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Items: 7


Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF.

Kitamura T, Kato Y, Brownlie D, Soong DYH, Sugano G, Kippen N, Li J, Doughty-Shenton D, Carragher N, Pollard JW.

Cancer Immunol Res. 2019 Dec;7(12):2052-2064. doi: 10.1158/2326-6066.CIR-19-0234. Epub 2019 Oct 15.


Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells.

Kitamura T, Doughty-Shenton D, Pollard JW, Carragher NO.

J Vis Exp. 2019 Jan 29;(143). doi: 10.3791/58841.


A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors.

De Simone A, Georgiou C, Ioannidis H, Gupta AA, Juárez-Jiménez J, Doughty-Shenton D, Blackburn EA, Wear MA, Richards JP, Barlow PN, Carragher N, Walkinshaw MD, Hulme AN, Michel J.

Chem Sci. 2018 Oct 23;10(2):542-547. doi: 10.1039/c8sc03831g. eCollection 2019 Jan 14.


Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer.

Kitamura T, Doughty-Shenton D, Cassetta L, Fragkogianni S, Brownlie D, Kato Y, Carragher N, Pollard JW.

Front Immunol. 2018 Jan 17;8:2004. doi: 10.3389/fimmu.2017.02004. eCollection 2017.


Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor.

Drebert Z, MacAskill M, Doughty-Shenton D, De Bosscher K, Bracke M, Hadoke PWF, Beck IM.

Vascul Pharmacol. 2017 Feb;89:19-30. doi: 10.1016/j.vph.2016.10.004. Epub 2016 Oct 4.


A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells.

Moreno E, Doughty-Shenton D, Plano D, Font M, Encío I, Palop JA, Sanmartín C.

Eur J Pharm Sci. 2014 Oct 15;63:87-95. doi: 10.1016/j.ejps.2014.06.020. Epub 2014 Jul 4.


Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ.

J Pharmacol Exp Ther. 2010 May;333(2):584-92. doi: 10.1124/jpet.109.163329. Epub 2010 Feb 18.

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