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Design and Validation of an Automated Process for the Expansion of Peripheral Blood-Derived CD34+ Cells for Clinical Use After Myocardial Infarction.

Saucourt C, Vogt S, Merlin A, Valat C, Criquet A, Harmand L, Birebent B, Rouard H, Himmelspach C, Jeandidier É, Chartois-Leauté AG, Derenne S, Koehl L, Salem JE, Hulot JS, Tancredi C, Aries A, Judé S, Martel E, Richard S, Douay L, Hénon P.

Stem Cells Transl Med. 2019 Aug;8(8):822-832. doi: 10.1002/sctm.17-0277. Epub 2019 Apr 29.


Mesenchymal Stem Cell Administration Attenuates Colon Cancer Progression by Modulating the Immune Component within the Colorectal Tumor Microenvironment.

François S, Usunier B, Forgue-Lafitte ME, L'Homme B, Benderitter M, Douay L, Gorin NC, Larsen AK, Chapel A.

Stem Cells Transl Med. 2019 Mar;8(3):285-300. doi: 10.1002/sctm.18-0117. Epub 2018 Nov 19.


Why industrial production of red blood cells from stem cells is essential for tomorrow's blood transfusion.

Douay L.

Regen Med. 2018 Sep;13(6):627-632. doi: 10.2217/rme-2018-0025. Epub 2018 Sep 24. No abstract available.


Author Correction: Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 α induction.

François S, Eder V, Belmokhtar K, Machet MC, Douay L, Gorin NC, Benderitter M, Chapel A.

Sci Rep. 2018 Apr 11;8(1):6050. doi: 10.1038/s41598-018-23594-x.


Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 α induction.

François S, Eder V, Belmokhtar K, Machet MC, Douay L, Gorin NC, Benderitter M, Chapel A.

Sci Rep. 2017 Jun 27;7(1):4272. doi: 10.1038/s41598-017-04496-w. Erratum in: Sci Rep. 2018 Apr 11;8(1):6050.


Precision and prognostic value of clone-specific minimal residual disease in acute myeloid leukemia.

Hirsch P, Tang R, Abermil N, Flandrin P, Moatti H, Favale F, Suner L, Lorre F, Marzac C, Fava F, Mamez AC, Lapusan S, Isnard F, Mohty M, Legrand O, Douay L, Bilhou-Nabera C, Delhommeau F.

Haematologica. 2017 Jul;102(7):1227-1237. doi: 10.3324/haematol.2016.159681. Epub 2017 Mar 16.


Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia.

Hirsch P, Zhang Y, Tang R, Joulin V, Boutroux H, Pronier E, Moatti H, Flandrin P, Marzac C, Bories D, Fava F, Mokrani H, Betems A, Lorre F, Favier R, Féger F, Mohty M, Douay L, Legrand O, Bilhou-Nabera C, Louache F, Delhommeau F.

Nat Commun. 2016 Aug 18;7:12475. doi: 10.1038/ncomms12475.


Comprehensive Proteomic Analysis of Human Erythropoiesis.

Gautier EF, Ducamp S, Leduc M, Salnot V, Guillonneau F, Dussiot M, Hale J, Giarratana MC, Raimbault A, Douay L, Lacombe C, Mohandas N, Verdier F, Zermati Y, Mayeux P.

Cell Rep. 2016 Aug 2;16(5):1470-1484. doi: 10.1016/j.celrep.2016.06.085. Epub 2016 Jul 21.


[In vitro generation of blood red cells from stem cells: a sketch of the future].

Mazurier C, Douay L.

Biol Aujourdhui. 2016;210(1):9-17. doi: 10.1051/jbio/2016008. Epub 2016 Jun 10. Review. French.


Bio-engineered and native red blood cells from cord blood exhibit the same metabolomic profile.

Darghouth D, Giarratana MC, Oliveira L, Jolly S, Marie T, Boudah S, Mario N, Junot C, Douay L, Romeo PH.

Haematologica. 2016 Jun;101(6):e220-2. doi: 10.3324/haematol.2015.141465. Epub 2016 Mar 11. No abstract available.


Clonal history of a cord blood donor cell leukemia with prenatal somatic JAK2 V617F mutation.

Hirsch P, Mamez AC, Belhocine R, Lapusan S, Tang R, Suner L, Bories D, Marzac C, Fava F, Legrand O, Mohty M, Douay L, Delhommeau F.

Leukemia. 2016 Aug;30(8):1756-9. doi: 10.1038/leu.2016.31. Epub 2016 Mar 1. No abstract available.


A novel micronucleus in vitro assay utilizing human hematopoietic stem cells.

Kotova N, Hebert N, Härnwall EL, Vare D, Mazurier C, Douay L, Jenssen D, Grawé J.

Toxicol In Vitro. 2015 Oct;29(7):1897-905. doi: 10.1016/j.tiv.2015.07.018. Epub 2015 Jul 21.


Molecular signature of erythroblast enucleation in human embryonic stem cells.

Rouzbeh S, Kobari L, Cambot M, Mazurier C, Hebert N, Faussat AM, Durand C, Douay L, Lapillonne H.

Stem Cells. 2015 Aug;33(8):2431-41. doi: 10.1002/stem.2027. Epub 2015 May 13.


Long-Term Quantitative Biodistribution and Side Effects of Human Mesenchymal Stem Cells (hMSCs) Engraftment in NOD/SCID Mice following Irradiation.

François S, Usunier B, Douay L, Benderitter M, Chapel A.

Stem Cells Int. 2014;2014:939275. doi: 10.1155/2014/939275. Epub 2014 Feb 11.


Large-scale production of red blood cells from stem cells: what are the technical challenges ahead?

Rousseau GF, Giarratana MC, Douay L.

Biotechnol J. 2014 Jan;9(1):28-38. doi: 10.1002/biot.201200368. Epub 2013 Oct 23. Review.


Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects.

Francois S, Mouiseddine M, Allenet-Lepage B, Voswinkel J, Douay L, Benderitter M, Chapel A.

Biomed Res Int. 2013;2013:151679. doi: 10.1155/2013/151679. Epub 2013 Nov 28.


Fifteen years of preclinical and clinical experiences about biotherapy treatment of lesions induced by accidental irradiation and radiotherapy.

Chapel A, Francois S, Douay L, Benderitter M, Voswinkel J.

World J Stem Cells. 2013 Jul 26;5(3):68-72. doi: 10.4252/wjsc.v5.i3.68.


JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

Bouchekioua A, Scourzic L, de Wever O, Zhang Y, Cervera P, Aline-Fardin A, Mercher T, Gaulard P, Nyga R, Jeziorowska D, Douay L, Vainchenker W, Louache F, Gespach C, Solary E, Coppo P.

Leukemia. 2014 Feb;28(2):338-48. doi: 10.1038/leu.2013.157. Epub 2013 May 21.


Caspase-3 is involved in the signalling in erythroid differentiation by targeting late progenitors.

Boehm D, Mazurier C, Giarratana MC, Darghouth D, Faussat AM, Harmand L, Douay L.

PLoS One. 2013 May 2;8(5):e62303. doi: 10.1371/journal.pone.0062303. Print 2013.


[Red blood cell production for transfusion purposes. A stem cell ex vivo fate].

Mazurier C, Douay L.

Transfus Clin Biol. 2013 May;20(2):90-4. doi: 10.1016/j.tracli.2013.02.020. Epub 2013 Apr 16. Review. French.


In vitro generated Rh(null) red cells recapitulate the in vivo deficiency: a model for rare blood group phenotypes and erythroid membrane disorders.

Cambot M, Mazurier C, Canoui-Poitrine F, Hebert N, Picot J, Clay D, Picard V, Ripoche P, Douay L, Dubart-Kupperschmitt A, Cartron JP.

Am J Hematol. 2013 May;88(5):343-9. doi: 10.1002/ajh.23414. Epub 2013 Mar 15.


Biological validation of bio-engineered red blood cell productions.

Giarratana MC, Marie T, Darghouth D, Douay L.

Blood Cells Mol Dis. 2013 Feb;50(2):69-79. doi: 10.1016/j.bcmd.2012.09.003. Epub 2012 Oct 4.


Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model.

Kobari L, Yates F, Oudrhiri N, Francina A, Kiger L, Mazurier C, Rouzbeh S, El-Nemer W, Hebert N, Giarratana MC, François S, Chapel A, Lapillonne H, Luton D, Bennaceur-Griscelli A, Douay L.

Haematologica. 2012 Dec;97(12):1795-803. doi: 10.3324/haematol.2011.055566. Epub 2012 Jun 24.


In vitro generation of red blood cells for transfusion: a model for regenerative medicine.

Douay L.

Regen Med. 2012 Jan;7(1):1-2. doi: 10.2217/rme.11.108. Review. No abstract available.


Human fetal liver: an in vitro model of erythropoiesis.

Pourcher G, Mazurier C, King YY, Giarratana MC, Kobari L, Boehm D, Douay L, Lapillonne H.

Stem Cells Int. 2011;2011:405429. doi: 10.4061/2011/405429. Epub 2011 Sep 22.


Proof of principle for transfusion of in vitro-generated red blood cells.

Giarratana MC, Rouard H, Dumont A, Kiger L, Safeukui I, Le Pennec PY, François S, Trugnan G, Peyrard T, Marie T, Jolly S, Hebert N, Mazurier C, Mario N, Harmand L, Lapillonne H, Devaux JY, Douay L.

Blood. 2011 Nov 10;118(19):5071-9. doi: 10.1182/blood-2011-06-362038. Epub 2011 Sep 1.


Red blood cells from induced pluripotent stem cells: hurdles and developments.

Mazurier C, Douay L, Lapillonne H.

Curr Opin Hematol. 2011 Jul;18(4):249-53. doi: 10.1097/MOH.0b013e3283476129. Review.


Banking of pluripotent adult stem cells as an unlimited source for red blood cell production: potential applications for alloimmunized patients and rare blood challenges.

Peyrard T, Bardiaux L, Krause C, Kobari L, Lapillonne H, Andreu G, Douay L.

Transfus Med Rev. 2011 Jul;25(3):206-16. doi: 10.1016/j.tmrv.2011.01.002. Epub 2011 Mar 4. Review.


From stem cell to red blood cells in vitro: "the 12 labors of Hercules".

Douay L.

Clin Lab Med. 2010 Jun;30(2):391-403. doi: 10.1016/j.cll.2010.02.003. Epub 2010 May 6. Retraction in: Clin Lab Med. 2011 Jun;31(2):359.


Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine.

Lapillonne H, Kobari L, Mazurier C, Tropel P, Giarratana MC, Zanella-Cleon I, Kiger L, Wattenhofer-Donzé M, Puccio H, Hebert N, Francina A, Andreu G, Viville S, Douay L.

Haematologica. 2010 Oct;95(10):1651-9. doi: 10.3324/haematol.2010.023556. Epub 2010 May 21.


Modulation of pathological phenotype of red blood cells generated ex vivo from hematopoietic stem cells in patients with sickle cell disease.

Dorn I, Mazurier C, El Nemer W, Picot J, Giarratana MC, Bernaudin F, Douay L.

J Stem Cells Regen Med. 2010 Oct 23;6(2):120-1. eCollection 2010. No abstract available.


Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study.

Garderet L, Kobari L, Mazurier C, De Witte C, Giarratana MC, Pérot C, Gorin NC, Lapillonne H, Douay L.

Haematologica. 2010 Mar;95(3):398-405. doi: 10.3324/haematol.2009.012773. Epub 2009 Oct 8.


Extensive mutational status of genes and clinical outcome in pediatric acute myeloid leukemia.

Lapillonne H, Llopis L, Auvrignon A, Renneville A, Labopin M, Mazingue F, Perot C, Lai JL, Philippe N, Ballerini P, Zurawski V, Adam M, Douay L, Leverger G, Landman-Parker J, Preudhomme C.

Leukemia. 2010 Jan;24(1):205-9. doi: 10.1038/leu.2009.172. Epub 2009 Sep 17. No abstract available.


STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma.

Coppo P, Gouilleux-Gruart V, Huang Y, Bouhlal H, Bouamar H, Bouchet S, Perrot C, Vieillard V, Dartigues P, Gaulard P, Agbalika F, Douay L, Lassoued K, Gorin NC.

Leukemia. 2009 Sep;23(9):1667-78. doi: 10.1038/leu.2009.91. Epub 2009 May 7.


[Cell culture for transfusion purposes: the case of red blood cells].

Douay L.

Transfus Clin Biol. 2009 May;16(2):134-7. doi: 10.1016/j.tracli.2009.03.010. Epub 2009 Apr 17. French.


Stem cells--a source of adult red blood cells for transfusion purposes: present and future.

Douay L, Lapillonne H, Turhan AG.

Crit Care Clin. 2009 Apr;25(2):383-98, Table of Contents. doi: 10.1016/j.ccc.2008.12.008. Review.


Ex vivo generation of human red blood cells: a new advance in stem cell engineering.

Douay L, Giarratana MC.

Methods Mol Biol. 2009;482:127-40. doi: 10.1007/978-1-59745-060-7_8.


Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.

Ballerini P, Landman-Parker J, Cayuela JM, Asnafi V, Labopin M, Gandemer V, Perel Y, Michel G, Leblanc T, Schmitt C, Fasola S, Hagemejier A, Sigaux F, Auclerc MF, Douay L, Leverger G, Baruchel A.

Haematologica. 2008 Nov;93(11):1658-65. doi: 10.3324/haematol.13291. Epub 2008 Oct 2.


High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia.

Lapillonne H, Renneville A, Auvrignon A, Flamant C, Blaise A, Perot C, Lai JL, Ballerini P, Mazingue F, Fasola S, Dehée A, Bellman F, Adam M, Labopin M, Douay L, Leverger G, Preudhomme C, Landman-Parker J.

J Clin Oncol. 2006 Apr 1;24(10):1507-15.


[In vitro generation of mature and functional human red blood cells: a model with multidisciplinary perspectives].

Douay L, Giarratana MC.

Bull Acad Natl Med. 2005 May;189(5):903-13; discussion 914-5. French.


The cultured red blood cell: a study tool with therapeutic perspectives.

Douay L, Giarratana MC.

Cell Cycle. 2005 Aug;4(8):999-1000. Epub 2005 Aug 25. No abstract available.


[Cultured red blood cells: a new step in cell engineering].

Giarratana MC, Douay L.

Med Sci (Paris). 2005 Mar;21(3):231-2. French. No abstract available.


Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells.

Giarratana MC, Kobari L, Lapillonne H, Chalmers D, Kiger L, Cynober T, Marden MC, Wajcman H, Douay L.

Nat Biotechnol. 2005 Jan;23(1):69-74. Epub 2004 Dec 26.


IgH DJ rearrangements within T-ALL correlate with cCD79a expression, an immature/TCRgammadelta phenotype and absence of IL7Ralpha/CD127 expression.

Asnafi V, Beldjord K, Garand R, Millien C, Bahloul M, LeTutour P, Douay L, Valensi F, Macintyre E.

Leukemia. 2004 Dec;18(12):1997-2001.


An efficient large-scale thawing procedure for cord blood cells destined for selection and ex vivo expansion of CD34+ cells.

Duchez P, Dazey B, Douay L, Vezon G, Ivanovic Z.

J Hematother Stem Cell Res. 2003 Oct;12(5):587-9. No abstract available.


Ex vivo expansion of autologous PB CD34+ cells provides a purging effect in children with neuroblastoma.

Kanold J, Halle P, Tchirkov A, Berger M, Giarratana MC, Kobari L, Boiret N, Paillard C, Deméocq F, Douay L.

Bone Marrow Transplant. 2003 Sep;32(5):485-8.


[From control of hematopoiesis to cellular therapy: the perspectives for transfusion].

Douay L.

Ann Biol Clin (Paris). 2003 May-Jun;61(3):259-67. Review. French.

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