Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 253

1.

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.

Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF.

Cancer Cell. 2018 Sep 10;34(3):513-528.e8. doi: 10.1016/j.ccell.2018.08.003.

PMID:
30205050
2.

Systematic discovery of natural CRISPR-Cas12a inhibitors.

Watters KE, Fellmann C, Bai HB, Ren SM, Doudna JA.

Science. 2018 Sep 6. pii: eaau5138. doi: 10.1126/science.aau5138. [Epub ahead of print]

PMID:
30190307
3.

CRISPR-Cas guides the future of genetic engineering.

Knott GJ, Doudna JA.

Science. 2018 Aug 31;361(6405):866-869. doi: 10.1126/science.aat5011. Review.

PMID:
30166482
4.

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.

Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR.

Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105.

5.

Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection.

Huang CH, Lee KC, Doudna JA.

Trends Cancer. 2018 Jul;4(7):499-512. doi: 10.1016/j.trecan.2018.05.006. Epub 2018 Jun 13. Review.

PMID:
29937048
6.

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.

Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte Barrón J, McLellan TJ, Bellenger J, Feng X, Varghese A, Chrunyk BA, Borzilleri K, Hesp KD, Zhou K, Ma N, Tu M, Dullea R, McClure KF, Wilson RC, Liras S, Mascitti V, Doudna JA.

J Am Chem Soc. 2018 May 30;140(21):6596-6603. doi: 10.1021/jacs.8b01551. Epub 2018 May 18.

7.

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JHD.

PLoS Biol. 2018 Apr 17;16(4):e1002628. doi: 10.1371/journal.pbio.1002628. eCollection 2018 Apr.

8.

Programmable RNA recognition using a CRISPR-associated Argonaute.

Lapinaite A, Doudna JA, Cate JHD.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3368-3373. doi: 10.1073/pnas.1717725115. Epub 2018 Mar 12.

PMID:
29531059
9.

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.

Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA.

Science. 2018 Apr 27;360(6387):436-439. doi: 10.1126/science.aar6245. Epub 2018 Feb 15.

PMID:
29449511
10.

Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna.

Kiessling LL, Doudna JA.

ACS Chem Biol. 2018 Feb 16;13(2):290-295. doi: 10.1021/acschembio.8b00108.

PMID:
29448761
11.

RNA-dependent RNA targeting by CRISPR-Cas9.

Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna JA.

Elife. 2018 Jan 5;7. pii: e32724. doi: 10.7554/eLife.32724.

12.

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing.

Moreno-Mateos MA, Fernandez JP, Rouet R, Vejnar CE, Lane MA, Mis E, Khokha MK, Doudna JA, Giraldez AJ.

Nat Commun. 2017 Dec 8;8(1):2024. doi: 10.1038/s41467-017-01836-2.

13.

Widespread Translational Remodeling during Human Neuronal Differentiation.

Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN.

Cell Rep. 2017 Nov 14;21(7):2005-2016. doi: 10.1016/j.celrep.2017.10.095.

14.

A thermostable Cas9 with increased lifetime in human plasma.

Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA.

Nat Commun. 2017 Nov 10;8(1):1424. doi: 10.1038/s41467-017-01408-4.

15.

Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.

Knight SC, Tjian R, Doudna JA.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4329-4337. doi: 10.1002/anie.201709201. Epub 2018 Feb 28. Review.

16.

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA.

Nature. 2017 Oct 19;550(7676):407-410. doi: 10.1038/nature24268. Epub 2017 Sep 20.

17.

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.

Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.

18.

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.

19.

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.

Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A.

Sci Adv. 2017 Aug 4;3(8):eaao0027. doi: 10.1126/sciadv.aao0027. eCollection 2017 Aug.

20.

Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.

21.

Disabling Cas9 by an anti-CRISPR DNA mimic.

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA.

Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul.

22.

DNA recognition by an RNA-guided bacterial Argonaute.

Doxzen KW, Doudna JA.

PLoS One. 2017 May 17;12(5):e0177097. doi: 10.1371/journal.pone.0177097. eCollection 2017.

23.

High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.

Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna JA, Greenleaf WJ.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5461-5466. doi: 10.1073/pnas.1700557114. Epub 2017 May 11.

24.

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.

Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.

25.

Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System.

Liu TY, Iavarone AT, Doudna JA.

PLoS One. 2017 Apr 6;12(4):e0175612. doi: 10.1371/journal.pone.0175612. eCollection 2017.

26.

CRISPR-Cas9 Structures and Mechanisms.

Jiang F, Doudna JA.

Annu Rev Biophys. 2017 May 22;46:505-529. doi: 10.1146/annurev-biophys-062215-010822. Epub 2017 Mar 30. Review.

PMID:
28375731
27.

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.

Gaj T, Staahl BT, Rodrigues GMC, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV.

Nucleic Acids Res. 2017 Jun 20;45(11):e98. doi: 10.1093/nar/gkx154.

28.

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH.

PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. eCollection 2017 Mar. Erratum in: PLoS Biol. 2018 Apr 17;16(4):e1002628.

29.

RNA-based recognition and targeting: sowing the seeds of specificity.

Gorski SA, Vogel J, Doudna JA.

Nat Rev Mol Cell Biol. 2017 Apr;18(4):215-228. doi: 10.1038/nrm.2016.174. Epub 2017 Feb 15. Review.

PMID:
28196981
30.

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes.

Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA.

Nat Biotechnol. 2017 May;35(5):431-434. doi: 10.1038/nbt.3806. Epub 2017 Feb 13.

PMID:
28191903
31.

RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System.

Liu TY, Iavarone AT, Doudna JA.

PLoS One. 2017 Jan 23;12(1):e0170552. doi: 10.1371/journal.pone.0170552. eCollection 2017. Erratum in: PLoS One. 2017 Apr 6;12 (4):e0175612.

32.

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair.

Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N.

Nat Biomed Eng. 2017;1:889-901. doi: 10.1038/s41551-017-0137-2. Epub 2017 Oct 2.

33.

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.

Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA.

Mol Cell. 2017 Jan 5;65(1):168-175. doi: 10.1016/j.molcel.2016.11.031. Epub 2016 Dec 22.

34.

Cornerstones of CRISPR-Cas in drug discovery and therapy.

Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE.

Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Review.

35.

New CRISPR-Cas systems from uncultivated microbes.

Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF.

Nature. 2017 Feb 9;542(7640):237-241. doi: 10.1038/nature21059. Epub 2016 Dec 22.

36.

ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing.

Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna JA, Greenleaf WJ, Liphardt JT, Chang HY.

Nat Methods. 2016 Dec;13(12):1013-1020. doi: 10.1038/nmeth.4031. Epub 2016 Oct 17.

37.

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.

Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH.

Elife. 2016 Oct 12;5. pii: e15910. doi: 10.7554/eLife.15910.

38.

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.

Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.

39.

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.

Singh D, Sternberg SH, Fei J, Doudna JA, Ha T.

Nat Commun. 2016 Sep 14;7:12778. doi: 10.1038/ncomms12778.

40.

Applications of CRISPR technologies in research and beyond.

Barrangou R, Doudna JA.

Nat Biotechnol. 2016 Sep 8;34(9):933-941. doi: 10.1038/nbt.3659. [Epub ahead of print]

41.

Protecting genome integrity during CRISPR immune adaptation.

Wright AV, Doudna JA.

Nat Struct Mol Biol. 2016 Oct;23(10):876-883. doi: 10.1038/nsmb.3289. Epub 2016 Sep 5.

PMID:
27595346
42.

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.

Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA.

Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027.

43.

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

Lee AS, Kranzusch PJ, Doudna JA, Cate JH.

Nature. 2016 Aug 4;536(7614):96-9. Epub 2016 Jul 27.

44.

Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies.

Carlson LA, Bai Y, Keane SC, Doudna JA, Hurley JH.

Elife. 2016 Jun 25;5. pii: e14663. doi: 10.7554/eLife.14663.

45.

CRISPR Immunological Memory Requires a Host Factor for Specificity.

Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA.

Mol Cell. 2016 Jun 16;62(6):824-833. doi: 10.1016/j.molcel.2016.04.027. Epub 2016 May 19.

46.

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch.

Oakes BL, Nadler DC, Flamholz A, Fellmann C, Staahl BT, Doudna JA, Savage DF.

Nat Biotechnol. 2016 Jun;34(6):646-51. doi: 10.1038/nbt.3528. Epub 2016 May 2.

47.

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.

Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R.

Elife. 2016 Apr 28;5. pii: e13450. doi: 10.7554/eLife.13450.

48.

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.

Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ.

Oncotarget. 2016 May 10;7(19):28169-82. doi: 10.18632/oncotarget.8612.

49.

A bacterial Argonaute with noncanonical guide RNA specificity.

Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4057-62. doi: 10.1073/pnas.1524385113. Epub 2016 Mar 30.

50.

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW.

Cell. 2016 Apr 7;165(2):488-96. doi: 10.1016/j.cell.2016.02.054. Epub 2016 Mar 17.

Supplemental Content

Loading ...
Support Center