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Items: 38


Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P.

J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27.


miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

Saul MJ, Baumann I, Bruno A, Emmerich AC, Wellstein J, Ottinger SM, Contursi A, Dovizio M, Donnini S, Tacconelli S, Raouf J, Idborg H, Stein S, Korotkova M, Savai R, Terzuoli E, Sala G, Seeger W, Jakobsson PJ, Patrignani P, Suess B, Steinhilber D.

FASEB J. 2019 Jun;33(6):6933-6947. doi: 10.1096/fj.201802547R. Epub 2019 Mar 28.


Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.

Grande R, Dovizio M, Marcone S, Szklanna PB, Bruno A, Ebhardt HA, Cassidy H, Ní Áinle F, Caprodossi A, Lanuti P, Marchisio M, Mingrone G, Maguire PB, Patrignani P.

Front Pharmacol. 2019 Jan 22;10:7. doi: 10.3389/fphar.2019.00007. eCollection 2019.


Platelets in cancer development and diagnosis.

Contursi A, Grande R, Dovizio M, Bruno A, Fullone R, Patrignani P.

Biochem Soc Trans. 2018 Dec 17;46(6):1517-1527. doi: 10.1042/BST20180159. Epub 2018 Nov 12. Review.


Antithrombotic Agents and Cancer.

Bruno A, Dovizio M, Tacconelli S, Contursi A, Ballerini P, Patrignani P.

Cancers (Basel). 2018 Jul 31;10(8). pii: E253. doi: 10.3390/cancers10080253. Review.


Platelets and extracellular vesicles in cancer: diagnostic and therapeutic implications.

Dovizio M, Bruno A, Contursi A, Grande R, Patrignani P.

Cancer Metastasis Rev. 2018 Sep;37(2-3):455-467. doi: 10.1007/s10555-018-9730-4. Review.


Reduced Variability to Aspirin Antiplatelet Effect by the Coadministration of Statins in High-Risk Patients for Cardiovascular Disease.

Tacconelli S, Dovizio M, Di Francesco L, Meneguzzi A, D'Agostino I, Evangelista V, Manarini S, Capone ML, Grossi L, Porreca E, Di Febbo C, Bruno A, Ballerini P, Levantesi G, Fava C, Minuz P, Patrignani P.

Clin Pharmacol Ther. 2018 Jul;104(1):111-119. doi: 10.1002/cpt.1075. Epub 2018 Apr 19.


P2Y12 Receptors in Tumorigenesis and Metastasis.

Ballerini P, Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Front Pharmacol. 2018 Feb 2;9:66. doi: 10.3389/fphar.2018.00066. eCollection 2018. Review.


Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting.

Contursi A, Sacco A, Grande R, Dovizio M, Patrignani P.

Cell Mol Life Sci. 2017 Oct;74(19):3491-3507. doi: 10.1007/s00018-017-2536-7. Epub 2017 May 9. Review.


Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer.

Patrignani P, Sacco A, Sostres C, Bruno A, Dovizio M, Piazuelo E, Di Francesco L, Contursi A, Zucchelli M, Schiavone S, Tacconelli S, Patrono C, Lanas A.

Clin Pharmacol Ther. 2017 Jul;102(1):52-61. doi: 10.1002/cpt.639. Epub 2017 Apr 4.


Curbing tumorigenesis and malignant progression through the pharmacological control of the wound healing process.

Dovizio M, Sacco A, Patrignani P.

Vascul Pharmacol. 2017 Feb;89:1-11. doi: 10.1016/j.vph.2017.01.003. Epub 2017 Jan 12. Review.


Time for Integrating Clinical, Lifestyle and Molecular Data to Predict Drug Responses.

Patrignani P, Dovizio M.

EBioMedicine. 2016 May;7:9-10. doi: 10.1016/j.ebiom.2016.03.031. Epub 2016 Mar 25. No abstract available.


Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.

Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P.

Oncotarget. 2016 May 31;7(22):32462-77. doi: 10.18632/oncotarget.8655.


Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk.

Dovizio M, Alberti S, Sacco A, Guillem-Llobat P, Schiavone S, Maier TJ, Steinhilber D, Patrignani P.

Biochem Soc Trans. 2015 Aug;43(4):707-14. doi: 10.1042/BST20140322. Epub 2015 Aug 3. Review.


Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells.

Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O'Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P.

Br J Pharmacol. 2015 Sep;172(18):4575-4587. doi: 10.1111/bph.13241. Epub 2015 Aug 3.


COX-2 and EGFR: Partners in Crime Split by Aspirin.

Patrignani P, Dovizio M.

EBioMedicine. 2015 Apr 21;2(5):372-3. doi: 10.1016/j.ebiom.2015.04.013. eCollection 2015 May. No abstract available.


Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.

Xiao B, Gu SM, Li MJ, Li J, Tao B, Wang Y, Wang Y, Zuo S, Shen Y, Yu Y, Chen D, Chen G, Kong D, Tang J, Liu Q, Chen DR, Liu Y, Alberti S, Dovizio M, Landolfi R, Mucci L, Miao PZ, Gao P, Zhu DL, Wang J, Li B, Patrignani P, Yu Y.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1687-95. doi: 10.1161/ATVBAHA.115.305445. Epub 2015 May 14.


Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1.

Marcantoni E, Dovizio M, O'Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:103-14. doi: 10.1016/j.prostaglandins.2015.03.004. Epub 2015 Mar 26.


Platelets, cyclooxygenases, and colon cancer.

Guillem-Llobat P, Dovizio M, Alberti S, Bruno A, Patrignani P.

Semin Oncol. 2014 Jun;41(3):385-96. doi: 10.1053/j.seminoncol.2014.04.008. Epub 2014 Apr 24. Review.


Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action.

Patrignani P, Tacconelli S, Piazuelo E, Di Francesco L, Dovizio M, Sostres C, Marcantoni E, Guillem-Llobat P, Del Boccio P, Zucchelli M, Patrono C, Lanas A.

J Thromb Haemost. 2014 Aug;12(8):1320-30. doi: 10.1111/jth.12637. Epub 2014 Jul 18.


Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M.

Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18.


Role of platelets in inflammation and cancer: novel therapeutic strategies.

Dovizio M, Alberti S, Guillem-Llobat P, Patrignani P.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):118-27. doi: 10.1111/bcpt.12156. Epub 2013 Nov 8. Review.


In vitro morphine metabolism by rat microglia.

Togna AR, Antonilli L, Dovizio M, Salemme A, De Carolis L, Togna GI, Patrignani P, Nencini P.

Neuropharmacology. 2013 Dec;75:391-8. doi: 10.1016/j.neuropharm.2013.08.019. Epub 2013 Aug 27.


Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.

Vitale P, Tacconelli S, Perrone MG, Malerba P, Simone L, Scilimati A, Lavecchia A, Dovizio M, Marcantoni E, Bruno A, Patrignani P.

J Med Chem. 2013 Jun 13;56(11):4277-99. doi: 10.1021/jm301905a. Epub 2013 May 16.


Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells.

Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P.

Mol Pharmacol. 2013 Jul;84(1):25-40. doi: 10.1124/mol.113.084988. Epub 2013 Apr 11.


Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

Anzini M, Di Capua A, Valenti S, Brogi S, Rovini M, Giuliani G, Cappelli A, Vomero S, Chiasserini L, Sega A, Poce G, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Benetti V, Giordani A, Anzellotti P, Dovizio M, Patrignani P, Biava M.

J Med Chem. 2013 Apr 25;56(8):3191-206. doi: 10.1021/jm301370e. Epub 2013 Apr 11. Erratum in: J Med Chem. 2013 Jun 13;56(11):4821.


Mechanisms of the antitumoural effects of aspirin in the gastrointestinal tract.

Bruno A, Dovizio M, Tacconelli S, Patrignani P.

Best Pract Res Clin Gastroenterol. 2012 Aug;26(4):e1-e13. doi: 10.1016/j.bpg.2012.10.001. Review.


Repeated exposure to codeine alters morphine glucuronidation by affecting UGT gene expression in the rat.

Antonilli L, De Carolis L, Brusadin V, Togna AR, Dovizio M, Togna GI, Patrignani P, Nencini P.

Eur J Pharmacol. 2012 Oct 15;693(1-3):7-14. doi: 10.1016/j.ejphar.2012.07.045. Epub 2012 Aug 21.


Mode of action of aspirin as a chemopreventive agent.

Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Recent Results Cancer Res. 2013;191:39-65. doi: 10.1007/978-3-642-30331-9_3. Review.


Novel insights into the vasoprotective role of heme oxygenase-1.

Marcantoni E, Di Francesco L, Dovizio M, Bruno A, Patrignani P.

Int J Hypertens. 2012;2012:127910. doi: 10.1155/2012/127910. Epub 2012 Feb 22.


Inside platelet-leukocyte cross-talk.

Patrignani P, Dovizio M.

Blood. 2012 Apr 19;119(16):3649-50. doi: 10.1182/blood-2012-02-406769. No abstract available.


Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis.

Dovizio M, Tacconelli S, Ricciotti E, Bruno A, Maier TJ, Anzellotti P, Di Francesco L, Sala P, Signoroni S, Bertario L, Dixon DA, Lawson JA, Steinhilber D, FitzGerald GA, Patrignani P.

J Pharmacol Exp Ther. 2012 Apr;341(1):242-50. doi: 10.1124/jpet.111.190785. Epub 2012 Jan 19.


Mechanistic and pharmacological issues of aspirin as an anticancer agent.

Dovizio M, Tacconelli S, Sostres C, Ricciotti E, Patrignani P.

Pharmaceuticals (Basel). 2012 Dec 5;5(12):1346-71. doi: 10.3390/ph5121346.


An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes.

Benfenati V, Caprini M, Dovizio M, Mylonakou MN, Ferroni S, Ottersen OP, Amiry-Moghaddam M.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8. doi: 10.1073/pnas.1012867108. Epub 2011 Jan 24.


NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes.

Ricciotti E, Dovizio M, Di Francesco L, Anzellotti P, Salvatore T, Di Francesco A, Sciulli MG, Pistritto G, Monopoli A, Patrignani P.

J Immunol. 2010 Feb 15;184(4):2140-7. doi: 10.4049/jimmunol.0903107. Epub 2010 Jan 11.


Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.

Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P.

Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi: 10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27.


Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia.

Benfenati V, Caprini M, Nicchia GP, Rossi A, Dovizio M, Cervetto C, Nobile M, Ferroni S.

Channels (Austin). 2009 Sep-Oct;3(5):323-36. Epub 2009 Sep 20.


Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.

Di Francesco L, Totani L, Dovizio M, Piccoli A, Di Francesco A, Salvatore T, Pandolfi A, Evangelista V, Dercho RA, Seta F, Patrignani P.

Circ Res. 2009 Feb 27;104(4):506-13. doi: 10.1161/CIRCRESAHA.108.191114. Epub 2009 Jan 2.


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