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Items: 49

1.

Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity.

Ito Y, Ashenberg O, Pyrdol J, Luoma AM, Rozenblatt-Rosen O, Hofree M, Christian E, Ferrari de Andrade L, Tay RE, Teyton L, Regev A, Dougan SK, Wucherpfennig KW.

J Exp Med. 2018 Sep 5. pii: jem.20180300. doi: 10.1084/jem.20180300. [Epub ahead of print]

PMID:
30185635
2.

One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice.

Lin YC, Pecetta S, Steichen JM, Kratochvil S, Melzi E, Arnold J, Dougan SK, Wu L, Kirsch KH, Nair U, Schief WR, Batista FD.

EMBO J. 2018 Sep 14;37(18). pii: e99243. doi: 10.15252/embj.201899243. Epub 2018 Aug 7.

3.

Unmasking Pancreatic Cancer: Epitope Spreading After Single Antigen Chimeric Antigen Receptor T-Cell Therapy in a Human Phase I Trial.

Heckler M, Dougan SK.

Gastroenterology. 2018 Jul;155(1):11-14. doi: 10.1053/j.gastro.2018.06.023. Epub 2018 Jun 6. No abstract available.

PMID:
29885301
4.

Regulation of innate and adaptive antitumor immunity by IAP antagonists.

Dougan SK, Dougan M.

Immunotherapy. 2018 Jul;10(9):787-796. doi: 10.2217/imt-2017-0185. Epub 2018 May 29.

5.

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.

PMID:
29643230
6.

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.

7.

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs.

Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK.

Cancer Immunol Res. 2018 Apr;6(4):389-401. doi: 10.1158/2326-6066.CIR-17-0495. Epub 2018 Feb 19.

PMID:
29459478
8.

Generation of Ca2+-independent sortase A mutants with enhanced activity for protein and cell surface labeling.

Jeong HJ, Abhiraman GC, Story CM, Ingram JR, Dougan SK.

PLoS One. 2017 Dec 4;12(12):e0189068. doi: 10.1371/journal.pone.0189068. eCollection 2017.

9.

The Pancreatic Cancer Microenvironment.

Dougan SK.

Cancer J. 2017 Nov/Dec;23(6):321-325. doi: 10.1097/PPO.0000000000000288. Review.

PMID:
29189327
10.

IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

Clancy-Thompson E, Ali L, Bruck PT, Exley MA, Blumberg RS, Dranoff G, Dougan M, Dougan SK.

Cancer Immunol Res. 2018 Jan;6(1):25-35. doi: 10.1158/2326-6066.CIR-17-0490. Epub 2017 Nov 29.

PMID:
29187357
11.

PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.

12.

CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation.

Zeissig S, Peuker K, Iyer S, Gensollen T, Dougan SK, Olszak T, Kaser A, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10449-10454. doi: 10.1073/pnas.1701428114. Epub 2017 Sep 11.

13.

Localized CD47 blockade enhances immunotherapy for murine melanoma.

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.

14.

Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.

Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL.

Sci Immunol. 2016 Aug 26;1(2):eaaf7471. doi: 10.1126/sciimmunol.aaf7471. Epub 2016 Aug 26.

PMID:
28783695
15.

Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.

Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK.

J Immunol. 2017 Jul 1;199(1):159-171. doi: 10.4049/jimmunol.1700214. Epub 2017 Jun 2.

16.

Targeting Immunotherapy to the Tumor Microenvironment.

Dougan M, Dougan SK.

J Cell Biochem. 2017 Oct;118(10):3049-3054. doi: 10.1002/jcb.26005. Epub 2017 May 15. Review.

PMID:
28332219
17.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3583. Dhesycka, Rhogerry [corrected to Deshycka, Rhogerry].

18.

Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy.

Tyler PM, Servos MM, de Vries RC, Klebanov B, Kashyap T, Sacham S, Landesman Y, Dougan M, Dougan SK.

Mol Cancer Ther. 2017 Mar;16(3):428-439. doi: 10.1158/1535-7163.MCT-16-0496. Epub 2017 Feb 1.

19.

Cocapture of cognate and bystander antigens can activate autoreactive B cells.

Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):734-739. doi: 10.1073/pnas.1614472114. Epub 2017 Jan 5.

20.

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.

Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM.

Immunology. 2016 Nov;149(3):270-279. doi: 10.1111/imm.12643. Epub 2016 Aug 17.

21.

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3599-608. doi: 10.1073/pnas.1515364113. Epub 2016 Jun 14.

22.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

23.

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL.

Nat Biotechnol. 2016 Feb;34(2):210. doi: 10.1038/nbt0216-210c. No abstract available.

PMID:
26849523
24.

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL.

Nat Biotechnol. 2015 May;33(5):538-42. doi: 10.1038/nbt.3190. Epub 2015 Mar 23. Erratum in: Nat Biotechnol. 2016 Feb;34(2):210.

25.

Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing.

Dura B, Dougan SK, Barisa M, Hoehl MM, Lo CT, Ploegh HL, Voldman J.

Nat Commun. 2015 Jan 13;6:5940. doi: 10.1038/ncomms6940.

PMID:
25585172
26.

Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice.

Strijbis K, Yilmaz OH, Dougan SK, Esteban A, Gröne A, Kumamoto CA, Ploegh HL.

PLoS One. 2014 Nov 7;9(11):e112472. doi: 10.1371/journal.pone.0112472. eCollection 2014.

27.

Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS.

Gut. 2015 Dec;64(12):1889-97. doi: 10.1136/gutjnl-2014-308541. Epub 2014 Nov 3.

28.

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Erratum in: Nature. 2016 Aug 18;536(7616):359.

29.

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10131-6. doi: 10.1073/pnas.1409861111. Epub 2014 Jun 30.

30.

In vivo discovery of immunotherapy targets in the tumour microenvironment.

Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.

Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29.

31.

Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.

Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL.

Cancer Immunol Res. 2013 Aug;1(2):99-111. doi: 10.1158/2326-6066.CIR-13-0047.

32.

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus.

Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL.

Nature. 2013 Nov 21;503(7476):406-9. doi: 10.1038/nature12637. Epub 2013 Oct 20.

33.

Stochastic cytokine expression induces mixed T helper cell States.

Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A.

PLoS Biol. 2013 Jul;11(7):e1001618. doi: 10.1371/journal.pbio.1001618. Epub 2013 Jul 30.

34.

Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.

Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL.

PLoS Pathog. 2013;9(6):e1003446. doi: 10.1371/journal.ppat.1003446. Epub 2013 Jun 27.

35.

IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.

Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13739-44. doi: 10.1073/pnas.1210273109. Epub 2012 Aug 6.

36.

Preparation of unnatural N-to-N and C-to-C protein fusions.

Witte MD, Cragnolini JJ, Dougan SK, Yoder NC, Popp MW, Ploegh HL.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11993-8. doi: 10.1073/pnas.1205427109. Epub 2012 Jul 9.

37.

M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins.

Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, Guimaraes CP.

Bioconjug Chem. 2012 Jul 18;23(7):1478-87. doi: 10.1021/bc300130z. Epub 2012 Jul 3.

38.

Sortase-catalyzed transformations that improve the properties of cytokines.

Popp MW, Dougan SK, Chuang TY, Spooner E, Ploegh HL.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3169-74. doi: 10.1073/pnas.1016863108. Epub 2011 Feb 4.

39.

Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes.

Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL.

Mol Cell Biol. 2011 Mar;31(6):1145-59. doi: 10.1128/MCB.00967-10. Epub 2011 Jan 10.

40.

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.

J Clin Invest. 2010 Aug;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1.

41.

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.

Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL.

J Exp Med. 2009 Oct 26;206(11):2429-40. doi: 10.1084/jem.20090782. Epub 2009 Oct 6.

42.

XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.

McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC.

J Immunol. 2009 Sep 15;183(6):3690-9. doi: 10.4049/jimmunol.0900953. Epub 2009 Aug 26.

43.

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.

Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL.

EMBO J. 2009 Jun 3;28(11):1624-36. doi: 10.1038/emboj.2009.117. Epub 2009 Apr 30.

44.

Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.

Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS.

Eur J Immunol. 2008 Aug;38(8):2351-9. doi: 10.1002/eji.200738102.

45.

Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism.

Hussain MM, Rava P, Pan X, Dai K, Dougan SK, Iqbal J, Lazare F, Khatun I.

Curr Opin Lipidol. 2008 Jun;19(3):277-84. doi: 10.1097/MOL.0b013e3282feea85. Review.

PMID:
18460919
46.

Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity.

Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS.

Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1101-5. Epub 2007 Aug 23.

47.

CD1 expression on antigen-presenting cells.

Dougan SK, Kaser A, Blumberg RS.

Curr Top Microbiol Immunol. 2007;314:113-41. Review.

PMID:
17593659
48.

MTP regulated by an alternate promoter is essential for NKT cell development.

Dougan SK, Rava P, Hussain MM, Blumberg RS.

J Exp Med. 2007 Mar 19;204(3):533-45. Epub 2007 Feb 20.

49.

Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.

Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS.

J Exp Med. 2005 Aug 15;202(4):529-39. Epub 2005 Aug 8.

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