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Items: 1 to 50 of 68

1.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
2.

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

Miles LA, Hermans SJ, Crespi GAN, Gooi JH, Doughty L, Nero TL, Markulić J, Ebneth A, Wroblowski B, Oehlrich D, Trabanco AA, Rives ML, Royaux I, Hancock NC, Parker MW.

iScience. 2019 Jul 19;19:110-118. doi: 10.1016/j.isci.2019.07.023. [Epub ahead of print]

3.

Early Protocolized Versus Usual Care Rehabilitation for Pediatric Neurocritical Care Patients: A Randomized Controlled Trial.

Fink EL, Beers SR, Houtrow AJ, Richichi R, Burns C, Doughty L, Ortiz-Aguayo R, Madurski CA, Valenta C, Chrisman M, Golightly L, Kiger M, Patrick C, Treble-Barna A, Pollon D, Smith CM, Kochanek P; PICU-Rehabilitation Study Group.

Pediatr Crit Care Med. 2019 Jun;20(6):540-550. doi: 10.1097/PCC.0000000000001881.

PMID:
30707210
4.

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228.

Liu X, Xie F, Doughty LB, Wang Q, Zhang L, Liu X, Cheng YQ.

Synth Syst Biotechnol. 2018 Nov 5;3(4):268-274. doi: 10.1016/j.synbio.2018.10.011. eCollection 2018 Dec.

5.

Reliability of modified adheremeter and digital pressure algometer in measuring normal abdominal tissue and C-section scars.

Kelly-Martin R, Doughty L, Garkavi M, Wasserman JB.

J Bodyw Mov Ther. 2018 Oct;22(4):972-979. doi: 10.1016/j.jbmt.2018.02.017. Epub 2018 Feb 17.

PMID:
30368344
6.

Educating new graduate nurses in their first year of practice: The perspective and experiences of the new graduate nurses and the director of nursing.

Doughty L, McKillop A, Dixon R, Sinnema C.

Nurse Educ Pract. 2018 May;30:101-105. doi: 10.1016/j.nepr.2018.03.006. Epub 2018 Mar 27.

PMID:
29698878
7.

Cytokine Help for Diagnosing Community-Acquired Pneumonia.

Conway SR, Doughty LA.

Pediatr Crit Care Med. 2017 Apr;18(4):391-393. doi: 10.1097/PCC.0000000000001107. No abstract available.

PMID:
28376009
8.

Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.

Carcillo JA, Podd B, Aneja R, Weiss SL, Hall MW, Cornell TT, Shanley TP, Doughty LA, Nguyen TC.

Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S32-S45. doi: 10.1097/PCC.0000000000001052. Review.

9.

Do We Still Have a Digital Divide in Mental Health? A Five-Year Survey Follow-up.

Robotham D, Satkunanathan S, Doughty L, Wykes T.

J Med Internet Res. 2016 Nov 22;18(11):e309.

10.
11.

Service user and carer priorities in a Biomedical Research Centre for mental health.

Robotham D, Wykes T, Rose D, Doughty L, Strange S, Neale J, Hotopf M.

J Ment Health. 2016 Jun;25(3):185-8. doi: 10.3109/09638237.2016.1167862. Epub 2016 Apr 11. No abstract available. Erratum in: J Ment Health. 2016 Jun;25(3):286.

12.

Adaptive immune function in critical illness.

Doughty L.

Curr Opin Pediatr. 2016 Jun;28(3):274-80. doi: 10.1097/MOP.0000000000000357. Review.

PMID:
27054955
13.

Reaching their potential: Perceived impact of a collaborative academic-clinical partnership programme for early career nurses in New Zealand.

McKillop A, Doughty L, Atherfold C, Shaw K.

Nurse Educ Today. 2016 Jan;36:145-51. doi: 10.1016/j.nedt.2015.09.005. Epub 2015 Sep 25.

PMID:
26438072
14.

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.

Mobbs JI, Koay A, Di Paolo A, Bieri M, Petrie EJ, Gorman MA, Doughty L, Parker MW, Stapleton DI, Griffin MD, Gooley PR.

Biochem J. 2015 Jun 1;468(2):245-57. doi: 10.1042/BJ20150270.

PMID:
25774984
15.

A chromogenic assay of substrate depletion by thiol dioxygenases.

Fellner M, Doughty LM, Jameson GN, Wilbanks SM.

Anal Biochem. 2014 Aug 15;459:56-60. doi: 10.1016/j.ab.2014.05.008. Epub 2014 May 22.

PMID:
24857787
16.

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Ascher DB, Wielens J, Nero TL, Doughty L, Morton CJ, Parker MW.

Sci Rep. 2014 Apr 23;4:4765. doi: 10.1038/srep04765.

17.

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Epa VC, Dolezal O, Doughty L, Xiao X, Jost C, Plückthun A, Adams TE.

PLoS One. 2013;8(3):e59163. doi: 10.1371/journal.pone.0059163. Epub 2013 Mar 19.

18.

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.

Miles LA, Crespi GA, Doughty L, Parker MW.

Sci Rep. 2013;3:1302. doi: 10.1038/srep01302.

19.

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin.

Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW.

Front Immunol. 2012 Nov 5;3:330. doi: 10.3389/fimmu.2012.00330. eCollection 2012.

20.

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

Wang C, Henkes LM, Doughty LB, He M, Wang D, Meyer-Almes FJ, Cheng YQ.

J Nat Prod. 2011 Oct 28;74(10):2031-8. doi: 10.1021/np200324x. Epub 2011 Jul 27.

21.

Acute renal replacement therapy in pediatrics.

Basu RK, Wheeler DS, Goldstein S, Doughty L.

Int J Nephrol. 2011;2011:785392. doi: 10.4061/2011/785392. Epub 2011 Jun 1.

22.

Validation of a gene expression-based subclassification strategy for pediatric septic shock.

Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE.

Crit Care Med. 2011 Nov;39(11):2511-7. doi: 10.1097/CCM.0b013e3182257675.

23.

The Accreditation Council for Graduate Medical Education proposed work hour regulations.

Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ.

Pediatr Crit Care Med. 2011 Jan;12(1):120-1. doi: 10.1097/PCC.0b013e3181fe3d4b. No abstract available.

PMID:
21209582
24.

Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept.

Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA.

Crit Care Med. 2010 Oct;38(10):1955-61. doi: 10.1097/CCM.0b013e3181eb924f.

25.

Pityriasis rubra pilaris with epidermolytic hyperkeratosis.

Doughty LE, Wells MJ, Stetson CL.

J Drugs Dermatol. 2008 Oct;7(10):978-9. No abstract available.

PMID:
19112765
26.
27.

Admission angiopoietin levels in children with septic shock.

Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS.

Shock. 2007 Dec;28(6):650-654.

28.

A systematic review of juvenile-onset clinically amyopathic dermatomyositis.

Gerami P, Walling HW, Lewis J, Doughty L, Sontheimer RD.

Br J Dermatol. 2007 Oct;157(4):637-44. Epub 2007 Jun 26. Review.

PMID:
17596148
29.

Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.

Wheeler DS, Lahni P, Odoms K, Jacobs BR, Carcillo JA, Doughty LA, Wong HR.

Inflamm Res. 2007 May;56(5):216-9.

PMID:
17588138
30.

SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis.

Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A.

Apoptosis. 2007 Jul;12(7):1143-53.

PMID:
17364147
31.

Dimerisation strategies for shark IgNAR single domain antibody fragments.

Simmons DP, Abregu FA, Krishnan UV, Proll DF, Streltsov VA, Doughty L, Hattarki MK, Nuttall SD.

J Immunol Methods. 2006 Aug 31;315(1-2):171-84. Epub 2006 Aug 28.

PMID:
16962608
32.

Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.

Doughty LA, Carlton S, Galen B, Cooma-Ramberan I, Chung CS, Ayala A.

Shock. 2006 Aug;26(2):187-94.

33.

Humoral immune response to primary rubella virus infection.

Wilson KM, Di Camillo C, Doughty L, Dax EM.

Clin Vaccine Immunol. 2006 Mar;13(3):380-6.

34.

In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.

Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A.

Blood. 2005 Oct 1;106(7):2295-301. Epub 2005 Jun 7.

35.

Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations.

Wilson KM, Johnson EI, Croom HA, Richards KM, Doughty L, Cunningham PH, Kemp BE, Branson BM, Dax EM.

AIDS. 2004 Nov 19;18(17):2253-9.

PMID:
15577537
36.

Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1.

Nuttall SD, Humberstone KS, Krishnan UV, Carmichael JA, Doughty L, Hattarki M, Coley AM, Casey JL, Anders RF, Foley M, Irving RA, Hudson PJ.

Proteins. 2004 Apr 1;55(1):187-97.

PMID:
14997552
37.

Biodistributions of intact monoclonal antibodies and fragments of BLCA-38, a new prostate cancer directed antibody.

Carter T, Sterling-Levis K, Ow K, Doughty L, Hattarki M, Shapira D, Hewish D, Kortt AA, Russell PJ.

Cancer Immunol Immunother. 2004 Jun;53(6):533-42. Epub 2004 Jan 13.

PMID:
14722669
38.

Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.

Russell PJ, Hewish D, Carter T, Sterling-Levis K, Ow K, Hattarki M, Doughty L, Guthrie R, Shapira D, Molloy PL, Werkmeister JA, Kortt AA.

Cancer Immunol Immunother. 2004 May;53(5):411-21. Epub 2004 Jan 13.

PMID:
14722668
39.

The role of STAT1 in viral sensitization to LPS.

Durbin J, Doughty L, Nguyen K, Caligiuri M, Van Deusen J, Biron C.

J Endotoxin Res. 2003;9(5):313-6.

PMID:
14577848
40.

Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70.

Nuttall SD, Krishnan UV, Doughty L, Pearson K, Ryan MT, Hoogenraad NJ, Hattarki M, Carmichael JA, Irving RA, Hudson PJ.

Eur J Biochem. 2003 Sep;270(17):3543-54.

41.

Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.

Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ.

Intensive Care Med. 2003 Jun;29(6):980-984. doi: 10.1007/s00134-003-1758-3. Epub 2003 Apr 16.

PMID:
12698250
42.

Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice.

Lomas JL, Chung CS, Grutkoski PS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A.

Shock. 2003 Apr;19(4):358-65.

PMID:
12688548
43.

Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis.

Han YY, Doughty LA, Kofos D, Sasser H, Carcillo JA.

Pediatr Crit Care Med. 2003 Jan;4(1):21-5.

PMID:
12656537
44.

Noncovalent scFv multimers of tumor-targeting anti-Lewis(y) hu3S193 humanized antibody.

Power BE, Doughty L, Shapira DR, Burns JE, Bayly AM, Caine JM, Liu Z, Scott AM, Hudson PJ, Kortt AA.

Protein Sci. 2003 Apr;12(4):734-47.

46.

PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK.

Ayala A, Ding Y, Rhee RJ, Doughty LA, Grutkoski PS, Chung CS.

Rec Res Dev Immunol. 2003 Jan 12;5:13-35.

47.

Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.

Ayala A, Chung CS, Lomas JL, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski PS.

Am J Pathol. 2002 Dec;161(6):2283-94.

48.

sFas and sFas ligand and pediatric sepsis-induced multiple organ failure syndrome.

Doughty L, Clark RS, Kaplan SS, Sasser H, Carcillo J.

Pediatr Res. 2002 Dec;52(6):922-7.

PMID:
12438671
49.

A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis.

Nuttall SD, Krishnan UV, Doughty L, Nathanielsz A, Ally N, Pike RN, Hudson PJ, Kortt AA, Irving RA.

FEBS Lett. 2002 Apr 10;516(1-3):80-6.

50.

The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure.

Green J, Doughty L, Kaplan SS, Sasser H, Carcillo JA.

Thromb Haemost. 2002 Feb;87(2):218-23.

PMID:
11858480

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