019 Nov 26;93(22):e2007-e2020. doi: 10.1212/WNL.0000000000008544. Epub 2019 Nov 12.


Does the etiology of a failed hemiarthroplasty affect outcomes when revised to a reverse shoulder arthroplasty?

Franke KJ, Christmas KN, Downes KL, Mighell MA, Frankle MA.

J Shoulder Elbow Surg. 2019 Nov 6. pii: S1058-2746(19)30593-2. doi: 10.1016/j.jse.2019.08.019. [Epub ahead of print]


Evaluating the impact of a standardized induction protocol to reduce adverse perinatal outcomes: a prospective cohort study.

Levine LD, Downes KL, Hamm RF, Srinivas SK.

J Matern Fetal Neonatal Med. 2019 Oct 24:1-8. doi: 10.1080/14767058.2019.1680629. [Epub ahead of print]


Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants.

Bury L, Megy K, Stephens JC, Grassi L, Greene D, Gleadall N, Althaus K, Allsup D, Bariana TK, Bonduel M, Butta NV, Collins P, Curry N, Deevi SVV, Downes K, Duarte D, Elliott K, Falcinelli E, Furie B, Keeling D, Lambert MP, Linger R, Mangles S, Mapeta R, Millar CM, Penkett C, Perry DJ, Stirrups KE, Turro E, Westbury SK, Wu J, BioResource N, Gomez K, Freson K, Ouwehand WH, Gresele P, Simeoni I.

Hum Mutat. 2020 Jan;41(1):277-290. doi: 10.1002/humu.23927. Epub 2019 Oct 15.


Persistent cardiac dysfunction on echocardiography in African American women with severe preeclampsia.

Levine LD, Lewey J, Koelper N, Downes KL, Arany Z, Elovitz MA, Sammel MD, Ky B.

Pregnancy Hypertens. 2019 Jul;17:127-132. doi: 10.1016/j.preghy.2019.05.021. Epub 2019 May 30.


Effect of Nail Size, Insertion, and Δ Canal-Nail on the Development of a Nonunion After Intramedullary Nailing of Femoral Shaft Fractures.

Serrano R, Mir HR, Gorman RA 2nd, Karsch J, Kim R, Shah A, Maxson B, Infante A, Watson D, Downes K, Sanders RW.

J Orthop Trauma. 2019 Nov;33(11):559-563. doi: 10.1097/BOT.0000000000001585.


Mechanisms of antimicrobial-induced nephrotoxicity in children.

Downes KJ, Hayes M, Fitzgerald JC, Pais GM, Liu J, Zane NR, Goldstein SL, Scheetz MH, Zuppa AF.

J Antimicrob Chemother. 2020 Jan 1;75(1):1-13. doi: 10.1093/jac/dkz325.


Acquired Hemophilia A After Nivolumab Therapy in a Patient With Metastatic Squamous Cell Carcinoma of the Lung Successfully Managed With Rituximab.

Gokozan HN, Friedman JD, Schmaier AH, Downes KA, Farah LA, Reeves HM.

Clin Lung Cancer. 2019 Sep;20(5):e560-e563. doi: 10.1016/j.cllc.2019.06.022. Epub 2019 Jun 26. No abstract available.


Early to midterm results of "low-friction" articulating antibiotic spacers for septic total knee arthroplasty.

Lyons S, Downes K, Habeck J, Whitham Z, Werger M, Stanat S.

Arthroplast Today. 2019 Apr 22;5(2):221-225. doi: 10.1016/j.artd.2019.03.004. eCollection 2019 Jun.


A novel missense variant in SLC18A2 causes recessive brain monoamine vesicular transport disease and absent serotonin in platelets.

Padmakumar M, Jaeken J, Ramaekers V, Lagae L, Greene D, Thys C, Van Geet C, BioResource N, Stirrups K, Downes K, Turro E, Freson K.

JIMD Rep. 2019 Mar 25;47(1):9-16. doi: 10.1002/jmd2.12030. eCollection 2019 May.


De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family.

De Kock L, Thys C, Downes K, Duarte D, Megy K, Van Geet C, Freson K.

Platelets. 2019;30(7):931-934. doi: 10.1080/09537104.2019.1628197. Epub 2019 Jun 17.


Is there a relationship between preoperative diagnosis and clinical outcomes in reverse shoulder arthroplasty? An experience in 699 shoulders.

Lindbloom BJ, Christmas KN, Downes K, Simon P, McLendon PB, Hess AV 2nd, Mighell MA, Frankle MA.

J Shoulder Elbow Surg. 2019 Jun;28(6S):S110-S117. doi: 10.1016/j.jse.2019.04.007.


Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH.

Megy K, Downes K, Simeoni I, Bury L, Morales J, Mapeta R, Bellissimo DB, Bray PF, Goodeve AC, Gresele P, Lambert M, Reitsma P, Ouwehand WH, Freson K; Subcommittee on Genomics in Thrombosis and Hemostasis.

J Thromb Haemost. 2019 Aug;17(8):1253-1260. doi: 10.1111/jth.14479. Epub 2019 Jun 9. No abstract available.


Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.

Hornik CP, Atz AM, Bendel C, Chan F, Downes K, Grundmeier R, Fogel B, Gipson D, Laughon M, Miller M, Smith M, Livingston C, Kluchar C, Heath A, Jarrett C, McKerlie B, Patel H, Hunter C; Best Pharmaceuticals for Children Act–Pediatric Trials Network.

Appl Clin Inform. 2019 Mar;10(2):307-315. doi: 10.1055/s-0039-1688477. Epub 2019 May 8.


Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders.

Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ; NIHR BioResource, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K.

Blood. 2019 Dec 5;134(23):2082-2091. doi: 10.1182/blood.2018891192.


Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T, Grundberg E.

Genome Biol. 2019 May 7;20(1):89. doi: 10.1186/s13059-019-1702-7.


Major Adverse Kidney Events in Pediatric Sepsis.

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL.

Clin J Am Soc Nephrol. 2019 May 7;14(5):664-672. doi: 10.2215/CJN.12201018. Epub 2019 Apr 18.


Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00079-19. doi: 10.1128/AAC.00079-19. Print 2019 Jul.


Vancomycin Prescribing and Therapeutic Drug Monitoring in Children With and Without Acute Kidney Injury After Cardiac Arrest.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF.

Paediatr Drugs. 2019 Apr;21(2):107-112. doi: 10.1007/s40272-019-00328-8.


Impact of lenalidomide on collected hematopoietic myeloid and erythroid progenitors: peripheral stem cell collection may not be affected.

Dosani T, Covut F, Pinto R, Kim BG, Ali N, Beck R, Maitta R, Downes K, Fox R, Reese J, de Lima M, Malek E.

Leuk Lymphoma. 2019 Sep;60(9):2199-2206. doi: 10.1080/10428194.2019.1573367. Epub 2019 Mar 7.


Inherited missense variants that affect GFI1B function do not necessarily cause bleeding diatheses.

van Oorschot R, Marneth AE, Bergevoet SM, van Bergen MGJM, Peerlinck K, Lentaigne CE, Millar CM, Westbury SK, Favier R, Erber WN, Turro E, Jansen JH, Ouwehand WH, McKinney HL; NIHR BioResource Collaborative Group, Downes K, Freson K, van der Reijden BA.

Haematologica. 2019 Jun;104(6):e260-e264. doi: 10.3324/haematol.2018.207712. Epub 2018 Dec 20. No abstract available.


High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM.

Haematologica. 2019 Jun;104(6):1256-1267. doi: 10.3324/haematol.2018.198853. Epub 2018 Dec 13.


Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Hamm RF, Downes KL, Srinivas SK, Levine LD.

Am J Perinatol. 2019 May;36(6):561-566. doi: 10.1055/s-0038-1675625. Epub 2018 Dec 3.


Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study.

Downes KJ, Fitzgerald JC, Schriver E, Boge CLK, Russo ME, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS; CDC Prevention Epicenters Program.

J Pediatric Infect Dis Soc. 2018 Nov 22. doi: 10.1093/jpids/piy113. [Epub ahead of print] Erratum in: J Pediatric Infect Dis Soc. 2019 Dec 27;8(6):585.


Posaconazole Administration in Hospitalized Children in the United States.

Lavigne S, Fisher BT, Ellis D, Zaoutis TE, Downes KJ.

J Pediatric Infect Dis Soc. 2019 Nov 6;8(5):481-484. doi: 10.1093/jpids/piy119.


The use of echinocandins in hospitalized children in the United States.

Downes KJ, Ellis D, Lavigne S, Bryan M, Zaoutis TE, Fisher BT.

Med Mycol. 2018 Sep 28. doi: 10.1093/mmy/myy084. [Epub ahead of print]


Phenotype description and response to thrombopoietin receptor agonist in DIAPH1-related disorder.

Westbury SK, Downes K, Burney C, Lozano ML, Obaji SG, Toh CH, Sevivas T, Morgan NV, Erber WN, Kempster C, Moore SF, Thys C, Papadia S, Ouwehand WH; NIHR BioResource–Rare Diseases, Laffan MA, Gomez K, Freson K, Rivera J, Mumford AD.

Blood Adv. 2018 Sep 25;2(18):2341-2346. doi: 10.1182/bloodadvances.2018020370. No abstract available.


GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting.

Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, Ouwehand WH, Downes K, Poncz M, Varon D, Lambert MP.

Blood. 2018 Oct 25;132(17):1851-1854. doi: 10.1182/blood-2018-04-845545. Epub 2018 Aug 31. No abstract available.


TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.

Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, Minter R, Al-Lamki RS, Pober JS, Bradley JR.

Sci Rep. 2018 Aug 13;8(1):12079. doi: 10.1038/s41598-018-30621-4.


Continuous-Infusion Vancomycin-Teaching an Old Dog New Tricks?

Downes KJ.

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e128-e130. doi: 10.1093/jpids/piy052. No abstract available.


Noninvasive blood tests for fetal development predict gestational age and preterm delivery.

Ngo TTM, Moufarrej MN, Rasmussen MH, Camunas-Soler J, Pan W, Okamoto J, Neff NF, Liu K, Wong RJ, Downes K, Tibshirani R, Shaw GM, Skotte L, Stevenson DK, Biggio JR, Elovitz MA, Melbye M, Quake SR.

Science. 2018 Jun 8;360(6393):1133-1136. doi: 10.1126/science.aar3819.



Levine LD, Downes KL.

Am J Obstet Gynecol. 2018 Oct;219(4):422-424. doi: 10.1016/j.ajog.2018.04.057. Epub 2018 May 9. No abstract available.


Quantitative fetal fibronectin and cervical length in symptomatic women: results from a prospective blinded cohort study.

Levine LD, Downes KL, Romero JA, Pappas H, Elovitz MA.

J Matern Fetal Neonatal Med. 2019 Nov;32(22):3792-3800. doi: 10.1080/14767058.2018.1472227. Epub 2018 May 15.


Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis.

Spyridakis E, Gerber JS, Schriver E, Grundmeier RW, Porsch EA, St Geme JW, Downes KJ.

J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):228-234. doi: 10.1093/jpids/piy034.


Comparing standard office-based follow-up with text-based remote monitoring in the management of postpartum hypertension: a randomised clinical trial.

Hirshberg A, Downes K, Srinivas S.

BMJ Qual Saf. 2018 Nov;27(11):871-877. doi: 10.1136/bmjqs-2018-007837. Epub 2018 Apr 27.


Measuring Endothelial Cell Loss on DMEK Grafts After Transplantation in Human Cadaveric Whole Eyes: Description of the Technique and Pilot Study.

Tran KD, Alabi RO, Odell K, Dye PK, Downes K, Sales CS.

Cornea. 2018 Aug;37(8):1075-1080. doi: 10.1097/ICO.0000000000001602.


Postdates induction with an unfavorable cervix and risk of cesarean.

McCoy J, Downes KL, Srinivas SK, Levine LD.

J Matern Fetal Neonatal Med. 2019 Sep;32(17):2874-2878. doi: 10.1080/14767058.2018.1450861. Epub 2018 Mar 21.


Cumulative Endothelial Cell Loss in Descemet Membrane Endothelial Keratoplasty Grafts From Preparation Through Insertion With Glass Injectors.

Downes K, Tran KD, Stoeger CG, Chamberlain W.

Cornea. 2018 Jun;37(6):698-704. doi: 10.1097/ICO.0000000000001588.


The Cost of Vancomycin and Piperacillin/Tazobactam Treatment-Reply.

Downes KJ, Laskin BL, Fisher BT.

JAMA Pediatr. 2018 May 1;172(5):494-495. doi: 10.1001/jamapediatrics.2018.0038. No abstract available.


A validated calculator to estimate risk of cesarean after an induction of labor with an unfavorable cervix.

Levine LD, Downes KL, Parry S, Elovitz MA, Sammel MD, Srinivas SK.

Am J Obstet Gynecol. 2018 Feb;218(2):254.e1-254.e7. doi: 10.1016/j.ajog.2017.11.603. Epub 2017 Dec 7. Erratum in: Am J Obstet Gynecol. 2018 May 22;:.


Predicting persistent impaired glucose tolerance in patients with gestational diabetes: The role of high sensitivity CRP and adiponectin.

Durnwald CP, Downes K, Leite R, Elovitz M, Parry S.

Diabetes Metab Res Rev. 2018 Feb;34(2). doi: 10.1002/dmrr.2958. Epub 2017 Dec 7.


Life-history strategies of the rock hind grouper Epinephelus adscensionis at Ascension Island.

Nolan ET, Downes KJ, Richardson A, Arkhipkin A, Brickle P, Brown J, Mrowicki RJ, Shcherbich Z, Weber N, Weber SB.

J Fish Biol. 2017 Dec;91(6):1549-1568. doi: 10.1111/jfb.13410. Epub 2017 Oct 25.


Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Patel D, Rorbach J, Downes K, Szukszto MJ, Pekalski ML, Minczuk M.

Sci Rep. 2017 Oct 10;7(1):12886. doi: 10.1038/s41598-017-13227-0.

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