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Conserved serum protein biomarkers associated with growing early colorectal adenomas.

Ivancic MM, Anson LW, Pickhardt PJ, Megna B, Pooler BD, Clipson L, Reichelderfer M, Sussman MR, Dove WF.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8471-8480. doi: 10.1073/pnas.1813212116. Epub 2019 Apr 10.


The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.

Pleiman JK, Irving AA, Wang Z, Toraason E, Clipson L, Dove WF, Deming DA, Newton MA.

PLoS Genet. 2018 Sep 6;14(9):e1007611. doi: 10.1371/journal.pgen.1007611. eCollection 2018 Sep.


Understanding Intratumoral Heterogeneity: Lessons from the Analysis of At-Risk Tissue and Premalignant Lesions in the Colon.

Sievers CK, Leystra AA, Clipson L, Dove WF, Halberg RB.

Cancer Prev Res (Phila). 2016 Aug;9(8):638-41. doi: 10.1158/1940-6207.CAPR-16-0096. Epub 2016 May 19.


Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer.

Irving AA, Plum LA, Blaser WJ, Ford MR, Weng C, Clipson L, DeLuca HF, Dove WF.

J Nutr. 2015 Feb;145(2):291-8. doi: 10.3945/jn.114.204396. Epub 2014 Dec 24.


Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.

Amos-Landgraf JM, Heijmans J, Wielenga MC, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V, Hommes DW, Shedlovsky A, Dove WF, van den Brink GR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16514-9. doi: 10.1073/pnas.1323064111. Epub 2014 Nov 3.


The utility of Apc-mutant rats in modeling human colon cancer.

Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, Kuramoto T, Dove WF, Amos-Landgraf JM.

Dis Model Mech. 2014 Nov;7(11):1215-25. doi: 10.1242/dmm.016980. Epub 2014 Oct 2. Review.


The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.

Ivancic MM, Irving AA, Jonakin KG, Dove WF, Sussman MR.

Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.


A strategy to identify dominant point mutant modifiers of a quantitative trait.

Dove WF, Shedlovsky A, Clipson L, Amos-Landgraf JM, Halberg RB, Krentz KJ, Boehm FJ, Newton MA, Adams DJ, Keane TM.

G3 (Bethesda). 2014 Apr 17;4(6):1113-21. doi: 10.1534/g3.114.010595.


A simple, quantitative method using alginate gel to determine rat colonic tumor volume in vivo.

Irving AA, Young LB, Pleiman JK, Konrath MJ, Marzella B, Nonte M, Cacciatore J, Ford MR, Clipson L, Amos-Landgraf JM, Dove WF.

Comp Med. 2014 Apr;64(2):128-34.


Candidate serum biomarkers for early intestinal cancer using 15N metabolic labeling and quantitative proteomics in the ApcMin/+ mouse.

Ivancic MM, Huttlin EL, Chen X, Pleiman JK, Irving AA, Hegeman AD, Dove WF, Sussman MR.

J Proteome Res. 2013 Sep 6;12(9):4152-66. doi: 10.1021/pr400467c. Epub 2013 Aug 8.


Pathology of rodent models of intestinal cancer: progress report and recommendations.

Washington MK, Powell AE, Sullivan R, Sundberg JP, Wright N, Coffey RJ, Dove WF.

Gastroenterology. 2013 Apr;144(4):705-17. doi: 10.1053/j.gastro.2013.01.067. Epub 2013 Feb 12. Review.


Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice.

Thliveris AT, Clipson L, Sommer LL, Schoenike BA, Hasenstein JR, Schlamp CL, Alexander CM, Newton MA, Dove WF, Amos-Landgraf JM.

G3 (Bethesda). 2012 May;2(5):569-78. doi: 10.1534/g3.112.002436. Epub 2012 May 1.


The many ways to open the gate to colon cancer.

Amos-Landgraf JM, Clipson L, Newton MA, Dove WF.

Cell Cycle. 2012 Apr 1;11(7):1261-2. doi: 10.4161/cc.19888. Epub 2012 Apr 1. No abstract available.


Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.

Amos-Landgraf JM, Irving AA, Hartman C, Hunter A, Laube B, Chen X, Clipson L, Newton MA, Dove WF.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2060-5. doi: 10.1073/pnas.1120753109. Epub 2012 Jan 23.


Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models.

Irving AA, Halberg RB, Albrecht DM, Plum LA, Krentz KJ, Clipson L, Drinkwater N, Amos-Landgraf JM, Dove WF, DeLuca HF.

Arch Biochem Biophys. 2011 Nov;515(1-2):64-71. doi: 10.1016/ Epub 2011 Sep 1.


Clonal structure of carcinogen-induced intestinal tumors in mice.

Thliveris AT, Clipson L, White A, Waggoner J, Plesh L, Skinner BL, Zahm CD, Sullivan R, Dove WF, Newton MA, Halberg RB.

Cancer Prev Res (Phila). 2011 Jun;4(6):916-23. doi: 10.1158/1940-6207.CAPR-11-0022.


APC and its modifiers in colon cancer.

Kwong LN, Dove WF.

Adv Exp Med Biol. 2009;656:85-106. Review.


Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy.

Durkee BY, Shinki K, Newton MA, Iverson CE, Weichert JP, Dove WF, Halberg RB.

Acad Radiol. 2009 Dec;16(12):1475-82. doi: 10.1016/j.acra.2009.07.023.


Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.

Huttlin EL, Chen X, Barrett-Wilt GA, Hegeman AD, Halberg RB, Harms AC, Newton MA, Dove WF, Sussman MR.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17235-40. doi: 10.1073/pnas.0909282106. Epub 2009 Sep 23.


Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.

Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF.

Cancer Res. 2009 Jul 15;69(14):5768-75. doi: 10.1158/0008-5472.CAN-09-0446. Epub 2009 Jul 7.


The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.

Halberg RB, Chen X, Amos-Landgraf JM, White A, Rasmussen K, Clipson L, Pasch C, Sullivan R, Pitot HC, Dove WF.

Genetics. 2008 Sep;180(1):601-9. doi: 10.1534/genetics.108.091967. Epub 2008 Aug 24.


Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition.

Chen X, Halberg RB, Burch RP, Dove WF.

J Mol Histol. 2008 Jun;39(3):283-94. doi: 10.1007/s10735-008-9164-3. Epub 2008 Mar 8.


Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis.

Bilger A, Sullivan R, Prunuske AJ, Clipson L, Drinkwater NR, Dove WF.

Carcinogenesis. 2008 Sep;29(9):1825-30. doi: 10.1093/carcin/bgn038. Epub 2008 Feb 28.


Cellular expression patterns of genes upregulated in murine and human colonic neoplasms.

Chen X, Ehrhardt WM, Halberg RB, Aronow BJ, Dove WF.

J Histochem Cytochem. 2008 May;56(5):433-41. doi: 10.1369/jhc.7A7359.2008. Epub 2008 Jan 7.


Atm is a negative regulator of intestinal neoplasia.

Kwong LN, Weiss KR, Haigis KM, Dove WF.

Oncogene. 2008 Feb 7;27(7):1013-8. Epub 2007 Aug 13.


Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.

Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ Jr, Aronow BJ.

Genome Biol. 2007;8(7):R131.


Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.

Kwong LN, Shedlovsky A, Biehl BS, Clipson L, Pasch CA, Dove WF.

Genetics. 2007 Jun;176(2):1237-44. Epub 2007 Apr 15.


A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.

Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.


Human biology: an ever-expanding subject.

Wilkins AS, Dove WF.

Bioessays. 2006 Nov;28(11):1146-9. No abstract available.


Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions.

Thliveris AT, Halberg RB, Clipson L, Dove WF, Sullivan R, Washington MK, Stanhope S, Newton MA.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6960-5. Epub 2005 May 3.


The knockout mouse project.

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B.

Nat Genet. 2004 Sep;36(9):921-4.


Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.

Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9769-73. Epub 2004 Jun 21.


Clusterin as a biomarker in murine and human intestinal neoplasia.

Chen X, Halberg RB, Ehrhardt WM, Torrealba J, Dove WF.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9530-5. Epub 2003 Jul 28.


Pathology of mouse models of intestinal cancer: consensus report and recommendations.

Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, Russell R, Besselsen DG, Godfrey VL, Doetschman T, Dove WF, Pitot HC, Halberg RB, Itzkowitz SH, Groden J, Coffey RJ.

Gastroenterology. 2003 Mar;124(3):762-77. Review. No abstract available.


A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

Haigis KM, Dove WF.

Nat Genet. 2003 Jan;33(1):33-9. Epub 2002 Nov 25.


Intestinal adenomas can develop with a stable karyotype and stable microsatellites.

Haigis KM, Caya JG, Reichelderfer M, Dove WF.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8927-31. Epub 2002 Jun 11.


The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64.

Cormier RT, Bilger A, Lillich AJ, Halberg RB, Hong KH, Gould KA, Borenstein N, Lander ES, Dove WF.

Oncogene. 2000 Jun 29;19(28):3182-92.


Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice.

Shoemaker AR, Haigis KM, Baker SM, Dudley S, Liskay RM, Dove WF.

Oncogene. 2000 May 25;19(23):2774-9.


Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.

Halberg RB, Katzung DS, Hoff PD, Moser AR, Cole CE, Lubet RA, Donehower LA, Jacoby RF, Dove WF.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3461-6.


Identification of three genes expressed primarily during development in Physarum polycephalum.

Bailey J, Cook LJ, Kilmer-Barber R, Swanston E, Solnica-Krezel L, Lohman K, Dove WF, Dee J, Anderson RW.

Arch Microbiol. 1999 Dec;172(6):364-76.


Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene.

Cox RD, Hugill A, Shedlovsky A, Noveroske JK, Best S, Justice MJ, Lehrach H, Dove WF.

Genomics. 1999 May 1;57(3):333-41.


A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.

Shoemaker AR, Moser AR, Midgley CA, Clipson L, Newton MA, Dove WF.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10826-31.


The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.

Dove WF, Cormier RT, Gould KA, Halberg RB, Merritt AJ, Newton MA, Shoemaker AR.

Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):915-23. Review.


Analysis of the Mom1 modifier of intestinal neoplasia in mice.

Gould KA, Dove WF.

Exp Lung Res. 1998 Jul-Aug;24(4):437-53. Review.


Birds' eye view: a decade of perspectives.

Crow JF, Dove WF.

Genetics. 1998 Apr;148(4):1405-7. No abstract available.


Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages.

Merritt AJ, Gould KA, Dove WF.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13927-31.


Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.

Cormier RT, Hong KH, Halberg RB, Hawkins TL, Richardson P, Mulherkar R, Dove WF, Lander ES.

Nat Genet. 1997 Sep;17(1):88-91.


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