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Items: 1 to 50 of 248

1.

Deubiquitination and stabilization of Estrogen Receptor α by Ubiquitin-Specific Protease 7 promotes breast tumorigenesis.

Xia X, Liao Y, Huang C, Liu Y, He J, Shao Z, Jiang L, Dou QP, Liu J, Huang H.

Cancer Lett. 2019 Sep 10. pii: S0304-3835(19)30467-7. doi: 10.1016/j.canlet.2019.09.003. [Epub ahead of print]

PMID:
31518603
2.

An Updated Review on Disulfiram: Molecular Targets and Strategies for Cancer Treatment.

Yang Q, Yao Y, Li K, Jiao L, Zhu J, Ni C, Li M, Dou QP, Yang H.

Curr Pharm Des. 2019 Aug 16. doi: 10.2174/1381612825666190816233755. [Epub ahead of print]

PMID:
31419930
3.

Repurposing Disulfiram as An Anti-Cancer Agent: Updated Review on Literature and Patents.

Ekinci E, Rohondia S, Khan R, Dou QP.

Recent Pat Anticancer Drug Discov. 2019;14(2):113-132. doi: 10.2174/1574892814666190514104035.

PMID:
31084595
4.

Tea in Health and Disease.

Dou QP.

Nutrients. 2019 Apr 25;11(4). pii: E929. doi: 10.3390/nu11040929.

5.

Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds.

Castro I, Ekinci E, Huang X, Cheaito HA, Ahn YH, Olivero-Verbel J, Dou QP.

J Cell Biochem. 2019 Aug;120(8):14065-14075. doi: 10.1002/jcb.28682. Epub 2019 Apr 8.

PMID:
30963630
6.

Are we seeing a resurgence in the use of natural products for new drug discovery?

Li F, Wang Y, Li D, Chen Y, Dou QP.

Expert Opin Drug Discov. 2019 May;14(5):417-420. doi: 10.1080/17460441.2019.1582639. Epub 2019 Feb 27. No abstract available.

PMID:
30810395
7.

Disulfiram and BKM120 in Combination with Chemotherapy Impede Tumor Progression and Delay Tumor Recurrence in Tumor Initiating Cell-Rich TNBC.

Wu L, Meng F, Dong L, Block CJ, Mitchell AV, Wu J, Jang H, Chen W, Polin L, Yang Q, Dou QP, Wu G.

Sci Rep. 2019 Jan 18;9(1):236. doi: 10.1038/s41598-018-35619-6.

8.

A patent review of the ubiquitin ligase system: 2015-2018.

Li X, Elmira E, Rohondia S, Wang J, Liu J, Dou QP.

Expert Opin Ther Pat. 2018 Dec;28(12):919-937. doi: 10.1080/13543776.2018.1549229. Epub 2018 Nov 23. Review.

PMID:
30449221
9.

Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.

Heyza JR, Arora S, Zhang H, Conner KL, Lei W, Floyd AM, Deshmukh RR, Sarver J, Trabbic CJ, Erhardt P, Chan TH, Dou QP, Patrick SM.

Nutrients. 2018 Nov 3;10(11). pii: E1644. doi: 10.3390/nu10111644.

10.

Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition.

Patel K, Ahmed ZS, Huang X, Yang Q, Ekinci E, Neslund-Dudas CM, Mitra B, Elnady FA, Ahn YH, Yang H, Liu J, Dou QP.

Future Med Chem. 2018 Sep 1;10(17):2087-2108. doi: 10.4155/fmc-2018-0091. Epub 2018 Aug 1. Review.

11.

Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.

Ahmed ZSO, Li X, Li F, Cheaito HA, Patel K, Mosallam EM, Elbargeesy GAEH, Dou QP.

J Cell Biochem. 2018 Nov;119(11):9006-9016. doi: 10.1002/jcb.27157. Epub 2018 Jul 17.

PMID:
30015387
12.

In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer.

Gambini V, Tilio M, Maina EW, Andreani C, Bartolacci C, Wang J, Iezzi M, Ferraro S, Ramadori AT, Simon OC, Pucciarelli S, Wu G, Dou QP, Marchini C, Galassi R, Amici A.

Eur J Med Chem. 2018 Jul 15;155:418-427. doi: 10.1016/j.ejmech.2018.06.002. Epub 2018 Jun 2.

PMID:
29906688
13.

Association between cadmium and androgen receptor protein expression differs in prostate tumors of African American and European American men.

Neslund-Dudas CM, McBride RB, Kandegedara A, Rybicki BA, Kryvenko ON, Chitale D, Gupta N, Williamson SR, Rogers CG, Cordon-Cardo C, Rundle AG, Levin AM, Dou QP, Mitra B.

J Trace Elem Med Biol. 2018 Jul;48:233-238. doi: 10.1016/j.jtemb.2018.04.006. Epub 2018 Apr 13.

14.

Perspectives on the recent developments with green tea polyphenols in drug discovery.

Li F, Wang Y, Li D, Chen Y, Qiao X, Fardous R, Lewandowski A, Liu J, Chan TH, Dou QP.

Expert Opin Drug Discov. 2018 Jul;13(7):643-660. doi: 10.1080/17460441.2018.1465923. Epub 2018 Apr 24. Review.

15.

Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.

Liao Y, Xia X, Liu N, Cai J, Guo Z, Li Y, Jiang L, Dou QP, Tang D, Huang H, Liu J.

Oncogene. 2018 Apr;37(14):1896-1910. doi: 10.1038/s41388-017-0069-z. Epub 2018 Jan 22.

16.

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Skrott Z, Mistrik M, Andersen KK, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Dzubak P, Vrobel I, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou QP, Olsen J, Hajduch M, Cvek B, Deshaies RJ, Bartek J.

Nature. 2017 Dec 14;552(7684):194-199. doi: 10.1038/nature25016. Epub 2017 Dec 6.

17.

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity.

Viola-Rhenals M, Patel KR, Jaimes-Santamaria L, Wu G, Liu J, Dou QP.

Curr Med Chem. 2018 Feb 12;25(4):506-524. doi: 10.2174/0929867324666171023161121. Review.

PMID:
29065820
18.

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing.

Soave CL, Guerin T, Liu J, Dou QP.

Cancer Metastasis Rev. 2017 Dec;36(4):717-736. doi: 10.1007/s10555-017-9705-x.

19.

Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.

Chen X, Yang Q, Xiao L, Tang D, Dou QP, Liu J.

Cancer Metastasis Rev. 2017 Dec;36(4):655-668. doi: 10.1007/s10555-017-9701-1. Review.

20.

Preface.

Dou QP.

Cancer Metastasis Rev. 2017 Dec;36(4):559-560. doi: 10.1007/s10555-017-9706-9. No abstract available.

PMID:
29039080
21.

Pharmacological Inhibitors of NAD Biosynthesis as Potential An ticancer Agents.

Lucas S, Soave C, Nabil G, Ahmed ZSO, Chen G, El-Banna HA, Dou QP, Wang J.

Recent Pat Anticancer Drug Discov. 2017;12(3):190-207. doi: 10.2174/1574892812666170619125503. Review.

PMID:
28637419
22.

Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest.

Peng T, Dou QP.

J Cell Biochem. 2017 Sep;118(9):2722-2730. doi: 10.1002/jcb.25921. Epub 2017 Apr 25.

PMID:
28165150
23.

Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.

Zhao C, Chen X, Yang C, Zang D, Lan X, Liao S, Zhang P, Wu J, Li X, Liu N, Liao Y, Huang H, Shi X, Jiang L, Liu X, Dou QP, Wang X, Liu J.

Oncotarget. 2017 Feb 21;8(8):13942-13956. doi: 10.18632/oncotarget.14572.

24.

Discovery of Natural Proteasome Inhibitors as Novel Anticancer Therapeutics: Current Status and Perspectives.

Wang H, Yang Q, Dou QP, Yang H.

Curr Protein Pept Sci. 2018 Feb 13;19(4):358-367. doi: 10.2174/1389203718666170111121856. Review.

PMID:
28079010
25.

The preclinical discovery and development of bortezomib for the treatment of mantle cell lymphoma.

Arkwright R, Pham TM, Zonder JA, Dou QP.

Expert Opin Drug Discov. 2017 Feb;12(2):225-235. doi: 10.1080/17460441.2017.1268596. Epub 2016 Dec 20. Review.

26.

P-Glycoprotein Inhibition Sensitizes Human Breast Cancer Cells to Proteasome Inhibitors.

Deshmukh RR, Kim S, Elghoul Y, Dou QP.

J Cell Biochem. 2017 May;118(5):1239-1248. doi: 10.1002/jcb.25783. Epub 2017 Jan 10.

PMID:
27813130
27.

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy.

Zhao C, Chen X, Zang D, Lan X, Liao S, Yang C, Zhang P, Wu J, Li X, Liu N, Liao Y, Huang H, Shi X, Jiang L, Liu X, He Z, Dou QP, Wang X, Liu J.

Oncogene. 2016 Nov 10;35(45):5916-5927. doi: 10.1038/onc.2016.114. Epub 2016 Apr 18.

28.

Biological and Mechanistic Characterization of Novel Prodrugs of Green Tea Polyphenol Epigallocatechin Gallate Analogs in Human Leiomyoma Cell Lines.

Ahmed RS, Liu G, Renzetti A, Farshi P, Yang H, Soave C, Saed G, El-Ghoneimy AA, El-Banna HA, Foldes R, Chan TH, Dou QP.

J Cell Biochem. 2016 Oct;117(10):2357-69. doi: 10.1002/jcb.25533. Epub 2016 Mar 28.

PMID:
26950525
29.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

30.

Proteasome inhibitors induce AMPK activation via CaMKKβ in human breast cancer cells.

Deshmukh RR, Dou QP.

Breast Cancer Res Treat. 2015 Aug;153(1):79-88. doi: 10.1007/s10549-015-3512-2. Epub 2015 Jul 31.

PMID:
26227473
31.

Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3.

Sun S, Liu J, Zhou N, Zhu W, Dou QP, Zhou K.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4382-5. doi: 10.1016/j.bmcl.2015.06.038. Epub 2015 Jun 25.

PMID:
27499453
32.

Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds.

Liu N, Huang H, Dou QP, Liu J.

Oncoscience. 2015 May 31;2(5):457-66. eCollection 2015. Review.

33.

Involvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal α2 Subunits.

Schmitt SM, Neslund-Dudas C, Shen M, Cui C, Mitra B, Dou QP.

J Cell Biochem. 2016 Jan;117(1):144-51. doi: 10.1002/jcb.25259.

34.

Deubiquitinases (DUBs) and DUB inhibitors: a patent review.

Farshi P, Deshmukh RR, Nwankwo JO, Arkwright RT, Cvek B, Liu J, Dou QP.

Expert Opin Ther Pat. 2015;25(10):1191-1208. doi: 10.1517/13543776.2015.1056737. Epub 2015 Jun 16. Review.

35.

Broad targeting of resistance to apoptosis in cancer.

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.

Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103. doi: 10.1016/j.semcancer.2015.03.001. Epub 2015 Apr 28. Review.

36.

Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics.

Arkwright RT, Deshmukh R, Adapa N, Stevens R, Zonder E, Zhang Z, Farshi P, Ahmed RS, El-Banna HA, Chan TH, Dou QP.

Anticancer Agents Med Chem. 2015;15(5):657-71. Review.

37.

L-Ornithine Schiff base-copper and -cadmium complexes as new proteasome inhibitors and apoptosis inducers in human cancer cells.

Zhang Z, Bi C, Fan Y, Zhang N, Deshmukh R, Yan X, Lv X, Zhang P, Zhang X, Dou QP.

J Biol Inorg Chem. 2015 Jan;20(1):109-21. doi: 10.1007/s00775-014-1219-1. Epub 2014 Dec 3.

PMID:
25467055
38.

Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.

Lu L, Shi W, Deshmukh RR, Long J, Cheng X, Ji W, Zeng G, Chen X, Zhang Y, Dou QP.

PLoS One. 2014 Nov 24;9(11):e113783. doi: 10.1371/journal.pone.0113783. eCollection 2014.

39.

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms.

Chen X, Shi X, Zhao C, Li X, Lan X, Liu S, Huang H, Liu N, Liao S, Zang D, Song W, Liu Q, Carter BZ, Dou QP, Wang X, Liu J.

Oncotarget. 2014 Oct 15;5(19):9118-32.

41.

Recent advances in proteasome inhibitor-based cancer therapies.

Dou QP.

Curr Cancer Drug Targets. 2014;14(6):505. No abstract available.

PMID:
25092106
42.

Metal-based 2,3-indolinedione derivatives as proteasome inhibitors and inducers of apoptosis in human cancer cells.

Zhang P, Bi C, Schmitt SM, Li X, Fan Y, Zhang N, Dou QP.

Int J Mol Med. 2014 Sep;34(3):870-9. doi: 10.3892/ijmm.2014.1838. Epub 2014 Jul 8.

43.

An analysis of the safety profile of proteasome inhibitors for treating various cancers.

Wang H, Guan F, Chen D, Dou QP, Yang H.

Expert Opin Drug Saf. 2014 Aug;13(8):1043-54. doi: 10.1517/14740338.2014.939953. Epub 2014 Jul 9. Review.

PMID:
25005844
44.

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.

Liu N, Liu C, Li X, Liao S, Song W, Yang C, Zhao C, Huang H, Guan L, Zhang P, Liu S, Hua X, Chen X, Zhou P, Lan X, Yi S, Wang S, Wang X, Dou QP, Liu J.

Sci Rep. 2014 Jun 10;4:5240. doi: 10.1038/srep05240.

45.

Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.

Huang H, Hua X, Liu N, Li X, Liu S, Chen X, Zhao C, Lan X, Yang C, Dou QP, Liu J.

Toxicol Lett. 2014 Aug 4;228(3):170-8. doi: 10.1016/j.toxlet.2014.05.012. Epub 2014 May 20.

PMID:
24853302
46.

Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men.

Neslund-Dudas C, Levin AM, Beebe-Dimmer JL, Bock CH, Nock NL, Rundle A, Jankowski M, Krajenta R, Dou QP, Mitra B, Tang D, Rebbeck TR, Rybicki BA.

Cancer Causes Control. 2014 Jul;25(7):869-79. doi: 10.1007/s10552-014-0387-1. Epub 2014 May 7.

47.

Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis.

Cheriyan VT, Wang Y, Muthu M, Jamal S, Chen D, Yang H, Polin LA, Tarca AL, Pass HI, Dou QP, Sharma S, Wali A, Rishi AK.

PLoS One. 2014 Apr 1;9(4):e93711. doi: 10.1371/journal.pone.0093711. eCollection 2014.

48.

Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer.

Neslund-Dudas C, Levin AM, Rundle A, Beebe-Dimmer J, Bock CH, Nock NL, Jankowski M, Datta I, Krajenta R, Dou QP, Mitra B, Tang D, Rybicki BA.

Prostate. 2014 May;74(6):637-46. doi: 10.1002/pros.22781. Epub 2014 Feb 5.

49.

Inhibition of the 26S proteasome as a possible mechanism for toxicity of heavy metal species.

Tomco D, Schmitt S, Heeg MJ, Dou QP, Verani CN.

J Inorg Biochem. 2014 Mar;132:96-103. doi: 10.1016/j.jinorgbio.2013.12.012. Epub 2014 Jan 8.

PMID:
24452142
50.

Proteasome inhibitor patents (2010 - present).

Metcalf R, Scott LM, Daniel KG, Dou QP.

Expert Opin Ther Pat. 2014 Apr;24(4):369-82. doi: 10.1517/13543776.2014.877444. Epub 2014 Jan 23. Review.

PMID:
24450483

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