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The influence of linkages between 1-hydroxy-2(1H)-pyridinone coordinating groups and a tris(2-aminoethyl)amine core in a novel series of synthetic hexadentate iron(III) chelators on antimicrobial activity.

Workman DG, Hunter M, Wang S, Brandel J, Hubscher V, Dover LG, Tétard D.

Bioorg Chem. 2019 Dec 2;95:103465. doi: 10.1016/j.bioorg.2019.103465. [Epub ahead of print]


Genomic analysis of a novel Rhodococcus (Prescottella) equi isolate from a bovine host.

Paterson ML, Ranasinghe D, Blom J, Dover LG, Sutcliffe IC, Lopes B, Sangal V.

Arch Microbiol. 2019 Nov;201(9):1317-1321. doi: 10.1007/s00203-019-01695-z. Epub 2019 Jul 13.


Antibacterial Metallic Touch Surfaces.

Villapún VM, Dover LG, Cross A, González S.

Materials (Basel). 2016 Aug 29;9(9). pii: E736. doi: 10.3390/ma9090736. Review.


Tuning the Mechanical and Antimicrobial Performance of a Cu-Based Metallic Glass Composite through Cooling Rate Control and Annealing.

Villapún VM, Esat F, Bull S, Dover LG, González S.

Materials (Basel). 2017 May 6;10(5). pii: E506. doi: 10.3390/ma10050506.


Comment on Tocheva et al. "Sporulation, bacterial cell envelopes and the origin of life".

Sutcliffe IC, Dover LG.

Nat Rev Microbiol. 2016 Sep;14(9):600. doi: 10.1038/nrmicro.2016.113. Epub 2016 Jul 25. No abstract available.


Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents.

Workman DG, Hunter M, Dover LG, Tétard D.

J Inorg Biochem. 2016 Jul;160:49-58. doi: 10.1016/j.jinorgbio.2016.04.018. Epub 2016 Apr 16.


Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi.

Okoko T, Blagova EV, Whittingham JL, Dover LG, Wilkinson AJ.

Vet Microbiol. 2015 Aug 31;179(1-2):42-52. doi: 10.1016/j.vetmic.2015.01.027. Epub 2015 Feb 9.


Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone.

Malik V, Zhang M, Dover LG, Northen JS, Flinn A, Perry JJ, Black GW.

Mol Biosyst. 2013 Nov;9(11):2816-22. doi: 10.1039/c3mb70303g.


Current status and research strategies in tuberculosis drug development.

Dover LG, Coxon GD.

J Med Chem. 2011 Sep 22;54(18):6157-65. doi: 10.1021/jm200305q. Epub 2011 Aug 16. Review. No abstract available. Erratum in: J Med Chem. 2011 Dec 8;54(23):8233.


Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium.

Young M, Artsatbanov V, Beller HR, Chandra G, Chater KF, Dover LG, Goh EB, Kahan T, Kaprelyants AS, Kyrpides N, Lapidus A, Lowry SR, Lykidis A, Mahillon J, Markowitz V, Mavromatis K, Mukamolova GV, Oren A, Rokem JS, Smith MC, Young DI, Greenblatt CL.

J Bacteriol. 2010 Feb;192(3):841-60. doi: 10.1128/JB.01254-09. Epub 2009 Nov 30.


Lipoteichoic acid biosynthesis: two steps forwards, one step sideways?

Rahman O, Dover LG, Sutcliffe IC.

Trends Microbiol. 2009 Jun;17(6):219-25. doi: 10.1016/j.tim.2009.03.003. Epub 2009 May 20.


Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis.

Usha V, Dover LG, Roper DI, Fütterer K, Besra GS.

Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):383-7. doi: 10.1107/S0907444909002522. Epub 2009 Mar 19.


Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter.

Schué M, Dover LG, Besra GS, Parkhill J, Brown NL.

J Bacteriol. 2009 Jan;191(1):439-44. doi: 10.1128/JB.01063-08. Epub 2008 Oct 17.


New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.

Dover LG, Bhatt A, Bhowruth V, Willcox BE, Besra GS.

Expert Rev Vaccines. 2008 May;7(4):481-97. doi: 10.1586/14760584.7.4.481. Review.


Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization.

Usha V, Dover LG, Roper DL, Besra GS.

FEMS Microbiol Lett. 2008 Mar;280(1):57-63. doi: 10.1111/j.1574-6968.2007.01049.x.


Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.

Alderwick LJ, Dover LG, Veerapen N, Gurcha SS, Kremer L, Roper DL, Pathak AK, Reynolds RC, Besra GS.

Protein Expr Purif. 2008 Apr;58(2):332-41. doi: 10.1016/j.pep.2007.11.012. Epub 2007 Dec 8.


Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

Alahari A, Trivelli X, Guérardel Y, Dover LG, Besra GS, Sacchettini JC, Reynolds RC, Coxon GD, Kremer L.

PLoS One. 2007 Dec 19;2(12):e1343.


Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

Brown AK, Papaemmanouil A, Bhowruth V, Bhatt A, Dover LG, Besra GS.

Microbiology. 2007 Oct;153(Pt 10):3314-3322. doi: 10.1099/mic.0.2007/009936-0.


Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.

Brown AK, Meng G, Ghadbane H, Scott DJ, Dover LG, Nigou J, Besra GS, Fütterer K.

BMC Struct Biol. 2007 Aug 28;7:55.


Structures and functions of microbial lipid antigens presented by CD1.

Willcox BE, Willcox CR, Dover LG, Besra G.

Curr Top Microbiol Immunol. 2007;314:73-110. Review.


Regulation of cell wall synthesis and growth.

Dover LG, Alderwick LJ, Brown AK, Futterer K, Besra GS.

Curr Mol Med. 2007 May;7(3):247-76. Review.


The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis.

Gande R, Dover LG, Krumbach K, Besra GS, Sahm H, Oikawa T, Eggeling L.

J Bacteriol. 2007 Jul;189(14):5257-64. Epub 2007 May 4.


Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.

Bacon J, Dover LG, Hatch KA, Zhang Y, Gomes JM, Kendall S, Wernisch L, Stoker NG, Butcher PD, Besra GS, Marsh PD.

Microbiology. 2007 May;153(Pt 5):1435-1444. doi: 10.1099/mic.0.2006/004317-0.


Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum.

Ren H, Dover LG, Islam ST, Alexander DC, Chen JM, Besra GS, Liu J.

Mol Microbiol. 2007 Mar;63(5):1345-59.


Tuberculosis chemotherapy: recent developments and future perspectives.

Bhowruth V, Dover LG, Besra GS.

Prog Med Chem. 2007;45:169-203. Review. No abstract available.


Mechanism of thioamide drug action against tuberculosis and leprosy.

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC.

J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.


EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L.

Antimicrob Agents Chemother. 2007 Mar;51(3):1055-63. Epub 2007 Jan 12.


Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.

Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS.

J Biol Chem. 2007 Feb 16;282(7):4561-72. Epub 2006 Dec 19.


X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC.

J Mol Biol. 2007 Feb 16;366(2):469-80. Epub 2006 Nov 7.


Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase.

Usha V, Dover LG, Roper DL, Lloyd AJ, Besra GS.

FEMS Microbiol Lett. 2006 Sep;262(1):39-47.


Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.

Alderwick LJ, Dover LG, Seidel M, Gande R, Sahm H, Eggeling L, Besra GS.

Glycobiology. 2006 Nov;16(11):1073-81. Epub 2006 Aug 4.


LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.

Burguière A, Hitchen PG, Dover LG, Kremer L, Ridell M, Alexander DC, Liu J, Morris HR, Minnikin DE, Dell A, Besra GS.

J Biol Chem. 2005 Dec 23;280(51):42124-33. Epub 2005 Oct 28.


Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS.

J Biol Chem. 2005 Sep 16;280(37):32539-47. Epub 2005 Jul 22.


Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.

Burguière A, Hitchen PG, Dover LG, Dell A, Besra GS.

Microbiology. 2005 Jun;151(Pt 6):2087-2095. doi: 10.1099/mic.0.27938-0.


Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L.

J Biol Chem. 2004 Oct 22;279(43):44847-57. Epub 2004 Aug 11.


Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.

Dover LG, Corsino PE, Daniels IR, Cocklin SL, Tatituri V, Besra GS, Fütterer K.

J Mol Biol. 2004 Jul 23;340(5):1095-105.


Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Guy MR, Illarionov PA, Gurcha SS, Dover LG, Gibson KJ, Smith PW, Minnikin DE, Besra GS.

Biochem J. 2004 Sep 15;382(Pt 3):905-12.


Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae.

Dover LG, Cerdeño-Tárraga AM, Pallen MJ, Parkhill J, Besra GS.

FEMS Microbiol Rev. 2004 May;28(2):225-50. Review.


The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.

Cerdeño-Tárraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG, Parkhill J.

Nucleic Acids Res. 2003 Nov 15;31(22):6516-23.


Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR Jr, Besra GS.

J Biol Chem. 2003 Jun 6;278(23):20547-54. Epub 2003 Mar 24.


Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.

Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG, Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A, Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J, Relman DA.

Lancet. 2003 Feb 22;361(9358):637-44.


Stable self-assembly of a protein engineering scaffold on gold surfaces.

Terrettaz S, Ulrich WP, Vogel H, Hong Q, Dover LG, Lakey JH.

Protein Sci. 2002 Aug;11(8):1917-25.


The methyl-branched fortifications of Mycobacterium tuberculosis.

Minnikin DE, Kremer L, Dover LG, Besra GS.

Chem Biol. 2002 May;9(5):545-53. Review.


Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS.

Biochem J. 2002 Jun 1;364(Pt 2):423-30.


The M. tuberculosis antigen 85 complex and mycolyltransferase activity.

Kremer L, Maughan WN, Wilson RA, Dover LG, Besra GS.

Lett Appl Microbiol. 2002;34(4):233-7.


Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.

Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS.

J Biol Chem. 2001 Jul 27;276(30):27967-74. Epub 2001 May 23.


Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.

Kremer L, Dover LG, Morehouse C, Hitchin P, Everett M, Morris HR, Dell A, Brennan PJ, McNeil MR, Flaherty C, Duncan K, Besra GS.

J Biol Chem. 2001 Jul 13;276(28):26430-40. Epub 2001 Apr 13.


Iron metabolism in pathogenic bacteria.

Ratledge C, Dover LG.

Annu Rev Microbiol. 2000;54:881-941. Review.


Colicin pore-forming domains bind to Escherichia coli trimeric porins.

Dover LG, Evans LJ, Fridd SL, Bainbridge G, Raggett EM, Lakey JH.

Biochemistry. 2000 Jul 25;39(29):8632-7.


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