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Mesenchymal stem cells for treatment of musculoskeletal disease in horses: Relative merits of allogeneic versus autologous stem cells.

Colbath AC, Dow SW, McIlwraith CW, Goodrich LR.

Equine Vet J. 2020 Jan 23. doi: 10.1111/evj.13233. [Epub ahead of print] Review.


High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.

Magnuson AM, Regan DP, Booth AD, Fouts JK, Solt CM, Hill JL, Dow SW, Foster MT.

Eur J Nutr. 2019 Jun 4. doi: 10.1007/s00394-019-02019-z. [Epub ahead of print]


Allogeneic vs. autologous intra-articular mesenchymal stem cell injection within normal horses: Clinical and cytological comparisons suggest safety.

Colbath AC, Dow SW, Hopkins LS, Phillips JN, McIlwraith CW, Goodrich LR.

Equine Vet J. 2020 Jan;52(1):144-151. doi: 10.1111/evj.13136. Epub 2019 Jun 24.


The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment.

Regan DP, Coy JW, Chahal KK, Chow L, Kurihara JN, Guth AM, Kufareva I, Dow SW.

J Immunol. 2019 May 15;202(10):3087-3102. doi: 10.4049/jimmunol.1800619. Epub 2019 Apr 10.


Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint?

Colbath AC, Dow SW, Hopkins LS, Phillips JN, McIlwraith CW, Goodrich LR.

Front Vet Sci. 2018 Aug 31;5:208. doi: 10.3389/fvets.2018.00208. eCollection 2018.


Evaluation of immunological parameters in pit bull terrier-type dogs with juvenile onset generalized demodicosis and age-matched healthy pit bull terrier-type dogs.

Souza CP, Schissler JR, Contreras ET, Dow SW, Hopkins LS, Coy JW, Rosychuk RAW, Hawley JR, Lappin MR.

Vet Dermatol. 2018 Dec;29(6):482-e162. doi: 10.1111/vde.12681. Epub 2018 Aug 23.


Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation.

Hartley GP, Chow L, Ammons DT, Wheat WH, Dow SW.

Cancer Immunol Res. 2018 Oct;6(10):1260-1273. doi: 10.1158/2326-6066.CIR-17-0537. Epub 2018 Jul 16.


Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.

Magnuson AM, Fouts JK, Regan DP, Booth AD, Dow SW, Foster MT.

Physiol Behav. 2018 Jun 1;190:71-81. doi: 10.1016/j.physbeh.2018.02.044. Epub 2018 Mar 1.


Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model.

Wheat WH, Arthun EN, Spencer JS, Regan DP, Titus RG, Dow SW.

Vaccine. 2017 Dec 4;35(48 Pt B):6611-6619. doi: 10.1016/j.vaccine.2017.10.039. Epub 2017 Oct 24.


Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.

Magnuson AM, Regan DP, Fouts JK, Booth AD, Dow SW, Foster MT.

Cell Prolif. 2017 Oct;50(5). doi: 10.1111/cpr.12365. Epub 2017 Aug 1.


Autologous and Allogeneic Equine Mesenchymal Stem Cells Exhibit Equivalent Immunomodulatory Properties In Vitro.

Colbath AC, Dow SW, Phillips JN, McIlwraith CW, Goodrich LR.

Stem Cells Dev. 2017 Apr 1;26(7):503-511. doi: 10.1089/scd.2016.0266. Epub 2017 Jan 12.


Comparison of proliferative and immunomodulatory potential of adipose-derived mesenchymal stem cells from young and geriatric cats.

Zajic LB, Webb TL, Webb P, Coy JW, Dow SW, Quimby JM.

J Feline Med Surg. 2017 Oct;19(10):1096-1102. doi: 10.1177/1098612X16680703. Epub 2016 Dec 5.


Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.

Wheat WH, Chow L, Kurihara JN, Regan DP, Coy JW, Webb TL, Dow SW.

Stem Cells Dev. 2017 Feb 15;26(4):249-262. doi: 10.1089/scd.2016.0199. Epub 2016 Dec 22.


Role of monocyte recruitment in hemangiosarcoma metastasis in dogs.

Regan DP, Escaffi A, Coy J, Kurihara J, Dow SW.

Vet Comp Oncol. 2017 Dec;15(4):1309-1322. doi: 10.1111/vco.12272. Epub 2016 Oct 25.


Concise Review: Stem Cell Trials Using Companion Animal Disease Models.

Hoffman AM, Dow SW.

Stem Cells. 2016 Jul;34(7):1709-29. doi: 10.1002/stem.2377. Epub 2016 May 3. Review.


Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study.

Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Liu H, Quimby JM, Dow SW, Reinero CR.

J Feline Med Surg. 2016 Dec;18(12):981-990. Epub 2015 Sep 17.


Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy.

Quimby JM, Dow SW.

Vet J. 2015 Jun;204(3):241-6. doi: 10.1016/j.tvjl.2015.04.007. Epub 2015 Apr 9. Review.


Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats.

Quimby JM, Webb TL, Randall E, Marolf A, Valdes-Martinez A, Dow SW.

J Feline Med Surg. 2016 Feb;18(2):165-71. doi: 10.1177/1098612X15576980. Epub 2015 Mar 17.


A Burkholderia pseudomallei colony variant necessary for gastric colonization.

Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI.

mBio. 2015 Feb 3;6(1). pii: e02462-14. doi: 10.1128/mBio.02462-14.


Long-term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma.

Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Cohn LA, Liu H, Quimby JM, Dow SW, Reinero CR.

Clin Exp Allergy. 2014 Dec;44(12):1546-57. doi: 10.1111/cea.12411.


Comparison of cancer stem cell antigen expression by tumor cell lines and by tumor biopsies from dogs with melanoma and osteosarcoma.

Guth AM, Deogracias M, Dow SW.

Vet Immunol Immunopathol. 2014 Oct 15;161(3-4):132-40. doi: 10.1016/j.vetimm.2014.07.006. Epub 2014 Jul 24.


Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.

Sun Z, Kang Y, Norris MH, Troyer RM, Son MS, Schweizer HP, Dow SW, Hoang TT.

PLoS One. 2014 Jul 28;9(7):e103778. doi: 10.1371/journal.pone.0103778. eCollection 2014.


Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

Silva EB, Goodyear A, Sutherland MD, Podnecky NL, Gonzalez-Juarrero M, Schweizer HP, Dow SW.

Infect Immun. 2013 Dec;81(12):4626-34. doi: 10.1128/IAI.00915-13. Epub 2013 Oct 7.


Development of Burkholderia mallei and pseudomallei vaccines.

Silva EB, Dow SW.

Front Cell Infect Microbiol. 2013 Mar 11;3:10. doi: 10.3389/fcimb.2013.00010. eCollection 2013. Review.


Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity.

Mitchell LA, Hansen RJ, Beaupre AJ, Gustafson DL, Dow SW.

Int Immunopharmacol. 2013 Feb;15(2):357-63. doi: 10.1016/j.intimp.2012.11.016. Epub 2012 Dec 13.


Suppression of vaccine immunity by inflammatory monocytes.

Mitchell LA, Henderson AJ, Dow SW.

J Immunol. 2012 Dec 15;189(12):5612-21. doi: 10.4049/jimmunol.1202151. Epub 2012 Nov 7.


Urinary cytokine levels in apparently healthy cats and cats with chronic kidney disease.

Habenicht LM, Webb TL, Clauss LA, Dow SW, Quimby JM.

J Feline Med Surg. 2013 Feb;15(2):99-104. doi: 10.1177/1098612X12461007. Epub 2012 Sep 18.


Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis.

Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP.

PLoS Negl Trop Dis. 2012;6(6):e1715. doi: 10.1371/journal.pntd.0001715. Epub 2012 Jun 26.


Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia.

Sutherland MD, Goodyear AW, Troyer RM, Chandler JC, Dow SW, Belisle JT.

Vaccine. 2012 Jul 13;30(33):4977-82. doi: 10.1016/j.vaccine.2012.05.037. Epub 2012 May 28.


Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice.

Kumar A, Henderson A, Forster GM, Goodyear AW, Weir TL, Leach JE, Dow SW, Ryan EP.

BMC Microbiol. 2012 Jul 4;12:71. doi: 10.1186/1471-2180-12-71.


Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft-tissue sarcoma.

Guth AM, Hafeman SD, Elmslie RE, Dow SW.

Vet Comp Oncol. 2013 Dec;11(4):296-305. doi: 10.1111/j.1476-5829.2012.00319.x. Epub 2012 Apr 27.


Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.

Skyberg JA, Rollins MF, Holderness JS, Marlenee NL, Schepetkin IA, Goodyear A, Dow SW, Jutila MA, Pascual DW.

PLoS Pathog. 2012;8(3):e1002587. doi: 10.1371/journal.ppat.1002587. Epub 2012 Mar 15.


Clinical evaluation of a single dose of immune plasma for treatment of canine parvovirus infection.

Bragg RF, Duffy AL, DeCecco FA, Chung DK, Green MT, Veir JK, Dow SW.

J Am Vet Med Assoc. 2012 Mar 15;240(6):700-4. doi: 10.2460/javma.240.6.700.


In vitro comparison of feline bone marrow-derived and adipose tissue-derived mesenchymal stem cells.

Webb TL, Quimby JM, Dow SW.

J Feline Med Surg. 2012 Feb;14(2):165-8. doi: 10.1177/1098612X11429224.


Induction of remission results in spontaneous enhancement of anti-tumor cytotoxic T-lymphocyte activity in dogs with B cell lymphoma.

Mitchell L, Dow SW, Slansky JE, Biller BJ.

Vet Immunol Immunopathol. 2012 Feb 15;145(3-4):597-603. doi: 10.1016/j.vetimm.2012.01.006. Epub 2012 Jan 14.


Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp.

Henderson AJ, Kumar A, Barnett B, Dow SW, Ryan EP.

J Med Food. 2012 May;15(5):469-75. doi: 10.1089/jmf.2011.0213. Epub 2012 Jan 16.


Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells.

Hafeman SD, Varland D, Dow SW.

Vet Comp Oncol. 2012 Mar;10(1):44-56. doi: 10.1111/j.1476-5829.2011.00274.x. Epub 2011 May 18.


The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice.

Norris MH, Propst KL, Kang Y, Dow SW, Schweizer HP, Hoang TT.

Infect Immun. 2011 Oct;79(10):4010-8. doi: 10.1128/IAI.05044-11. Epub 2011 Aug 1.


Low-dose cyclophosphamide selectively decreases regulatory T cells and inhibits angiogenesis in dogs with soft tissue sarcoma.

Burton JH, Mitchell L, Thamm DH, Dow SW, Biller BJ.

J Vet Intern Med. 2011 Jul-Aug;25(4):920-6. doi: 10.1111/j.1939-1676.2011.0753.x. Epub 2011 Jul 7.


Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft.

Sottnik JL, Hansen RJ, Gustafson DL, Dow SW, Thamm DH.

Vet Comp Oncol. 2011 Jun;9(2):118-30. doi: 10.1111/j.1476-5829.2010.00240.x. Epub 2010 Sep 13.


Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study.

Quimby JM, Webb TL, Gibbons DS, Dow SW.

J Feline Med Surg. 2011 Jun;13(6):418-26. doi: 10.1016/j.jfms.2011.01.005. Epub 2011 Feb 22.


Increased monocyte chemotactic protein-1 concentration and monocyte count independently associate with a poor prognosis in dogs with lymphoma.

Perry JA, Thamm DH, Eickhoff J, Avery AC, Dow SW.

Vet Comp Oncol. 2011 Mar;9(1):55-64. doi: 10.1111/j.1476-5829.2010.00235.x. Epub 2010 Sep 10.


Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.

Kingry LC, Troyer RM, Marlenee NL, Bielefeldt-Ohmann H, Bowen RA, Schenkel AR, Dow SW, Slayden RA.

Microbes Infect. 2011 Mar;13(3):261-75. doi: 10.1016/j.micinf.2010.10.022. Epub 2010 Nov 9.


Association of blood monocyte and lymphocyte count and disease-free interval in dogs with osteosarcoma.

Sottnik JL, Rao S, Lafferty MH, Thamm DH, Morley PS, Withrow SJ, Dow SW.

J Vet Intern Med. 2010 Nov-Dec;24(6):1439-44. doi: 10.1111/j.1939-1676.2010.0591.x. Epub 2010 Sep 14.


Minimally invasive assessment of tumor angiogenesis by fine needle aspiration and flow cytometry.

Sottnik JL, Guth AM, Mitchell LA, Dow SW.

Angiogenesis. 2010 Sep;13(3):251-8. doi: 10.1007/s10456-010-9182-0. Epub 2010 Aug 24.


Decreased ratio of CD8+ T cells to regulatory T cells associated with decreased survival in dogs with osteosarcoma.

Biller BJ, Guth A, Burton JH, Dow SW.

J Vet Intern Med. 2010 Sep-Oct;24(5):1118-23. doi: 10.1111/j.1939-1676.2010.0557.x. Epub 2010 Jul 28.

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