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Items: 1 to 50 of 83

1.

Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of β-Hemoglobinopathies.

Bhukhai K, de Dreuzy E, Giorgi M, Colomb C, Negre O, Denaro M, Gillet-Legrand B, Cheuzeville J, Paulard A, Trebeden-Negre H, Borwornpinyo S, Sii-Felice K, Maouche L, Down JD, Leboulch P, Payen E.

Mol Ther. 2018 Feb 7;26(2):480-495. doi: 10.1016/j.ymthe.2017.10.015. Epub 2017 Oct 24.

2.

A survey of changing trends in modelling radiation lung injury in mice: bringing out the good, the bad, and the uncertain.

Dabjan MB, Buck CM, Jackson IL, Vujaskovic Z, Marples B, Down JD.

Lab Invest. 2016 Sep;96(9):936-49. doi: 10.1038/labinvest.2016.76. Epub 2016 Aug 1. Review.

3.

Microdosimetric and Biological Effects of Photon Irradiation at Different Energies in Bone Marrow.

Belley MD, Ashcraft KA, Lee CT, Cornwall-Brady MR, Chen JJ, Gunasingha R, Burkhart M, Dewhirst M, Yoshizumi TT, Down JD.

Radiat Res. 2015 Oct;184(4):378-91. doi: 10.1667/RR14095.1. Epub 2015 Sep 24.

PMID:
26401594
4.

Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER.

J Radiat Res. 2015 Mar;56(2):248-60. doi: 10.1093/jrr/rru095. Epub 2014 Nov 3.

5.

Characterization of the dose response relationship for lung injury following acute radiation exposure in three well-established murine strains: developing an interspecies bridge to link animal models with human lung.

Jackson IL, Xu PT, Nguyen G, Down JD, Johnson CS, Katz BP, Hadley CC, Vujaskovic Z.

Health Phys. 2014 Jan;106(1):48-55. doi: 10.1097/HP.0b013e3182a32ccf.

PMID:
24276549
6.

Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates?

Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z.

Radiat Res. 2013 Aug;180(2):216-21. doi: 10.1667/RR3245.1. Epub 2013 Jul 2.

7.

A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule.

Jackson IL, Xu P, Hadley C, Katz BP, McGurk R, Down JD, Vujaskovic Z.

Health Phys. 2012 Oct;103(4):463-73.

8.

Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.

Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, Brady T, Fusil F, Gillet-Legrand B, Hehir K, Beuzard Y, Leboulch P, Down JD, Payen E, Bushman FD.

Mol Ther. 2011 Jul;19(7):1273-86. doi: 10.1038/mt.2011.20. Epub 2011 Mar 8.

10.

The spleen as a site for hematopoiesis.

Dor FJ, Ramirez ML, Down JD, Cooper DK.

Transplantation. 2010 Nov 15;90(9):1040-1; author reply 1041-2. doi: 10.1097/TP.0b013e3181ef8a7b. No abstract available.

PMID:
21037464
11.
12.
13.

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.

Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5431-6. Epub 2007 Mar 20.

14.

Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human.

Dor FJ, Ramirez ML, Parmar K, Altman EL, Huang CA, Down JD, Cooper DK.

Exp Hematol. 2006 Nov;34(11):1573-82.

PMID:
17046577
15.

Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model.

Ploemacher RE, Johnson KW, Rombouts EJ, Etienne K, Westerhof GR, Baumgart J, White-Scharf ME, Down JD.

Biol Blood Marrow Transplant. 2004 Apr;10(4):236-45.

16.

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning.

Kim YM, Mapara MY, Down JD, Johnson KW, Boisgerault F, Akiyama Y, Benichou G, Pelot M, Zhao G, Sykes M.

Blood. 2004 Jan 15;103(2):732-9. Epub 2003 Sep 25.

PMID:
14512313
17.

Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine.

Lima B, Gleit ZL, Cameron AM, Germana S, Murphy MC, Consorti R, Chang Q, Down JD, LeGuern C, Sachs DH, Huang CA.

Biol Blood Marrow Transplant. 2003 Sep;9(9):571-82.

18.

Stem cell activity of porcine c-kit+ hematopoietic cells.

Le Guern AC, Giovino MA, Abe M, Theodore PR, Qi J, Down JD, Sachs DH, Sykes M, Yang YG.

Exp Hematol. 2003 Sep;31(9):833-40.

PMID:
12962730
19.

Engraftment of retroviral EGFP-transduced bone marrow in mice prevents rejection of EGFP-transgenic skin grafts.

Andersson G, Denaro M, Johnson K, Morgan P, Sullivan A, Houser S, Patience C, White-Scharf ME, Down JD.

Mol Ther. 2003 Sep;8(3):385-91.

20.

Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice.

Andersson G, Illigens BM, Johnson KW, Calderhead D, LeGuern C, Benichou G, White-Scharf ME, Down JD.

Blood. 2003 Jun 1;101(11):4305-12. Epub 2003 Feb 6.

PMID:
12576326
21.

Reprogramming immune responses: enabling cellular therapies and regenerative medicine.

Down JD, White-Scharf ME.

Stem Cells. 2003;21(1):21-32. Review.

22.

Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.

Bühler L, Kurilla-Mahon B, Chang Q, Abraham S, Alwayn IP, Appel JZ 3rd, Newman D, Awwad M, White-Scharf ME, Sackstein R, Sachs DH, Cooper DK, Down JD.

Transplantation. 2002 Oct 27;74(8):1159-66.

PMID:
12438964
23.

Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model.

Teranishi K, Alwayn IP, Bühler L, Gollackner B, Knosalla C, Correa L, Down JD, White-Scharf ME, Sachs DH, Duthaler R, Katopodis A, Awwad M, Cooper DK.

Transplant Proc. 2002 Nov;34(7):2757-8. No abstract available.

PMID:
12431597
24.

Use of CD9 expression to enrich for porcine hematopoietic progenitors.

Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA.

Exp Hematol. 2002 Jul;30(7):809-15.

PMID:
12135680
25.

Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies.

Giovino MA, Down JD, Jackson JD, Sykes M, Monroy RL, White-Scharf ME.

Transplantation. 2002 Mar 15;73(5):723-31.

PMID:
11907417
26.

Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides.

Teranishi K, Gollackner B, Bühler L, Knosalla C, Correa L, Down JD, White-Scharf ME, Sachs DH, Awwad M, Cooper DK.

Transplantation. 2002 Jan 15;73(1):129-39.

PMID:
11792992
27.

Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.

Bühler L, Awwad M, Treter S, Chang Q, Basker M, Alwayn IP, Teranishi K, Ericsson T, Moran K, Harper D, Kurilla-Mahon B, Huang CA, Sackstein R, Sykes M, White-Scharf ME, Sachs DH, Down JD, Cooper DK.

Transplantation. 2002 Jan 15;73(1):12-22.

PMID:
11792972
28.

Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy.

Bühler L, Goepfert C, Kitamura H, Basker M, Gojo S, Alwayn IP, Chang Q, Down JD, Tsai H, Wise R, Sachs DH, Cooper DK, Robson SC, Sackstein R.

Bone Marrow Transplant. 2001 Jun;27(12):1227-36.

29.

O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.

Westerhof GR, Down JD, Blokland I, Wood M, Boudewijn A, Watson AJ, McGown AT, Ploemacher RE, Margison GP.

Exp Hematol. 2001 May;29(5):633-8.

PMID:
11376877
30.

Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients.

Westerhof GR, Ploemacher RE, Boudewijn A, Blokland I, Dillingh JH, McGown AT, Hadfield JA, Dawson MJ, Down JD.

Cancer Res. 2000 Oct 1;60(19):5470-8.

31.

Induction of mixed hematopoietic chimerism in the pig-to-baboon model.

Bühler L, Awwad M, Treter S, Basker M, Ericson T, Lachance A, Oldmixon B, Kurilla-Mahon B, Gojo S, Huang C, Thall A, Down JD, White-Scharf ME, Sachs DH, Cooper DK.

Transplant Proc. 2000 Aug;32(5):1101. No abstract available.

PMID:
10936378
32.

A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.

Bühler L, Awwad M, Basker M, Gojo S, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK.

Transplant Proc. 2000 Aug;32(5):1100. No abstract available.

PMID:
10936377
33.

Increases in autologous hematopoietic progenitors in the blood of baboons following irradiation and treatment with porcine stem cell factor and interleukin-3.

Down JD, Awwad M, Kurilla-Mahon B, Moran K, Ericsson T, Oldmixon B, Lachance A, Watts A, Treter S, Nash K, Gojo S, Sachs DH, White-Scharf ME, Cooper DK.

Transplant Proc. 2000 Aug;32(5):1045-6. No abstract available.

PMID:
10936345
34.

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.

Bühler L, Awwad M, Basker M, Gojo S, Watts A, Treter S, Nash K, Oravec G, Chang Q, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK.

Transplantation. 2000 Jun 15;69(11):2296-304.

PMID:
10868629
35.

Peripheral blood progenitor cell mobilization and leukapheresis in pigs.

Nash K, Chang Q, Watts A, Treter S, Oravec G, Ferrara V, Buhler L, Basker M, Gojo S, Sachs DH, White-Scharf M, Down JD, Cooper DK.

Lab Anim Sci. 1999 Dec;49(6):645-9.

PMID:
10638501
36.

Maintaining high levels of syngeneic bone marrow engraftment while omitting cyclophosphamide in busulfan-containing conditioning regimens.

Robbin Westerhof G, Ploemacher RE, Down JD.

Blood. 1998 Aug 15;92(4):1462-3. No abstract available.

PMID:
9694742
37.

Radiological and functional assessment of radiation-induced lung injury in the rat.

Vujaskovic Z, Down JD, van t' Veld AA, Mooyaart EL, Meertens H, Piers DA, Szabo BG, Konings AW.

Exp Lung Res. 1998 Mar-Apr;24(2):137-48.

PMID:
9555572
38.

Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice.

Down JD, Westerhof GR, Boudewijn A, Setroikromo R, Ploemacher RE.

Bone Marrow Transplant. 1998 Feb;21(4):327-30.

39.

Plasma TGFbeta level in rats after hemithoracic irradiation.

Vujaskovic Z, Down JD, van Waarde MA, van Assen AJ, Szabo BG, Konings AW.

Radiother Oncol. 1997 Jul;44(1):41-3.

PMID:
9288856
40.

Increased rejection of murine allogeneic bone marrow in presensitized recipients.

van Os R, de Witte T, Dillingh JH, Mauch PM, Down JD.

Leukemia. 1997 Jul;11(7):1045-8.

42.

RBE of fast neutrons for apoptosis in mouse thymocytes.

Warenius HM, Down JD.

Int J Radiat Biol. 1995 Dec;68(6):625-9.

PMID:
8551105
43.

Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation.

Down JD, Boudewijn A, van Os R, Thames HD, Ploemacher RE.

Blood. 1995 Jul 1;86(1):122-7.

PMID:
7795217
46.

Radiation sensitivity and heterogeneity of hemopoietic stem cells.

Down JD, Mauch PM.

Int J Radiat Oncol Biol Phys. 1994 Apr 30;29(1):218-9. No abstract available.

PMID:
8175438
47.

Compromising effect of low dose-rate total body irradiation on allogeneic bone marrow engraftment.

van Os R, Konings AW, Down JD.

Int J Radiat Biol. 1993 Dec;64(6):761-70.

PMID:
7903344
48.

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