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Items: 1 to 50 of 248

1.

Concluding remarks on the Lasker/IRRF initiative on amblyopia.

Dowling JE.

Vis Neurosci. 2018 Jan;35:E019. doi: 10.1017/S0952523817000268. Review. No abstract available.

PMID:
29905120
2.

Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.

Gingipalli L, Block MH, Bao L, Cooke E, Dakin LA, Denz CR, Ferguson AD, Johannes JW, Larsen NA, Lyne PD, Pontz TW, Wang T, Wu X, Wu A, Zhang HJ, Zheng X, Dowling JE, Lamb ML.

Bioorg Med Chem Lett. 2018 May 1;28(8):1336-1341. doi: 10.1016/j.bmcl.2018.03.018. Epub 2018 Mar 7.

PMID:
29559278
3.

Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay.

Shaw J, Leveridge M, Norling C, Karén J, Molina DM, O'Neill D, Dowling JE, Davey P, Cowan S, Dabrowski M, Main M, Gianni D.

Sci Rep. 2018 Jan 9;8(1):163. doi: 10.1038/s41598-017-18650-x.

4.

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.

Scott JS, Degorce SL, Anjum R, Culshaw J, Davies RDM, Davies NL, Dillman KS, Dowling JE, Drew L, Ferguson AD, Groombridge SD, Halsall CT, Hudson JA, Lamont S, Lindsay NA, Marden SK, Mayo MF, Pease JE, Perkins DR, Pink JH, Robb GR, Rosen A, Shen M, McWhirter C, Wu D.

J Med Chem. 2017 Dec 28;60(24):10071-10091. doi: 10.1021/acs.jmedchem.7b01290. Epub 2017 Dec 11.

PMID:
29172502
5.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

PMID:
29144972
6.

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

Mukherjee H, Debreczeni J, Breed J, Tentarelli S, Aquila B, Dowling JE, Whitty A, Grimster NP.

Org Biomol Chem. 2017 Nov 22;15(45):9685-9695. doi: 10.1039/c7ob02028g.

PMID:
29119993
7.

Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.

Casás-Selves M, Zhang AX, Dowling JE, Hallén S, Kawatkar A, Pace NJ, Denz CR, Pontz T, Garahdaghi F, Cao Q, Sabirsh A, Thakur K, O'Connell N, Hu J, Cornella-Taracido I, Weerapana E, Zinda M, Goodnow RA Jr, Castaldi MP.

ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26.

PMID:
28371485
8.

Astrocytes and glaucomatous neurodegeneration.

Tamm ER, Dowling JE.

Exp Eye Res. 2017 Apr;157:1-4. doi: 10.1016/j.exer.2017.02.013. Epub 2017 Mar 8. No abstract available.

PMID:
28284956
9.

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.

McCoull W, Hennessy EJ, Blades K, Chuaqui C, Dowling JE, Ferguson AD, Goldberg FW, Howe N, Jones CR, Kemmitt PD, Lamont G, Varnes JG, Ward RA, Yang B.

ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123. eCollection 2016 Dec 8.

10.

Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.

Dowling JE, Alimzhanov M, Bao L, Chuaqui C, Denz CR, Jenkins E, Larsen NA, Lyne PD, Pontz T, Ye Q, Holdgate GA, Snow L, O'Connell N, Ferguson AD.

ACS Med Chem Lett. 2016 Jan 20;7(3):300-5. doi: 10.1021/acsmedchemlett.5b00452. eCollection 2016 Mar 10.

11.

Restoring Vision to the Blind: Concluding Remarks.

Dowling JE.

Transl Vis Sci Technol. 2014 Dec 30;3(7):11. eCollection 2014 Dec. No abstract available.

12.

Restoring Vision to the Blind: Introduction.

Dowling JE.

Transl Vis Sci Technol. 2014 Dec 30;3(7):2. eCollection 2014 Dec. No abstract available.

13.

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

Yang B, Lamb ML, Zhang T, Hennessy EJ, Grewal G, Sha L, Zambrowski M, Block MH, Dowling JE, Su N, Wu J, Deegan T, Mikule K, Wang W, Kaspera R, Chuaqui C, Chen H.

J Med Chem. 2014 Dec 11;57(23):9958-70. doi: 10.1021/jm501179r. Epub 2014 Dec 2.

PMID:
25458601
14.

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.

Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA, Peng B, Pontz TW, Rivard-Costa C, Saeh JC, Thakur K, Ye Q, Zhang T, Lyne PD.

ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. doi: 10.1021/ml400197u. eCollection 2013 Aug 8.

15.

myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.

Wasfy MM, Matsui JI, Miller J, Dowling JE, Perkins BD.

Exp Eye Res. 2014 May;122:65-76. doi: 10.1016/j.exer.2014.03.007. Epub 2014 Apr 1.

16.

Understanding RPE lipofuscin.

Sparrow JR, Dowling JE, Bok D.

Invest Ophthalmol Vis Sci. 2013 Dec 19;54(13):8325-6. doi: 10.1167/iovs.13-13214. No abstract available.

17.

Olfaction and vision meet in the retina.

Dowling JE.

Neuron. 2013 Jul 10;79(1):1-3. doi: 10.1016/j.neuron.2013.06.024.

18.

The effects of nicotine on cone and rod b-wave responses in larval zebrafish.

Moyano M, Porteros A, Dowling JE.

Vis Neurosci. 2013 Jul;30(4):141-5. doi: 10.1017/S0952523813000187. Epub 2013 Jun 28.

PMID:
23809941
19.

Spotlight on the evolution of vision.

Colley NJ, Dowling JE.

Vis Neurosci. 2013 Mar;30(1-2):1-3. No abstract available.

PMID:
23705139
20.

Early retinoic acid deprivation in developing zebrafish results in microphthalmia.

Le HG, Dowling JE, Cameron DJ.

Vis Neurosci. 2012 Sep;29(4-5):219-28.

21.

Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1α in zebrafish.

Darland T, Mauch JT, Meier EM, Hagan SJ, Dowling JE, Darland DC.

Pharmacol Biochem Behav. 2012 Dec;103(2):157-67. doi: 10.1016/j.pbb.2012.07.017. Epub 2012 Aug 15.

22.

Bipolar cell-photoreceptor connectivity in the zebrafish (Danio rerio) retina.

Li YN, Tsujimura T, Kawamura S, Dowling JE.

J Comp Neurol. 2012 Nov 1;520(16):3786-802. doi: 10.1002/cne.23168.

23.

What can a zebrafish see with only an off-pathway and other fish stories?

Dowling JE.

J Ophthalmic Vis Res. 2012 Jan;7(1):97-9. No abstract available.

24.

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, Wu AJ, Zhang T, Zheng X.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. doi: 10.1016/j.bmcl.2012.05.098. Epub 2012 Jun 6.

PMID:
22727640
25.

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.

Dowling JE, Chuaqui C, Pontz TW, Lyne PD, Larsen NA, Block MH, Chen H, Su N, Wu A, Russell D, Pollard H, Lee JW, Peng B, Thakur K, Ye Q, Zhang T, Brassil P, Racicot V, Bao L, Denz CR, Cooke E.

ACS Med Chem Lett. 2012 Jan 24;3(4):278-83. doi: 10.1021/ml200257n. eCollection 2012 Apr 12.

26.

Cellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas.

Hensley MR, Emran F, Bonilla S, Zhang L, Zhong W, Grosu P, Dowling JE, Leung YF.

BMC Dev Biol. 2011 Jul 14;11:45. doi: 10.1186/1471-213X-11-45.

27.

The bugeye mutant zebrafish exhibits visual deficits that arise with the onset of an enlarged eye phenotype.

Stujenske JM, Dowling JE, Emran F.

Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4200-7. doi: 10.1167/iovs.10-6434.

28.

Larval zebrafish turn off their photoreceptors at night.

Emran F, Dowling JE.

Commun Integr Biol. 2010 Sep;3(5):430-2. doi: 10.4161/cib.3.5.12158.

29.

Zebrafish larvae lose vision at night.

Emran F, Rihel J, Adolph AR, Dowling JE.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6034-9. doi: 10.1073/pnas.0914718107. Epub 2010 Mar 11.

30.

Specificity of the horizontal cell-photoreceptor connections in the zebrafish (Danio rerio) retina.

Li YN, Matsui JI, Dowling JE.

J Comp Neurol. 2009 Oct 10;516(5):442-53. doi: 10.1002/cne.22135.

31.

A behavioral assay to measure responsiveness of zebrafish to changes in light intensities.

Emran F, Rihel J, Dowling JE.

J Vis Exp. 2008 Oct 3;(20). pii: 923. doi: 10.3791/923.

32.

Factorial microarray analysis of zebrafish retinal development.

Leung YF, Ma P, Link BA, Dowling JE.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12909-14. doi: 10.1073/pnas.0806038105. Epub 2008 Aug 27.

33.

Probing pineal-specific gene expression with transgenic zebrafish.

Kojima D, Dowling JE, Fukada Y.

Photochem Photobiol. 2008 Jul-Aug;84(4):1011-5. doi: 10.1111/j.1751-1097.2008.00363.x. Epub 2008 May 6.

34.

Glutamatergic mechanisms in the outer retina of larval zebrafish: analysis of electroretinogram b- and d-waves using a novel preparation.

Wong KY, Gray J, Hayward CJ, Adolph AR, Dowling JE.

Zebrafish. 2004;1(2):121-31. doi: 10.1089/zeb.2004.1.121.

PMID:
18248224
35.

Directional asymmetries in the optokinetic response of larval zebrafish (Danio rerio).

Qian H, Zhu Y, Ramsey DJ, Chappell RL, Dowling JE, Ripps H.

Zebrafish. 2005;2(3):189-96. doi: 10.1089/zeb.2005.2.189.

PMID:
18248193
36.

Gene expression profiling of zebrafish embryonic retina.

Leung YF, Dowling JE.

Zebrafish. 2005;2(4):269-83. doi: 10.1089/zeb.2005.2.269.

PMID:
18248185
37.

Differential expression of duplicated VAL-opsin genes in the developing zebrafish.

Kojima D, Torii M, Fukada Y, Dowling JE.

J Neurochem. 2008 Mar;104(5):1364-71. Epub 2007 Nov 23.

38.

OFF ganglion cells cannot drive the optokinetic reflex in zebrafish.

Emran F, Rihel J, Adolph AR, Wong KY, Kraves S, Dowling JE.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19126-31. Epub 2007 Nov 19.

39.
40.

Zebrafish: a model system for the study of eye genetics.

Fadool JM, Dowling JE.

Prog Retin Eye Res. 2008 Jan;27(1):89-110. Epub 2007 Sep 7. Review.

41.

Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo.

Leung YF, Ma P, Dowling JE.

Invest Ophthalmol Vis Sci. 2007 Feb;48(2):881-90.

42.

Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.

Kiesman WF, Zhao J, Conlon PR, Dowling JE, Petter RC, Lutterodt F, Jin X, Smits G, Fure M, Jayaraj A, Kim J, Sullivan G, Linden J.

J Med Chem. 2006 Nov 30;49(24):7119-31.

PMID:
17125264
43.

Effects of ethanol on photoreceptors and visual function in developing zebrafish.

Matsui JI, Egana AL, Sponholtz TR, Adolph AR, Dowling JE.

Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4589-97.

44.

Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.

Dowling JE, Vessels JT, Haque S, Chang HX, van Vloten K, Kumaravel G, Engber T, Jin X, Phadke D, Wang J, Ayyub E, Petter RC.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4809-13.

PMID:
16153830
45.

dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina.

Perkins BD, Nicholas CS, Baye LM, Link BA, Dowling JE.

Dev Dyn. 2005 Jun;233(2):680-94.

46.
47.

Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina.

Gross JM, Dowling JE.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4371-6. Epub 2005 Mar 8.

48.

Identification of zebrafish insertional mutants with defects in visual system development and function.

Gross JM, Perkins BD, Amsterdam A, Egaña A, Darland T, Matsui JI, Sciascia S, Hopkins N, Dowling JE.

Genetics. 2005 May;170(1):245-61. Epub 2005 Feb 16.

49.

Photoreceptor structure and development: analyses using GFP transgenes.

Perkins BD, Fadool JM, Dowling JE.

Methods Cell Biol. 2004;76:315-31. No abstract available.

PMID:
15602882
50.

Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells.

Wong KY, Cohen ED, Dowling JE.

J Neurophysiol. 2005 Jan;93(1):94-107. Epub 2004 Jun 30.

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