Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 131


Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection.

Wallis E, Al-Hakim B, Holmes P, Douthwaite S, Kulasegaram R.

Int J STD AIDS. 2019 Sep;30(10):1031-1033. doi: 10.1177/0956462419856231. Epub 2019 Aug 12. No abstract available.


An innovative approach to increase viral hepatitis diagnoses and linkage to care using opt-out testing and an integrated care pathway in a London Emergency Department.

Evans H, Balasegaram S, Douthwaite S, Hunter L, Kulasegaram R, Wong T, Querol-Rubiera A, Nebbia G.

PLoS One. 2018 Jul 25;13(7):e0198520. doi: 10.1371/journal.pone.0198520. eCollection 2018.


Integrative and Conjugative Elements (ICEs) in Pasteurellaceae Species and Their Detection by Multiplex PCR.

Beker M, Rose S, Lykkebo CA, Douthwaite S.

Front Microbiol. 2018 Jun 26;9:1329. doi: 10.3389/fmicb.2018.01329. eCollection 2018.


Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606.

Avalos M, Boetzer M, Pirovano W, Arenas NE, Douthwaite S, van Wezel GP.

Genome Announc. 2018 May 3;6(18). pii: e00385-18. doi: 10.1128/genomeA.00385-18.


Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward.

Vecino-Ortiz AI, Goldenberg SD, Douthwaite ST, Cheng CY, Glover RE, Mak C, Adams EJ.

Diagn Microbiol Infect Dis. 2018 Aug;91(4):331-335. doi: 10.1016/j.diagmicrobio.2018.03.013. Epub 2018 Apr 4.


Biofilm Formation and Motility Are Promoted by Cj0588-Directed Methylation of rRNA in Campylobacter jejuni.

Sałamaszyńska-Guz A, Rose S, Lykkebo CA, Taciak B, Bącal P, Uśpieński T, Douthwaite S.

Front Cell Infect Microbiol. 2018 Jan 18;7:533. doi: 10.3389/fcimb.2017.00533. eCollection 2017.


Treating chronic hepatitis E: when is enough enough?

Evans TJ, Hilton R, Douthwaite S.

BMJ Case Rep. 2018 Feb 1;2018. pii: bcr-2017-223592. doi: 10.1136/bcr-2017-223592.


Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual.

Lee MJ, Douthwaite S, Kulasegaram R.

Sex Transm Infect. 2018 Feb;94(1):30-31. doi: 10.1136/sextrans-2017-053246. Epub 2017 Aug 31.


Point-of-care tests for infectious diseases: barriers to implementation across three London teaching hospitals.

Bustinduy AL, Jeyaratnam D, Douthwaite S, Tonkin-Crine S, Shaw R, Hyrapetian L, Sevdalis N, Goldenberg S, Adams EJ, Sharland M; CLAHRC South London; Paediatric Infection Network.

Acta Paediatr. 2017 Jul;106(7):1192-1195. doi: 10.1111/apa.13867. Epub 2017 May 10. No abstract available.


Bypassing rRNA methylation by RsmA/Dim1during ribosome maturation in the hyperthermophilic archaeon Nanoarchaeum equitans.

Seistrup KH, Rose S, Birkedal U, Nielsen H, Huber H, Douthwaite S.

Nucleic Acids Res. 2017 Feb 28;45(4):2007-2015. doi: 10.1093/nar/gkw839.


Immune Complex Mediated Glomerulonephritis with Acute Thrombotic Microangiopathy following Newly Detected Hepatitis B Virus Infection in a Kidney Transplant Recipient.

Salter T, Burton H, Douthwaite S, Newsholme W, Horsfield C, Hilton R.

Case Rep Transplant. 2016;2016:3152495. Epub 2016 Oct 9.


Zika infection: From obscurity to public health emergency.

Nebbia G, Douthwaite ST.

Obstet Med. 2016 Jun;9(2):53-4. doi: 10.1177/1753495X16648078. Epub 2016 May 15. No abstract available.


Short Communication: Diagnosis of Pneumocystis jirovecii Pneumonia by Detection of DNA in Blood and Oropharyngeal Wash, Compared with Sputum.

van Halsema C, Johnson L, Baxter J, Douthwaite S, Clowes Y, Guiver M, Ustianowski A.

AIDS Res Hum Retroviruses. 2016 May;32(5):463-6. doi: 10.1089/AID.2015.0213. Epub 2016 Feb 11.


Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination.

Otter JA, Donskey C, Yezli S, Douthwaite S, Goldenberg SD, Weber DJ.

J Hosp Infect. 2016 Mar;92(3):235-50. doi: 10.1016/j.jhin.2015.08.027. Epub 2015 Oct 3. Review.


Performance of a Novel Point-of-Care Molecular Assay for Detection of Influenza A and B Viruses and Respiratory Syncytial Virus (Enigma MiniLab) in Children with Acute Respiratory Infection.

Douthwaite ST, Walker C, Adams EJ, Mak C, Vecino Ortiz A, Martinez-Alier N, Goldenberg SD.

J Clin Microbiol. 2016 Jan;54(1):212-5. doi: 10.1128/JCM.02887-15. Epub 2015 Nov 11.


Erratum to: the role of previously unmeasured organic acids in the pathogenesis of severe malaria.

Herdman MT, Sriboonvorakul N, Leopold SJ, Douthwaite S, Mohanty S, Hassan MM, Maude RJ, Kingston HW, Plewes K, Charunwatthana P, Silamut K, Woodrow CJ, Ghose A, Chotinavich K, Hossain MA, Faiz MA, Mishra S, Leepipatpiboon N, White NJ, Day NP, Tarning J, Dondorp AM.

Crit Care. 2015 Nov 2;19:382. doi: 10.1186/s13054-015-1116-1. No abstract available.


Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing.

Lee S, Rose S, Metodiev MD, Becker L, Vernaleken A, Klopstock T, Gailus-Durner V, Fuchs H, Hrabě De Angelis M, Douthwaite S, Larsson NG.

Hum Mol Genet. 2015 Dec 20;24(25):7286-94. doi: 10.1093/hmg/ddv427. Epub 2015 Oct 12.


Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12956-61. doi: 10.1073/pnas.1512090112. Epub 2015 Oct 5.


The role of previously unmeasured organic acids in the pathogenesis of severe malaria.

Herdman MT, Sriboonvorakul N, Leopold SJ, Douthwaite S, Mohanty S, Hassan MM, Maude RJ, Kingston HW, Plewes K, Charunwatthana P, Silamut K, Woodrow CJ, Ghose A, Chotinavich K, Hossain MA, Faiz MA, Mishra S, Leepipatpiboon N, White NJ, Day NP, Tarning J, Dondorp AM.

Crit Care. 2015 Sep 7;19:317. doi: 10.1186/s13054-015-1023-5. Erratum in: Crit Care. 2015;19:382. Ghose, Aniruddha [added].


Cross-sectional study of Ebola virus disease preparedness among National Health Service hospital trusts in England.

Martin TC, Chand MA, Bogue P, Aryee A, Mabey D, Douthwaite SD, Reece S, Stoller P, Price NM.

J Hosp Infect. 2015 Sep;91(1):11-8. doi: 10.1016/j.jhin.2015.04.021. Epub 2015 May 28.


Macrolide resistance conferred by rRNA mutations in field isolates of Mannheimia haemolytica and Pasteurella multocida.

Olsen AS, Warrass R, Douthwaite S.

J Antimicrob Chemother. 2015 Feb;70(2):420-3. doi: 10.1093/jac/dku385. Epub 2014 Sep 25.


The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA.

Lartigue C, Lebaudy A, Blanchard A, El Yacoubi B, Rose S, Grosjean H, Douthwaite S.

Nucleic Acids Res. 2014 Jul;42(12):8073-82. doi: 10.1093/nar/gku518. Epub 2014 Jun 17.


Indigenous and acquired modifications in the aminoglycoside binding sites of Pseudomonas aeruginosa rRNAs.

Gutierrez B, Douthwaite S, Gonzalez-Zorn B.

RNA Biol. 2013 Aug;10(8):1324-32. doi: 10.4161/rna.25984. Epub 2013 Aug 5.


Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK.

Hidalgo L, Hopkins KL, Gutierrez B, Ovejero CM, Shukla S, Douthwaite S, Prasad KN, Woodford N, Gonzalez-Zorn B.

J Antimicrob Chemother. 2013 Jul;68(7):1543-50. doi: 10.1093/jac/dkt078. Epub 2013 Apr 11.


Real-life outcomes of maraviroc-based regimens in HIV-1-infected individuals.

Babiker ZO, Douthwaite ST, Collier LE, Pennell A, Uriel AJ, Wilkins E.

J Int Assoc Provid AIDS Care. 2013 Jan-Feb;12(1):12-4. doi: 10.1177/1545109712462454. Epub 2012 Oct 16.


Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S.

Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27.


Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits.

Monshupanee T, Johansen SK, Dahlberg AE, Douthwaite S.

Mol Microbiol. 2012 Sep;85(6):1194-203. doi: 10.1111/j.1365-2958.2012.08168.x. Epub 2012 Aug 1.


Multiplex PCR to identify macrolide resistance determinants in Mannheimia haemolytica and Pasteurella multocida.

Rose S, Desmolaize B, Jaju P, Wilhelm C, Warrass R, Douthwaite S.

Antimicrob Agents Chemother. 2012 Jul;56(7):3664-9. doi: 10.1128/AAC.00266-12. Epub 2012 May 7.


Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.

Poehlsgaard J, Andersen NM, Warrass R, Douthwaite S.

ACS Chem Biol. 2012 Aug 17;7(8):1351-5. doi: 10.1021/cb300105p. Epub 2012 May 14.


Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA.

Wang KT, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S, Su XD.

Nucleic Acids Res. 2012 Jun;40(11):5138-48. doi: 10.1093/nar/gks160. Epub 2012 Feb 22.


A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.

Desmolaize B, Fabret C, Brégeon D, Rose S, Grosjean H, Douthwaite S.

Nucleic Acids Res. 2011 Nov;39(21):9368-75. doi: 10.1093/nar/gkr626. Epub 2011 Aug 8.


Laboratory prediction of the requirement for renal replacement in acute falciparum malaria.

Hanson J, Hasan MM, Royakkers AA, Alam S, Charunwatthana P, Maude RJ, Douthwaite ST, Yunus EB, Mantha ML, Schultz MJ, Faiz MA, White NJ, Day NP, Dondorp AM.

Malar J. 2011 Aug 3;10:217. doi: 10.1186/1475-2875-10-217.


General physicians do not take adequate travel histories.

Price VA, Smith RA, Douthwaite S, Thomas S, Almond DS, Miller AR, Beeching NJ, Thompson G, Ustianowski A, Beadsworth MB.

J Travel Med. 2011 Jul-Aug;18(4):271-4. doi: 10.1111/j.1708-8305.2011.00521.x. Epub 2011 Jun 15.


Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.

Desmolaize B, Rose S, Wilhelm C, Warrass R, Douthwaite S.

Antimicrob Agents Chemother. 2011 Sep;55(9):4128-33. doi: 10.1128/AAC.00450-11. Epub 2011 Jun 27.


A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida.

Desmolaize B, Rose S, Warrass R, Douthwaite S.

Mol Microbiol. 2011 Apr;80(1):184-94. doi: 10.1111/j.1365-2958.2011.07567.x. Epub 2011 Mar 3.


Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.

Hansen LH, Lobedanz S, Douthwaite S, Arar K, Wengel J, Kirpekar F, Vester B.

Chembiochem. 2011 Mar 7;12(4):610-4. doi: 10.1002/cbic.201000606. Epub 2011 Jan 24.


Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM.

Galimand M, Schmitt E, Panvert M, Desmolaize B, Douthwaite S, Mechulam Y, Courvalin P.

RNA. 2011 Feb;17(2):251-62. doi: 10.1261/rna.2233511. Epub 2010 Dec 15.


Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases.

Auxilien S, Rasmussen A, Rose S, Brochier-Armanet C, Husson C, Fourmy D, Grosjean H, Douthwaite S.

RNA. 2011 Jan;17(1):45-53. doi: 10.1261/rna.2323411. Epub 2010 Nov 4.


Designer drugs for discerning bugs.

Douthwaite S.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17065-6. doi: 10.1073/pnas.1012547107. Epub 2010 Sep 27. No abstract available.


YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors.

Benítez-Páez A, Villarroya M, Douthwaite S, Gabaldón T, Armengod ME.

RNA. 2010 Nov;16(11):2131-43. doi: 10.1261/rna.2245910. Epub 2010 Sep 20.


Studies on severe malaria are still possible and essential.

Maude RJ, Hassan MU, Ghose A, Douthwaite ST, Faiz MA, Dondorp AM.

Clin Infect Dis. 2010 Jan 15;50(2):281-2. doi: 10.1086/649547. No abstract available.


The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site.

Cubrilo S, Babić F, Douthwaite S, Maravić Vlahovicek G.

RNA. 2009 Aug;15(8):1492-7. doi: 10.1261/rna.1618809. Epub 2009 Jun 9.


YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA.

Purta E, O'Connor M, Bujnicki JM, Douthwaite S.

Mol Microbiol. 2009 Jun;72(5):1147-58. doi: 10.1111/j.1365-2958.2009.06709.x. Epub 2009 Apr 28.


Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications.

Monshupanee T, Gregory ST, Douthwaite S, Chungjatupornchai W, Dahlberg AE.

J Bacteriol. 2008 Dec;190(23):7754-61. doi: 10.1128/JB.00984-08. Epub 2008 Sep 19.


Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes.

Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J.

J Mol Biol. 2008 Nov 14;383(3):652-66. doi: 10.1016/j.jmb.2008.08.062. Epub 2008 Aug 29.


YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962.

Purta E, O'Connor M, Bujnicki JM, Douthwaite S.

J Mol Biol. 2008 Nov 14;383(3):641-51. doi: 10.1016/j.jmb.2008.08.061. Epub 2008 Aug 29.


YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA.

Purta E, Kaminska KH, Kasprzak JM, Bujnicki JM, Douthwaite S.

RNA. 2008 Oct;14(10):2234-44. doi: 10.1261/rna.1198108. Epub 2008 Aug 28.


The activity of rRNA resistance methyltransferases assessed by MALDI mass spectrometry.

Douthwaite S, Jensen RL, Kirpekar F.

Methods Mol Med. 2008;142:223-37. doi: 10.1007/978-1-59745-246-5_18.


Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I.

Douthwaite S, Jakobsen L, Yoshizawa S, Fourmy D.

J Mol Biol. 2008 May 16;378(5):969-75. doi: 10.1016/j.jmb.2008.03.024. Epub 2008 Mar 19.


Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.

Wolter N, Smith AM, Farrell DJ, Northwood JB, Douthwaite S, Klugman KP.

Antimicrob Agents Chemother. 2008 Feb;52(2):435-40. Epub 2007 Dec 3.

Supplemental Content

Loading ...
Support Center