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Items: 34


CaMKII Activity in the Inflammatory Response of Cardiac Diseases.

Rusciano MR, Sommariva E, Douin-Echinard V, Ciccarelli M, Poggio P, Maione AS.

Int J Mol Sci. 2019 Sep 6;20(18). pii: E4374. doi: 10.3390/ijms20184374. Review.


Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.

Martini H, Iacovoni JS, Maggiorani D, Dutaur M, Marsal DJ, Roncalli J, Itier R, Dambrin C, Pizzinat N, Mialet-Perez J, Cussac D, Parini A, Lefevre L, Douin-Echinard V.

Aging Cell. 2019 Oct;18(5):e13015. doi: 10.1111/acel.13015. Epub 2019 Jul 29.


Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.


Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.

Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J.

Aging Cell. 2018 Oct;17(5):e12811. doi: 10.1111/acel.12811. Epub 2018 Jul 12.


Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction.

Abbadi D, Laroumanie F, Bizou M, Pozzo J, Daviaud D, Delage C, Calise D, Gaits-Iacovoni F, Dutaur M, Tortosa F, Renaud-Gabardos E, Douin-Echinard V, Prats AC, Roncalli J, Parini A, Pizzinat N.

Cardiovasc Res. 2018 Jan 1;114(1):123-137. doi: 10.1093/cvr/cvx221.


[Ageing: a matter of heart?].

Mialet-Perez J, Douin-Echinard V, Cussac D, Bril A, Parini A.

Med Sci (Paris). 2015 Nov;31(11):1006-13. doi: 10.1051/medsci/20153111015. Epub 2015 Nov 17. Review. French.


The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.

Garidou L, Pomié C, Klopp P, Waget A, Charpentier J, Aloulou M, Giry A, Serino M, Stenman L, Lahtinen S, Dray C, Iacovoni JS, Courtney M, Collet X, Amar J, Servant F, Lelouvier B, Valet P, Eberl G, Fazilleau N, Douin-Echinard V, Heymes C, Burcelin R.

Cell Metab. 2015 Jul 7;22(1):100-12. doi: 10.1016/j.cmet.2015.06.001.


CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.

Laroumanie F, Douin-Echinard V, Pozzo J, Lairez O, Tortosa F, Vinel C, Delage C, Calise D, Dutaur M, Parini A, Pizzinat N.

Circulation. 2014 May 27;129(21):2111-24. doi: 10.1161/CIRCULATIONAHA.113.007101. Epub 2014 Mar 21.


Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor α.

Seillet C, Rouquié N, Foulon E, Douin-Echinard V, Krust A, Chambon P, Arnal JF, Guéry JC, Laffont S.

J Immunol. 2013 Jun 1;190(11):5459-70. doi: 10.4049/jimmunol.1203312. Epub 2013 Apr 26.


The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

Seillet C, Laffont S, Trémollières F, Rouquié N, Ribot C, Arnal JF, Douin-Echinard V, Gourdy P, Guéry JC.

Blood. 2012 Jan 12;119(2):454-64. doi: 10.1182/blood-2011-08-371831. Epub 2011 Nov 16.


Estradiol administration controls eosinophilia through estrogen receptor-alpha activation during acute peritoneal inflammation.

Douin-Echinard V, Calippe B, Billon-Galès A, Fontaine C, Lenfant F, Trémollières F, Bayard F, Guéry JC, Arnal JF, Gourdy P.

J Leukoc Biol. 2011 Jul;90(1):145-54. doi: 10.1189/jlb.0210073. Epub 2011 Apr 15.


17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

Calippe B, Douin-Echinard V, Delpy L, Laffargue M, Lélu K, Krust A, Pipy B, Bayard F, Arnal JF, Guéry JC, Gourdy P.

J Immunol. 2010 Jul 15;185(2):1169-76. doi: 10.4049/jimmunol.0902383. Epub 2010 Jun 16.


Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

Billon-Galés A, Fontaine C, Douin-Echinard V, Delpy L, Berges H, Calippe B, Lenfant F, Laurell H, Guéry JC, Gourdy P, Arnal JF.

Circulation. 2009 Dec 22;120(25):2567-76. doi: 10.1161/CIRCULATIONAHA.109.898445. Epub 2009 Dec 7.


FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.

Montfort A, de Badts B, Douin-Echinard V, Martin PG, Iacovoni J, Nevoit C, Therville N, Garcia V, Bertrand MA, Bessières MH, Trombe MC, Levade T, Benoist H, Ségui B.

J Immunol. 2009 Oct 15;183(8):5369-78. doi: 10.4049/jimmunol.0803384. Epub 2009 Sep 28.


The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.

Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8. doi: 10.1073/pnas.0808742106. Epub 2009 Feb 2.


Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

Calippe B, Douin-Echinard V, Laffargue M, Laurell H, Rana-Poussine V, Pipy B, Guéry JC, Bayard F, Arnal JF, Gourdy P.

J Immunol. 2008 Jun 15;180(12):7980-8.


IL-13 attenuates gastrointestinal candidiasis in normal and immunodeficient RAG-2(-/-) mice via peroxisome proliferator-activated receptor-gamma activation.

Coste A, Lagane C, Filipe C, Authier H, Galès A, Bernad J, Douin-Echinard V, Lepert JC, Balard P, Linas MD, Arnal JF, Auwerx J, Pipy B.

J Immunol. 2008 Apr 1;180(7):4939-47.


Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.

Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, Gourdy P, Arnal JF, Guéry JC.

J Immunol. 2008 Mar 15;180(6):3661-9. Erratum in: J Immunol. 2008 May 15;180(10):7047.


Role of inflammatory cytokines in the effect of estradiol on atheroma.

Gourdy P, Calippe B, Laurell H, Trémollières F, Douin-Echinard V, Lenfant F, Bayard F, Guery JC, Arnal JF.

Clin Exp Pharmacol Physiol. 2008 Apr;35(4):396-401. doi: 10.1111/j.1440-1681.2008.04885.x.


Understanding the controversy about hormonal replacement therapy: insights from estrogen effects on experimental and clinical atherosclerosis.

Arnal JF, Douin-Echinard V, Tremollières F, Terrisse AD, Sié P, Payrastre B, Guery JC, Bayard F, Gourdy P.

Arch Mal Coeur Vaiss. 2007 Jun-Jul;100(6-7):554-62. Review.


Estradiol action in atherosclerosis and reendothelialization.

Arnal JF, Laurell H, Lenfant F, Douin-Echinard V, Brouchet L, Gourdy P.

Ernst Schering Found Symp Proc. 2006;(1):69-86. Review.


Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice.

Gourdy P, Schambourg A, Filipe C, Douin-Echinard V, Garmy-Susini B, Calippe B, Tercé F, Bayard F, Arnal JF.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2214-21. Epub 2007 Aug 9.


Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction.

Favre J, Musette P, Douin-Echinard V, Laude K, Henry JP, Arnal JF, Thuillez C, Richard V.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1064-71. Epub 2007 Mar 1.


Understanding the oestrogen action in experimental and clinical atherosclerosis.

Arnal JF, Douin-Echinard V, Brouchet L, Tremollières F, Laurell H, Lenfant F, Gadeau AP, Guery JC, Gourdy P.

Fundam Clin Pharmacol. 2006 Dec;20(6):539-48. Review.


Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses.

Delpy L, Douin-Echinard V, Garidou L, Bruand C, Saoudi A, Guéry JC.

J Immunol. 2005 Oct 15;175(8):5050-7.


Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis.

Garidou L, Laffont S, Douin-Echinard V, Coureau C, Krust A, Chambon P, Guéry JC.

J Immunol. 2004 Aug 15;173(4):2435-42.


Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12.

Peron JM, Couderc B, Rochaix P, Douin-Echinard V, Asnacios A, Souque A, Voigt JJ, Buscail L, Vinel JP, Favre G.

J Gastroenterol Hepatol. 2004 Apr;19(4):388-96.


Involvement of CD70 and CD80 intracytoplasmic domains in the co-stimulatory signal required to provide an antitumor immune response.

Douin-Echinard V, Péron JM, Lauwers-Cancès V, Favre G, Couderc B.

Int Immunol. 2003 Mar;15(3):359-72.


In vivo induction of antitumor immunity and protection against tumor growth by injection of CD154-expressing tumor cells.

Grangeon C, Cormary C, Douin-Echinard V, Favre G, Couderc B, Tilkin-Mariamé AF.

Cancer Gene Ther. 2002 Mar;9(3):282-8.


The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status.

Douin-Echinard V, Bornes S, Rochaix P, Tilkin AF, Peron JM, Bonnet J, Favre G, Couderc B.

Cancer Gene Ther. 2000 Dec;7(12):1543-56.


Retrovirus-mediated transfer of a suicide gene into lens epithelial cells in vitro and in an experimental model of posterior capsule opacification.

Couderc BC, de Neuville S, Douin-Echinard V, Serres B, Manenti S, Darbon JM, Malecaze F.

Curr Eye Res. 1999 Dec;19(6):472-82.


Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits.

Malecaze F, Couderc B, de Neuville S, Serres B, Mallet J, Douin-Echinard V, Manenti S, Revah F, Darbon JM.

Hum Gene Ther. 1999 Sep 20;10(14):2365-72.


Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70.

Douin-Echinard V, Robbins PD, Lotze MT, Favre G, Couderc B.

Adv Exp Med Biol. 1998;451:353-7. No abstract available.


Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.

Couderc B, Zitvogel L, Douin-Echinard V, Djennane L, Tahara H, Favre G, Lotze MT, Robbins PD.

Cancer Gene Ther. 1998 May-Jun;5(3):163-75.


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