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Items: 35

1.

Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants.

Dowling DJ.

Immunohorizons. 2018 Jul 2;2(6):185-197. doi: 10.4049/immunohorizons.1700063. Review.

PMID:
31022686
2.

Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro.

Queenan AM, Dowling DJ, Cheng WK, Faé K, Fernandez J, Flynn PJ, Joshi S, Brightman SE, Ramirez J, Serroyen J, Wiertsema S, Fortanier A, van den Dobbelsteen G, Levy O, Poolman J.

Vaccine. 2019 Jan 3;37(1):80-89. doi: 10.1016/j.vaccine.2018.11.028. Epub 2018 Nov 23.

PMID:
30478007
3.

Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro.

Speer EM, Diago-Navarro E, Ozog LS, Dowling DJ, Hou W, Raheel M, Fries BC, Levy O.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01462-18. doi: 10.1128/AAC.01462-18. Print 2018 Dec.

4.

Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.

Speer EM, Dowling DJ, Xu J, Ozog LS, Mathew JA, Chander A, Yin D, Levy O.

PLoS One. 2018 May 1;13(5):e0196352. doi: 10.1371/journal.pone.0196352. eCollection 2018.

5.

Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.

Scheid A, Borriello F, Pietrasanta C, Christou H, Diray-Arce J, Pettengill MA, Joshi S, Li N, Bergelson I, Kollmann T, Dowling DJ, Levy O.

Front Immunol. 2018 Jan 24;9:29. doi: 10.3389/fimmu.2018.00029. eCollection 2018.

6.

Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.

Borriello F, Pietrasanta C, Lai JCY, Walsh LM, Sharma P, O'Driscoll DN, Ramirez J, Brightman S, Pugni L, Mosca F, Burkhart DJ, Dowling DJ, Levy O.

Front Immunol. 2017 Dec 12;8:1772. doi: 10.3389/fimmu.2017.01772. eCollection 2017.

7.

TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.

Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O.

JCI Insight. 2017 Mar 23;2(6):e91020. doi: 10.1172/jci.insight.91020.

8.

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.

Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninković J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O.

J Allergy Clin Immunol. 2017 Nov;140(5):1339-1350. doi: 10.1016/j.jaci.2016.12.985. Epub 2017 Mar 23.

9.

Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

Speer EM, Dowling DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O.

Pediatr Res. 2017 May;81(5):806-816. doi: 10.1038/pr.2017.6. Epub 2017 Jan 10.

PMID:
28072760
10.

A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.

Dowling DJ, Sanders H, Cheng WK, Joshi S, Brightman S, Bergelson I, Pietrasanta C, van Haren SD, van Amsterdam S, Fernandez J, van den Dobbelsteen GP, Levy O.

Front Immunol. 2016 Dec 8;7:562. doi: 10.3389/fimmu.2016.00562. eCollection 2016.

11.

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.

van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O.

J Immunol. 2016 Dec 1;197(11):4413-4424. Epub 2016 Oct 28.

12.

Early life immune ontogeny - understanding how we build and sustain immunity to infection.

Dowling DJ.

Perspect Public Health. 2016 Jul;136(4):205-7. doi: 10.1177/1757913916641586. No abstract available.

PMID:
27354502
13.

Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.

Pettengill MA, van Haren SD, Li N, Dowling DJ, Bergelson I, Jans J, Ferwerda G, Levy O.

Innate Immun. 2016 Aug;22(6):433-43. doi: 10.1177/1753425916651985. Epub 2016 Jun 1.

14.

Osteopathic Manipulative Treatment Technique Scores on the COMLEX-USA Level 2-PE: An Analysis of the Skills Assessed.

Smith LL, Xu W, Sandella JM, Dowling DJ.

J Am Osteopath Assoc. 2016 Jun 1;116(6):392-7. doi: 10.7556/jaoa.2016.080.

PMID:
27214776
15.

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

van Haren SD, Ganapathi L, Bergelson I, Dowling DJ, Banks M, Samuels RC, Reed SG, Marshall JD, Levy O.

Cytokine. 2016 Jul;83:99-109. doi: 10.1016/j.cyto.2016.04.001. Epub 2016 Apr 12.

16.

Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.

Oh DY, Dowling DJ, Ahmed S, Choi H, Brightman S, Bergelson I, Berger ST, Sauld JF, Pettengill M, Kho AT, Pollack HJ, Steen H, Levy O.

Mol Cell Proteomics. 2016 Jun;15(6):1877-94. doi: 10.1074/mcp.M115.055541. Epub 2016 Mar 1.

17.

Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox.

Dowling DJ, Levy O.

Pediatr Infect Dis J. 2015 Dec;34(12):1395-8. doi: 10.1097/INF.0000000000000893. Review. No abstract available.

18.

Effect of Table Trainer-to-Student Ratios on Outcome in Student Assessments of Cervical Muscle Energy Techniques.

Snider KT, Dowling DJ, Seffinger MA, Channell MK, Yao SC, Gustowski SM, Johnson JC, Pryor MJ.

J Am Osteopath Assoc. 2015 Sep;115(9):556-64. doi: 10.7556/jaoa.2015.113.

PMID:
26322934
19.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O.

PLoS One. 2015 Aug 14;10(8):e0134640. doi: 10.1371/journal.pone.0134640. eCollection 2015.

20.

The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells.

Palmer CD, Ninković J, Prokopowicz ZM, Mancuso CJ, Marin A, Andrianov AK, Dowling DJ, Levy O.

Biomaterials. 2014 Oct;35(31):8876-8886. doi: 10.1016/j.biomaterials.2014.06.043. Epub 2014 Jul 11.

PMID:
25023392
21.

Ontogeny of early life immunity.

Dowling DJ, Levy O.

Trends Immunol. 2014 Jul;35(7):299-310. doi: 10.1016/j.it.2014.04.007. Epub 2014 May 28. Review.

22.

Consistency of interrater scoring of student performances of osteopathic manipulative treatment on COMLEX-USA Level 2-PE.

Sandella JM, Smith LA, Dowling DJ.

J Am Osteopath Assoc. 2014 Apr;114(4):253-8. doi: 10.7556/jaoa.2014.050.

PMID:
24677464
23.

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O.

PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4.

24.

Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum.

Noone C, Parkinson M, Dowling DJ, Aldridge A, Kirwan P, Molloy SF, Asaolu SO, Holland C, O'Neill SM.

Malar J. 2013 Jan 7;12:5. doi: 10.1186/1475-2875-12-5.

25.

Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40.

Morphew RM, Hamilton CM, Wright HA, Dowling DJ, O'Neill SM, Brophy PM.

Vet Parasitol. 2013 Jan 31;191(3-4):379-85. doi: 10.1016/j.vetpar.2012.08.029. Epub 2012 Sep 11.

26.

Frequency of specific osteopathic manipulative treatment modalities used by candidates while taking COMLEX-USA Level 2-PE.

Langenau EE, Dowling DJ, Dyer C, Roberts WL.

J Am Osteopath Assoc. 2012 Aug;112(8):509-13.

PMID:
22904248
27.

The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.

LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O'Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Pérez Arévalo J, Brophy PM.

PLoS Negl Trop Dis. 2012;6(5):e1666. doi: 10.1371/journal.pntd.0001666. Epub 2012 May 29.

28.

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.

Philbin VJ, Dowling DJ, Gallington LC, Cortés G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O.

J Allergy Clin Immunol. 2012 Jul;130(1):195-204.e9. doi: 10.1016/j.jaci.2012.02.042. Epub 2012 Apr 21.

29.

Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo.

Dowling DJ, Noone CM, Adams PN, Vukman KV, Molloy SF, Forde J, Asaolu S, O'Neill SM.

Int J Parasitol. 2011 Feb;41(2):255-61. doi: 10.1016/j.ijpara.2010.09.007. Epub 2010 Oct 23.

PMID:
20974144
30.

Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.

Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM.

Infect Immun. 2010 Feb;78(2):793-801. doi: 10.1128/IAI.00573-09. Epub 2009 Nov 16.

31.

The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.

Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM.

Infect Immun. 2009 Jun;77(6):2488-98. doi: 10.1128/IAI.00919-08. Epub 2009 Mar 30.

32.

Assessing the ability of medical students to perform osteopathic manipulative treatment techniques.

Boulet JR, Gimpel JR, Dowling DJ, Finley M.

J Am Osteopath Assoc. 2004 May;104(5):203-11.

PMID:
15176519
33.

Yield from colonoscopic screening in people with a strong family history of common colorectal cancer.

Dowling DJ, St John DJ, Macrae FA, Hopper JL.

J Gastroenterol Hepatol. 2000 Aug;15(8):939-44.

PMID:
11022837
34.

Progressive inhibition of neuromuscular structures (PINS) technique.

Dowling DJ.

J Am Osteopath Assoc. 2000 May;100(5):285-6, 289-98.

PMID:
10850014
35.

Artificial liver support in acute liver failure.

Dowling DJ, Mutimer DJ.

Eur J Gastroenterol Hepatol. 1999 Sep;11(9):991-6. Review.

PMID:
10503835

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