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Genomic sequencing is required for identification of tuberculosis transmission in Hawaii.

Koster KJ, Largen A, Foster JT, Drees KP, Qian L, Desmond E, Wan X, Hou S, Douglas JT.

BMC Infect Dis. 2018 Dec 3;18(1):608. doi: 10.1186/s12879-018-3502-1.


Whole genome SNP analysis suggests unique virulence factor differences of the Beijing and Manila families of Mycobacterium tuberculosis found in Hawaii.

Koster K, Largen A, Foster JT, Drees KP, Qian L, Desmond EP, Wan X, Hou S, Douglas JT.

PLoS One. 2018 Jul 23;13(7):e0201146. doi: 10.1371/journal.pone.0201146. eCollection 2018.


NMR Studies of a MnIII-hydroxo Adduct Reveal an Equilibrium between MnIII-hydroxo and μ-Oxodimanganese(III,III) Species.

Rice DB, Jones SD, Douglas JT, Jackson TA.

Inorg Chem. 2018 Jul 2;57(13):7825-7837. doi: 10.1021/acs.inorgchem.8b00917. Epub 2018 Jun 21.


Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.

Lan L, Xing M, Douglas JT, Gao P, Hanzlik RP, Xu L.

Oncotarget. 2017 Nov 20;8(63):106587-106597. doi: 10.18632/oncotarget.22540. eCollection 2017 Dec 5.


Genomic analyses of the ancestral Manila family of Mycobacterium tuberculosis.

Wan X, Koster K, Qian L, Desmond E, Brostrom R, Hou S, Douglas JT.

PLoS One. 2017 Apr 10;12(4):e0175330. doi: 10.1371/journal.pone.0175330. eCollection 2017.


F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline.

Yan S, Du F, Wu L, Zhang Z, Zhong C, Yu Q, Wang Y, Lue LF, Walker DG, Douglas JT, Yan SS.

Diabetes. 2016 Nov;65(11):3482-3494. Epub 2016 Aug 23.


Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer's disease Mouse Brain.

Fang D, Zhang Z, Li H, Yu Q, Douglas JT, Bratasz A, Kuppusamy P, Yan SS.

J Alzheimers Dis. 2016;51(2):571-80. doi: 10.3233/JAD-150917.


Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast.

Yang Q, Gong M, Cai S, Zhang T, Douglas JT, Chikan V, Davies NM, Lee P, Choi IY, Ren S, Forrest ML.

Ther Deliv. 2015;6(10):1195-210. doi: 10.4155/tde.15.68. Epub 2015 Oct 8.


Dual Catalytic Decarboxylative Allylations of α-Amino Acids and Their Divergent Mechanisms.

Lang SB, O'Nele KM, Douglas JT, Tunge JA.

Chemistry. 2015 Dec 14;21(51):18589-93. doi: 10.1002/chem.201503644. Epub 2015 Nov 3.


Complete Genome Sequences of Beijing and Manila Family Strains of Mycobacterium tuberculosis.

Wan X, Qian L, Hou S, Drees KP, Foster JT, Douglas JT.

Genome Announc. 2014 Nov 13;2(6). pii: e01135-14. doi: 10.1128/genomeA.01135-14.


Adaptation to Early-Stage Nonfluent/Agrammatic Variant Primary Progressive Aphasia: A First-Person Account.

Douglas JT.

Am J Alzheimers Dis Other Demen. 2014 Jun;29(4):289-92. doi: 10.1177/1533317514523669. Epub 2014 Feb 24.


Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides.

Painter TO, Kaszas K, Gross J, Douglas JT, Day VW, Iadarola MJ, Santini C.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):963-8. doi: 10.1016/j.bmcl.2013.12.061. Epub 2013 Dec 21.


Copper-mediated deoxygenative trifluoromethylation of benzylic xanthates: generation of a C-CF(3) bond from an O-based electrophile.

Zhu L, Liu S, Douglas JT, Altman RA.

Chemistry. 2013 Sep 16;19(38):12800-5. doi: 10.1002/chem.201302328. Epub 2013 Aug 6.


Geographical differences associated with single-nucleotide polymorphisms (SNPs) in nine gene targets among resistant clinical isolates of Mycobacterium tuberculosis.

Hoshide M, Qian L, Rodrigues C, Warren R, Victor T, Evasco HB 2nd, Tupasi T, Crudu V, Douglas JT.

J Clin Microbiol. 2014 May;52(5):1322-9. doi: 10.1128/JCM.00857-13. Epub 2013 Jun 19.


Synthesis of a family of spirocyclic scaffolds: building blocks for the exploration of chemical space.

Kumar S, Thornton PD, Painter TO, Jain P, Downard J, Douglas JT, Santini C.

J Org Chem. 2013 Jul 5;78(13):6529-39. doi: 10.1021/jo400738b. Epub 2013 Jun 26.


Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9.

Miller MR, Zou B, Shi J, Flaherty DP, Simpson DS, Yao T, Maki BE, Day VW, Douglas JT, Wu M, McManus OB, Golden JE, Aubé J, Li M.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 Feb 28].


Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.

Vasiljevik T, Franks LN, Ford BM, Douglas JT, Prather PL, Fantegrossi WE, Prisinzano TE.

J Med Chem. 2013 Jun 13;56(11):4537-50. doi: 10.1021/jm400268b. Epub 2013 May 22.


Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols.

Painter TO, Bunn JR, Schoenen FJ, Douglas JT, Day VW, Santini C.

J Org Chem. 2013 Apr 19;78(8):3720-30. doi: 10.1021/jo400077m. Epub 2013 Apr 1.


Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model.

Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Ashley JW, Meleth S, Feng X, Siegal GP, Douglas JT.

Lab Invest. 2013 Mar;93(3):268-78. doi: 10.1038/labinvest.2012.179. Epub 2013 Jan 28.


A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice.

Lopez MV, Rivera AA, Viale DL, Benedetti L, Cuneo N, Kimball KJ, Wang M, Douglas JT, Zhu ZB, Bravo AI, Gidekel M, Alvarez RD, Curiel DT, Podhajcer OL.

Mol Ther. 2012 Dec;20(12):2222-33. doi: 10.1038/mt.2012.147. Epub 2012 Sep 4.


Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A.

Prevatt-Smith KM, Lovell KM, Simpson DS, Day VW, Douglas JT, Bosch P, Dersch CM, Rothman RB, Kivell B, Prisinzano TE.

Medchemcomm. 2011 Dec;2(12):1217-1222.


Conditionally replicating adenovirus expressing TIMP2 increases survival in a mouse model of disseminated ovarian cancer.

Yang SW, Chanda D, Cody JJ, Rivera AA, Waehler R, Siegal GP, Douglas JT, Ponnazhagan S.

PLoS One. 2011;6(10):e25131. doi: 10.1371/journal.pone.0025131. Epub 2011 Oct 12.


A simplified method for the generation of human osteoclasts in vitro.

Cody JJ, Rivera AA, Liu J, Liu JM, Douglas JT, Feng X.

Int J Biochem Mol Biol. 2011;2(2):183-189. Epub 2011 Apr 23.


Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine.

Li F, Miao Y, Zhang L, Neuenswander SA, Douglas JT, Ma X.

Drug Metab Pharmacokinet. 2011;26(6):569-76. doi: 10.2133/dmpk.DMPK-11-RG-055. Epub 2011 Aug 16.


Rapid deletion-based subtyping system for the Manila family of Mycobacterium tuberculosis.

Frink S, Qian L, Yu S, Cruz L, Desmond E, Douglas JT.

J Clin Microbiol. 2011 May;49(5):1951-5. doi: 10.1128/JCM.01338-10. Epub 2011 Mar 2.


Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A.

Lozama A, Cunningham CW, Caspers MJ, Douglas JT, Dersch CM, Rothman RB, Prisinzano TE.

J Nat Prod. 2011 Apr 25;74(4):718-26. doi: 10.1021/np1007872. Epub 2011 Feb 21.


Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy.

Yang SW, Cody JJ, Rivera AA, Waehler R, Wang M, Kimball KJ, Alvarez RA, Siegal GP, Douglas JT, Ponnazhagan S.

Clin Cancer Res. 2011 Feb 1;17(3):538-49. doi: 10.1158/1078-0432.CCR-10-1628. Epub 2010 Nov 29.


Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.

Cody JJ, Rivera AA, Lyons GR, Yang SW, Wang M, Sarver DB, Wang D, Selander KS, Kuo HC, Meleth S, Feng X, Siegal GP, Douglas JT.

Cancer Gene Ther. 2010 Dec;17(12):893-905. doi: 10.1038/cgt.2010.47. Epub 2010 Aug 27. Erratum in: Cancer Gene Ther. 2010 Dec;17(12):906. Siegall, G P [corrected to Siegal, G P].


Mechanistic origin of the stereodivergence in decarboxylative allylation.

Chattopadhyay K, Jana R, Day VW, Douglas JT, Tunge JA.

Org Lett. 2010 Jul 2;12(13):3042-5. doi: 10.1021/ol101042x.


Ex vivo transfer of the Hoxc-8-interacting domain of Smad1 by a tropism-modified adenoviral vector results in efficient bone formation in a rabbit model of spinal fusion.

Douglas JT, Rivera AA, Lyons GR, Lott PF, Wang D, Zayzafoon M, Siegal GP, Cao X, Theiss SM.

J Spinal Disord Tech. 2010 Feb;23(1):63-73. doi: 10.1097/BSD.0b013e318193b693.


Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer.

Kimball KJ, Rivera AA, Zinn KR, Icyuz M, Saini V, Li J, Zhu ZB, Siegal GP, Douglas JT, Curiel DT, Alvarez RD, Borovjagin AV.

Mol Imaging. 2009 Sep-Oct;8(5):264-77.


One-pot synthesis of lactams using domino reactions: combination of Schmidt reaction with Sakurai and aldol reactions.

Huh CW, Somal GK, Katz CE, Pei H, Zeng Y, Douglas JT, Aubé J.

J Org Chem. 2009 Oct 16;74(20):7618-26. doi: 10.1021/jo901843w.


The evaluation of a user-friendly lateral flow assay for the serodiagnosis of human brucellosis in Kazakhstan.

Mizanbayeva S, Smits HL, Zhalilova K, Abdoel TH, Kozakov S, Ospanov KS, Elzer PH, Douglas JT.

Diagn Microbiol Infect Dis. 2009 Sep;65(1):14-20. doi: 10.1016/j.diagmicrobio.2009.05.002.


Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody.

Kashentseva EA, Douglas JT, Zinn KR, Curiel DT, Dmitriev IP.

J Mol Biol. 2009 May 8;388(3):443-61. doi: 10.1016/j.jmb.2009.03.016. Epub 2009 Mar 13.


Armed replicating adenoviruses for cancer virotherapy.

Cody JJ, Douglas JT.

Cancer Gene Ther. 2009 Jun;16(6):473-88. doi: 10.1038/cgt.2009.3. Epub 2009 Feb 6. Review.


Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy.

Ulasov IV, Tyler MA, Rivera AA, Nettlebeck DM, Douglas JT, Lesniak MS.

J Med Virol. 2008 Sep;80(9):1595-603. doi: 10.1002/jmv.21264.


High-resolution pyrimidine- and ribose-specific 4D HCCH-COSY spectra of RNA using the filter diagonalization method.

Douglas JT, Latham MP, Armstrong GS, Bendiak B, Pardi A.

J Biomol NMR. 2008 Aug;41(4):209-19. doi: 10.1007/s10858-008-9253-3. Epub 2008 Jul 15.


Immunization with hybrid recombinant Mycobacterium tuberculosis H37Rv proteins increases the TH1 cytokine response in mice following a pulmonary instillation of irradiated mycobacteria.

Walton CB, Inos AB, Andres OA, Jube S, de Couet HG, Douglas JT, Patek PQ, Borthakur D.

Vaccine. 2008 Aug 12;26(34):4396-402. doi: 10.1016/j.vaccine.2008.05.093. Epub 2008 Jun 26.


An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.

Ulasov IV, Rivera AA, Nettelbeck DM, Rivera LB, Mathis JM, Sonabend AM, Tyler M, Wang M, Douglas JT, Lesniak MS.

Int J Oncol. 2007 Nov;31(5):1177-85.


Adenoviral vectors for gene therapy.

Douglas JT.

Mol Biotechnol. 2007 May;36(1):71-80. Review.


Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob.

Miura Y, Yoshida K, Nishimoto T, Hatanaka K, Ohnami S, Asaka M, Douglas JT, Curiel DT, Yoshida T, Aoki K.

Gene Ther. 2007 Oct;14(20):1448-60. Epub 2007 Aug 16.


Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma.

Stoff-Khalili MA, Rivera AA, Mathis JM, Banerjee NS, Moon AS, Hess A, Rocconi RP, Numnum TM, Everts M, Chow LT, Douglas JT, Siegal GP, Zhu ZB, Bender HG, Dall P, Stoff A, Pereboeva L, Curiel DT.

Breast Cancer Res Treat. 2007 Oct;105(2):157-67. Epub 2007 Jan 13.


Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer.

Stoff-Khalili MA, Rivera AA, Stoff A, Michael Mathis J, Rocconi RP, Matthews QL, Numnum MT, Herrmann I, Dall P, Eckhoff DE, Douglas JT, Siegal GP, Zhu ZB, Curiel DT.

Int J Cancer. 2007 Feb 15;120(4):935-41.


Tissue inhibitor of metalloproteinases-2 improves antitumor efficacy of a replicating adenovirus in vivo.

Kim MH, Bodenstine TM, Sumerel LA, Rivera AA, Baker AH, Douglas JT.

Cancer Biol Ther. 2006 Dec;5(12):1647-53. Epub 2006 Dec 7.


An adenovirus serotype 5 vector with fibers derived from ovine atadenovirus demonstrates CAR-independent tropism and unique biodistribution in mice.

Nakayama M, Both GW, Banizs B, Tsuruta Y, Yamamoto S, Kawakami Y, Douglas JT, Tani K, Curiel DT, Glasgow JN.

Virology. 2006 Jun 20;350(1):103-15. Epub 2006 Mar 3.


Generation and selection of targeted adenoviruses embodying optimized vector properties.

Noureddini SC, Krendelshchikov A, Simonenko V, Hedley SJ, Douglas JT, Curiel DT, Korokhov N.

Virus Res. 2006 Mar;116(1-2):185-95. Epub 2005 Nov 15.


RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity.

Meyers VE, Zayzafoon M, Douglas JT, McDonald JM.

J Bone Miner Res. 2005 Oct;20(10):1858-66. Epub 2005 Jun 27.


An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery.

Hedley SJ, Auf der Maur A, Hohn S, Escher D, Barberis A, Glasgow JN, Douglas JT, Korokhov N, Curiel DT.

Gene Ther. 2006 Jan;13(1):88-94.


High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN.

Korokhov N, de Gruijl TD, Aldrich WA, Triozzi PL, Banerjee PT, Gillies SD, Curiel TJ, Douglas JT, Scheper RJ, Curiel DT.

Cancer Biol Ther. 2005 Mar;4(3):289-94. Epub 2005 Mar 20.


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