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Items: 46

1.

Adenine base editing in an adult mouse model of tyrosinaemia.

Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W.

Nat Biomed Eng. 2019 Feb 25. doi: 10.1038/s41551-019-0357-8. [Epub ahead of print]

PMID:
31740768
2.

Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.

Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC.

Nat Med. 2019 Nov;25(11):1739-1747. doi: 10.1038/s41591-019-0610-4. Epub 2019 Nov 7.

PMID:
31700183
3.

A rectal cancer organoid platform to study individual responses to chemoradiation.

Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ.

Nat Med. 2019 Oct;25(10):1607-1614. doi: 10.1038/s41591-019-0584-2. Epub 2019 Oct 7.

PMID:
31591597
4.

Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome.

Romesser PB, Kim AS, Jeong J, Mayle A, Dow LE, Lowe SW.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20672-20678. doi: 10.1073/pnas.1906611116. Epub 2019 Sep 24.

5.

Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.

Schatoff EM, Goswami S, Zafra MP, Foronda M, Shusterman M, Leach BI, Katti A, Diaz BJ, Dow LE.

Cancer Discov. 2019 Oct;9(10):1358-1371. doi: 10.1158/2159-8290.CD-19-0289. Epub 2019 Jul 23.

PMID:
31337618
6.

Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.

Mishra A, Emamgholi F, Erlangga Z, Hartleben B, Unger K, Wolff K, Teichmann U, Kessel M, Woller N, Kühnel F, Dow LE, Manns MP, Vogel A, Lowe SW, Saborowski A, Saborowski M.

Carcinogenesis. 2019 Jun 6. pii: bgz108. doi: 10.1093/carcin/bgz108. [Epub ahead of print]

PMID:
31170286
7.

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW.

J Clin Invest. 2019 Jun 4;130:3640-3656. doi: 10.1172/JCI124099.

8.

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC.

Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070.

9.

Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro.

Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, Becker D, Dow LE, Marhenke S, Woller N, Unger K, Schirmacher P, Manns MP, Marquardt JU, Vogel A, Saborowski M.

Hepatol Commun. 2019 Feb 5;3(3):423-436. doi: 10.1002/hep4.1312. eCollection 2019 Mar.

10.

Base editing the mammalian genome.

Schatoff EM, Zafra MP, Dow LE.

Methods. 2019 Jul 15;164-165:100-108. doi: 10.1016/j.ymeth.2019.02.022. Epub 2019 Mar 2. Review.

PMID:
30836137
11.

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.

Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ.

Cell Rep. 2019 Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036.

12.

CRISPR: Stressed about p53?

Foronda M, Dow LE.

Trends Mol Med. 2018 Sep;24(9):731-733. doi: 10.1016/j.molmed.2018.06.010. Epub 2018 Jul 17.

PMID:
30017531
13.

Optimized base editors enable efficient editing in cells, organoids and mice.

Zafra MP, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E, Thibado J, Kastenhuber ER, Sánchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE.

Nat Biotechnol. 2018 Oct;36(9):888-893. doi: 10.1038/nbt.4194. Epub 2018 Jul 3.

14.

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.

Han T, Schatoff EM, Murphy C, Zafra MP, Wilkinson JE, Elemento O, Dow LE.

Nat Commun. 2017 Jul 11;8:15945. doi: 10.1038/ncomms15945.

15.

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.

O'Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE, Lowe SW.

Nat Biotechnol. 2017 Jun;35(6):577-582. doi: 10.1038/nbt.3837. Epub 2017 May 1.

16.

Wnt Signaling and Colorectal Cancer.

Schatoff EM, Leach BI, Dow LE.

Curr Colorectal Cancer Rep. 2017 Apr;13(2):101-110. doi: 10.1007/s11888-017-0354-9. Epub 2017 Feb 28.

17.

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells.

O'Rourke KP, Ackerman S, Dow LE, Lowe SW.

Bio Protoc. 2016 Feb 20;6(4). pii: e1733.

18.

Immunofluorescent Staining of Mouse Intestinal Stem Cells.

O'Rourke KP, Dow LE, Lowe SW.

Bio Protoc. 2016 Feb 20;6(4). pii: e1732.

19.

Somatic Genome Editing Goes Viral.

Zafra MP, Dow LE.

Trends Mol Med. 2016 Oct;22(10):831-833. doi: 10.1016/j.molmed.2016.08.004. Epub 2016 Aug 20.

20.

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer.

Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW.

Cell. 2016 Jun 2;165(6):1546-1547. doi: 10.1016/j.cell.2016.05.058. No abstract available.

21.

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.

Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3030-5. doi: 10.1073/pnas.1523693113. Epub 2016 Feb 29.

22.

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC.

Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5.

23.

Modeling Disease In Vivo With CRISPR/Cas9.

Dow LE.

Trends Mol Med. 2015 Oct;21(10):609-621. doi: 10.1016/j.molmed.2015.07.006. Review.

24.

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryń ŁM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, Valent P, Stark A, Kraut N, Vakoc CR, Zuber J.

Nature. 2015 Sep 24;525(7570):543-547. doi: 10.1038/nature14898. Epub 2015 Sep 14.

25.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW.

Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033.

26.

The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C.

PLoS Biol. 2015 Mar 25;13(3):e1002107. doi: 10.1371/journal.pbio.1002107. eCollection 2015 Mar.

27.

Inducible in vivo genome editing with CRISPR-Cas9.

Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW.

Nat Biotechnol. 2015 Apr;33(4):390-394. doi: 10.1038/nbt.3155. Epub 2015 Feb 18.

28.

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.

Cell Rep. 2014 Sep 25;8(6):1919-1929. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.

29.

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW.

Cell. 2014 Jul 31;158(3):579-92. doi: 10.1016/j.cell.2014.05.051. Erratum in: Cell. 2016 Jun 2;165(6):1546-1547.

30.

Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

Dow LE, Nasr Z, Saborowski M, Ebbesen SH, Manchado E, Tasdemir N, Lee T, Pelletier J, Lowe SW.

PLoS One. 2014 Apr 17;9(4):e95236. doi: 10.1371/journal.pone.0095236. eCollection 2014.

31.

A modular and flexible ESC-based mouse model of pancreatic cancer.

Saborowski M, Saborowski A, Morris JP 4th, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW.

Genes Dev. 2014 Jan 1;28(1):85-97. doi: 10.1101/gad.232082.113.

32.

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.

Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA Jr, Lowe SW, Pelletier J.

BMC Pharmacol Toxicol. 2013 Nov 13;14:58. doi: 10.1186/2050-6511-14-58.

33.

Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW.

Cold Spring Harb Protoc. 2013 Sep 1;2013(9):835-42. doi: 10.1101/pdb.prot077057.

34.

Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice.

Takiguchi M, Dow LE, Prier JE, Carmichael CL, Kile BT, Turner SJ, Lowe SW, Huang DC, Dickins RA.

PLoS One. 2013;8(1):e54009. doi: 10.1371/journal.pone.0054009. Epub 2013 Jan 11.

35.

Life in the fast lane: mammalian disease models in the genomics era.

Dow LE, Lowe SW.

Cell. 2012 Mar 16;148(6):1099-109. doi: 10.1016/j.cell.2012.02.023.

36.

A pipeline for the generation of shRNA transgenic mice.

Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW.

Nat Protoc. 2012 Feb 2;7(2):374-93. doi: 10.1038/nprot.2011.446.

37.

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO.

J Clin Invest. 2011 Nov;121(11):4257-67. doi: 10.1172/JCI58509. Epub 2011 Oct 3.

38.

Reversible suppression of an essential gene in adult mice using transgenic RNA interference.

McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B, Lowe SW.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7113-8. doi: 10.1073/pnas.1104097108. Epub 2011 Apr 11.

39.

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW.

Cell. 2011 Apr 1;145(1):145-58. doi: 10.1016/j.cell.2011.03.012.

40.

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW.

Nat Biotechnol. 2011 Jan;29(1):79-83. doi: 10.1038/nbt.1720. Epub 2010 Dec 5.

41.

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.

Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO.

Oncogene. 2008 Oct 9;27(46):5988-6001. doi: 10.1038/onc.2008.219. Epub 2008 Jul 21.

PMID:
18641685
42.
43.

The Scribble and Par complexes in polarity and migration: friends or foes?

Humbert PO, Dow LE, Russell SM.

Trends Cell Biol. 2006 Dec;16(12):622-30. Epub 2006 Oct 25. Review.

PMID:
17067797
44.

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge.

Dow LE, Kauffman JS, Caddy J, Zarbalis K, Peterson AS, Jane SM, Russell SM, Humbert PO.

Oncogene. 2007 Apr 5;26(16):2272-82. Epub 2006 Oct 9. Erratum in: Oncogene. 2007 Aug 16;26(38):5692. Zarbalis, K [added].

PMID:
17043654
45.

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, Kershaw MH, Darcy PK, Humbert PO, Russell SM.

Immunity. 2005 Jun;22(6):737-48.

46.

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE, Humbert PO.

Oncogene. 2003 Dec 18;22(58):9225-30.

PMID:
14681682

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