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Items: 40


Use of real-world evidence in postmarketing medicines regulation in the European Union: a systematic assessment of European Medicines Agency referrals 2013-2017.

Brown JP, Wing K, Evans SJ, Bhaskaran K, Smeeth L, Douglas IJ.

BMJ Open. 2019 Oct 28;9(10):e028133. doi: 10.1136/bmjopen-2018-028133.


Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression.

Root A, Brown JP, Forbes HJ, Bhaskaran K, Hayes J, Smeeth L, Douglas IJ.

JAMA Pediatr. 2019 Sep 23. doi: 10.1001/jamapediatrics.2019.3194. [Epub ahead of print]


Thromboembolic, bleeding, and mortality risks among patients with nonvalvular atrial fibrillation treated with dual antiplatelet therapy versus oral anticoagulants: A population-based study.

Lau WCY, Douglas IJ, Wong ICK, Smeeth L, Lip GYH, Leung WK, Siu CW, Cheung BMY, Mok MTC, Chan EW.

Heart Rhythm. 2019 Aug 1. pii: S1547-5271(19)30720-9. doi: 10.1016/j.hrthm.2019.07.034. [Epub ahead of print]


The comparative effectiveness of fourth-line drugs in resistant hypertension: An application in electronic health record data.

Sinnott SJ, Smeeth L, Williamson E, Perel P, Nitsch D, Tomlinson LA, Douglas IJ.

Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1267-1277. doi: 10.1002/pds.4808. Epub 2019 Jul 16.


How to validate a diagnosis recorded in electronic health records.

Nissen F, Quint JK, Morales DR, Douglas IJ.

Breathe (Sheff). 2019 Mar;15(1):64-68. doi: 10.1183/20734735.0344-2018.


Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink).

Nissen F, Douglas IJ, Müllerová H, Pearce N, Bloom CI, Smeeth L, Quint JK.

J Asthma Allergy. 2019 Jan 8;12:7-19. doi: 10.2147/JAA.S182013. eCollection 2019.


Factors associated with choice of intensification treatment for type 2 diabetes after metformin monotherapy: a cohort study in UK primary care.

Wilkinson S, Douglas IJ, Williamson E, Stirnadel-Farrant HA, Fogarty D, Pokrajac A, Smeeth L, Tomlinson LA.

Clin Epidemiol. 2018 Nov 8;10:1639-1648. doi: 10.2147/CLEP.S176142. eCollection 2018.


Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK.

Bhaskaran K, Dos-Santos-Silva I, Leon DA, Douglas IJ, Smeeth L.

Lancet Diabetes Endocrinol. 2018 Dec;6(12):944-953. doi: 10.1016/S2213-8587(18)30288-2. Epub 2018 Oct 30.


Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care.

Nissen F, Morales DR, Mullerova H, Smeeth L, Douglas IJ, Quint JK.

Br J Gen Pract. 2018 Nov;68(676):e775-e782. doi: 10.3399/bjgp18X699389. Epub 2018 Sep 24.


Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population-based cohort study.

Iwagami M, Tomlinson LA, Mansfield KE, Douglas IJ, Smeeth L, Nitsch D.

Br J Clin Pharmacol. 2018 Sep;84(9):2142-2151. doi: 10.1111/bcp.13660. Epub 2018 Jul 8.


Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink.

Koppe U, Nitsch D, Mansfield KE, Mathur R, Bhaskaran K, Batterham RL, Smeeth L, Douglas IJ.

BMJ Open. 2018 May 16;8(5):e020371. doi: 10.1136/bmjopen-2017-020371.


Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

Crellin E, Mansfield KE, Leyrat C, Nitsch D, Douglas IJ, Root A, Williamson E, Smeeth L, Tomlinson LA.

BMJ. 2018 Feb 9;360:k341. doi: 10.1136/bmj.k341.


Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.

Mansfield KE, Douglas IJ, Nitsch D, Thomas SL, Smeeth L, Tomlinson LA.

Clin Epidemiol. 2018 Jan 30;10:187-202. doi: 10.2147/CLEP.S146757. eCollection 2018.


Validation of asthma recording in electronic health records: a systematic review.

Nissen F, Quint JK, Wilkinson S, Mullerova H, Smeeth L, Douglas IJ.

Clin Epidemiol. 2017 Dec 1;9:643-656. doi: 10.2147/CLEP.S143718. eCollection 2017. Review.


Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

Yates TA, Tomlinson LA, Bhaskaran K, Langan S, Thomas S, Smeeth L, Douglas IJ.

PLoS Med. 2017 Nov 21;14(11):e1002457. doi: 10.1371/journal.pmed.1002457. eCollection 2017 Nov.


Investigating the assumptions of the self-controlled case series method.

Whitaker HJ, Ghebremichael-Weldeselassie Y, Douglas IJ, Smeeth L, Farrington CP.

Stat Med. 2018 Feb 20;37(4):643-658. doi: 10.1002/sim.7536. Epub 2017 Nov 2.


Exacerbation risk and characterisation of the UK's asthma population from infants to old age.

Bloom CI, Nissen F, Douglas IJ, Smeeth L, Cullinan P, Quint JK.

Thorax. 2018 Apr;73(4):313-320. doi: 10.1136/thoraxjnl-2017-210650. Epub 2017 Oct 26.


Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015.

Sinnott SJ, Smeeth L, Williamson E, Douglas IJ.

BMJ. 2017 Sep 22;358:j3984. doi: 10.1136/bmj.j3984.


Validation of asthma recording in the Clinical Practice Research Datalink (CPRD).

Nissen F, Morales DR, Mullerova H, Smeeth L, Douglas IJ, Quint JK.

BMJ Open. 2017 Aug 11;7(8):e017474. doi: 10.1136/bmjopen-2017-017474.


Validation of asthma recording in electronic health records: protocol for a systematic review.

Nissen F, Quint JK, Wilkinson S, Mullerova H, Smeeth L, Douglas IJ.

BMJ Open. 2017 May 29;7(5):e014694. doi: 10.1136/bmjopen-2016-014694.


Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.

Sinnott SJ, Tomlinson LA, Root AA, Mathur R, Mansfield KE, Smeeth L, Douglas IJ.

Eur J Prev Cardiol. 2017 Feb;24(3):228-238. doi: 10.1177/2047487316675194. Epub 2016 Nov 19. Review.


Oral Fluoroquinolone Use and Retinal Detachment.

Douglas IJ, Root A, Krishnan B.

JAMA Ophthalmol. 2016 Dec 1;134(12):1448. doi: 10.1001/jamaophthalmol.2016.3477. No abstract available.


Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink.

Matthews A, Langan SM, Douglas IJ, Smeeth L, Bhaskaran K.

PLoS Med. 2016 Jun 14;13(6):e1002037. doi: 10.1371/journal.pmed.1002037. eCollection 2016 Jun.


Association between oral fluoroquinolones and seizures: A self-controlled case series study.

Chui CS, Chan EW, Wong AY, Root A, Douglas IJ, Wong IC.

Neurology. 2016 May 3;86(18):1708-15. doi: 10.1212/WNL.0000000000002633. Epub 2016 Apr 6.


Case-only designs for studying the association of antidepressants and hip or femur fracture.

de Groot MC, Candore G, Uddin MJ, Souverein PC, Ali MS, Belitser SV, Huerta C, Groenwold RH, Alvarez Y, Slattery J, Korevaar J, Hoes AW, Roes KC, de Boer A, Douglas IJ, Schlienger RG, Reynolds R, Klungel OH, Gardarsdottir H.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:103-13. doi: 10.1002/pds.3850.


Cardiovascular outcomes associated with use of clarithromycin: population based study.

Wong AY, Root A, Douglas IJ, Chui CS, Chan EW, Ghebremichael-Weldeselassie Y, Siu CW, Smeeth L, Wong IC.

BMJ. 2016 Jan 14;352:h6926. doi: 10.1136/bmj.h6926.


Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.

Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L.

PLoS Med. 2015 Dec 22;12(12):e1001925. doi: 10.1371/journal.pmed.1001925. eCollection 2015 Dec.


Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines.

Requena G, Logie J, Martin E, Boudiaf N, González González R, Huerta C, Alvarez A, Webb D, Bate A, García Rodríguez LA, Reynolds R, Schlienger R, Gardarsdottir H, de Groot M, Klungel OH, de Abajo F, Douglas IJ.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:79-87. doi: 10.1002/pds.3822. Epub 2015 Jun 26.


The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort.

Douglas IJ, Bhaskaran K, Batterham RL, Smeeth L.

Br J Clin Pharmacol. 2015 Jun;79(6):1020-7. doi: 10.1111/bcp.12578.


Angiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink.

Goh KL, Bhaskaran K, Minassian C, Evans SJ, Smeeth L, Douglas IJ.

Br J Clin Pharmacol. 2015 Feb;79(2):337-50. doi: 10.1111/bcp.12511.


Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink.

Douglas IJ, Langham J, Bhaskaran K, Brauer R, Smeeth L.

BMJ. 2013 Apr 12;346:f1936. doi: 10.1136/bmj.f1936.


Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs.

Douglas IJ, Evans SJ, Hingorani AD, Grosso AM, Timmis A, Hemingway H, Smeeth L.

BMJ. 2012 Jul 10;345:e4388. doi: 10.1136/bmj.e4388.


Cutting feedback in Bayesian regression adjustment for the propensity score.

McCandless LC, Douglas IJ, Evans SJ, Smeeth L.

Int J Biostat. 2010;6(2):Article 16.


The risk of fractures associated with thiazolidinediones: a self-controlled case-series study.

Douglas IJ, Evans SJ, Pocock S, Smeeth L.

PLoS Med. 2009 Sep;6(9):e1000154. doi: 10.1371/journal.pmed.1000154. Epub 2009 Sep 29.


Exposure to antipsychotics and risk of stroke: self controlled case series study.

Douglas IJ, Smeeth L.

BMJ. 2008 Aug 28;337:a1227. doi: 10.1136/bmj.a1227.


A case-control study of drug risk factors for age-related macular degeneration.

Douglas IJ, Cook C, Chakravarthy U, Hubbard R, Fletcher AE, Smeeth L.

Ophthalmology. 2007 Jun;114(6):1164-9.


The role of calcium in the volume regulation of rat lacrimal acinar cells.

Speake T, Douglas IJ, Brown PD.

J Membr Biol. 1998 Aug 1;164(3):283-91.


Regulatory volume increase in rat lacrimal gland acinar cells.

Douglas IJ, Brown PD.

J Membr Biol. 1996 Mar;150(2):209-17.


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