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Detection and dynamics of anti-platelet antibodies in thrombocytopenic dogs with and without idiopathic immune thrombocytopenia.

Shropshire S, Dow S, Lappin M.

J Vet Intern Med. 2020 Mar;34(2):700-709. doi: 10.1111/jvim.15737. Epub 2020 Feb 18.


A Role for Dogs in Advancing Cancer Immunotherapy Research.

Dow S.

Front Immunol. 2020 Jan 17;10:2935. doi: 10.3389/fimmu.2019.02935. eCollection 2019. Review.


Amikacin induces rapid dose-dependent apoptotic cell death in equine chondrocytes and synovial cells in vitro.

Pezzanite L, Chow L, Soontararak S, Phillips J, Goodrich L, Dow S.

Equine Vet J. 2020 Jan 29. doi: 10.1111/evj.13243. [Epub ahead of print]


Mesenchymal stem cells for treatment of musculoskeletal disease in horses: Relative merits of allogeneic versus autologous stem cells.

Colbath AC, Dow SW, McIlwraith CW, Goodrich LR.

Equine Vet J. 2020 Jan 23. doi: 10.1111/evj.13233. [Epub ahead of print] Review.


Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells.

Chow L, Johnson V, Impastato R, Coy J, Strumpf A, Dow S.

Stem Cells Transl Med. 2020 Feb;9(2):235-249. doi: 10.1002/sctm.19-0092. Epub 2019 Nov 8.


Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs.

Wheat W, Chow L, Kuzmik A, Soontararak S, Kurihara J, Lappin M, Dow S.

BMC Vet Res. 2019 Sep 13;15(1):330. doi: 10.1186/s12917-019-2073-8.


Humoral immune responses against gut bacteria in dogs with inflammatory bowel disease.

Soontararak S, Chow L, Johnson V, Coy J, Webb C, Wennogle S, Dow S.

PLoS One. 2019 Aug 1;14(8):e0220522. doi: 10.1371/journal.pone.0220522. eCollection 2019.


PrPC knockdown by liposome-siRNA-peptide complexes (LSPCs) prolongs survival and normal behavior of prion-infected mice immunotolerant to treatment.

Bender H, Noyes N, Annis JL, Hitpas A, Mollnow L, Croak K, Kane S, Wagner K, Dow S, Zabel M.

PLoS One. 2019 Jul 22;14(7):e0219995. doi: 10.1371/journal.pone.0219995. eCollection 2019.


High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.

Magnuson AM, Regan DP, Booth AD, Fouts JK, Solt CM, Hill JL, Dow SW, Foster MT.

Eur J Nutr. 2019 Jun 4. doi: 10.1007/s00394-019-02019-z. [Epub ahead of print]


Allogeneic vs. autologous intra-articular mesenchymal stem cell injection within normal horses: Clinical and cytological comparisons suggest safety.

Colbath AC, Dow SW, Hopkins LS, Phillips JN, McIlwraith CW, Goodrich LR.

Equine Vet J. 2020 Jan;52(1):144-151. doi: 10.1111/evj.13136. Epub 2019 Jun 24.


The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment.

Regan DP, Coy JW, Chahal KK, Chow L, Kurihara JN, Guth AM, Kufareva I, Dow SW.

J Immunol. 2019 May 15;202(10):3087-3102. doi: 10.4049/jimmunol.1800619. Epub 2019 Apr 10.


Evaluation of Intravenously Delivered Allogeneic Mesenchymal Stem Cells for Treatment of Elbow Osteoarthritis in Dogs: A Pilot Study.

Olsen A, Johnson V, Webb T, Santangelo KS, Dow S, Duerr FM.

Vet Comp Orthop Traumatol. 2019 May;32(3):173-181. doi: 10.1055/s-0039-1678547. Epub 2019 Mar 14.


Evaluation of liposome toll-like receptor ligand complexes for non-specific mucosal immunoprotection from feline herpesvirus-1 infection.

Contreras ET, Olea-Popelka F, Wheat W, Dow S, Hawley J, Lappin MR.

J Vet Intern Med. 2019 Mar;33(2):831-837. doi: 10.1111/jvim.15427. Epub 2019 Mar 7.


Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically.

Wheat W, Chow L, Coy J, Contreras E, Lappin M, Dow S.

J Vet Intern Med. 2019 Mar;33(2):838-845. doi: 10.1111/jvim.15426. Epub 2019 Feb 15.


Cancer stem cell populations in lymphoma in dogs and impact of cytotoxic chemotherapy.

Hartley G, Elmslie R, Murphy B, Hopkins L, Guth A, Dow S.

Vet Comp Oncol. 2019 Mar;17(1):69-79. doi: 10.1111/vco.12447. Epub 2018 Oct 21.


Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint?

Colbath AC, Dow SW, Hopkins LS, Phillips JN, McIlwraith CW, Goodrich LR.

Front Vet Sci. 2018 Aug 31;5:208. doi: 10.3389/fvets.2018.00208. eCollection 2018.


Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance.

Jones SM, Vijayakumar S, Dow SA, Holt JC, Jordan PM, Luebke AE.

Front Mol Neurosci. 2018 Aug 24;11:289. doi: 10.3389/fnmol.2018.00289. eCollection 2018.


Evaluation of immunological parameters in pit bull terrier-type dogs with juvenile onset generalized demodicosis and age-matched healthy pit bull terrier-type dogs.

Souza CP, Schissler JR, Contreras ET, Dow SW, Hopkins LS, Coy JW, Rosychuk RAW, Hawley JR, Lappin MR.

Vet Dermatol. 2018 Dec;29(6):482-e162. doi: 10.1111/vde.12681. Epub 2018 Aug 23.


Validation of a clinically applicable flow cytometric assay for the detection of immunoglobulin associated platelets in dogs.

Shropshire S, Dow S, Lappin M.

Vet Immunol Immunopathol. 2018 Aug;202:109-114. doi: 10.1016/j.vetimm.2018.07.003. Epub 2018 Jul 6.


Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation.

Hartley GP, Chow L, Ammons DT, Wheat WH, Dow SW.

Cancer Immunol Res. 2018 Oct;6(10):1260-1273. doi: 10.1158/2326-6066.CIR-17-0537. Epub 2018 Jul 16.


Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose-Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model.

Soontararak S, Chow L, Johnson V, Coy J, Wheat W, Regan D, Dow S.

Stem Cells Transl Med. 2018 Jun;7(6):456-467. doi: 10.1002/sctm.17-0305. Epub 2018 Apr 10.


Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.

Magnuson AM, Fouts JK, Regan DP, Booth AD, Dow SW, Foster MT.

Physiol Behav. 2018 Jun 1;190:71-81. doi: 10.1016/j.physbeh.2018.02.044. Epub 2018 Mar 1.


Checkpoint molecule expression by B and T cell lymphomas in dogs.

Hartley G, Elmslie R, Dow S, Guth A.

Vet Comp Oncol. 2018 Sep;16(3):352-360. doi: 10.1111/vco.12386. Epub 2018 Jan 30.


Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation.

Takeda K, Webb TL, Ning F, Shiraishi Y, Regan DP, Chow L, Smith MJ, Ashino S, Guth AM, Hopkins S, Gelfand EW, Dow S.

J Immunol. 2018 Feb 15;200(4):1261-1269. doi: 10.4049/jimmunol.1700562. Epub 2018 Jan 19.


Safety and immune regulatory properties of canine induced pluripotent stem cell-derived mesenchymal stem cells.

Chow L, Johnson V, Regan D, Wheat W, Webb S, Koch P, Dow S.

Stem Cell Res. 2017 Dec;25:221-232. doi: 10.1016/j.scr.2017.11.010. Epub 2017 Nov 14.


Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model.

Wheat WH, Arthun EN, Spencer JS, Regan DP, Titus RG, Dow SW.

Vaccine. 2017 Dec 4;35(48 Pt B):6611-6619. doi: 10.1016/j.vaccine.2017.10.039. Epub 2017 Oct 24.


Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections.

Johnson V, Webb T, Norman A, Coy J, Kurihara J, Regan D, Dow S.

Sci Rep. 2017 Aug 29;7(1):9575. doi: 10.1038/s41598-017-08311-4.


Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.

Magnuson AM, Regan DP, Fouts JK, Booth AD, Dow SW, Foster MT.

Cell Prolif. 2017 Oct;50(5). doi: 10.1111/cpr.12365. Epub 2017 Aug 1.


Regulation of PD-L1 expression on murine tumor-associated monocytes and macrophages by locally produced TNF-α.

Hartley G, Regan D, Guth A, Dow S.

Cancer Immunol Immunother. 2017 Apr;66(4):523-535. doi: 10.1007/s00262-017-1955-5. Epub 2017 Feb 9.


PD-1 expression by canine T cells and functional effects of PD-1 blockade.

Coy J, Caldwell A, Chow L, Guth A, Dow S.

Vet Comp Oncol. 2017 Dec;15(4):1487-1502. doi: 10.1111/vco.12294. Epub 2017 Jan 25.


Autologous and Allogeneic Equine Mesenchymal Stem Cells Exhibit Equivalent Immunomodulatory Properties In Vitro.

Colbath AC, Dow SW, Phillips JN, McIlwraith CW, Goodrich LR.

Stem Cells Dev. 2017 Apr 1;26(7):503-511. doi: 10.1089/scd.2016.0266. Epub 2017 Jan 12.


Comparison of proliferative and immunomodulatory potential of adipose-derived mesenchymal stem cells from young and geriatric cats.

Zajic LB, Webb TL, Webb P, Coy JW, Dow SW, Quimby JM.

J Feline Med Surg. 2017 Oct;19(10):1096-1102. doi: 10.1177/1098612X16680703. Epub 2016 Dec 5.


Mechanisms of Immune Suppression Utilized by Canine Adipose and Bone Marrow-Derived Mesenchymal Stem Cells.

Chow L, Johnson V, Coy J, Regan D, Dow S.

Stem Cells Dev. 2017 Mar 1;26(5):374-389. doi: 10.1089/scd.2016.0207. Epub 2017 Jan 24.


Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.

Wheat WH, Chow L, Kurihara JN, Regan DP, Coy JW, Webb TL, Dow SW.

Stem Cells Dev. 2017 Feb 15;26(4):249-262. doi: 10.1089/scd.2016.0199. Epub 2016 Dec 22.


Distinct Effects of Left or Right Atrial Cannulation on Left Ventricular Hemodynamics in a Swine Model of Acute Myocardial Injury.

Esposito ML, Shah N, Dow S, Kang S, Paruchuri V, Karas RH, Kapur NK.

ASAIO J. 2016 Nov/Dec;62(6):671-676.


Role of monocyte recruitment in hemangiosarcoma metastasis in dogs.

Regan DP, Escaffi A, Coy J, Kurihara J, Dow SW.

Vet Comp Oncol. 2017 Dec;15(4):1309-1322. doi: 10.1111/vco.12272. Epub 2016 Oct 25.


Comparison of cytokine responses between dogs with sepsis and dogs with immune-mediated hemolytic anemia.

Johnson V, Burgess B, Morley P, Bragg R, Avery A, Dow S.

Vet Immunol Immunopathol. 2016 Nov 1;180:15-20. doi: 10.1016/j.vetimm.2016.08.010. Epub 2016 Aug 20.


Concise Review: Stem Cell Trials Using Companion Animal Disease Models.

Hoffman AM, Dow SW.

Stem Cells. 2016 Jul;34(7):1709-29. doi: 10.1002/stem.2377. Epub 2016 May 3. Review.


Immune regulation of canine tumour and macrophage PD-L1 expression.

Hartley G, Faulhaber E, Caldwell A, Coy J, Kurihara J, Guth A, Regan D, Dow S.

Vet Comp Oncol. 2017 Jun;15(2):534-549. doi: 10.1111/vco.12197. Epub 2016 Feb 4.


Manipulation of Innate Immunity for Cancer Therapy in Dogs.

Regan D, Dow S.

Vet Sci. 2015 Dec 1;2(4):423-439. doi: 10.3390/vetsci2040423. Review.


Cancer immunotherapy in veterinary medicine: Current options and new developments.

Regan D, Guth A, Coy J, Dow S.

Vet J. 2016 Jan;207:20-28. doi: 10.1016/j.tvjl.2015.10.008. Epub 2015 Oct 13. Review.


Mechanical Pre-Conditioning With Acute Circulatory Support Before Reperfusion Limits Infarct Size in Acute Myocardial Infarction.

Kapur NK, Qiao X, Paruchuri V, Morine KJ, Syed W, Dow S, Shah N, Pandian N, Karas RH.

JACC Heart Fail. 2015 Nov;3(11):873-82. doi: 10.1016/j.jchf.2015.06.010.


Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study.

Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Liu H, Quimby JM, Dow SW, Reinero CR.

J Feline Med Surg. 2016 Dec;18(12):981-990. Epub 2015 Sep 17.


Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy.

Quimby JM, Dow SW.

Vet J. 2015 Jun;204(3):241-6. doi: 10.1016/j.tvjl.2015.04.007. Epub 2015 Apr 9. Review.


Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats.

Quimby JM, Webb TL, Randall E, Marolf A, Valdes-Martinez A, Dow SW.

J Feline Med Surg. 2016 Feb;18(2):165-71. doi: 10.1177/1098612X15576980. Epub 2015 Mar 17.


A Burkholderia pseudomallei colony variant necessary for gastric colonization.

Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI.

mBio. 2015 Feb 3;6(1). pii: e02462-14. doi: 10.1128/mBio.02462-14.


Our approach to changing the culture of caring for the acutely unwell patient at a large UK teaching hospital: A service improvement focus on Early Warning Scoring tools.

Wood SD, Candeland JL, Dinning A, Dow S, Hunkin H, McHale S, McNeill G, Taylor N.

Intensive Crit Care Nurs. 2015 Apr;31(2):106-15. doi: 10.1016/j.iccn.2014.11.006. Epub 2015 Jan 17.


Long-term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma.

Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Cohn LA, Liu H, Quimby JM, Dow SW, Reinero CR.

Clin Exp Allergy. 2014 Dec;44(12):1546-57. doi: 10.1111/cea.12411.


Comparison of cancer stem cell antigen expression by tumor cell lines and by tumor biopsies from dogs with melanoma and osteosarcoma.

Guth AM, Deogracias M, Dow SW.

Vet Immunol Immunopathol. 2014 Oct 15;161(3-4):132-40. doi: 10.1016/j.vetimm.2014.07.006. Epub 2014 Jul 24.

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