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Items: 1 to 50 of 177

1.

FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.

Toh WH, Louber J, Mahmoud IS, Chia J, Bass GT, Dower SK, Verhagen AM, Gleeson PA.

J Cell Sci. 2019 Aug 23. pii: jcs.235416. doi: 10.1242/jcs.235416. [Epub ahead of print]

PMID:
31444284
2.

Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway.

Chia J, Louber J, Glauser I, Taylor S, Bass GT, Dower SK, Gleeson PA, Verhagen AM.

J Biol Chem. 2018 Apr 27;293(17):6363-6373. doi: 10.1074/jbc.M117.817064. Epub 2018 Mar 9.

3.

Signal dependent transport of a membrane cargo from early endosomes to recycling endosomes.

Mahmoud IS, Louber J, Dower SK, Verhagen AM, Gleeson PA.

Eur J Cell Biol. 2017 Aug;96(5):418-431. doi: 10.1016/j.ejcb.2017.06.005. Epub 2017 Jun 17.

PMID:
28684042
4.

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways.

Guan H, Shuaib A, Leon DD, Angyal A, Salazar M, Velasco G, Holcombe M, Dower SK, Kiss-Toth E.

Sci Rep. 2016 Sep 7;6:32667. doi: 10.1038/srep32667.

5.

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells.

de Graaf CA, Choi J, Baldwin TM, Bolden JE, Fairfax KA, Robinson AJ, Biben C, Morgan C, Ramsay K, Ng AP, Kauppi M, Kruse EA, Sargeant TJ, Seidenman N, D'Amico A, D'Ombrain MC, Lucas EC, Koernig S, Baz Morelli A, Wilson MJ, Dower SK, Williams B, Heazlewood SY, Hu Y, Nilsson SK, Wu L, Smyth GK, Alexander WS, Hilton DJ.

Stem Cell Reports. 2016 Sep 13;7(3):571-582. doi: 10.1016/j.stemcr.2016.07.007. Epub 2016 Aug 4.

6.

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.

Ward JR, Francis SE, Marsden L, Suddason T, Lord GM, Dower SK, Crossman DC, Sabroe I.

Immunology. 2009 Sep;128(1):58-68. doi: 10.1111/j.1365-2567.2009.03071.x.

7.

Tribbles-2 is a novel regulator of inflammatory activation of monocytes.

Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK, Francis SE, Crossman DC, Kiss-Toth E.

Int Immunol. 2008 Dec;20(12):1543-50. doi: 10.1093/intimm/dxn116. Epub 2008 Oct 24.

8.

Pathological networking: a new approach to understanding COPD.

Sabroe I, Parker LC, Calverley PM, Dower SK, Whyte MK.

Postgrad Med J. 2008 May;84(991):259-64. doi: 10.1136/thx.2007.077768.

PMID:
18508983
9.

Fluorescent protein reporter systems for single-cell measurements.

Dower SK, Qwarnstrom EE, Kiss-Toth E.

Methods Mol Biol. 2007;411:111-9. doi: 10.1007/978-1-59745-549-7_8.

PMID:
18287641
10.

The role of TLR activation in inflammation.

Sabroe I, Parker LC, Dower SK, Whyte MK.

J Pathol. 2008 Jan;214(2):126-35. Review.

PMID:
18161748
11.

Analysis of innate immune signal transduction with autocatalytic expression vectors.

Guan H, Kiss-Toth E, Dower SK.

J Immunol Methods. 2008 Jan 31;330(1-2):96-108. Epub 2007 Dec 7.

PMID:
18155720
12.

Practical and conceptual models of chronic obstructive pulmonary disease.

Sabroe I, Parker LC, Dower SK, Whyte MK.

Proc Am Thorac Soc. 2007 Dec;4(8):606-10. Review.

PMID:
18073391
13.

Pathological networking: a new approach to understanding COPD.

Sabroe I, Parker LC, Calverley PM, Dower SK, Whyte MK.

Thorax. 2007 Aug;62(8):733-8. Review.

14.

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.

Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE, Crossman DC, Kiss-Toth E.

J Biol Chem. 2007 Jun 22;282(25):18379-87. Epub 2007 Apr 23.

15.

Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins.

Guan H, Holland K, Qwarnstrom E, Dower SK, Kiss-Toth E.

Cell Immunol. 2006 Dec;244(2):158-61. Epub 2007 Apr 9.

PMID:
17416355
16.

P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.

Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC.

Br J Pharmacol. 2007 May;151(1):115-27. Epub 2007 Mar 12.

17.

Identifying and hurdling obstacles to translational research.

Sabroe I, Dockrell DH, Vogel SN, Renshaw SA, Whyte MK, Dower SK.

Nat Rev Immunol. 2007 Jan;7(1):77-82. Review.

PMID:
17186032
18.

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK, Whyte MK.

Am J Respir Crit Care Med. 2007 Feb 15;175(4):306-11. Epub 2006 Nov 30. Review.

PMID:
17138954
19.

Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics.

Moore LJ, Gilbey AM, Dowson CG, Pridmore AC, Dower SK, Read RC.

J Antimicrob Chemother. 2007 Jan;59(1):35-42. Epub 2006 Oct 31.

PMID:
17079241
20.

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

Morris GE, Parker LC, Ward JR, Jones EC, Whyte MK, Brightling CE, Bradding P, Dower SK, Sabroe I.

FASEB J. 2006 Oct;20(12):2153-5. Epub 2006 Aug 25.

PMID:
16935934
21.

Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway.

Evans I, Dower SK, Francis SE, Crossman DC, Wilson HL.

Cytokine. 2006 Mar 7;33(5):274-80. Epub 2006 Mar 27.

PMID:
16564702
22.

Potentiation of TLR4 signalling by plasmin activity.

Ward JR, Dower SK, Whyte MK, Buttle DJ, Sabroe I.

Biochem Biophys Res Commun. 2006 Mar 10;341(2):299-303. Epub 2006 Jan 10.

PMID:
16413499
23.

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor.

Ward JR, Bingle L, Judge HM, Brown SB, Storey RF, Whyte MK, Dower SK, Buttle DJ, Sabroe I.

Thromb Haemost. 2005 Oct;94(4):831-8.

PMID:
16270639
24.

Functional mapping of Toll/interleukin-1 signalling networks by expression cloning.

Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE, Dower SK.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1405-6.

PMID:
16246130
25.

Endotoxin tolerance induces selective alterations in neutrophil function.

Parker LC, Jones EC, Prince LR, Dower SK, Whyte MK, Sabroe I.

J Leukoc Biol. 2005 Dec;78(6):1301-5. Epub 2005 Oct 21.

PMID:
16244113
26.

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis.

Sabroe I, Dower SK, Whyte MK.

Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S421-6. Review.

PMID:
16237641
27.

Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.

Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár A, Dower SK, Duda E.

Ann N Y Acad Sci. 2005 Jun;1051:515-28.

PMID:
16126992
28.

Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.

Morton AC, Arnold ND, Gunn J, Varcoe R, Francis SE, Dower SK, Crossman DC.

Cardiovasc Res. 2005 Dec 1;68(3):493-501. Epub 2005 Aug 15.

PMID:
16099441
29.

Toll-like receptors and chronic lung disease.

Chaudhuri N, Dower SK, Whyte MK, Sabroe I.

Clin Sci (Lond). 2005 Aug;109(2):125-33. Review.

PMID:
16033327
30.

Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.

Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE, Dower SK.

Cell Signal. 2006 Feb;18(2):202-14. Epub 2005 Jun 29.

PMID:
15990277
31.
32.

The expression and roles of Toll-like receptors in the biology of the human neutrophil.

Parker LC, Whyte MK, Dower SK, Sabroe I.

J Leukoc Biol. 2005 Jun;77(6):886-92. Epub 2005 Feb 22. Review.

PMID:
15728244
33.

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.

Morris GE, Whyte MK, Martin GF, Jose PJ, Dower SK, Sabroe I.

Am J Respir Crit Care Med. 2005 Apr 15;171(8):814-22. Epub 2005 Jan 18.

PMID:
15657467
34.

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.

Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MK, Sabroe I.

Am J Pathol. 2004 Nov;165(5):1819-26.

35.

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'neill LA, Qwarnstrom EE, Dower SK.

J Biol Chem. 2004 Oct 8;279(41):42703-8. Epub 2004 Aug 6.

36.

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation.

Wilson HL, Francis SE, Dower SK, Crossman DC.

J Immunol. 2004 Jul 15;173(2):1202-8.

37.

The glycopeptide vancomycin does not enhance toll-like receptor 2 (TLR2) activation by Streptococcus pneumoniae.

Moore LJ, Pridmore AC, Dower SK, Read RC.

J Antimicrob Chemother. 2004 Jul;54(1):76-8. Epub 2004 Jun 9.

PMID:
15190028
38.

What can we learn from highly purified neutrophils?

Sabroe I, Prince LR, Dower SK, Walmsley SR, Chilvers ER, Whyte MK.

Biochem Soc Trans. 2004 Jun;32(Pt3):468-9. Review.

PMID:
15157162
39.

Hunting for genes by functional screens.

Kiss-Toth E, Qwarnstrom EE, Dower SK.

Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):97-102. Review.

PMID:
15110793
40.

Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.

Parker LC, Whyte MK, Vogel SN, Dower SK, Sabroe I.

J Immunol. 2004 Apr 15;172(8):4977-86.

41.

Toll-like receptor (TLR) 4 polymorphisms and COPD.

Sabroe I, Whyte MK, Wilson AG, Dower SK, Hubbard R, Hall I.

Thorax. 2004 Jan;59(1):81. No abstract available.

42.

Signalling networks, inflammation and innate immunity.

Dower SK, Qwarnstrom EE.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1462-71. Review.

PMID:
14641090
43.

Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.

Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC, Newman CM.

Ultrasound Med Biol. 2003 Oct;29(10):1453-61.

PMID:
14597342
44.

Three novel Bid proteins generated by alternative splicing of the human Bid gene.

Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD, Whyte MK.

J Biol Chem. 2004 Jan 23;279(4):2846-55. Epub 2003 Oct 28.

45.

Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae.

Moore LJ, Pridmore AC, Dower SK, Read RC.

J Infect Dis. 2003 Oct 1;188(7):1040-8. Epub 2003 Sep 17.

PMID:
14513425
46.

Toll-like receptors in health and disease: complex questions remain.

Sabroe I, Read RC, Whyte MK, Dockrell DH, Vogel SN, Dower SK.

J Immunol. 2003 Aug 15;171(4):1630-5. Review. No abstract available.

48.

Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.

Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK, Whyte MK.

J Immunol. 2003 May 15;170(10):5268-75.

49.

Acceleration of human neutrophil apoptosis by TRAIL.

Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER, Whyte MK.

J Immunol. 2003 Jan 15;170(2):1027-33.

50.

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