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Therapy-related acute lymphoblastic leukemia: Where do we stand with regards to its definition and characterization?

Aldoss I, Douer D, Pullarkat V.

Blood Rev. 2019 Jun 19. pii: S0268-960X(19)30031-1. doi: 10.1016/j.blre.2019.06.001. [Epub ahead of print] Review.


Combination chemotherapy plus dasatinib leads to comparable overall survival and relapse-free survival rates as allogeneic hematopoietic stem cell transplantation in Philadelphia positive acute lymphoblastic leukemia.

Chang J, Douer D, Aldoss I, Vahdani G, Jeong AR, Ghaznavi Z, Zhang S, Yaghmour G, Lee KJ, Weissman A, Akhtari M.

Cancer Med. 2019 Jun;8(6):2832-2839. doi: 10.1002/cam4.2153. Epub 2019 Apr 23.


High-Dose Vincristine Sulfate Liposome Injection, for Advanced, Relapsed, or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in an Adolescent and Young Adult Subgroup of a Phase 2 Clinical Trial.

Schiller GJ, Damon LE, Coutre SE, Hsu P, Bhat G, Douer D.

J Adolesc Young Adult Oncol. 2018 Oct;7(5):546-552. doi: 10.1089/jayao.2018.0041. Epub 2018 Sep 21.


The emerging story of acute lymphoblastic leukemia among the Latin American population - biological and clinical implications.

Quiroz E, Aldoss I, Pullarkat V, Rego E, Marcucci G, Douer D.

Blood Rev. 2019 Jan;33:98-105. doi: 10.1016/j.blre.2018.08.002. Epub 2018 Aug 14. Review.


Treatment of young adults with Philadelphia-negative acute lymphoblastic leukemia and lymphoblastic lymphoma: Hyper-CVAD vs. pediatric-inspired regimens.

Siegel SE, Advani A, Seibel N, Muffly L, Stock W, Luger S, Shah B, DeAngelo DJ, Freyer DR, Douer D, Johnson RH, Hayes-Lattin B, Lewis M, Jaboin JJ, Coccia PF, Bleyer A.

Am J Hematol. 2018 Oct;93(10):1254-1266. doi: 10.1002/ajh.25229. Epub 2018 Sep 3. Review.


Very poor long-term survival in past and more recent studies for relapsed AML patients: The ECOG-ACRIN experience.

Ganzel C, Sun Z, Cripe LD, Fernandez HF, Douer D, Rowe JM, Paietta EM, Ketterling R, O'Connell MJ, Wiernik PH, Bennett JM, Litzow MR, Luger SM, Lazarus HM, Tallman MS.

Am J Hematol. 2018 Jun 15. doi: 10.1002/ajh.25162. [Epub ahead of print]


Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review.

Siegel SE, Stock W, Johnson RH, Advani A, Muffly L, Douer D, Reed D, Lewis M, Freyer DR, Shah B, Luger S, Hayes-Lattin B, Jaboin JJ, Coccia PF, DeAngelo DJ, Seibel N, Bleyer A.

JAMA Oncol. 2018 May 1;4(5):725-734. doi: 10.1001/jamaoncol.2017.5305.


Pegaspargase-related high-grade hepatotoxicity in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not predict recurrent hepatotoxicity with subsequent doses.

Burke PW, Aldoss I, Lunning MA, Devlin SM, Tallman MS, Pullarkat V, Mohrbacher AM, Douer D.

Leuk Res. 2018 Mar;66:49-56. doi: 10.1016/j.leukres.2017.12.013. Epub 2018 Jan 3.


Phase 2 trial of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia.

Maslak PG, Dao T, Bernal Y, Chanel SM, Zhang R, Frattini M, Rosenblat T, Jurcic JG, Brentjens RJ, Arcila ME, Rampal R, Park JH, Douer D, Katz L, Sarlis N, Tallman MS, Scheinberg DA.

Blood Adv. 2018 Feb 13;2(3):224-234. doi: 10.1182/bloodadvances.2017014175.


Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia.

Byun HM, Eshaghian S, Douer D, Trent J, Garcia-Manero G, Bhatia R, Siegmund K, Yang AS.

Open Med (Wars). 2017 May 4;12:76-85. doi: 10.1515/med-2017-0014. eCollection 2017.


A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia.

Yao J, Douer D, Wang L, Arcila ME, Nafa K, Chiu A.

Leuk Res Rep. 2017 Jan 31;7:17-19. doi: 10.1016/j.lrr.2017.01.003. eCollection 2017.


Overall survival among older US adults with ALL remains low despite modest improvement since 1980: SEER analysis.

Geyer MB, Hsu M, Devlin SM, Tallman MS, Douer D, Park JH.

Blood. 2017 Mar 30;129(13):1878-1881. doi: 10.1182/blood-2016-11-749507. Epub 2017 Jan 25. No abstract available.


Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era.

Mantha S, Goldman DA, Devlin SM, Lee JW, Zannino D, Collins M, Douer D, Iland HJ, Litzow MR, Stein EM, Appelbaum FR, Larson RA, Stone R, Powell BL, Geyer S, Laumann K, Rowe JM, Erba H, Coutre S, Othus M, Park JH, Wiernik PH, Tallman MS.

Blood. 2017 Mar 30;129(13):1763-1767. doi: 10.1182/blood-2016-10-747170. Epub 2017 Jan 12.


Hypoalbuminemia is significantly associated with increased clearance time of high dose methotrexate in patients being treated for lymphoma or leukemia.

Reiss SN, Buie LW, Adel N, Goldman DA, Devlin SM, Douer D.

Ann Hematol. 2016 Dec;95(12):2009-2015. Epub 2016 Aug 20.


The use of Erwinia asparaginase for adult patients with acute lymphoblastic leukemia after pegaspargase intolerance.

Horvat TZ, Pecoraro JJ, Daley RJ, Buie LW, King AC, Rampal RK, Tallman MS, Park JH, Douer D.

Leuk Res. 2016 Nov;50:17-20. doi: 10.1016/j.leukres.2016.08.014. Epub 2016 Aug 26.


A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.

Reed GA, Schiller GJ, Kambhampati S, Tallman MS, Douer D, Minden MD, Yee KW, Gupta V, Brandwein J, Jitkova Y, Gronda M, Hurren R, Shamas-Din A, Schuh AC, Schimmer AD.

Cancer Med. 2016 Nov;5(11):3031-3040. doi: 10.1002/cam4.845. Epub 2016 Oct 13.


Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008.

Ganzel C, Manola J, Douer D, Rowe JM, Fernandez HF, Paietta EM, Litzow MR, Lee JW, Luger SM, Lazarus HM, Cripe LD, Wiernik PH, Tallman MS.

J Clin Oncol. 2016 Oct 10;34(29):3544-3553. Erratum in: J Clin Oncol. 2017 Jan 10;35(2):263.


Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia.

Douer D.

Oncologist. 2016 Jul;21(7):840-7. doi: 10.1634/theoncologist.2015-0391. Epub 2016 Jun 21. Review.


Autologous transplant remains the preferred therapy for relapsed APL in CR2.

Ganzel C, Mathews V, Alimoghaddam K, Ghavamzadeh A, Kuk D, Devlin S, Wang H, Zhang MJ, Weisdorf D, Douer D, Rowe JM, Polge E, Esteve J, Nagler A, Mohty M, Tallman MS.

Bone Marrow Transplant. 2016 Sep;51(9):1180-3. doi: 10.1038/bmt.2016.96. Epub 2016 Apr 18.


Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: A Case-Study Compendium.

Wang ES, Jabbour EJ, Douer D.

Clin Adv Hematol Oncol. 2016 Mar;14(3 Suppl 4):1-23.


Very late relapse of AML after allogeneic hematopoietic cell transplantation is often extramedullary.

Watts JM, Wang XV, Swords RT, Paietta E, Douer D, Lugar SM, Fernandez HF, Rowe JM, Lazarus HM, Tallman MS, Litzow MR.

Bone Marrow Transplant. 2016 Jul;51(7):1013-5. doi: 10.1038/bmt.2016.44. Epub 2016 Mar 14. No abstract available.


L-Carnitine for Treatment of Pegasparaginase-Induced Hepatotoxicity.

Alshiekh-Nasany R, Douer D.

Acta Haematol. 2016;135(4):208-10. doi: 10.1159/000442342. Epub 2016 Feb 4.


Acute Lymphoblastic Leukemia, Version 2.2015.

Alvarnas JC, Brown PA, Aoun P, Ballen KK, Barta SK, Borate U, Boyer MW, Burke PW, Cassaday R, Castro JE, Coccia PF, Coutre SE, Damon LE, DeAngelo DJ, Douer D, Frankfurt O, Greer JP, Johnson RA, Kantarjian HM, Klisovic RB, Kupfer G, Litzow M, Liu A, Rao AV, Shah B, Uy GL, Wang ES, Zelenetz AD, Gregory K, Smith C.

J Natl Compr Canc Netw. 2015 Oct;13(10):1240-79.


Novel Management Options for Adult Patients With Progressive Acute Lymphoblastic Leukemia: A Case-Study Compendium.

Wang ES, Jabbour EJ, Douer D.

Clin Adv Hematol Oncol. 2015 Jun;13(6 Suppl 7):1-23. Review.


Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia.

Aldoss I, Douer D, Behrendt CE, Chaudhary P, Mohrbacher A, Vrona J, Pullarkat V.

Eur J Haematol. 2016 Apr;96(4):375-80. doi: 10.1111/ejh.12600. Epub 2015 Jun 25.


Secondary acute lymphoblastic leukaemia is constitutional and probably not related to prior therapy.

Ganzel C, Devlin S, Douer D, Rowe JM, Stein EM, Tallman MS.

Br J Haematol. 2015 Jul;170(1):50-5. doi: 10.1111/bjh.13386. Epub 2015 Mar 30.


New developments in acute lymphoblastic leukemia.

Douer D, Thomas DA.

Clin Adv Hematol Oncol. 2014 Jun;12(6 Suppl 12):13-22. Review.


Advances in the treatment of relapsed/refractory acute lymphoblastic leukemia: a case study compendium.

Roboz GJ, Jabbour EJ, Faderl S, Douer D.

Clin Adv Hematol Oncol. 2014 Dec;12(12 Suppl 20):8-18, 1.


High-dose cytarabine as salvage therapy for relapsed or refractory acute myeloid leukemia--is more better or more of the same?

Wolach O, Itchaki G, Bar-Natan M, Yeshurun M, Ram R, Herscovici C, Shpilberg O, Douer D, Tallman MS, Raanani P.

Hematol Oncol. 2016 Mar;34(1):28-35. doi: 10.1002/hon.2191. Epub 2015 Feb 17.


Will novel agents for ALL finally change the natural history?

Douer D.

Best Pract Res Clin Haematol. 2014 Sep-Dec;27(3-4):247-58. doi: 10.1016/j.beha.2014.10.006. Epub 2014 Oct 14. Review.


Acute lymphoblastic leukemia in adolescents and young adults.

Burke PW, Douer D.

Acta Haematol. 2014;132(3-4):264-73. doi: 10.1159/000360204. Epub 2014 Sep 10. Review.


Younger adults with acute myeloid leukemia in remission for ≥ 3 years have a high likelihood of cure: The ECOG experience in over 1200 patients.

Watts JM, Wang XV, Litzow MR, Luger SM, Lazarus HM, Cassileth PA, Fernandez HF, Douer D, Zickl L, Paietta E, Rowe JM, Tallman MS.

Leuk Res. 2014 Aug;38(8):901-6. doi: 10.1016/j.leukres.2014.05.018. Epub 2014 Jun 2.


Extramedullary disease in APL: a real phenomenon to contend with or not?

Ganzel C, Douer D.

Best Pract Res Clin Haematol. 2014 Mar;27(1):63-8. doi: 10.1016/j.beha.2014.04.001. Epub 2014 Apr 12. Review.


Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia.

Aldoss I, Mark L, Vrona J, Ramezani L, Weitz I, Mohrbacher AM, Douer D.

Ann Hematol. 2014 Nov;93(11):1839-43. doi: 10.1007/s00277-014-2124-y. Epub 2014 Jun 7.


Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia.

Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, Chung SS, Stefanski J, Borquez-Ojeda O, Olszewska M, Qu J, Wasielewska T, He Q, Fink M, Shinglot H, Youssif M, Satter M, Wang Y, Hosey J, Quintanilla H, Halton E, Bernal Y, Bouhassira DC, Arcila ME, Gonen M, Roboz GJ, Maslak P, Douer D, Frattini MG, Giralt S, Sadelain M, Brentjens R.

Sci Transl Med. 2014 Feb 19;6(224):224ra25. doi: 10.1126/scitranslmed.3008226.


Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia.

Douer D, Aldoss I, Lunning MA, Burke PW, Ramezani L, Mark L, Vrona J, Park JH, Tallman MS, Avramis VI, Pullarkat V, Mohrbacher AM.

J Clin Oncol. 2014 Mar 20;32(9):905-11. doi: 10.1200/JCO.2013.50.2708. Epub 2014 Feb 10.


Postconsolidation maintenance and monitoring in patients with acute promyelocytic leukemia.

Ganzel C, Douer D, Tallman MS.

J Natl Compr Canc Netw. 2013 Dec 1;11(12):1512-21. Review.


An effective reinduction regimen for first relapse of adult acute lymphoblastic leukemia.

Aldoss I, Pullarkat V, Patel R, Watkins K, Mohrbacher A, Levine AM, Douer D.

Med Oncol. 2013 Dec;30(4):744. doi: 10.1007/s12032-013-0744-z. Epub 2013 Oct 18.


Adult acute lymphoblastic leukemia: a cancer with no standard of care.

Douer D.

Acta Haematol. 2013;130(3):196-8. doi: 10.1159/000351601. Epub 2013 Jun 19. No abstract available.


Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death.

Altman JK, Rademaker A, Cull E, Weitner BB, Ofran Y, Rosenblat TL, Haidau A, Park JH, Ram SL, Orsini JM Jr, Sandhu S, Catchatourian R, Trifilio SM, Adel NG, Frankfurt O, Stein EM, Mallios G, Deblasio T, Jurcic JG, Nimer S, Peterson LC, Kwaan HC, Rowe JM, Douer D, Tallman MS.

Leuk Res. 2013 Sep;37(9):1004-9. doi: 10.1016/j.leukres.2013.05.007. Epub 2013 Jun 14.


All-trans retinoic acid and late relapses in acute promyelocytic leukemia: very long-term follow-up of the North American Intergroup Study I0129.

Douer D, Zickl LN, Schiffer CA, Appelbaum FR, Feusner JH, Shepherd L, Willman CL, Bloomfield CD, Paietta E, Gallagher RE, Park JH, Rowe JM, Wiernik PH, Tallman MS.

Leuk Res. 2013 Jul;37(7):795-801. doi: 10.1016/j.leukres.2013.03.001. Epub 2013 Mar 23.


What is the impact, present and future, of novel targeted agents in acute lymphoblastic leukemia?

Douer D.

Best Pract Res Clin Haematol. 2012 Dec;25(4):453-64. doi: 10.1016/j.beha.2012.10.008. Epub 2012 Nov 9. Review.


High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia.

O'Brien S, Schiller G, Lister J, Damon L, Goldberg S, Aulitzky W, Ben-Yehuda D, Stock W, Coutre S, Douer D, Heffner LT, Larson M, Seiter K, Smith S, Assouline S, Kuriakose P, Maness L, Nagler A, Rowe J, Schaich M, Shpilberg O, Yee K, Schmieder G, Silverman JA, Thomas D, Deitcher SR, Kantarjian H.

J Clin Oncol. 2013 Feb 20;31(6):676-83. doi: 10.1200/JCO.2012.46.2309. Epub 2012 Nov 19.


Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia.

Baljevic M, Abdel-Wahab O, Rampal R, Maslak PG, Klimek VM, Rosenblat TL, Douer D, Levine RL, Tallman MS.

Acta Haematol. 2013;129(1):48-54. doi: 10.1159/000342493. Epub 2012 Nov 7.


Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis.

Diab A, Zickl L, Abdel-Wahab O, Jhanwar S, Gulam MA, Panageas KS, Patel JP, Jurcic J, Maslak P, Paietta E, Mangan JK, Carroll M, Fernandez HF, Teruya-Feldstein J, Luger SM, Douer D, Litzow MR, Lazarus HM, Rowe JM, Levine RL, Tallman MS.

Leuk Res. 2013 Jan;37(1):32-6. doi: 10.1016/j.leukres.2012.08.025. Epub 2012 Oct 24.


Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium.

Mascarenhas J, Heaney ML, Najfeld V, Hexner E, Abdel-Wahab O, Rampal R, Ravandi F, Petersen B, Roboz G, Feldman E, Podoltsev N, Douer D, Levine R, Tallman M, Hoffman R; Post-myeloproliferative neoplasm acute myeloid leukemia consortium.

Leuk Res. 2012 Dec;36(12):1500-4. doi: 10.1016/j.leukres.2012.08.013. Epub 2012 Aug 28.


Acute lymphoblastic leukemia.

Alvarnas JC, Brown PA, Aoun P, Ballen KK, Bellam N, Blum W, Boyer MW, Carraway HE, Coccia PF, Coutre SE, Cultrera J, Damon LE, DeAngelo DJ, Douer D, Frangoul H, Frankfurt O, Goorha S, Millenson MM, O'Brien S, Petersdorf SH, Rao AV, Terezakis S, Uy G, Wetzler M, Zelenetz AD, Naganuma M, Gregory KM; National Comprehensive Cancer Network.

J Natl Compr Canc Netw. 2012 Jul 1;10(7):858-914.


Curing all patients with acute promyelocytic leukemia: are we there yet?

Baljevic M, Park JH, Stein E, Douer D, Altman JK, Tallman MS.

Hematol Oncol Clin North Am. 2011 Dec;25(6):1215-33, viii. doi: 10.1016/j.hoc.2011.10.002. Review.


Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.

Stock W, Douer D, DeAngelo DJ, Arellano M, Advani A, Damon L, Kovacsovics T, Litzow M, Rytting M, Borthakur G, Bleyer A.

Leuk Lymphoma. 2011 Dec;52(12):2237-53. doi: 10.3109/10428194.2011.596963. Epub 2011 Aug 10.


How I treat extramedullary acute myeloid leukemia.

Bakst RL, Tallman MS, Douer D, Yahalom J.

Blood. 2011 Oct 6;118(14):3785-93. doi: 10.1182/blood-2011-04-347229. Epub 2011 Jul 27.

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