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Maternal Fluoxetine Exposure Alters Cortical Hemodynamic and Calcium Response of Offspring to Somatosensory Stimuli.

Rahn RM, Maloney SE, Brier LM, Dougherty JD, Culver JP.

eNeuro. 2019 Dec 27;6(6). pii: ENEURO.0238-19.2019. doi: 10.1523/ENEURO.0238-19.2019. Print 2019 Nov/Dec.


The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.

Li Z, Farias FHG, Dube U, Del-Aguila JL, Mihindukulasuriya KA, Fernandez MV, Ibanez L, Budde JP, Wang F, Lake AM, Deming Y, Perez J, Yang C, Bahena JA, Qin W, Bradley JL, Davenport R, Bergmann K, Morris JC, Perrin RJ, Benitez BA, Dougherty JD, Harari O, Cruchaga C.

Acta Neuropathol. 2020 Jan;139(1):45-61. doi: 10.1007/s00401-019-02066-0. Epub 2019 Aug 27.


Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models.

Kopp N, McCullough K, Maloney SE, Dougherty JD.

Hum Mol Genet. 2019 Oct 15;28(20):3443-3465. doi: 10.1093/hmg/ddz176.


A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.

Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR.

Cell. 2019 Jul 25;178(3):653-671.e19. doi: 10.1016/j.cell.2019.06.034.


Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.

Maloney SE, Rieger MA, Al-Hasani R, Bruchas MR, Wozniak DF, Dougherty JD.

Genes Brain Behav. 2019 Sep;18(7):e12593. doi: 10.1111/gbb.12593. Epub 2019 Jun 19.


Erroneous inference based on a lack of preference within one group: Autism, mice, and the social approach task.

Nygaard KR, Maloney SE, Dougherty JD.

Autism Res. 2019 Aug;12(8):1171-1183. doi: 10.1002/aur.2154. Epub 2019 Jun 11.


The Differences in Local Translatome across Distinct Neuron Types Is Mediated by Both Baseline Cellular Differences and Post-transcriptional Mechanisms.

Ouwenga R, Lake AM, Aryal S, Lagunas T Jr, Dougherty JD.

eNeuro. 2019 Feb 4;5(6). pii: ENEURO.0320-18.2018. doi: 10.1523/ENEURO.0320-18.2018. eCollection 2018 Nov-Dec.


Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain.

Sapkota D, Lake AM, Yang W, Yang C, Wesseling H, Guise A, Uncu C, Dalal JS, Kraft AW, Lee JM, Sands MS, Steen JA, Dougherty JD.

Cell Rep. 2019 Jan 15;26(3):594-607.e7. doi: 10.1016/j.celrep.2018.12.077.


Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity.

Coe BP, Stessman HAF, Sulovari A, Geisheker MR, Bakken TE, Lake AM, Dougherty JD, Lein ES, Hormozdiari F, Bernier RA, Eichler EE.

Nat Genet. 2019 Jan;51(1):106-116. doi: 10.1038/s41588-018-0288-4. Epub 2018 Dec 17.


Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome.

Cheng C, Deng PY, Ikeuchi Y, Yuede C, Li D, Rensing N, Huang J, Baldridge D, Maloney SE, Dougherty JD, Constantino J, Jahani-Asl A, Wong M, Wozniak DF, Wang T, Klyachko VA, Bonni A.

Cell Rep. 2018 Nov 6;25(6):1404-1414.e6. doi: 10.1016/j.celrep.2018.10.043.


Altered social behavior in mice carrying a cortical Foxp2 deletion.

Medvedeva VP, Rieger MA, Vieth B, Mombereau C, Ziegenhain C, Ghosh T, Cressant A, Enard W, Granon S, Dougherty JD, Groszer M.

Hum Mol Genet. 2019 Mar 1;28(5):701-717. doi: 10.1093/hmg/ddy372.


Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure.

Maloney SE, Akula S, Rieger MA, McCullough KB, Chandler K, Corbett AM, McGowin AE, Dougherty JD.

eNeuro. 2018 Jul 9;5(4). pii: ENEURO.0120-18.2018. doi: 10.1523/ENEURO.0120-18.2018. eCollection 2018 Jul-Aug.


Exome sequencing of 85 Williams-Beuren syndrome cases rules out coding variation as a major contributor to remaining variance in social behavior.

Kopp ND, Parrish PCR, Lugo M, Dougherty JD, Kozel BA.

Mol Genet Genomic Med. 2018 Sep;6(5):749-765. doi: 10.1002/mgg3.429. Epub 2018 Jul 15.


Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis.

Hoye ML, Regan MR, Jensen LA, Lake AM, Reddy LV, Vidensky S, Richard JP, Maragakis NJ, Rothstein JD, Dougherty JD, Miller TM.

Brain. 2018 Sep 1;141(9):2561-2575. doi: 10.1093/brain/awy182.


Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ; Dominantly Inherited Alzheimer Network (DIAN), Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O.

Genome Med. 2018 Jun 8;10(1):43. doi: 10.1186/s13073-018-0551-4.


Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.

Mulvey B, Bhatti DL, Gyawali S, Lake AM, Kriaucionis S, Ford CP, Bruchas MR, Heintz N, Dougherty JD.

Cell Rep. 2018 May 22;23(8):2225-2235. doi: 10.1016/j.celrep.2018.04.054.


Muscularis macrophage development in the absence of an enteric nervous system.

Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701. doi: 10.1073/pnas.1802490115. Epub 2018 Apr 17.


Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes.

Mulvey B, Dougherty JD.

Cell. 2018 Jan 11;172(1-2):10-13. doi: 10.1016/j.cell.2017.12.037.


Group and Individual Variability in Mouse Pup Isolation Calls Recorded on the Same Day Show Stability.

Barnes TD, Rieger MA, Dougherty JD, Holy TE.

Front Behav Neurosci. 2017 Dec 15;11:243. doi: 10.3389/fnbeh.2017.00243. eCollection 2017.


The Expanding Toolkit of Translating Ribosome Affinity Purification.

Dougherty JD.

J Neurosci. 2017 Dec 13;37(50):12079-12087. doi: 10.1523/JNEUROSCI.1929-17.2017.


Systems biology in the central nervous system: a brief perspective on essential recent advancements.

Dougherty JD, Yang C, Lake AM.

Curr Opin Syst Biol. 2017 Jun;3:67-76. doi: 10.1016/j.coisb.2017.04.011. Epub 2017 Apr 27.


MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.

Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS.

Cell Stem Cell. 2017 Sep 7;21(3):332-348.e9. doi: 10.1016/j.stem.2017.08.002.


Different Mixed Astrocyte Populations Derived from Embryonic Stem Cells Have Variable Neuronal Growth Support Capacities.

Thompson RE, Lake A, Kenny P, Saunders MN, Sakers K, Iyer NR, Dougherty JD, Sakiyama-Elbert SE.

Stem Cells Dev. 2017 Nov 15;26(22):1597-1611. doi: 10.1089/scd.2017.0121. Epub 2017 Oct 17.


Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.

Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD.

Autism Res. 2018 Jan;11(1):44-58. doi: 10.1002/aur.1853. Epub 2017 Aug 26.


Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In Vivo.

Ouwenga R, Lake AM, O'Brien D, Mogha A, Dani A, Dougherty JD.

J Neurosci. 2017 Sep 6;37(36):8688-8705. doi: 10.1523/JNEUROSCI.3044-16.2017. Epub 2017 Aug 8.


Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons.

Dougherty JD.

Sci Rep. 2017 Aug 14;7(1):8117. doi: 10.1038/s41598-017-08618-2.


Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T.

Science. 2017 Apr 28;356(6336):406-411. doi: 10.1126/science.aal3231.


Astrocytes locally translate transcripts in their peripheral processes.

Sakers K, Lake AM, Khazanchi R, Ouwenga R, Vasek MJ, Dani A, Dougherty JD.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3830-E3838. doi: 10.1073/pnas.1617782114. Epub 2017 Apr 24. Review.


MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.

Hoye ML, Koval ED, Wegener AJ, Hyman TS, Yang C, O'Brien DR, Miller RL, Cole T, Schoch KM, Shen T, Kunikata T, Richard JP, Gutmann DH, Maragakis NJ, Kordasiewicz HB, Dougherty JD, Miller TM.

J Neurosci. 2017 May 31;37(22):5574-5586. doi: 10.1523/JNEUROSCI.3582-16.2017. Epub 2017 Apr 17.


A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells.

Maricque BB, Dougherty JD, Cohen BA.

Nucleic Acids Res. 2017 Feb 28;45(4):e16. doi: 10.1093/nar/gkw942.


Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural Cells.

Dalal JS, Yang C, Sapkota D, Lake AM, O'Brien DR, Dougherty JD.

Front Mol Neurosci. 2017 Jan 27;10:9. doi: 10.3389/fnmol.2017.00009. eCollection 2017.


A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.

Dutta M, Robertson SJ, Okumura A, Scott DP, Chang J, Weiss JM, Sturdevant GL, Feldmann F, Haddock E, Chiramel AI, Ponia SS, Dougherty JD, Katze MG, Rasmussen AL, Best SM.

Cell Rep. 2017 Jan 17;18(3):816-829. doi: 10.1016/j.celrep.2016.12.069.


Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40.

Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, Holtzman DM, Morris JC, Goate AM, Dougherty JD, Cruchaga C.

BMC Neurol. 2016 Nov 10;16(1):217.


Dexmedetomidine protects against glucocorticoid induced progenitor cell apoptosis in neonatal mouse cerebellum.

O'Connor SD, Cabrera OH, Dougherty JD, Singh S, Swiney BS, Salinas-Contreras P, Farber NB, Noguchi KK.

J Matern Fetal Neonatal Med. 2017 Sep;30(18):2156-2162. doi: 10.1080/14767058.2016.1241763. Epub 2017 Feb 6.


FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga.

Chiramel AI, Dougherty JD, Nair V, Robertson SJ, Best SM.

J Infect Dis. 2016 Oct 15;214(suppl 3):S319-S325. Epub 2016 Aug 10.


Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga.

Chiramel AI, Banadyga L, Dougherty JD, Falzarano D, Martellaro C, Brees D, Taylor RT, Ebihara H, Best SM.

J Infect Dis. 2016 Oct 15;214(suppl 3):S355-S359. Epub 2016 Aug 10.


A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain.

Reddy AS, O'Brien D, Pisat N, Weichselbaum CT, Sakers K, Lisci M, Dalal JS, Dougherty JD.

Biol Psychiatry. 2017 Feb 1;81(3):252-264. doi: 10.1016/j.biopsych.2016.02.021. Epub 2016 Feb 24.


Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.

Usui N, Co M, Harper M, Rieger MA, Dougherty JD, Konopka G.

Biol Psychiatry. 2017 Feb 1;81(3):220-230. doi: 10.1016/j.biopsych.2016.02.008. Epub 2016 Feb 13.


Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules.

Dougherty JD, Tsai WC, Lloyd RE.

Viruses. 2015 Nov 25;7(12):6127-40. doi: 10.3390/v7122922.


The anatomical distribution of genetic associations.

Wells A, Kopp N, Xu X, O'Brien DR, Yang W, Nehorai A, Adair-Kirk TL, Kopan R, Dougherty JD.

Nucleic Acids Res. 2015 Dec 15;43(22):10804-20. doi: 10.1093/nar/gkv1262. Epub 2015 Nov 19.


Moving from capstones toward cornerstones: successes and challenges in applying systems biology to identify mechanisms of autism spectrum disorders.

Kopp N, Climer S, Dougherty JD.

Front Genet. 2015 Oct 7;6:301. doi: 10.3389/fgene.2015.00301. eCollection 2015. Review.


FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.

Araujo DJ, Anderson AG, Berto S, Runnels W, Harper M, Ammanuel S, Rieger MA, Huang HC, Rajkovich K, Loerwald KW, Dekker JD, Tucker HO, Dougherty JD, Gibson JR, Konopka G.

Genes Dev. 2015 Oct 15;29(20):2081-96. doi: 10.1101/gad.267989.115.


The female protective effect in autism spectrum disorder is not mediated by a single genetic locus.

Gockley J, Willsey AJ, Dong S, Dougherty JD, Constantino JN, Sanders SJ.

Mol Autism. 2015 May 13;6:25. doi: 10.1186/s13229-015-0014-3. eCollection 2015.


The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain.

Maloney SE, Khangura E, Dougherty JD.

Brain Struct Funct. 2016 May;221(4):1809-31. doi: 10.1007/s00429-015-1005-z. Epub 2015 Feb 15.


Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors.

Tupal S, Rieger MA, Ling GY, Park TJ, Dougherty JD, Goodchild AK, Gray PA.

Eur J Neurosci. 2014 Oct;40(7):3067-77. doi: 10.1111/ejn.12669. Epub 2014 Jul 21.


Investigation of maternal genotype effects in autism by genome-wide association.

Yuan H, Dougherty JD.

Autism Res. 2014 Apr;7(2):245-53. doi: 10.1002/aur.1363. Epub 2014 Feb 25.


Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders.

Xu X, Wells AB, O'Brien DR, Nehorai A, Dougherty JD.

J Neurosci. 2014 Jan 22;34(4):1420-31. doi: 10.1523/JNEUROSCI.4488-13.2014.


Identifying essential cell types and circuits in autism spectrum disorders.

Maloney SE, Rieger MA, Dougherty JD.

Int Rev Neurobiol. 2013;113:61-96. doi: 10.1016/B978-0-12-418700-9.00003-4. Review.

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