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Items: 1 to 50 of 69

1.

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia.

Annageldiyev C, Gowda K, Patel T, Bhattacharya P, Tan SF, Iyer S, Desai D, Dovat S, Feith DJ, Loughran TP Jr, Amin S, Claxton D, Sharma A.

Haematologica. 2019 May 23. pii: haematol.2018.212886. doi: 10.3324/haematol.2018.212886. [Epub ahead of print]

2.

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity.

Ding Y, Zhang B, Payne JL, Song C, Ge Z, Gowda C, Iyer S, Dhanyamraju PK, Dorsam G, Reeves ME, Desai D, Huang S, Payne KJ, Yue F, Dovat S.

Leukemia. 2019 May 9. doi: 10.1038/s41375-019-0474-0. [Epub ahead of print]

PMID:
31073152
3.

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries.

Luo H, Sobh A, Vulpe CD, Brewer E, Dovat S, Qiu Y, Huang S.

J Vis Exp. 2019 Mar 31;(145). doi: 10.3791/59382.

PMID:
30985763
4.

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells.

Nicolae CM, O'Connor MJ, Schleicher EM, Song C, Gowda R, Robertson G, Dovat S, Moldovan GL.

Oncogene. 2019 Apr 9. doi: 10.1038/s41388-019-0810-x. [Epub ahead of print]

PMID:
30967629
5.

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia.

Ge Z, Han Q, Gu Y, Ge Q, Ma J, Sloane J, Gao G, Payne KJ, Szekely L, Song C, Dovat S.

Oncogenesis. 2018 Nov 12;7(11):84. doi: 10.1038/s41389-018-0095-x.

6.

New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time.

Tong YQ, Zhao ZJ, Liu B, Bao AY, Zheng HY, Gu J, Xia Y, McGrath M, Dovat S, Song CH, Li Y.

Leuk Res. 2018 Jun;69:47-53. doi: 10.1016/j.leukres.2018.04.001. Epub 2018 Apr 4.

PMID:
29655153
7.

Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.

Ge Z, Gu Y, Han Q, Sloane J, Ge Q, Gao G, Ma J, Song H, Hu J, Chen B, Dovat S, Song C.

Epigenomics. 2018 Jan;10(1):59-69. doi: 10.2217/epi-2017-0092. Epub 2017 Oct 10.

8.

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis.

Pandey MK, Gowda K, Sung SS, Abraham T, Budak-Alpdogan T, Talamo G, Dovat S, Amin S.

Exp Hematol. 2017 Sep;53:31-42. doi: 10.1016/j.exphem.2017.06.003. Epub 2017 Jun 22.

PMID:
28647392
9.

Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.

Gowda C, Soliman M, Kapadia M, Ding Y, Payne K, Dovat S.

Adv Biol Regul. 2017 Aug;65:16-25. doi: 10.1016/j.jbior.2017.06.001. Epub 2017 Jun 13. Review.

10.

STAT5 alters the state of transcriptional networks, driving aggressive leukemia.

Dovat S, Payne KJ.

Nat Immunol. 2017 May 18;18(6):597-598. doi: 10.1038/ni.3747. No abstract available.

PMID:
28518152
11.

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia.

Yoshida N, Sakaguchi H, Muramatsu H, Okuno Y, Song C, Dovat S, Shimada A, Ozeki M, Ohnishi H, Teramoto T, Fukao T, Kondo N, Takahashi Y, Matsumoto K, Kato K, Kojima S.

Leukemia. 2017 May;31(5):1221-1223. doi: 10.1038/leu.2017.25. Epub 2017 Jan 18. No abstract available.

PMID:
28096536
12.

Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.

Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C.

Sci Rep. 2017 Jan 11;7:40457. doi: 10.1038/srep40457. No abstract available.

13.

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia.

Ge Z, Zhou X, Gu Y, Han Q, Li J, Chen B, Ge Q, Dovat E, Payne JL, Sun T, Song C, Dovat S.

Oncotarget. 2017 Jan 31;8(5):8022-8034. doi: 10.18632/oncotarget.14038.

14.

Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.

Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C.

Sci Rep. 2016 Nov 25;6:38004. doi: 10.1038/srep38004. Erratum in: Sci Rep. 2017 Jan 11;7:40457.

15.

WDR5 high expression and its effect on tumorigenesis in leukemia.

Ge Z, Song EJ, Kawasawa YI, Li J, Dovat S, Song C.

Oncotarget. 2016 Jun 21;7(25):37740-37754. doi: 10.18632/oncotarget.9312.

16.

Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies.

Gowda C, Sachdev M, Muthusami S, Kapadia M, Petrovic-Dovat L, Hartman M, Ding Y, Song C, Payne JL, Tan BH, Dovat S.

Curr Pharm Des. 2017;23(1):95-107. doi: 10.2174/1381612822666161006154311. Review.

PMID:
27719640
17.

Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia.

Ge Z, Li M, Zhao G, Xiao L, Gu Y, Zhou X, Yu MD, Li J, Dovat S, Song C.

Oncol Lett. 2016 Oct;12(4):2746-2751. Epub 2016 Aug 10.

18.

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.

Bao L, Chen SJ, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Wang HG, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA.

J Biol Chem. 2016 Nov 18;291(47):24449-24464. Epub 2016 Sep 30.

19.

Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros.

Gowda C, Song C, Kapadia M, Payne JL, Hu T, Ding Y, Dovat S.

Adv Biol Regul. 2017 Jan;63:71-80. doi: 10.1016/j.jbior.2016.09.003. Epub 2016 Sep 18. Review.

20.

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement.

Ge Z, Gu Y, Zhao G, Li J, Chen B, Han Q, Guo X, Liu J, Li H, Yu MD, Olson J, Steffens S, Payne KJ, Song C, Dovat S.

Oncotarget. 2016 Aug 2;7(31):49722-49732. doi: 10.18632/oncotarget.10437.

21.

TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis.

Milford TA, Su RJ, Francis OL, Baez I, Martinez SR, Coats JS, Weldon AJ, Calderon MN, Nwosu MC, Botimer AR, Suterwala BT, Zhang XB, Morris CL, Weldon DJ, Dovat S, Payne KJ.

Eur J Immunol. 2016 Sep;46(9):2155-61. doi: 10.1002/eji.201646307. Epub 2016 Jul 12.

22.

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction.

Ge Z, Gu Y, Xiao L, Han Q, Li J, Chen B, Yu J, Kawasawa YI, Payne KJ, Dovat S, Song C.

Oncotarget. 2016 Jul 19;7(29):46014-46027. doi: 10.18632/oncotarget.10014.

23.

Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer.

Xiang M, Su H, Shu G, Wan D, He F, Loaec M, Ding Y, Li J, Dovat S, Yang G, Song C.

Oncotarget. 2016 Apr 5;7(14):18521-30. doi: 10.18632/oncotarget.7848.

24.

Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis.

Gowda CS, Song C, Ding Y, Kapadia M, Dovat S.

J Investig Med. 2016 Mar;64(3):735-9. doi: 10.1136/jim-2016-000075. Epub 2016 Feb 9. Review.

PMID:
26912004
25.

Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.

Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S.

J Biol Chem. 2016 Feb 19;291(8):4004-18. doi: 10.1074/jbc.M115.679332. Epub 2015 Dec 10.

26.

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia.

Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S.

Leukemia. 2016 Jun;30(6):1436-40. doi: 10.1038/leu.2015.331. Epub 2015 Dec 7. No abstract available.

27.

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis.

Francis OL, Milford TA, Martinez SR, Baez I, Coats JS, Mayagoitia K, Concepcion KR, Ginelli E, Beldiman C, Benitez A, Weldon AJ, Arogyaswamy K, Shiraz P, Fisher R, Morris CL, Zhang XB, Filippov V, Van Handel B, Ge Z, Song C, Dovat S, Su RJ, Payne KJ.

Haematologica. 2016 Apr;101(4):417-26. doi: 10.3324/haematol.2015.125336. Epub 2015 Nov 26.

28.

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia.

Ge Z, Guo X, Li J, Hartman M, Kawasawa YI, Dovat S, Song C.

Oncotarget. 2015 Dec 8;6(39):42300-11. doi: 10.18632/oncotarget.5982.

29.

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S.

Blood. 2015 Oct 8;126(15):1813-22. doi: 10.1182/blood-2015-06-651505. Epub 2015 Jul 28.

30.

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia.

Guo X, Zhang R, Liu J, Li M, Song C, Dovat S, Li J, Ge Z.

PLoS One. 2015 May 5;10(5):e0125429. doi: 10.1371/journal.pone.0125429. eCollection 2015.

31.

Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis.

Hu RM, Tan BH, Tester DJ, Song C, He Y, Dovat S, Peterson BZ, Ackerman MJ, Makielski JC.

PLoS One. 2015 Apr 29;10(4):e0124921. doi: 10.1371/journal.pone.0124921. eCollection 2015.

32.

Translating basic science discoveries to clinical practice-Let us not repeat the naiveté of the pre-omics era.

Payne KJ, Benitez A, Dovat S.

Ann Transl Med. 2015 Mar;3(4):46. doi: 10.3978/j.issn.2305-5839.2015.01.39. No abstract available.

33.

Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.

Wang H, Song C, Gurel Z, Song N, Ma J, Ouyang H, Lai L, Payne KJ, Dovat S.

Pediatr Blood Cancer. 2014 Dec;61(12):2230-5. doi: 10.1002/pbc.25221. Epub 2014 Sep 11.

34.

Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways.

Pandey MK, Kale VP, Song C, Sung SS, Sharma AK, Talamo G, Dovat S, Amin SG.

Exp Hematol. 2014 Oct;42(10):883-96. doi: 10.1016/j.exphem.2014.07.261. Epub 2014 Jul 14.

PMID:
25034231
35.

Pathogenesis and regulation of cellular proliferation in acute lymphoblastic leukemia - the role of Ikaros.

Wang H, Ouyang H, Lai L, Petrovic-Dovat L, Stankov K, Bogdanovic G, Dovat S.

J BUON. 2014 Jan-Mar;19(1):22-8. Review.

36.

Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.

Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE.

J Virol. 2014 May;88(9):4811-27. doi: 10.1128/JVI.03706-13. Epub 2014 Feb 12.

37.

G0S2--a new player in leukemia.

Payne KJ, Dovat S.

Leuk Res. 2014 Feb;38(2):147-8. doi: 10.1016/j.leukres.2013.11.011. Epub 2013 Nov 24. No abstract available.

38.

Ikaros: the enhancer makes the difference.

Dovat S.

Blood. 2013 Oct 31;122(18):3091-2. doi: 10.1182/blood-2013-09-526343. No abstract available.

39.

Induction of senescence by adenosine suppressing the growth of lung cancer cells.

Yang D, Song J, Wu L, Ma Y, Song C, Dovat S, Nishizaki T, Liu J.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):62-7. doi: 10.1016/j.bbrc.2013.09.030. Epub 2013 Sep 17.

PMID:
24051088
40.

Genetic targets in pediatric acute lymphoblastic leukemia.

Gowda C, Dovat S.

Adv Exp Med Biol. 2013;779:327-40. doi: 10.1007/978-1-4614-6176-0_15. Review.

PMID:
23288647
41.

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.

Uckun FM, Ma H, Zhang J, Ozer Z, Dovat S, Mao C, Ishkhanian R, Goodman P, Qazi S.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18072-7. doi: 10.1073/pnas.1209828109. Epub 2012 Oct 15.

42.

Angiogenesis and survival in patients with myelodysplastic syndrome.

Savic A, Cemerikic-Martinovic V, Dovat S, Rajic N, Urosevic I, Sekulic B, Kvrgic V, Popovic S.

Pathol Oncol Res. 2012 Jul;18(3):681-90. doi: 10.1007/s12253-012-9495-y. Epub 2012 Jan 24.

PMID:
22270865
43.

Ikaros and tumor suppression in acute lymphoblastic leukemia.

Payne KJ, Dovat S.

Crit Rev Oncog. 2011;16(1-2):3-12. Review.

44.

Cell cycle-specific function of Ikaros in human leukemia.

Li Z, Song C, Ouyang H, Lai L, Payne KJ, Dovat S.

Pediatr Blood Cancer. 2012 Jul 15;59(1):69-76. doi: 10.1002/pbc.23406. Epub 2011 Nov 21.

45.

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.

Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M.

Blood. 2011 Oct 13;118(15):4174-8. doi: 10.1182/blood-2011-01-331181. Epub 2011 Aug 19.

46.

Ikaros isoforms: The saga continues.

Li Z, Perez-Casellas LA, Savic A, Song C, Dovat S.

World J Biol Chem. 2011 Jun 26;2(6):140-5. doi: 10.4331/wjbc.v2.i6.140.

47.

Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1.

Song C, Li Z, Erbe AK, Savic A, Dovat S.

World J Biol Chem. 2011 Jun 26;2(6):126-31. doi: 10.4331/wjbc.v2.i6.126.

48.

Ikaros in hematopoiesis and leukemia.

Dovat S.

World J Biol Chem. 2011 Jun 26;2(6):105-7. doi: 10.4331/wjbc.v2.i6.105.

49.

Ikaros, CK2 kinase, and the road to leukemia.

Dovat S, Song C, Payne KJ, Li Z.

Mol Cell Biochem. 2011 Oct;356(1-2):201-7. doi: 10.1007/s11010-011-0964-5. Epub 2011 Jul 13. Review.

50.

Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene.

Goldman FD, Gurel Z, Al-Zubeidi D, Fried AJ, Icardi M, Song C, Dovat S.

Pediatr Blood Cancer. 2012 Apr;58(4):591-7. doi: 10.1002/pbc.23160. Epub 2011 May 5.

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