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Items: 1 to 50 of 183

1.

Mechanisms of antimicrobial-induced nephrotoxicity in children.

Downes KJ, Hayes M, Fitzgerald JC, Pais GM, Liu J, Zane NR, Goldstein SL, Scheetz MH, Zuppa AF.

J Antimicrob Chemother. 2019 Aug 1. pii: dkz325. doi: 10.1093/jac/dkz325. [Epub ahead of print]

PMID:
31369087
2.

Acquired Hemophilia A After Nivolumab Therapy in a Patient With Metastatic Squamous Cell Carcinoma of the Lung Successfully Managed With Rituximab.

Gokozan HN, Friedman JD, Schmaier AH, Downes KA, Farah LA, Reeves HM.

Clin Lung Cancer. 2019 Sep;20(5):e560-e563. doi: 10.1016/j.cllc.2019.06.022. Epub 2019 Jun 26. No abstract available.

PMID:
31311716
3.

Early to midterm results of "low-friction" articulating antibiotic spacers for septic total knee arthroplasty.

Lyons S, Downes K, Habeck J, Whitham Z, Werger M, Stanat S.

Arthroplast Today. 2019 Apr 22;5(2):221-225. doi: 10.1016/j.artd.2019.03.004. eCollection 2019 Jun.

4.

A novel missense variant in SLC18A2 causes recessive brain monoamine vesicular transport disease and absent serotonin in platelets.

Padmakumar M, Jaeken J, Ramaekers V, Lagae L, Greene D, Thys C, Van Geet C, BioResource N, Stirrups K, Downes K, Turro E, Freson K.

JIMD Rep. 2019 Mar 25;47(1):9-16. doi: 10.1002/jmd2.12030. eCollection 2019 May.

5.

De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family.

De Kock L, Thys C, Downes K, Duarte D, Megy K, Van Geet C, Freson K.

Platelets. 2019 Jun 17:1-4. doi: 10.1080/09537104.2019.1628197. [Epub ahead of print]

PMID:
31204551
6.

Is there a relationship between preoperative diagnosis and clinical outcomes in reverse shoulder arthroplasty? An experience in 699 shoulders.

Lindbloom BJ, Christmas KN, Downes K, Simon P, McLendon PB, Hess AV 2nd, Mighell MA, Frankle MA.

J Shoulder Elbow Surg. 2019 Jun;28(6S):S110-S117. doi: 10.1016/j.jse.2019.04.007.

PMID:
31196504
7.

Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH.

Megy K, Downes K, Simeoni I, Bury L, Morales J, Mapeta R, Bellissimo DB, Bray PF, Goodeve AC, Gresele P, Lambert M, Reitsma P, Ouwehand WH, Freson K; Subcommittee on Genomics in Thrombosis and Hemostasis.

J Thromb Haemost. 2019 Aug;17(8):1253-1260. doi: 10.1111/jth.14479. Epub 2019 Jun 9. No abstract available.

PMID:
31179617
8.

Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.

Hornik CP, Atz AM, Bendel C, Chan F, Downes K, Grundmeier R, Fogel B, Gipson D, Laughon M, Miller M, Smith M, Livingston C, Kluchar C, Heath A, Jarrett C, McKerlie B, Patel H, Hunter C; Best Pharmaceuticals for Children Act–Pediatric Trials Network.

Appl Clin Inform. 2019 Mar;10(2):307-315. doi: 10.1055/s-0039-1688477. Epub 2019 May 8.

PMID:
31067576
9.

Diagnostic high-throughput sequencing of 2,396 patients with bleeding, thrombotic and platelet disorders.

Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K.

Blood. 2019 May 7. pii: blood.2018891192. doi: 10.1182/blood.2018891192. [Epub ahead of print]

PMID:
31064749
10.

Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T, Grundberg E.

Genome Biol. 2019 May 7;20(1):89. doi: 10.1186/s13059-019-1702-7.

11.

Major Adverse Kidney Events in Pediatric Sepsis.

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL.

Clin J Am Soc Nephrol. 2019 May 7;14(5):664-672. doi: 10.2215/CJN.12201018. Epub 2019 Apr 18.

PMID:
31000518
12.

Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00079-19. doi: 10.1128/AAC.00079-19. Print 2019 Jul.

PMID:
30988153
13.

Vancomycin Prescribing and Therapeutic Drug Monitoring in Children With and Without Acute Kidney Injury After Cardiac Arrest.

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF.

Paediatr Drugs. 2019 Apr;21(2):107-112. doi: 10.1007/s40272-019-00328-8.

PMID:
30864056
14.

Impact of lenalidomide on collected hematopoietic myeloid and erythroid progenitors: peripheral stem cell collection may not be affected.

Dosani T, Covut F, Pinto R, Kim BG, Ali N, Beck R, Maitta R, Downes K, Fox R, Reese J, de Lima M, Malek E.

Leuk Lymphoma. 2019 Mar 7:1-8. doi: 10.1080/10428194.2019.1573367. [Epub ahead of print]

PMID:
30845862
15.

Inherited missense variants that affect GFI1B function do not necessarily cause bleeding diatheses.

van Oorschot R, Marneth AE, Bergevoet SM, van Bergen MGJM, Peerlinck K, Lentaigne CE, Millar CM, Westbury SK, Favier R, Erber WN, Turro E, Jansen JH, Ouwehand WH, McKinney HL; NIHR BioResource Collaborative Group, Downes K, Freson K, van der Reijden BA.

Haematologica. 2019 Jun;104(6):e260-e264. doi: 10.3324/haematol.2018.207712. Epub 2018 Dec 20. No abstract available.

16.

High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM.

Haematologica. 2019 Jun;104(6):1256-1267. doi: 10.3324/haematol.2018.198853. Epub 2018 Dec 13.

17.

Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Hamm RF, Downes KL, Srinivas SK, Levine LD.

Am J Perinatol. 2019 May;36(6):561-566. doi: 10.1055/s-0038-1675625. Epub 2018 Dec 3.

18.

Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study.

Downes KJ, Fitzgerald JC, Schriver E, Boge CLK, Russo ME, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS; CDC Prevention Epicenters Program.

J Pediatric Infect Dis Soc. 2018 Nov 22. doi: 10.1093/jpids/piy113. [Epub ahead of print]

PMID:
30476186
19.

Posaconazole Administration in Hospitalized Children in the United States.

Lavigne S, Fisher BT, Ellis D, Zaoutis TE, Downes KJ.

J Pediatric Infect Dis Soc. 2018 Nov 16. doi: 10.1093/jpids/piy119. [Epub ahead of print]

PMID:
30445549
20.

The use of echinocandins in hospitalized children in the United States.

Downes KJ, Ellis D, Lavigne S, Bryan M, Zaoutis TE, Fisher BT.

Med Mycol. 2018 Sep 28. doi: 10.1093/mmy/myy084. [Epub ahead of print]

PMID:
30265325
21.

Phenotype description and response to thrombopoietin receptor agonist in DIAPH1-related disorder.

Westbury SK, Downes K, Burney C, Lozano ML, Obaji SG, Toh CH, Sevivas T, Morgan NV, Erber WN, Kempster C, Moore SF, Thys C, Papadia S, Ouwehand WH; NIHR BioResource–Rare Diseases, Laffan MA, Gomez K, Freson K, Rivera J, Mumford AD.

Blood Adv. 2018 Sep 25;2(18):2341-2346. doi: 10.1182/bloodadvances.2018020370. No abstract available.

22.

GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting.

Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, Ouwehand WH, Downes K, Poncz M, Varon D, Lambert MP.

Blood. 2018 Oct 25;132(17):1851-1854. doi: 10.1182/blood-2018-04-845545. Epub 2018 Aug 31. No abstract available.

PMID:
30171045
23.

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.

Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, Minter R, Al-Lamki RS, Pober JS, Bradley JR.

Sci Rep. 2018 Aug 13;8(1):12079. doi: 10.1038/s41598-018-30621-4.

24.

Continuous-Infusion Vancomycin-Teaching an Old Dog New Tricks?

Downes KJ.

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e128-e130. doi: 10.1093/jpids/piy052. No abstract available.

PMID:
29905839
25.

Noninvasive blood tests for fetal development predict gestational age and preterm delivery.

Ngo TTM, Moufarrej MN, Rasmussen MH, Camunas-Soler J, Pan W, Okamoto J, Neff NF, Liu K, Wong RJ, Downes K, Tibshirani R, Shaw GM, Skotte L, Stevenson DK, Biggio JR, Elovitz MA, Melbye M, Quake SR.

Science. 2018 Jun 8;360(6393):1133-1136. doi: 10.1126/science.aar3819.

PMID:
29880692
26.

Reply.

Levine LD, Downes KL.

Am J Obstet Gynecol. 2018 Oct;219(4):422-424. doi: 10.1016/j.ajog.2018.04.057. Epub 2018 May 9. No abstract available.

PMID:
29752933
27.

Quantitative fetal fibronectin and cervical length in symptomatic women: results from a prospective blinded cohort study.

Levine LD, Downes KL, Romero JA, Pappas H, Elovitz MA.

J Matern Fetal Neonatal Med. 2019 Nov;32(22):3792-3800. doi: 10.1080/14767058.2018.1472227. Epub 2018 May 15.

PMID:
29727248
28.

Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis.

Spyridakis E, Gerber JS, Schriver E, Grundmeier RW, Porsch EA, St Geme JW 3rd, Downes KJ.

J Pediatric Infect Dis Soc. 2018 Apr 30. doi: 10.1093/jpids/piy034. [Epub ahead of print]

PMID:
29718310
29.

Comparing standard office-based follow-up with text-based remote monitoring in the management of postpartum hypertension: a randomised clinical trial.

Hirshberg A, Downes K, Srinivas S.

BMJ Qual Saf. 2018 Nov;27(11):871-877. doi: 10.1136/bmjqs-2018-007837. Epub 2018 Apr 27.

PMID:
29703800
30.

Measuring Endothelial Cell Loss on DMEK Grafts After Transplantation in Human Cadaveric Whole Eyes: Description of the Technique and Pilot Study.

Tran KD, Alabi RO, Odell K, Dye PK, Downes K, Sales CS.

Cornea. 2018 Aug;37(8):1075-1080. doi: 10.1097/ICO.0000000000001602.

PMID:
29634671
31.

Postdates induction with an unfavorable cervix and risk of cesarean.

McCoy J, Downes KL, Srinivas SK, Levine LD.

J Matern Fetal Neonatal Med. 2019 Sep;32(17):2874-2878. doi: 10.1080/14767058.2018.1450861. Epub 2018 Mar 21.

PMID:
29562794
32.

Cumulative Endothelial Cell Loss in Descemet Membrane Endothelial Keratoplasty Grafts From Preparation Through Insertion With Glass Injectors.

Downes K, Tran KD, Stoeger CG, Chamberlain W.

Cornea. 2018 Jun;37(6):698-704. doi: 10.1097/ICO.0000000000001588.

PMID:
29561351
33.

The Cost of Vancomycin and Piperacillin/Tazobactam Treatment-Reply.

Downes KJ, Laskin BL, Fisher BT.

JAMA Pediatr. 2018 May 1;172(5):494-495. doi: 10.1001/jamapediatrics.2018.0038. No abstract available.

PMID:
29507935
34.

A validated calculator to estimate risk of cesarean after an induction of labor with an unfavorable cervix.

Levine LD, Downes KL, Parry S, Elovitz MA, Sammel MD, Srinivas SK.

Am J Obstet Gynecol. 2018 Feb;218(2):254.e1-254.e7. doi: 10.1016/j.ajog.2017.11.603. Epub 2017 Dec 7. Erratum in: Am J Obstet Gynecol. 2018 May 22;:.

35.

Predicting persistent impaired glucose tolerance in patients with gestational diabetes: The role of high sensitivity CRP and adiponectin.

Durnwald CP, Downes K, Leite R, Elovitz M, Parry S.

Diabetes Metab Res Rev. 2018 Feb;34(2). doi: 10.1002/dmrr.2958. Epub 2017 Dec 7.

PMID:
29078256
36.

Life-history strategies of the rock hind grouper Epinephelus adscensionis at Ascension Island.

Nolan ET, Downes KJ, Richardson A, Arkhipkin A, Brickle P, Brown J, Mrowicki RJ, Shcherbich Z, Weber N, Weber SB.

J Fish Biol. 2017 Dec;91(6):1549-1568. doi: 10.1111/jfb.13410. Epub 2017 Oct 25.

PMID:
29068043
37.

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Patel D, Rorbach J, Downes K, Szukszto MJ, Pekalski ML, Minczuk M.

Sci Rep. 2017 Oct 10;7(1):12886. doi: 10.1038/s41598-017-13227-0.

38.

Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children.

Downes KJ, Cowden C, Laskin BL, Huang YS, Gong W, Bryan M, Fisher BT, Goldstein SL, Zaoutis TE.

JAMA Pediatr. 2017 Dec 4;171(12):e173219. doi: 10.1001/jamapediatrics.2017.3219. Epub 2017 Dec 4.

39.

Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Burren OS, Rubio García A, Javierre BM, Rainbow DB, Cairns J, Cooper NJ, Lambourne JJ, Schofield E, Castro Dopico X, Ferreira RC, Coulson R, Burden F, Rowlston SP, Downes K, Wingett SW, Frontini M, Ouwehand WH, Fraser P, Spivakov M, Todd JA, Wicker LS, Cutler AJ, Wallace C.

Genome Biol. 2017 Sep 4;18(1):165. doi: 10.1186/s13059-017-1285-0.

40.

Cephalomedullary Nail Fixation of Intertrochanteric Femur Fractures: Are Two Proximal Screws Better Than One?

Serrano R, Blair JA, Watson DT, Infante AF Jr, Shah AR, Mir HR, Maxson BJ, Downes KL, Sanders RW.

J Orthop Trauma. 2017 Nov;31(11):577-582. doi: 10.1097/BOT.0000000000000967. Erratum in: J Orthop Trauma. 2018 Feb;32(2):e75.

PMID:
28827501
41.

Prophylactic Wound Vacuum Therapy after Cesarean Section to Prevent Wound Complications in the Obese Population: A Randomized Controlled Trial (the ProVac Study).

Ruhstaller K, Downes KL, Chandrasekaran S, Srinivas S, Durnwald C.

Am J Perinatol. 2017 Sep;34(11):1125-1130. doi: 10.1055/s-0037-1604161. Epub 2017 Jul 13. No abstract available.

42.

Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

Petersen R, Lambourne JJ, Javierre BM, Grassi L, Kreuzhuber R, Ruklisa D, Rosa IM, Tomé AR, Elding H, van Geffen JP, Jiang T, Farrow S, Cairns J, Al-Subaie AM, Ashford S, Attwood A, Batista J, Bouman H, Burden F, Choudry FA, Clarke L, Flicek P, Garner SF, Haimel M, Kempster C, Ladopoulos V, Lenaerts AS, Materek PM, McKinney H, Meacham S, Mead D, Nagy M, Penkett CJ, Rendon A, Seyres D, Sun B, Tuna S, van der Weide ME, Wingett SW, Martens JH, Stegle O, Richardson S, Vallier L, Roberts DJ, Freson K, Wernisch L, Stunnenberg HG, Danesh J, Fraser P, Soranzo N, Butterworth AS, Heemskerk JW, Turro E, Spivakov M, Ouwehand WH, Astle WJ, Downes K, Kostadima M, Frontini M.

Nat Commun. 2017 Jul 13;8:16058. doi: 10.1038/ncomms16058.

43.

Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding.

Westbury SK, Canault M, Greene D, Bermejo E, Hanlon K, Lambert MP, Millar CM, Nurden P, Obaji SG, Revel-Vilk S, Van Geet C, Downes K, Papadia S, Tuna S, Watt C; NIHR BioResource–Rare Diseases Consortium, Freson K, Laffan MA, Ouwehand WH, Alessi MC, Turro E, Mumford AD.

Blood. 2017 Aug 24;130(8):1026-1030. doi: 10.1182/blood-2017-03-776773. Epub 2017 Jun 21.

44.

Neonatal Outcomes Associated With Placental Abruption.

Downes KL, Shenassa ED, Grantz KL.

Am J Epidemiol. 2017 Dec 15;186(12):1319-1328. doi: 10.1093/aje/kwx202.

45.

Short Maternal Stature and Increased Risk of Ischaemic Placental Disease: Is the Association Driven by Unmeasured Confounding?

Downes KL, Ananth CV.

Paediatr Perinat Epidemiol. 2017 May;31(3):206-208. doi: 10.1111/ppe.12355. Epub 2017 Apr 7. No abstract available.

PMID:
28387420
46.

Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.

Downes KL, Grantz KL, Shenassa ED.

Am J Perinatol. 2017 Aug;34(10):935-957. doi: 10.1055/s-0037-1599149. Epub 2017 Mar 22. Review.

47.

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T, Grundberg E.

Genome Biol. 2017 Mar 10;18(1):50. doi: 10.1186/s13059-017-1173-7. Erratum in: Genome Biol. 2019 May 7;20(1):89.

48.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

49.

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

Ecker S, Chen L, Pancaldi V, Bagger FO, Fernández JM, Carrillo de Santa Pau E, Juan D, Mann AL, Watt S, Casale FP, Sidiropoulos N, Rapin N, Merkel A; BLUEPRINT Consortium, Stunnenberg HG, Stegle O, Frontini M, Downes K, Pastinen T, Kuijpers TW, Rico D, Valencia A, Beck S, Soranzo N, Paul DS.

Genome Biol. 2017 Jan 26;18(1):18. doi: 10.1186/s13059-017-1156-8.

50.

Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.

Sivapalaratnam S, Westbury SK, Stephens JC, Greene D, Downes K, Kelly AM, Lentaigne C, Astle WJ, Huizinga EG, Nurden P, Papadia S, Peerlinck K, Penkett CJ, Perry DJ, Roughley C, Simeoni I, Stirrups K, Hart DP, Tait RC, Mumford AD; NIHR BioResource, Laffan MA, Freson K, Ouwehand WH, Kunishima S, Turro E.

Blood. 2017 Jan 26;129(4):520-524. doi: 10.1182/blood-2016-08-732248. Epub 2016 Nov 14.

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