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SMAC mimetics throw a molecular switch to control TH17 responses.

Dougan SK, Dougan M.

Sci Signal. 2019 Aug 27;12(596). pii: eaay3986. doi: 10.1126/scisignal.aay3986. Review.


Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events.

Badran YR, Cohen JV, Brastianos PK, Parikh AR, Hong TS, Dougan M.

J Immunother Cancer. 2019 Aug 22;7(1):226. doi: 10.1186/s40425-019-0711-0.


Immune-Related Adverse Events in the Gastrointestinal Tract: Diagnostic Utility of Upper Gastrointestinal Biopsies.

Zhang ML, Neyaz A, Patil D, Chen J, Dougan M, Deshpande V.

Histopathology. 2019 Jul 30. doi: 10.1111/his.13963. [Epub ahead of print]


Prognostic Implications of Co-Occurring Dermatologic and Gastrointestinal Toxicity from Immune Checkpoint Inhibition Therapy for Advanced Malignancies: A Retrospective Cohort Study.

Molina GE, Allen IM, Hughes MS, Zubiri L, Lee H, Mooradian MJ, Reynolds KL, Dougan M, Chen ST.

J Am Acad Dermatol. 2019 Jul 23. pii: S0190-9622(19)32432-6. doi: 10.1016/j.jaad.2019.07.049. [Epub ahead of print] No abstract available.


Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control.

Hughes MS, Zheng H, Zubiri L, Molina GE, Chen ST, Mooradian MJ, Allen IM, Reynolds KL, Dougan M.

Cancer Med. 2019 Sep;8(11):4986-4999. doi: 10.1002/cam4.2397. Epub 2019 Jul 9.


Programmable bacteria as cancer therapy.

Dougan M, Dougan SK.

Nat Med. 2019 Jul;25(7):1030-1031. doi: 10.1038/s41591-019-0513-4. No abstract available.


Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities.

Pauken KE, Dougan M, Rose NR, Lichtman AH, Sharpe AH.

Trends Immunol. 2019 Jun;40(6):511-523. doi: 10.1016/ Epub 2019 Apr 30. Review.


GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

Dougan M, Dranoff G, Dougan SK.

Immunity. 2019 Apr 16;50(4):796-811. doi: 10.1016/j.immuni.2019.03.022. Review.


Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.

Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7624-7631. doi: 10.1073/pnas.1817147116. Epub 2019 Apr 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16656.


Antitumor response to microscopic melanoma in the gastric mucosa mimicking ipilimumab-induced gastritis.

Bello E, Cohen JV, Mino-Kenudson M, Dougan M.

J Immunother Cancer. 2019 Feb 11;7(1):41. doi: 10.1186/s40425-019-0524-1.


De novo design of potent and selective mimics of IL-2 and IL-15.

Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D.

Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9.


Incidence of Second Malignancy in Patients with Papillary Thyroid Cancer from Surveillance, Epidemiology, and End Results 13 Dataset.

Endo M, Liu JB, Dougan M, Lee JS.

J Thyroid Res. 2018 Jun 26;2018:8765369. doi: 10.1155/2018/8765369. eCollection 2018.


Diagnosis and Management of Hepatitis in Patients on Checkpoint Blockade.

Reynolds K, Thomas M, Dougan M.

Oncologist. 2018 Sep;23(9):991-997. doi: 10.1634/theoncologist.2018-0174. Epub 2018 May 31.


Regulation of innate and adaptive antitumor immunity by IAP antagonists.

Dougan SK, Dougan M.

Immunotherapy. 2018 Jul;10(9):787-796. doi: 10.2217/imt-2017-0185. Epub 2018 May 29. Review.


Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry.

Dougan MM, Li Y, Chu LW, Haile RW, Whittemore AS, Han SS, Moore SC, Sampson JN, Andrulis IL, John EM, Hsing AW.

BMC Cancer. 2018 May 5;18(1):532. doi: 10.1186/s12885-018-4437-z.


CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment.

Lee-Sayer SSM, Dougan MN, Cooper J, Sanderson L, Dosanjh M, Maxwell CA, Johnson P.

PLoS One. 2018 Apr 23;13(4):e0196011. doi: 10.1371/journal.pone.0196011. eCollection 2018.


The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.


Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.


Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs.

Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK.

Cancer Immunol Res. 2018 Apr;6(4):389-401. doi: 10.1158/2326-6066.CIR-17-0495. Epub 2018 Feb 19.


Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells.

Lee-Sayer SSM, Maeshima N, Dougan MN, Dahiya A, Arif AA, Dosanjh M, Maxwell CA, Johnson P.

Eur J Immunol. 2018 May;48(5):803-814. doi: 10.1002/eji.201747263. Epub 2018 Jan 19.


Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract.

Dougan M.

Front Immunol. 2017 Nov 15;8:1547. doi: 10.3389/fimmu.2017.01547. eCollection 2017. Review.


IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

Clancy-Thompson E, Ali L, Bruck PT, Exley MA, Blumberg RS, Dranoff G, Dougan M, Dougan SK.

Cancer Immunol Res. 2018 Jan;6(1):25-35. doi: 10.1158/2326-6066.CIR-17-0490. Epub 2017 Nov 29.


PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.


Localized CD47 blockade enhances immunotherapy for murine melanoma.

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.


Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.


Targeting Immunotherapy to the Tumor Microenvironment.

Dougan M, Dougan SK.

J Cell Biochem. 2017 Oct;118(10):3049-3054. doi: 10.1002/jcb.26005. Epub 2017 May 15. Review.


Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy.

Tyler PM, Servos MM, de Vries RC, Klebanov B, Kashyap T, Sacham S, Landesman Y, Dougan M, Dougan SK.

Mol Cancer Ther. 2017 Mar;16(3):428-439. doi: 10.1158/1535-7163.MCT-16-0496. Epub 2017 Feb 1.


Maternal Anthropometry and Mammographic Density in Adult Daughters.

Michels KB, Cohn BA, Goldberg M, Flom JD, Dougan M, Terry MB.

Pediatrics. 2016 Nov;138(Suppl 1):S34-S41.


Durable antitumor responses to CD47 blockade require adaptive immune stimulation.

Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54. doi: 10.1073/pnas.1604268113. Epub 2016 Apr 18.


The use of 18F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.

Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H.

ACS Cent Sci. 2015 Jun 24;1(3):142-147. Epub 2015 Jun 3.


Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.

Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL.

PLoS Pathog. 2015 Oct 2;11(10):e1005188. doi: 10.1371/journal.ppat.1005188. eCollection 2015 Oct.


Is grand-parental smoking associated with adolescent obesity? A three-generational study.

Dougan MM, Field AE, Rich-Edwards JW, Hankinson SE, Glynn RJ, Willett WC, Michels KB.

Int J Obes (Lond). 2016 Mar;40(3):531-7. doi: 10.1038/ijo.2015.186. Epub 2015 Sep 21.


Presentation skills.

Dougan M.

Nurs Stand. 2015 Jul 8;29(45):61. doi: 10.7748/ns.29.45.61.s45. No abstract available.


Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women.

Dougan MM, Hankinson SE, Vivo ID, Tworoger SS, Glynn RJ, Michels KB.

Int J Cancer. 2015 Aug 1;137(3):625-37. doi: 10.1002/ijc.29427. Epub 2015 Feb 5.


6Cs of nursing.

Dougan M.

Nurs Stand. 2014 Oct 28;29(8):54. doi: 10.7748/ns.29.8.54.s49. No abstract available.


Prenatal vitamin intake during pregnancy and offspring obesity.

Dougan MM, Willett WC, Michels KB.

Int J Obes (Lond). 2015 Jan;39(1):69-74. doi: 10.1038/ijo.2014.107. Epub 2013 Jun 19.


Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.

Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL.

Cancer Immunol Res. 2013 Aug;1(2):99-111. doi: 10.1158/2326-6066.CIR-13-0047.


Supporting mentors.

Dougan M.

Nurs Stand. 2013 Aug 21-27;27(51):59. No abstract available.


A dual role for the immune response in a mouse model of inflammation-associated lung cancer.

Dougan M, Li D, Neuberg D, Mihm M, Googe P, Wong KK, Dranoff G.

J Clin Invest. 2011 Jun;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.


Who will manage American patients with diabetes? Residents' career preferences and perceptions of diabetes care.

Yarchoan M, Dougan ML, Tjota MY, Milliner BH, Adler BL, Armah KA, Gooley TA, Close KL, Close J, Hirsch IB.

Endocr Pract. 2011 Mar-Apr;17(2):235-9. doi: 10.4158/EP10250.OR.


IAP inhibitors enhance co-stimulation to promote tumor immunity.

Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G.

J Exp Med. 2010 Sep 27;207(10):2195-206. doi: 10.1084/jem.20101123. Epub 2010 Sep 13.


Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome.

Stein CR, Savitz DA, Dougan M.

Am J Epidemiol. 2009 Oct 1;170(7):837-46. doi: 10.1093/aje/kwp212. Epub 2009 Aug 19.


The immune response to tumors.

Dougan M, Dranoff G.

Curr Protoc Immunol. 2009 Apr;Chapter 20:Unit 20.11. doi: 10.1002/0471142735.im2011s85.


Immune therapy for cancer.

Dougan M, Dranoff G.

Annu Rev Immunol. 2009;27:83-117. doi: 10.1146/annurev.immunol.021908.132544. Review.


Inciting inflammation: the RAGE about tumor promotion.

Dougan M, Dranoff G.

J Exp Med. 2008 Feb 18;205(2):267-70. doi: 10.1084/jem.20080136. Epub 2008 Feb 11.


MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.

Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G.

J Clin Invest. 2007 Jul;117(7):1902-13.


Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.

Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G.

Blood. 2007 Aug 1;110(3):954-61. Epub 2007 May 4.


Rapid cleavage of cyclic tertiary amides of Kemp's triacid: effects of ring structure.

Dougan ML, Chin JL, Solt K, Hansen DE.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4153-6.


Medical malpractice in Arkansas in the twentieth century.

Dougan MB.

Res Pap Hist Med Assoc. 1999;(2):139-60. No abstract available.


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