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Improving end-of-rotation transitions of care among ICU patients.

Denson JL, Knoeckel J, Kjerengtroen S, Johnson R, McNair B, Thornton O, Douglas IS, Wechsler ME, Burke RE.

BMJ Qual Saf. 2019 Nov 4. pii: bmjqs-2019-009867. doi: 10.1136/bmjqs-2019-009867. [Epub ahead of print]


One-Year Outcomes Following Tracheostomy for Acute Respiratory Failure.

Mehta AB, Walkey AJ, Curran-Everett D, Douglas IS.

Crit Care Med. 2019 Nov;47(11):1572-1581. doi: 10.1097/CCM.0000000000003959.


Update in Critical Care and Acute Respiratory Distress Syndrome 2018.

Douglas IS, Bednash JS, Fein DG, Mallampalli RK, Mansoori JN, Gershengorn HB.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1335-1343. doi: 10.1164/rccm.201903-0550UP. No abstract available.


Hospital Mechanical Ventilation Volume and Patient Outcomes: Too Much of a Good Thing?

Mehta AB, Walkey AJ, Curran-Everett D, Matlock D, Douglas IS.

Crit Care Med. 2019 Mar;47(3):360-368. doi: 10.1097/CCM.0000000000003590.


Alcohol misuse and outpatient follow-up after hospital discharge: a retrospective cohort study.

Borg B, Douglas IS, Hull M, Keniston A, Moss M, Clark BJ.

Addict Sci Clin Pract. 2018 Dec 4;13(1):24. doi: 10.1186/s13722-018-0125-1.


Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.

Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators.

N Engl J Med. 2018 Dec 27;379(26):2506-2516. doi: 10.1056/NEJMoa1808217. Epub 2018 Oct 22.


Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.

Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM; American Thoracic Society Assembly on Pulmonary Circulation.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST.


Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI; CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators.

Ann Emerg Med. 2018 Oct;72(4):457-466. doi: 10.1016/j.annemergmed.2018.03.039. Epub 2018 May 10.


Erythropoietin-Producing Hepatoma Receptor Tyrosine Kinase A2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury.

Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):519-529. doi: 10.1165/rcmb.2017-0143OC.


Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients.

Fang WF, Douglas IS, Chen YM, Lin CY, Kao HC, Fang YT, Huang CH, Chang YT, Huang KT, Wang YH, Wang CC, Lin MC.

PLoS One. 2017 Oct 26;12(10):e0187088. doi: 10.1371/journal.pone.0187088. eCollection 2017.


All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling.

Leem AY, Shin MH, Douglas IS, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):721-726. doi: 10.1016/j.bbrc.2017.07.122. Epub 2017 Jul 22.


David Cockburn OAM MScOptom DSc (Honoris Causa) FACO 25 August 1923-26 September 2016: A tribute to David Cockburn, a consummate clinician and educator.

Gutteridge IF, Douglas IS, Anjou MD.

Clin Exp Optom. 2017 Jul;100(4):399-401. doi: 10.1111/cxo.12572. No abstract available.


Evidence-based Utilization of Noninvasive Ventilation and Patient Outcomes.

Mehta AB, Douglas IS, Walkey AJ.

Ann Am Thorac Soc. 2017 Nov;14(11):1667-1673. doi: 10.1513/AnnalsATS.201703-208OC.


The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study.

Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M.

Ann Am Thorac Soc. 2017 Jul;14(7):1154-1161. doi: 10.1513/AnnalsATS.201611-854OC.


Innate Immune Function and Organ Failure Recovery in Adults With Sepsis.

Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS.

J Intensive Care Med. 2019 Jun;34(6):486-494. doi: 10.1177/0885066617701903. Epub 2017 Apr 4.


The history of risk: a review.

Stahel PF, Douglas IS, VanderHeiden TF, Weckbach S.

World J Emerg Surg. 2017 Mar 14;12:15. doi: 10.1186/s13017-017-0125-6. eCollection 2017. Review.


Pulmonary infections in critical/intensive care - rapid diagnosis and optimizing antimicrobial usage.

Douglas IS.

Curr Opin Pulm Med. 2017 May;23(3):198-203. doi: 10.1097/MCP.0000000000000366. Review.


Respiratory Health in Migrant Populations: A Crisis Overlooked.

Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J.

Ann Am Thorac Soc. 2017 Feb;14(2):153-159. doi: 10.1513/AnnalsATS.201608-592PS. Review.


Reply: Hospital Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Another Look at the Same Coin.

Mehta AB, Douglas IS, Walkey AJ.

Ann Am Thorac Soc. 2016 Dec;13(12):2279-2280. No abstract available.


Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia.

Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ.

Ann Am Thorac Soc. 2017 Jan;14(1):103-109. doi: 10.1513/AnnalsATS.201608-617OC.


Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury.

Hong JY, Shin MH, Douglas IS, Chung KS, Kim EY, Jung JY, Kang YA, Kim SK, Chang J, Kim YS, Park MS.

Clin Sci (Lond). 2016 Nov 1;130(21):1993-2003. Epub 2016 Aug 22.


An Official American Thoracic Society Workshop Report. A Framework for Addressing Multimorbidity in Clinical Practice Guidelines for Pulmonary Disease, Critical Illness, and Sleep Disorders.

Wilson KC, Gould MK, Krishnan JA, Boyd CM, Brozek JL, Cooke CR, Douglas IS, Goodman RA, Joo MJ, Lareau S, Mularski RA, Patel MR, Rosenfeld RM, Shanawani H, Slatore C, Sockrider M, Sufian B, Thomson CC, Wiener RS; ATS Guideline Methodology Working Group.

Ann Am Thorac Soc. 2016 Mar;13(3):S12-21. doi: 10.1513/AnnalsATS.201601-007ST.


Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome.

Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ.

Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. doi: 10.1164/rccm.201511-2281OC.


New diagnostic methods for pneumonia in the ICU.

Douglas IS.

Curr Opin Infect Dis. 2016 Apr;29(2):197-204. doi: 10.1097/QCO.0000000000000249. Review.


Update on the Affordable Care Act. King v. Burwell and Obergefell v. Hodge.

Lyon SM, Moore N, Douglas IS, Cooke CR.

Ann Am Thorac Soc. 2016 Mar;13(3):324-8. doi: 10.1513/AnnalsATS.201510-670AR.


Implications of Marijuana Decriminalization on the Practice of Pulmonary, Critical Care, and Sleep Medicine. A Report of the American Thoracic Society Marijuana Workgroup.

Douglas IS, Albertson TE, Folan P, Hanania NA, Tashkin DP, Upson DJ, Leone FT.

Ann Am Thorac Soc. 2015 Nov;12(11):1700-10. doi: 10.1513/AnnalsATS.201504-195AR. No abstract available.


Development and Validation of a Mortality Prediction Model for Patients Receiving 14 Days of Mechanical Ventilation.

Hough CL, Caldwell ES, Cox CE, Douglas IS, Kahn JM, White DB, Seeley EJ, Bangdiwala SI, Rubenfeld GD, Angus DC, Carson SS; ProVent Investigators and the National Heart Lung and Blood Institute’s Acute Respiratory Distress Syndrome Network.

Crit Care Med. 2015 Nov;43(11):2339-45. doi: 10.1097/CCM.0000000000001205.


Response to fluid boluses in the fluid and catheter treatment trial.

Lammi MR, Aiello B, Burg GT, Rehman T, Douglas IS, Wheeler AP, deBoisblanc BP; National Institutes of Health, National Heart, Lung, and Blood Institute ARDS Network Investigators.

Chest. 2015 Oct;148(4):919-926. doi: 10.1378/chest.15-0445.


Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry.

Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ.

Anal Chem. 2015 Jun 16;87(12):6220-7. doi: 10.1021/acs.analchem.5b00913. Epub 2015 Jun 2.


Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?

Maddux AB, Douglas IS.

Immunology. 2015 May;145(1):1-10. doi: 10.1111/imm.12454. Review.


Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia.

Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC.

Am J Respir Crit Care Med. 2015 Mar 1;191(5):566-73. doi: 10.1164/rccm.201408-1468OC.


Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis.

Goodson CM, Clark BJ, Douglas IS.

Alcohol Clin Exp Res. 2014 Oct;38(10):2664-77. doi: 10.1111/acer.12529. Review.


Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients.

Liao MM, Lezotte D, Lowenstein SR, Howard K, Finley Z, Feng Z, Byyny RL, Sankoff JD, Douglas IS, Haukoos JS.

Am J Emerg Med. 2014 Nov;32(11):1319-25. doi: 10.1016/j.ajem.2014.07.035. Epub 2014 Aug 8.


5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation.

Fang WF, Douglas IS, Wang CC, Kao HC, Chang YT, Tseng CC, Huang KT, Chang HC, Lin MC.

PLoS One. 2014 Jul 15;9(7):e102622. doi: 10.1371/journal.pone.0102622. eCollection 2014.


Rosuvastatin for sepsis-associated acute respiratory distress syndrome.

National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT.

N Engl J Med. 2014 Jun 5;370(23):2191-200. doi: 10.1056/NEJMoa1401520. Epub 2014 May 18.


An official American thoracic society workshop report: developing performance measures from clinical practice guidelines.

Kahn JM, Gould MK, Krishnan JA, Wilson KC, Au DH, Cooke CR, Douglas IS, Feemster LC, Mularski RA, Slatore CG, Wiener RS; ATS Ad Hoc Committee on the Development of Performance Measures from ATS Guidelines.

Ann Am Thorac Soc. 2014 May;11(4):S186-95. doi: 10.1513/AnnalsATS.201403-106ST.


Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs.

Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T.

Anesthesiology. 2014 Sep;121(3):469-81. doi: 10.1097/ALN.0000000000000301.


The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury.

Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL.

J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. doi: 10.1124/jpet.114.213769. Epub 2014 Apr 11.


Medicaid expansion under the Affordable Care Act. Implications for insurance-related disparities in pulmonary, critical care, and sleep.

Lyon SM, Douglas IS, Cooke CR.

Ann Am Thorac Soc. 2014 May;11(4):661-7. doi: 10.1513/AnnalsATS.201402-072PS.


The emergence of e-cigarettes: a triumph of wishful thinking over science.

Leone FT, Douglas IS.

Ann Am Thorac Soc. 2014 Feb;11(2):216-9. doi: 10.1513/AnnalsATS.201312-428ED. No abstract available.


The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.

Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ.

J Biol Chem. 2014 Mar 21;289(12):8194-202. doi: 10.1074/jbc.M113.539452. Epub 2014 Feb 7.


Comparison of bag-valve-mask hand-sealing techniques in a simulated model.

Otten D, Liao MM, Wolken R, Douglas IS, Mishra R, Kao A, Barrett W, Drasler E, Byyny RL, Haukoos JS.

Ann Emerg Med. 2014 Jan;63(1):6-12.e3. doi: 10.1016/j.annemergmed.2013.07.014. Epub 2013 Aug 9.


Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal.

Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M.

Alcohol Clin Exp Res. 2013 Sep;37(9):1536-43. doi: 10.1111/acer.12124. Epub 2013 May 3.


Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup.

Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.


Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup.

Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.


The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.

Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM.

Nat Med. 2012 Aug;18(8):1217-23. doi: 10.1038/nm.2843. Epub 2012 Jul 22.


Drotrecogin alfa (activated) in adults with septic shock.

Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD; PROWESS-SHOCK Study Group.

N Engl J Med. 2012 May 31;366(22):2055-64. doi: 10.1056/NEJMoa1202290. Epub 2012 May 22.


An official multi-society statement: the role of clinical research results in the practice of critical care medicine.

Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM; ACCP/ATS/SCCM Working Group.

Am J Respir Crit Care Med. 2012 May 15;185(10):1117-24. doi: 10.1164/rccm.201204-0638ST.


Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs.

Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS.

Am J Respir Crit Care Med. 2012 Jul 1;186(1):72-81. doi: 10.1164/rccm.201109-1593OC. Epub 2012 May 10.

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