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Items: 1 to 50 of 67

1.

PTEN Nuclear Functions.

Ho J, Cruise ES, Dowling RJO, Stambolic V.

Cold Spring Harb Perspect Med. 2019 Nov 11. pii: a036079. doi: 10.1101/cshperspect.a036079. [Epub ahead of print]

PMID:
31712221
2.

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy.

Pimentel I, Lohmann AE, Ennis M, Dowling RJO, Cescon D, Elser C, Potvin KR, Haq R, Hamm C, Chang MC, Stambolic V, Goodwin PJ.

Breast. 2019 Dec;48:17-23. doi: 10.1016/j.breast.2019.08.003. Epub 2019 Aug 22.

PMID:
31472446
3.

Response to Late-Window Endovascular Revascularization Is Associated With Collateral Status in Basilar Artery Occlusion.

Alemseged F, Van der Hoeven E, Di Giuliano F, Shah D, Sallustio F, Arba F, Kleinig TJ, Bush S, Dowling RJ, Yan B, Sharma G, Limbucci N, Floris R, Donnan GA, Puetz V, Diomedi M, Parsons MW, Mitchell PJ, Davis SM, Yassi N, Schonewille WJ, Campbell BCV; Basilar Artery Treatment and Management (BATMAN) Collaboration * ; Basilar Artery Treatment and Management (BATMAN) collaborators.

Stroke. 2019 May 16:STROKEAHA118023361. doi: 10.1161/STROKEAHA.118.023361. [Epub ahead of print]

PMID:
31092168
4.

Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study.

Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML.

Clin Cancer Res. 2019 Sep 1;25(17):5398-5406. doi: 10.1158/1078-0432.CCR-18-3143. Epub 2019 Apr 24.

PMID:
31018921
5.

Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke.

Boers AMM, Jansen IGH, Brown S, Lingsma HF, Beenen LFM, Devlin TG, Román LS, Heo JH, Ribó M, Almekhlafi MA, Liebeskind DS, Teitelbaum J, Cuadras P, du Mesnil de Rochemont R, Beaumont M, Brown MM, Yoo AJ, Donnan GA, Mas JL, Oppenheim C, Dowling RJ, Moulin T, Agrinier N, Lopes DK, Aja Rodríguez L, Compagne KCJ, Al-Ajlan FS, Madigan J, Albers GW, Soize S, Blasco J, Davis SM, Nogueira RG, Dávalos A, Menon BK, van der Lugt A, Muir KW, Roos YBWEM, White P, Mitchell PJ, Demchuk AM, van Zwam WH, Jovin TG, van Oostenbrugge RJ, Dippel DWJ, Campbell BCV, Guillemin F, Bracard S, Hill MD, Goyal M, Marquering HA, Majoie CBLM.

JAMA Neurol. 2019 Feb 1;76(2):194-202. doi: 10.1001/jamaneurol.2018.3661.

PMID:
30615038
6.

Association of Metabolic, Inflammatory, and Tumor Markers With Circulating Tumor Cells in Metastatic Breast Cancer.

Lohmann AE, Dowling RJO, Ennis M, Amir E, Elser C, Brezden-Masley C, Vandenberg T, Lee E, Fazaee K, Stambolic V, Goodwin PJ, Chang MC.

JNCI Cancer Spectr. 2018 Apr;2(2):pky028. doi: 10.1093/jncics/pky028. Epub 2018 Jul 12.

7.

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke.

Campbell BCV, Mitchell PJ, Churilov L, Yassi N, Kleinig TJ, Dowling RJ, Yan B, Bush SJ, Dewey HM, Thijs V, Scroop R, Simpson M, Brooks M, Asadi H, Wu TY, Shah DG, Wijeratne T, Ang T, Miteff F, Levi CR, Rodrigues E, Zhao H, Salvaris P, Garcia-Esperon C, Bailey P, Rice H, de Villiers L, Brown H, Redmond K, Leggett D, Fink JN, Collecutt W, Wong AA, Muller C, Coulthard A, Mitchell K, Clouston J, Mahady K, Field D, Ma H, Phan TG, Chong W, Chandra RV, Slater LA, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Bladin CF, Sharma G, Desmond PM, Parsons MW, Donnan GA, Davis SM; EXTEND-IA TNK Investigators.

N Engl J Med. 2018 Apr 26;378(17):1573-1582. doi: 10.1056/NEJMoa1716405.

8.

Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials.

Boers AMM, Jansen IGH, Beenen LFM, Devlin TG, San Roman L, Heo JH, Ribó M, Brown S, Almekhlafi MA, Liebeskind DS, Teitelbaum J, Lingsma HF, van Zwam WH, Cuadras P, du Mesnil de Rochemont R, Beaumont M, Brown MM, Yoo AJ, van Oostenbrugge RJ, Menon BK, Donnan GA, Mas JL, Roos YBWEM, Oppenheim C, van der Lugt A, Dowling RJ, Hill MD, Davalos A, Moulin T, Agrinier N, Demchuk AM, Lopes DK, Aja Rodríguez L, Dippel DWJ, Campbell BCV, Mitchell PJ, Al-Ajlan FS, Jovin TG, Madigan J, Albers GW, Soize S, Guillemin F, Reddy VK, Bracard S, Blasco J, Muir KW, Nogueira RG, White PM, Goyal M, Davis SM, Marquering HA, Majoie CBLM.

J Neurointerv Surg. 2018 Dec;10(12):1137-1142. doi: 10.1136/neurintsurg-2017-013724. Epub 2018 Apr 7.

PMID:
29627794
9.

Endovascular Thrombectomy for Ischemic Stroke Increases Disability-Free Survival, Quality of Life, and Life Expectancy and Reduces Cost.

Campbell BCV, Mitchell PJ, Churilov L, Keshtkaran M, Hong KS, Kleinig TJ, Dewey HM, Yassi N, Yan B, Dowling RJ, Parsons MW, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Rice H, de Villiers L, Ma H, Desmond PM, Meretoja A, Cadilhac DA, Donnan GA, Davis SM; EXTEND-IA Investigators.

Front Neurol. 2017 Dec 14;8:657. doi: 10.3389/fneur.2017.00657. eCollection 2017.

10.

Association between hemorrhagic transformation after endovascular therapy and poststroke seizures.

Thevathasan A, Naylor J, Churilov L, Mitchell PJ, Dowling RJ, Yan B, Kwan P.

Epilepsia. 2018 Feb;59(2):403-409. doi: 10.1111/epi.13982. Epub 2017 Dec 30.

11.

Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion.

Alemseged F, Shah DG, Bivard A, Kleinig TJ, Yassi N, Diomedi M, Di Giuliano F, Sharma G, Drew R, Yan B, Dowling RJ, Bush S, Sallustio F, Caltagirone C, Mercuri NB, Floris R, Parsons MW, Levi CR, Mitchell PJ, Davis SM, Campbell BC.

Int J Stroke. 2019 Jul;14(5):540-547. doi: 10.1177/1747493017744465. Epub 2017 Nov 21.

PMID:
29160168
12.

Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study.

Campbell BC, Mitchell PJ, Churilov L, Yassi N, Kleinig TJ, Yan B, Dowling RJ, Bush SJ, Dewey HM, Thijs V, Simpson M, Brooks M, Asadi H, Wu TY, Shah DG, Wijeratne T, Ang T, Miteff F, Levi C, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Bailey P, Rice H, de Villiers L, Scroop R, Collecutt W, Wong AA, Coulthard A, Barber PA, McGuinness B, Field D, Ma H, Chong W, Chandra RV, Bladin CF, Brown H, Redmond K, Leggett D, Cloud G, Madan A, Mahant N, O'Brien B, Worthington J, Parker G, Desmond PM, Parsons MW, Donnan GA, Davis SM; EXTEND-IA TNK Investigators.

Int J Stroke. 2018 Apr;13(3):328-334. doi: 10.1177/1747493017733935. Epub 2017 Sep 27.

PMID:
28952914
13.

The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion.

Alemseged F, Shah DG, Diomedi M, Sallustio F, Bivard A, Sharma G, Mitchell PJ, Dowling RJ, Bush S, Yan B, Caltagirone C, Floris R, Parsons MW, Levi CR, Davis SM, Campbell BC.

Stroke. 2017 Mar;48(3):631-637. doi: 10.1161/STROKEAHA.116.015492. Epub 2017 Feb 22.

PMID:
28228577
14.

Association of Obesity-Related Metabolic Disruptions With Cancer Risk and Outcome.

Lohmann AE, Goodwin PJ, Chlebowski RT, Pan K, Stambolic V, Dowling RJ.

J Clin Oncol. 2016 Dec 10;34(35):4249-4255. Epub 2016 Nov 7. Review.

PMID:
27903146
15.

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

Dowling RJ, Lam S, Bassi C, Mouaaz S, Aman A, Kiyota T, Al-Awar R, Goodwin PJ, Stambolic V.

Cell Metab. 2016 Apr 12;23(4):567-8. doi: 10.1016/j.cmet.2016.03.006. No abstract available.

16.

Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy.

Lin M, Todaro M, Chan J, Churilov L, Zhu WS, Ramdave S, Mitchell PJ, Dowling RJ, Kwan P, Yan B.

AJNR Am J Neuroradiol. 2016 Jan;37(1):108-13. doi: 10.3174/ajnr.A4481. Epub 2015 Sep 3.

17.

Endovascular Therapy Proven for Stroke – Finally!

Campbell BC, Mitchell PJ, Dowling RJ, Yan B, Donnan GA, Davis SM.

Heart Lung Circ. 2015 Aug;24(8):733-5. doi: 10.1016/j.hlc.2015.04.001. Epub 2015 Apr 21.

PMID:
25939723
18.

Every 15-min delay in recanalization by intra-arterial therapy in acute ischemic stroke increases risk of poor outcome.

He AH, Churilov L, Mitchell PJ, Dowling RJ, Yan B.

Int J Stroke. 2015 Oct;10(7):1062-7. doi: 10.1111/ijs.12495. Epub 2015 Apr 28.

PMID:
25918863
19.

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study.

Dowling RJ, Niraula S, Chang MC, Done SJ, Ennis M, McCready DR, Leong WL, Escallon JM, Reedijk M, Goodwin PJ, Stambolic V.

Breast Cancer Res. 2015 Mar 3;17:32. doi: 10.1186/s13058-015-0540-0.

20.

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial.

Hadad SM, Coates P, Jordan LB, Dowling RJ, Chang MC, Done SJ, Purdie CA, Goodwin PJ, Stambolic V, Moulder-Thompson S, Thompson AM.

Breast Cancer Res Treat. 2015 Feb;150(1):149-55. doi: 10.1007/s10549-015-3307-5. Epub 2015 Feb 15.

PMID:
25682077
21.

Endovascular therapy for ischemic stroke with perfusion-imaging selection.

Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM; EXTEND-IA Investigators.

N Engl J Med. 2015 Mar 12;372(11):1009-18. doi: 10.1056/NEJMoa1414792. Epub 2015 Feb 11.

22.

Intracranial aneurysms with perianeurysmal edema: long-term outcomes post-endovascular treatment.

Sim KJ, Yan B, Dowling RJ, Mitchell PJ.

J Neuroradiol. 2015 Apr;42(2):72-9. doi: 10.1016/j.neurad.2014.05.001. Epub 2014 Jun 23.

PMID:
24970462
23.

Picture-to-puncture time in acute stroke endovascular intervention: are we getting faster?

van Heerden J, Yan B, Churilov L, Dowling RJ, Mitchell PJ.

J Neurointerv Surg. 2015 Aug;7(8):564-8. doi: 10.1136/neurintsurg-2014-011177. Epub 2014 Jun 26.

PMID:
24968880
24.

Efficacy, complications and clinical outcome of endovascular treatment for intracranial intradural arterial dissections.

So TY, Mitchell PJ, Dowling RJ, Yan B.

Clin Neurol Neurosurg. 2014 Feb;117:6-11. doi: 10.1016/j.clineuro.2013.11.015. Epub 2013 Dec 1.

PMID:
24438797
25.

A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA).

Campbell BC, Mitchell PJ, Yan B, Parsons MW, Christensen S, Churilov L, Dowling RJ, Dewey H, Brooks M, Miteff F, Levi C, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Kleinig T, Scroop R, Chryssidis S, Barber A, Hope A, Moriarty M, McGuinness B, Wong AA, Coulthard A, Wijeratne T, Lee A, Jannes J, Leyden J, Phan TG, Chong W, Holt ME, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM; EXTEND-IA investigators.

Int J Stroke. 2014 Jan;9(1):126-32. doi: 10.1111/ijs.12206. Epub 2013 Nov 10.

PMID:
24207098
26.

Can CT angiography rule out aneurysmal subarachnoid haemorrhage in CT scan-negative subarachnoid haemorrhage patients?

Lim LK, Dowling RJ, Yan B, Mitchell PJ.

J Clin Neurosci. 2014 Jan;21(1):191-3. doi: 10.1016/j.jocn.2013.03.020. Epub 2013 Aug 15.

PMID:
23954458
27.

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.

Bassi C, Ho J, Srikumar T, Dowling RJ, Gorrini C, Miller SJ, Mak TW, Neel BG, Raught B, Stambolic V.

Science. 2013 Jul 26;341(6144):395-9. doi: 10.1126/science.1236188. Erratum in: Science. 2013 Sep 6;341(6150):1064.

28.

Current status of pipeline embolization device in the treatment of intracranial aneurysms: a review.

Tse MM, Yan B, Dowling RJ, Mitchell PJ.

World Neurosurg. 2013 Dec;80(6):829-35. doi: 10.1016/j.wneu.2012.09.023. Epub 2012 Oct 3. Review.

PMID:
23041067
29.

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.

Niraula S, Dowling RJ, Ennis M, Chang MC, Done SJ, Hood N, Escallon J, Leong WL, McCready DR, Reedijk M, Stambolic V, Goodwin PJ.

Breast Cancer Res Treat. 2012 Oct;135(3):821-30. doi: 10.1007/s10549-012-2223-1. Epub 2012 Aug 30.

PMID:
22933030
30.

Imaging predictors of clinical deterioration in cerebral venous thrombosis.

Yii IY, Mitchell PJ, Dowling RJ, Yan B.

J Clin Neurosci. 2012 Nov;19(11):1525-9. doi: 10.1016/j.jocn.2012.02.005. Epub 2012 Jul 15.

PMID:
22796274
31.

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I, Furic L, Dowling RJO, Sylvestre A, Rong L, Colina R, Costa-Mattioli M, Fritz JH, Olivier M, Brown E, Mohr I, Sonenberg N.

Nat Immunol. 2012 Apr 29;13(6):543-550. doi: 10.1038/ni.2291.

32.

Antiplatelet resistance and thromboembolic complications in neurointerventional procedures.

Oxley TJ, Dowling RJ, Mitchell PJ, Davis S, Yan B.

Front Neurol. 2011 Dec 26;2:83. doi: 10.3389/fneur.2011.00083. eCollection 2011.

33.

Metformin in cancer: translational challenges.

Dowling RJ, Niraula S, Stambolic V, Goodwin PJ.

J Mol Endocrinol. 2012 Mar 29;48(3):R31-43. doi: 10.1530/JME-12-0007. Print 2012 Jun. Review.

PMID:
22355097
34.

A single centre study of coil embolization of intracranial aneurysms comparing bare platinum and PGLA-coated coils.

Bose RS, Dowling RJ, Yan B, Mitchell PJ.

J Clin Neurosci. 2012 Feb;19(2):271-6. doi: 10.1016/j.jocn.2011.08.006. Epub 2012 Jan 18.

PMID:
22260957
35.

Does treatment of ruptured intracranial aneurysms within 24 hours improve clinical outcome?

Phillips TJ, Dowling RJ, Yan B, Laidlaw JD, Mitchell PJ.

Stroke. 2011 Jul;42(7):1936-45. doi: 10.1161/STROKEAHA.110.602888. Epub 2011 Jun 16. Erratum in: Stroke. 2011 Nov;42(11):e631.

PMID:
21680909
36.

Understanding the benefit of metformin use in cancer treatment.

Dowling RJ, Goodwin PJ, Stambolic V.

BMC Med. 2011 Apr 6;9:33. doi: 10.1186/1741-7015-9-33. Review.

37.

Glasgow coma scale does not predict outcome post-intra-arterial treatment for basilar artery thrombosis.

Chandra RV, Law CP, Yan B, Dowling RJ, Mitchell PJ.

AJNR Am J Neuroradiol. 2011 Mar;32(3):576-80. doi: 10.3174/ajnr.A2325. Epub 2011 Feb 24.

38.

Bone subtraction CT angiography for the detection of intracranial aneurysms.

Ramasundara S, Mitchell PJ, Dowling RJ.

J Med Imaging Radiat Oncol. 2010 Dec;54(6):526-33. doi: 10.1111/j.1754-9485.2010.02211.x.

PMID:
21199429
39.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N.

Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532.

40.

A collection of caged compounds for probing roles of local translation in neurobiology.

Sadovski O, Jaikaran AS, Samanta S, Fabian MR, Dowling RJ, Sonenberg N, Woolley GA.

Bioorg Med Chem. 2010 Nov 15;18(22):7746-52. doi: 10.1016/j.bmc.2010.04.005. Epub 2010 Apr 7.

41.

Dissecting the role of mTOR: lessons from mTOR inhibitors.

Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N.

Biochim Biophys Acta. 2010 Mar;1804(3):433-9. doi: 10.1016/j.bbapap.2009.12.001. Epub 2009 Dec 11. Review.

PMID:
20005306
42.

p53-dependent translational control of senescence and transformation via 4E-BPs.

Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M, Costa-Mattioli M, Teodoro JG, Sonenberg N.

Cancer Cell. 2009 Nov 6;16(5):439-46. doi: 10.1016/j.ccr.2009.09.025.

43.

Current status and challenges associated with targeting mTOR for cancer therapy.

Dowling RJ, Pollak M, Sonenberg N.

BioDrugs. 2009;23(2):77-91. doi: 10.2165/00063030-200923020-00002. Review.

PMID:
19489650
44.
45.

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.

Zakikhani M, Dowling RJ, Sonenberg N, Pollak MN.

Cancer Prev Res (Phila). 2008 Oct;1(5):369-75. doi: 10.1158/1940-6207.CAPR-08-0081. Erratum in: Cancer Prev Res (Phila Pa). 2009 Jan;2(1):95.

46.

Translational control of the innate immune response through IRF-7.

Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N.

Nature. 2008 Mar 20;452(7185):323-8. doi: 10.1038/nature06730. Epub 2008 Feb 13.

PMID:
18272964
47.

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N.

Cancer Res. 2007 Nov 15;67(22):10804-12.

48.

Rational approach to diagnosis and management of blunt scrotal trauma.

Chandra RV, Dowling RJ, Ulubasoglu M, Haxhimolla H, Costello AJ.

Urology. 2007 Aug;70(2):230-4.

PMID:
17826476
49.

Iliocaval arteriovenous fistula presenting with multiple organ failure.

Lim RP, Stella DL, Dowling RJ, Campbell WA, Hebbard GS.

Australas Radiol. 2006 Aug;50(4):381-5.

PMID:
16884429
50.

Unusual presentation of perirenal lung metastases.

D'Souza DL, Heinze SB, Dowling RJ.

Australas Radiol. 2006 Jun;50(3):246-8.

PMID:
16732823

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