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Items: 1 to 50 of 168


Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.

Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin J, Looger L, Lester HA.

J Gen Physiol. 2019 Feb 4. pii: jgp.201812201. doi: 10.1085/jgp.201812201. [Epub ahead of print]


Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing.

Henderson BJ, Grant S, Chu BW, Shahoei R, Huard SM, Saladi SSM, Tajkhorshid E, Dougherty DA, Lester HA.

eNeuro. 2019 Jan 4;5(6). pii: ENEURO.0465-18.2018. doi: 10.1523/ENEURO.0465-18.2018. eCollection 2018 Nov-Dec.


Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

Mosesso R, Dougherty DA, Lummis SCR.

Biochemistry. 2018 Jul 10;57(27):4036-4043. doi: 10.1021/acs.biochem.8b00379. Epub 2018 Jun 21.


A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors.

Mosesso R, Dougherty DA.

J Biol Chem. 2018 Feb 23;293(8):2903-2914. doi: 10.1074/jbc.M117.810432. Epub 2018 Jan 3.


Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors.

Post MR, Tender GS, Lester HA, Dougherty DA.

eNeuro. 2017 Mar 30;4(2). pii: ENEURO.0032-17.2017. doi: 10.1523/ENEURO.0032-17.2017. eCollection 2017 Mar-Apr.


A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock.

Walton DP, Dougherty DA.

J Am Chem Soc. 2017 Apr 5;139(13):4655-4658. doi: 10.1021/jacs.7b01548. Epub 2017 Mar 24.


Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors.

Post MR, Lester HA, Dougherty DA.

Biochemistry. 2017 Apr 4;56(13):1836-1840. doi: 10.1021/acs.biochem.7b00213. Epub 2017 Mar 21.


Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process.

Regan CJ, Walton DP, Shafaat OS, Dougherty DA.

J Am Chem Soc. 2017 Apr 5;139(13):4729-4736. doi: 10.1021/jacs.6b12007. Epub 2017 Mar 24.


Beyond research literature: Occupational therapists' perspectives on and uses of "evidence" in everyday practice.

Dougherty DA, Toth-Cohen SE, Tomlin GS.

Can J Occup Ther. 2016 Dec;83(5):288-296. doi: 10.1177/0008417416660990.


Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression.

Nichols WA, Henderson BJ, Marotta CB, Yu CY, Richards C, Dougherty DA, Lester HA, Cohen BN.

PLoS One. 2016 Jun 23;11(6):e0158032. doi: 10.1371/journal.pone.0158032. eCollection 2016.


Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain.

Shafaat OS, Winkler JR, Gray HB, Dougherty DA.

Chembiochem. 2016 Jul 15;17(14):1323-7. doi: 10.1002/cbic.201600230. Epub 2016 Jun 2.


Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC.

J Biol Chem. 2016 Mar 18;291(12):6272-80. doi: 10.1074/jbc.M115.694372. Epub 2015 Dec 14.


Cation-π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation.

Davis MR, Dougherty DA.

Phys Chem Chem Phys. 2015 Nov 21;17(43):29262-70. doi: 10.1039/c5cp04668h.


An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.

Marotta CB, Lester HA, Dougherty DA.

Chem Biol. 2015 Aug 20;22(8):1063-73. doi: 10.1016/j.chembiol.2015.06.018. Epub 2015 Jul 23.


Ketamine inside neurons?

Lester HA, Lavis LD, Dougherty DA.

Am J Psychiatry. 2015 Nov 1;172(11):1064-6. doi: 10.1176/appi.ajp.2015.14121537. Epub 2015 Jul 17. No abstract available.


The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.

Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.

Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986.


Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.

Post MR, Limapichat W, Lester HA, Dougherty DA.

Neuropharmacology. 2015 Oct;97:376-82. doi: 10.1016/j.neuropharm.2015.04.009. Epub 2015 Apr 20.


Allosteric activation of the 5-HT3AB receptor by mCPBG.

Miles TF, Lester HA, Dougherty DA.

Neuropharmacology. 2015 Apr;91:103-8. doi: 10.1016/j.neuropharm.2014.12.018. Epub 2014 Dec 23.


Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs.

Rienzo M, Lummis SC, Dougherty DA.

Chem Biol. 2014 Dec 18;21(12):1700-6. doi: 10.1016/j.chembiol.2014.10.019.


Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.

Daeffler KN, Lester HA, Dougherty DA.

ACS Chem Biol. 2014 Oct 17;9(10):2283-90. doi: 10.1021/cb500323d. Epub 2014 Aug 5.


In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool.

Dougherty DA, Van Arnam EB.

Chembiochem. 2014 Aug 18;15(12):1710-20. doi: 10.1002/cbic.201402080. Epub 2014 Jul 2. Review.


Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors.

Limapichat W, Dougherty DA, Lester HA.

Mol Pharmacol. 2014 Sep;86(3):263-74. doi: 10.1124/mol.114.093179. Epub 2014 Jun 25.


Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground.

Van Arnam EB, Dougherty DA.

J Med Chem. 2014 Aug 14;57(15):6289-300. doi: 10.1021/jm500023m. Epub 2014 Mar 10. Review.


Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors.

Marotta CB, Rreza I, Lester HA, Dougherty DA.

ACS Chem Biol. 2014 May 16;9(5):1153-9. doi: 10.1021/cb400937d. Epub 2014 Mar 5.


Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.

Marotta CB, Dilworth CN, Lester HA, Dougherty DA.

Neuropharmacology. 2014 Feb;77:342-9. doi: 10.1016/j.neuropharm.2013.09.028. Epub 2013 Oct 18.


The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.

Miles TF, Dougherty DA, Lester HA.

Biophys J. 2013 Aug 20;105(4):887-98. doi: 10.1016/j.bpj.2013.07.015.


An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.

Van Arnam EB, Blythe EE, Lester HA, Dougherty DA.

Mol Pharmacol. 2013 Aug;84(2):201-7. doi: 10.1124/mol.113.085795. Epub 2013 May 16.


Key binding interactions for memantine in the NMDA receptor.

Limapichat W, Yu WY, Branigan E, Lester HA, Dougherty DA.

ACS Chem Neurosci. 2013 Feb 20;4(2):255-60. doi: 10.1021/cn300180a. Epub 2012 Dec 7.


Binding interactions with the complementary subunit of nicotinic receptors.

Blum AP, Van Arnam EB, German LA, Lester HA, Dougherty DA.

J Biol Chem. 2013 Mar 8;288(10):6991-7. doi: 10.1074/jbc.M112.439968. Epub 2013 Jan 24.


The cation-π interaction.

Dougherty DA.

Acc Chem Res. 2013 Apr 16;46(4):885-93. doi: 10.1021/ar300265y. Epub 2012 Dec 7.


GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

Ashby JA, McGonigle IV, Price KL, Cohen N, Comitani F, Dougherty DA, Molteni C, Lummis SC.

Biophys J. 2012 Nov 21;103(10):2071-81. doi: 10.1016/j.bpj.2012.10.016. Epub 2012 Nov 20.


A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way.

Miles TF, Bower KS, Lester HA, Dougherty DA.

ACS Chem Neurosci. 2012 Oct 17;3(10):753-60. doi: 10.1021/cn3000586. Epub 2012 Jul 20.


Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.

Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3.


Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.

Srinivasan R, Richards CI, Dilworth C, Moss FJ, Dougherty DA, Lester HA.

Int J Mol Sci. 2012;13(8):10022-40. doi: 10.3390/ijms130810022. Epub 2012 Aug 10.


Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.

Daeffler KN, Lester HA, Dougherty DA.

J Am Chem Soc. 2012 Sep 12;134(36):14890-6. doi: 10.1021/ja304560x. Epub 2012 Aug 31.


Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis.

Duffy NH, Lester HA, Dougherty DA.

ACS Chem Biol. 2012 Oct 19;7(10):1738-45. doi: 10.1021/cb300246j. Epub 2012 Aug 15.


Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.

Tavares Xda S, Blum AP, Nakamura DT, Puskar NL, Shanata JA, Lester HA, Dougherty DA.

J Am Chem Soc. 2012 Jul 18;134(28):11474-80. doi: 10.1021/ja3011379. Epub 2012 Jul 9.


Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.

Richards CI, Luong K, Srinivasan R, Turner SW, Dougherty DA, Korlach J, Lester HA.

Nano Lett. 2012 Jul 11;12(7):3690-4. doi: 10.1021/nl301480h. Epub 2012 Jun 8.


Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket.

Lummis SC, Harrison NJ, Wang J, Ashby JA, Millen KS, Beene DL, Dougherty DA.

ACS Chem Neurosci. 2012 Mar 21;3(3):186-192. Epub 2011 Dec 15.


Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.

Srinivasan R, Richards CI, Xiao C, Rhee D, Pantoja R, Dougherty DA, Miwa JM, Lester HA.

Mol Pharmacol. 2012 Jun;81(6):759-69. doi: 10.1124/mol.112.077792. Epub 2012 Feb 29.


Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor.

Puskar NL, Lester HA, Dougherty DA.

ACS Chem Biol. 2012 May 18;7(5):841-6. doi: 10.1021/cb200448j. Epub 2012 Feb 14.


Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors.

Shanata JA, Frazier SJ, Lester HA, Dougherty DA.

Methods Mol Biol. 2012;796:97-113. doi: 10.1007/978-1-61779-334-9_6.


Two amino acid residues contribute to a cation-π binding interaction in the binding site of an insect GABA receptor.

Lummis SC, McGonigle I, Ashby JA, Dougherty DA.

J Neurosci. 2011 Aug 24;31(34):12371-6. doi: 10.1523/JNEUROSCI.1610-11.2011.


Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.

Van Arnam EB, Lester HA, Dougherty DA.

ACS Chem Biol. 2011 Oct 21;6(10):1063-8. doi: 10.1021/cb200153g. Epub 2011 Jul 28.


Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit.

Blum AP, Gleitsman KR, Lester HA, Dougherty DA.

J Biol Chem. 2011 Sep 16;286(37):32251-8. doi: 10.1074/jbc.M111.254235. Epub 2011 Jul 13.


Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes.

Puskar NL, Xiu X, Lester HA, Dougherty DA.

J Biol Chem. 2011 Apr 22;286(16):14618-27. doi: 10.1074/jbc.M110.206565. Epub 2011 Feb 22. Erratum in: J Biol Chem. 2011 Aug 19;286(33):29442.


A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.

Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC.

Mol Pharmacol. 2011 Apr;79(4):742-8. doi: 10.1124/mol.110.069583. Epub 2011 Jan 25.


Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates.

Kedrowski SM, Dougherty DA.

Org Lett. 2010 Sep 17;12(18):3990-3. doi: 10.1021/ol1015493.


Preparation of translationally competent tRNA by direct chemical acylation.

Duffy NH, Dougherty DA.

Org Lett. 2010 Sep 3;12(17):3776-9. doi: 10.1021/ol101408f.


Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.

Blum AP, Lester HA, Dougherty DA.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13206-11. doi: 10.1073/pnas.1007140107. Epub 2010 Jun 28.

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