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An updated understanding of the mechanisms involved in chemotherapy-induced neuropathy.

Boyette-Davis JA, Hou S, Abdi S, Dougherty PM.

Pain Manag. 2018 Sep 1;8(5):363-375. doi: 10.2217/pmt-2018-0020. Epub 2018 Sep 13.


Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations.

Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O'Mara A, Smith AG, Dastros-Pitei D, Gauthier LR, Haroutounian S, Jarpe M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R.

Neurology. 2018 Aug 28;91(9):403-413. doi: 10.1212/WNL.0000000000006083. Epub 2018 Jul 27. Review.


Subclinical Peripheral Neuropathy in Patients with Head and Neck Cancer: A Quantitative Sensory Testing (QST) Study.

Roldan CJ, Johnson C, Lee SO, Peng A, Dougherty PM, Huh B.

Pain Physician. 2018 Jul;21(4):E419-E427.


Somatotopy and Organization of Spinothalamic Tracts in the Human Cervical Spinal Cord.

Vedantam A, Bruera E, Hess KR, Dougherty PM, Viswanathan A.

Neurosurgery. 2018 Jul 13. doi: 10.1093/neuros/nyy330. [Epub ahead of print]


Morphological and Physiological Plasticity of Spinal Lamina II GABA Neurons Is Induced by Sciatic Nerve Chronic Constriction Injury in Mice.

Zhang H, Li Y, Yang Q, Liu XG, Dougherty PM.

Front Cell Neurosci. 2018 May 24;12:143. doi: 10.3389/fncel.2018.00143. eCollection 2018.


Radiation induces age-dependent deficits in cortical synaptic plasticity.

Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Wang Q, Duman JG, Dougherty PM, Grosshans DR.

Neuro Oncol. 2018 Aug 2;20(9):1207-1214. doi: 10.1093/neuonc/noy052.


Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity.

Illias AM, Gist AC, Zhang H, Kosturakis AK, Dougherty PM.

Pain. 2018 Jul;159(7):1308-1316. doi: 10.1097/j.pain.0000000000001212.


Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.

Ma J, Kavelaars A, Dougherty PM, Heijnen CJ.

Cancer. 2018 Jun 1;124(11):2289-2298. doi: 10.1002/cncr.31248. Epub 2018 Feb 20. Review.


Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.

Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A.

Pain. 2018 May;159(5):884-893. doi: 10.1097/j.pain.0000000000001160.


DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.

Li Y, North RY, Rhines LD, Tatsui CE, Rao G, Edwards DD, Cassidy RM, Harrison DS, Johansson CA, Zhang H, Dougherty PM.

J Neurosci. 2018 Jan 31;38(5):1124-1136. doi: 10.1523/JNEUROSCI.0899-17.2017. Epub 2017 Dec 18.


Psychometric Study of the Pain Drawing.

Trahan LH, Cox-Martin E, Johnson CE, Dougherty PM, Yu J, Feng L, Cook C, Novy DM.

J Appl Biobehav Res. 2017 Dec;22(4). pii: e12095. doi: 10.1111/jabr.12095. Epub 2017 Apr 7.


Limited Midline Myelotomy for Intractable Visceral Pain: Surgical Techniques and Outcomes.

Vedantam A, Koyyalagunta D, Bruel BM, Dougherty PM, Viswanathan A.

Neurosurgery. 2018 Oct 1;83(4):783-789. doi: 10.1093/neuros/nyx549.


Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review.

Flatters SJL, Dougherty PM, Colvin LA.

Br J Anaesth. 2017 Oct 1;119(4):737-749. doi: 10.1093/bja/aex229.


Postoperative MRI Evaluation of a Radiofrequency Cordotomy Lesion for Intractable Cancer Pain.

Vedantam A, Hou P, Chi TL, Hess KR, Dougherty PM, Bruera E, Viswanathan A.

AJNR Am J Neuroradiol. 2017 Apr;38(4):835-839. doi: 10.3174/ajnr.A5100. Epub 2017 Feb 16.


Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy.

Cox-Martin E, Trahan LH, Cox MG, Dougherty PM, Lai EA, Novy DM.

Support Care Cancer. 2017 Jun;25(6):1873-1879. doi: 10.1007/s00520-017-3571-5. Epub 2017 Jan 26.


Use of Spinal Cord Diffusion Tensor Imaging to Quantify Neural Ablation and Evaluate Outcome after Percutaneous Cordotomy for Intractable Cancer Pain.

Vedantam A, Hou P, Chi TL, Dougherty PM, Hess KR, Viswanathan A.

Stereotact Funct Neurosurg. 2017;95(1):34-39. doi: 10.1159/000453279. Epub 2017 Jan 14.


Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy.

Li Y, Tatsui CE, Rhines LD, North RY, Harrison DS, Cassidy RM, Johansson CA, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM.

Pain. 2017 Mar;158(3):417-429. doi: 10.1097/j.pain.0000000000000774.


AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.

Paice JA, Mulvey M, Bennett M, Dougherty PM, Farrar JT, Mantyh PW, Miaskowski C, Schmidt B, Smith TJ.

J Pain. 2017 Mar;18(3):233-246. doi: 10.1016/j.jpain.2016.10.020. Epub 2016 Nov 21. Review.


Chemotherapy-Induced Peripheral Neuropathy: A Challenge for Clinicians.

Abdi S, Dougherty PM.

Oncology (Williston Park). 2016 Nov 15;30(11):1030, C3. No abstract available.


CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A.

J Neurosci. 2016 Oct 26;36(43):11074-11083.


Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505).

Pachman DR, Qin R, Seisler D, Smith EM, Kaggal S, Novotny P, Ruddy KJ, Lafky JM, Ta LE, Beutler AS, Wagner-Johnston ND, Staff NP, Grothey A, Dougherty PM, Cavaletti G, Loprinzi CL.

Support Care Cancer. 2016 Dec;24(12):5059-5068. Epub 2016 Aug 18.


Relationship of membrane properties, spike burst responses, laminar location, and functional class of dorsal horn neurons recorded in vitro.

Dougherty PM, Chen J.

J Neurophysiol. 2016 Sep 1;116(3):1137-51. doi: 10.1152/jn.00187.2016. Epub 2016 Jun 22.


Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.

Zhang H, Li Y, de Carvalho-Barbosa M, Kavelaars A, Heijnen CJ, Albrecht PJ, Dougherty PM.

J Pain. 2016 Jul;17(7):775-86. doi: 10.1016/j.jpain.2016.02.011. Epub 2016 Mar 12.


Is Chemotherapy-induced Peripheral Neuropathy More Than Just a Peripheral Nervous System Disorder?

Dougherty PM.

Anesthesiology. 2016 May;124(5):992-3. doi: 10.1097/ALN.0000000000001085. No abstract available.


Prechemotherapy Touch Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer.

Wang XS, Shi Q, Dougherty PM, Eng C, Mendoza TR, Williams LA, Fogelman DR, Cleeland CS.

Oncology. 2016;90(3):127-35. doi: 10.1159/000443377. Epub 2016 Feb 17.


Painful Hands and Feet After Cancer Treatment: Inflammation Affecting the Mind-Body Connection.

Ganz PA, Dougherty PM.

J Clin Oncol. 2016 Mar 1;34(7):649-52. doi: 10.1200/JCO.2015.64.7479. Epub 2015 Dec 23. No abstract available.


The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.

Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM.

J Neurosci. 2015 Sep 30;35(39):13487-500. doi: 10.1523/JNEUROSCI.1956-15.2015.


Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis.

Shah N, Shi Q, Williams LA, Mendoza TR, Wang XS, Reuben JM, Dougherty PM, Bashir Q, Qazilbash MH, Champlin RE, Cleeland CS, Giralt SA.

Biol Blood Marrow Transplant. 2016 Feb;22(2):226-231. doi: 10.1016/j.bbmt.2015.07.036. Epub 2015 Aug 5.


Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment Scale.

Mendoza TR, Wang XS, Williams LA, Shi Q, Vichaya EG, Dougherty PM, Thomas SK, Yucel E, Bastida CC, Woodruff JF, Cleeland CS.

J Pain. 2015 Oct;16(10):1032-43. doi: 10.1016/j.jpain.2015.07.002. Epub 2015 Jul 22.


Mechanisms involved in the development of chemotherapy-induced neuropathy.

Boyette-Davis JA, Walters ET, Dougherty PM.

Pain Manag. 2015;5(4):285-96. doi: 10.2217/pmt.15.19. Epub 2015 Jun 19. Review.


MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy.

Li Y, Zhang H, Kosturakis AK, Cassidy RM, Zhang H, Kennamer-Chapman RM, Jawad AB, Colomand CM, Harrison DS, Dougherty PM.

Brain Behav Immun. 2015 Oct;49:255-66. doi: 10.1016/j.bbi.2015.06.003. Epub 2015 Jun 9.


Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy.

Kim JH, Dougherty PM, Abdi S.

Gynecol Oncol. 2015 Mar;136(3):453-9. doi: 10.1016/j.ygyno.2015.01.524. Epub 2015 Jan 10. Review.


Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy.

Robinson CR, Dougherty PM.

Neuroscience. 2015 Jan 29;285:1-10. doi: 10.1016/j.neuroscience.2014.11.009. Epub 2014 Nov 13.


Peripheral neuropathic pain: signs, symptoms, mechanisms, and causes: are they linked?

Colvin LA, Dougherty PM.

Br J Anaesth. 2015 Mar;114(3):361-3. doi: 10.1093/bja/aeu323. Epub 2014 Sep 24. No abstract available.


A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy.

de Carvalho Barbosa M, Kosturakis AK, Eng C, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Wang XS, Cleeland CS, Dougherty PM.

Cancer Res. 2014 Nov 1;74(21):5955-62. doi: 10.1158/0008-5472.CAN-14-2060. Epub 2014 Sep 2.


Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density.

Kosturakis AK, He Z, Li Y, Boyette-Davis JA, Shah N, Thomas SK, Zhang H, Vichaya EG, Wang XS, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Cleeland CS, Dougherty PM.

J Clin Oncol. 2014 Oct 1;32(28):3156-62. doi: 10.1200/JCO.2013.54.5418. Epub 2014 Aug 25.


Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy.

Robinson CR, Zhang H, Dougherty PM.

Brain Res. 2014 Jul 29;1574:6-13. doi: 10.1016/j.brainres.2014.06.013. Epub 2014 Jun 17.


Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat.

Robinson CR, Zhang H, Dougherty PM.

Neuroscience. 2014 Aug 22;274:308-17. doi: 10.1016/j.neuroscience.2014.05.051. Epub 2014 Jun 4.


Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy.

Li Y, Zhang H, Zhang H, Kosturakis AK, Jawad AB, Dougherty PM.

J Pain. 2014 Jul;15(7):712-25. doi: 10.1016/j.jpain.2014.04.001. Epub 2014 Apr 19.


An overview of animal models of pain: disease models and outcome measures.

Gregory NS, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA.

J Pain. 2013 Nov;14(11):1255-69. doi: 10.1016/j.jpain.2013.06.008. Epub 2013 Sep 12. Review.


Dynamic effects of TNF-α on synaptic transmission in mice over time following sciatic nerve chronic constriction injury.

Zhang H, Zhang H, Dougherty PM.

J Neurophysiol. 2013 Oct;110(7):1663-71. doi: 10.1152/jn.01088.2012. Epub 2013 Jul 17.


Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy.

Zhang H, Boyette-Davis JA, Kosturakis AK, Li Y, Yoon SY, Walters ET, Dougherty PM.

J Pain. 2013 Oct;14(10):1031-44. doi: 10.1016/j.jpain.2013.03.012. Epub 2013 May 31.


Subclinical pretreatment sensory deficits appear to predict the development of pain and numbness in patients with multiple myeloma undergoing chemotherapy.

Vichaya EG, Wang XS, Boyette-Davis JA, Mendoza TR, He Z, Thomas SK, Shah N, Williams LA, Cleeland CS, Dougherty PM.

Cancer Chemother Pharmacol. 2013 Jun;71(6):1531-40. doi: 10.1007/s00280-013-2152-7. Epub 2013 Mar 31.


Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity.

Yoon SY, Robinson CR, Zhang H, Dougherty PM.

J Pain. 2013 Feb;14(2):205-14. doi: 10.1016/j.jpain.2012.11.002.


Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine.

Boyette-Davis JA, Cata JP, Driver LC, Novy DM, Bruel BM, Mooring DL, Wendelschafer-Crabb G, Kennedy WR, Dougherty PM.

Cancer Chemother Pharmacol. 2013 Mar;71(3):619-26. doi: 10.1007/s00280-012-2047-z. Epub 2012 Dec 11.


Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes.

Yoon SY, Patel D, Dougherty PM.

Neuroscience. 2012 Sep 27;221:214-24. doi: 10.1016/j.neuroscience.2012.06.024. Epub 2012 Jun 26.


Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy.

Boyette-Davis JA, Eng C, Wang XS, Cleeland CS, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Zhang H, Dougherty PM.

Clin Cancer Res. 2012 Jun 1;18(11):3180-7. doi: 10.1158/1078-0432.CCR-12-0205. Epub 2012 Apr 10.


Wireless peripheral nerve stimulation increases pain threshold in two neuropathic rat models.

Rosellini W, Casavant R, Engineer N, Beall P, Pierce D, Jain R, Dougherty PM.

Exp Neurol. 2012 Jun;235(2):621-6. doi: 10.1016/j.expneurol.2012.03.016. Epub 2012 Apr 1.


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