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Items: 28

1.

41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model.

Homer BL, Dower K.

Toxicol Pathol. 2018 Dec;46(8):976-977. doi: 10.1177/0192623318803278. Epub 2018 Oct 3.

PMID:
30278832
2.

Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy.

Zhang C, Dower K, Zhang B, Martinez RV, Lin LL, Zhao S.

Sci Rep. 2018 May 16;8(1):7624. doi: 10.1038/s41598-018-26035-x.

3.

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K.

PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017.

4.

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy.

Dower K, Zhao S, Schlerman FJ, Savary L, Campanholle G, Johnson BG, Xi L, Nguyen V, Zhan Y, Lech MP, Wang J, Nie Q, Karsdal MA, Genovese F, Boucher G, Brown TP, Zhang B, Homer BL, Martinez RV.

PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.

5.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW.

J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14.

PMID:
28498658
6.

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.

Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP.

J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12.

7.

Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.

Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH.

Assay Drug Dev Technol. 2015 Jan-Feb;13(1):34-43. doi: 10.1089/adt.2014.613. Epub 2015 Feb 3.

8.

Vaccinia reporter viruses for quantifying viral function at all stages of gene expression.

Rozelle DK, Filone CM, Dower K, Connor JH.

J Vis Exp. 2014 May 15;(87). doi: 10.3791/51522.

9.

Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.

Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, Hirschfield M, Casanova JL, Picard C, Puel A, Lin LL, Rao VR.

J Biol Chem. 2014 Apr 11;289(15):10865-75. doi: 10.1074/jbc.M113.544809. Epub 2014 Feb 24.

10.

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J.

PLoS Pathog. 2014 Feb 6;10(2):e1003904. doi: 10.1371/journal.ppat.1003904. eCollection 2014 Feb.

11.

Myxoma and vaccinia viruses bind differentially to human leukocytes.

Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G.

J Virol. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6.

12.

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself.

Luong M, Zhang Y, Chamberlain T, Zhou T, Wright JF, Dower K, Hall JP.

J Inflamm (Lond). 2012 Mar 26;9:11. doi: 10.1186/1476-9255-9-11.

13.

Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.

Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH.

J Virol. 2012 Mar;86(5):2632-40. doi: 10.1128/JVI.05416-11. Epub 2011 Dec 28.

14.

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression.

Dower K, Rubins KH, Hensley LE, Connor JH.

Antiviral Res. 2011 Jul;91(1):72-80. doi: 10.1016/j.antiviral.2011.04.014. Epub 2011 May 5.

15.

Formation of antiviral cytoplasmic granules during orthopoxvirus infection.

Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH.

J Virol. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8.

16.

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, Carito B, O'Toole M, Ramsey R, Adolfsson O, Shields KM, Dower K, Hall JP, Kurdi Y, Beech JT, Nanchahal J, Feldmann M, Foxwell BM, Brennan FM, Winkler DG, Lin LL.

Rheumatology (Oxford). 2009 Nov;48(11):1352-8. doi: 10.1093/rheumatology/kep235. Epub 2009 Aug 27.

PMID:
19713442
17.
18.

3'-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation.

Abruzzi KC, Belostotsky DA, Chekanova JA, Dower K, Rosbash M.

EMBO J. 2006 Sep 20;25(18):4253-62. Epub 2006 Aug 31.

19.

Nonsense-mediated decay does not occur within the yeast nucleus.

Kuperwasser N, Brogna S, Dower K, Rosbash M.

RNA. 2004 Dec;10(12):1907-15.

20.

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.

Dower K, Kuperwasser N, Merrikh H, Rosbash M.

RNA. 2004 Dec;10(12):1888-99.

21.

Early formation of mRNP: license for export or quality control?

Jensen TH, Dower K, Libri D, Rosbash M.

Mol Cell. 2003 May;11(5):1129-38. Review.

22.

Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation.

Libri D, Dower K, Boulay J, Thomsen R, Rosbash M, Jensen TH.

Mol Cell Biol. 2002 Dec;22(23):8254-66.

23.

T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export.

Dower K, Rosbash M.

RNA. 2002 May;8(5):686-97. Erratum in: RNA 2002 Jun;8(6):852.

24.

A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen.

Li D, Dower K, Ma Y, Tian Y, Benjamin TL.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14619-24.

25.

Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways.

Vainberg IE, Dower K, Rosbash M.

Mol Cell Biol. 2000 Jun;20(11):3996-4005.

26.

Identification of a potent DNase activity associated with RNase T of Escherichia coli.

Viswanathan M, Dower KW, Lovett ST.

J Biol Chem. 1998 Dec 25;273(52):35126-31.

27.

Enhancement of habitat heterogeneity and species richness on rocky shores inundated by sand.

McQuaid CD, Dower KM.

Oecologia. 1990 Aug;84(1):142-144. doi: 10.1007/BF00665608.

PMID:
28312788
28.

The developmental success of Amblyomma hebraeum and Amblyomma marmoreum on the leopard tortoise, Geochelone pardalis.

Dower KM, Petney TN, Horak IG.

Onderstepoort J Vet Res. 1988 Mar;55(1):11-3.

PMID:
3353093

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