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Items: 11


DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.

Douarre C, Mergui X, Sidibe A, Gomez D, Alberti P, Mailliet P, Trentesaux C, Riou JF.

Nucleic Acids Res. 2013 Apr 1;41(6):3588-99. doi: 10.1093/nar/gkt073. Epub 2013 Feb 8.


Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon CE, Zhang H, Neckers L, Pommier Y.

PLoS One. 2012;7(7):e41094. doi: 10.1371/journal.pone.0041094. Epub 2012 Jul 20.


Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.

Zoppoli G, Douarre C, Dalla Rosa I, Liu H, Reinhold W, Pommier Y.

Nucleic Acids Res. 2011 Aug;39(15):6620-32. doi: 10.1093/nar/gkr208. Epub 2011 Apr 29.


Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.

Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.

EMBO Rep. 2009 Aug;10(8):887-93. doi: 10.1038/embor.2009.97. Epub 2009 Jun 26.


Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.

Temime-Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, Giraud-Panis MJ, Londono-Vallejo A, Gilson E, Amor-Guéret M, Riou JF.

EMBO J. 2008 May 21;27(10):1513-24. doi: 10.1038/emboj.2008.74. Epub 2008 Apr 17.


Targeting telomeres and telomerase.

De Cian A, Lacroix L, Douarre C, Temime-Smaali N, Trentesaux C, Riou JF, Mergny JL.

Biochimie. 2008 Jan;90(1):131-55. Epub 2007 Jul 24. Review.


Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

Gomez D, Wenner T, Brassart B, Douarre C, O'Donohue MF, El Khoury V, Shin-Ya K, Morjani H, Trentesaux C, Riou JF.

J Biol Chem. 2006 Dec 15;281(50):38721-9. Epub 2006 Oct 17.


The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.

Gomez D, O'Donohue MF, Wenner T, Douarre C, Macadré J, Koebel P, Giraud-Panis MJ, Kaplan H, Kolkes A, Shin-ya K, Riou JF.

Cancer Res. 2006 Jul 15;66(14):6908-12.


Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence.

Douarre C, Gomez D, Morjani H, Zahm JM, O'donohue MF, Eddabra L, Mailliet P, Riou JF, Trentesaux C.

Nucleic Acids Res. 2005 Apr 14;33(7):2192-203. Print 2005.


Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase.

Gomez D, Aouali N, Renaud A, Douarre C, Shin-Ya K, Tazi J, Martinez S, Trentesaux C, Morjani H, Riou JF.

Cancer Res. 2003 Oct 1;63(19):6149-53.


Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration.

Gomez D, Aouali N, Londoño-Vallejo A, Lacroix L, Mégnin-Chanet F, Lemarteleur T, Douarre C, Shin-ya K, Mailliet P, Trentesaux C, Morjani H, Mergny JL, Riou JF.

J Biol Chem. 2003 Dec 12;278(50):50554-62. Epub 2003 Oct 2.

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