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Gender Medicine and Oncology: Report and consensus of an ESMO Workshop.

Wagner AD, Oertelt-Prigione S, Adjei A, Buclin T, Cristina V, Csajka C, Coukos G, Dafni U, Dotto GP, Ducreux M, Fellay J, Haanen J, Hocquelet A, Klinge I, Lemmens V, Letsch A, Mauer M, Moehler M, Peters S, Özdemir BC.

Ann Oncol. 2019 Oct 15. pii: mdz414. doi: 10.1093/annonc/mdz414. [Epub ahead of print]


Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant.

Bordignon P, Bottoni G, Xu X, Popescu AS, Truan Z, Guenova E, Kofler L, Jafari P, Ostano P, Röcken M, Neel V, Dotto GP.

Cell Rep. 2019 Aug 27;28(9):2358-2372.e6. doi: 10.1016/j.celrep.2019.07.092.


Retraction Notice to: RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress.

Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW.

Curr Biol. 2019 Jun 17;29(12):2107. doi: 10.1016/j.cub.2019.05.065. No abstract available.


Gender and sex-time to bridge the gap.

Dotto GP.

EMBO Mol Med. 2019 May;11(5). pii: e10668. doi: 10.15252/emmm.201910668. No abstract available.


Sex Hormones and Anticancer Immunity.

Özdemir BC, Dotto GP.

Clin Cancer Res. 2019 Aug 1;25(15):4603-4610. doi: 10.1158/1078-0432.CCR-19-0137. Epub 2019 Mar 19. Review.


A role for stromal autophagy in cancer-associated fibroblast activation.

Goruppi S, Clocchiatti A, Dotto GP.

Autophagy. 2019 Apr;15(4):738-739. doi: 10.1080/15548627.2019.1569936. Epub 2019 Jan 22.


Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation.

Clocchiatti A, Ghosh S, Procopio MG, Mazzeo L, Bordignon P, Ostano P, Goruppi S, Bottoni G, Katarkar A, Levesque M, Kölblinger P, Dummer R, Neel V, Özdemir BC, Dotto GP.

J Clin Invest. 2018 Dec 3;128(12):5531-5548. doi: 10.1172/JCI99159. Epub 2018 Nov 5.


Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism.

Goruppi S, Jo SH, Laszlo C, Clocchiatti A, Neel V, Dotto GP.

Cell Rep. 2018 Sep 18;24(12):3108-3114.e4. doi: 10.1016/j.celrep.2018.08.043.


Sex Differences in Efficacy and Toxicity of Systemic Treatments: An Undervalued Issue in the Era of Precision Oncology.

Özdemir BC, Csajka C, Dotto GP, Wagner AD.

J Clin Oncol. 2018 Sep 10;36(26):2680-2683. doi: 10.1200/JCO.2018.78.3290. Epub 2018 Jul 13. No abstract available.


Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.

Al Labban D, Jo SH, Ostano P, Saglietti C, Bongiovanni M, Panizzon R, Dotto GP.

J Clin Invest. 2018 Jun 1;128(6):2581-2599. doi: 10.1172/JCI96915. Epub 2018 May 14.


miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS.

Neu J, Dziunycz PJ, Dzung A, Lefort K, Falke M, Denzler R, Freiberger SN, Iotzova-Weiss G, Kuzmanov A, Levesque MP, Dotto GP, Hofbauer GFL.

PLoS One. 2017 Sep 20;12(9):e0185028. doi: 10.1371/journal.pone.0185028. eCollection 2017.


The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI.

Goruppi S, Procopio MG, Jo S, Clocchiatti A, Neel V, Dotto GP.

Cell Rep. 2017 Sep 5;20(10):2468-2479. doi: 10.1016/j.celrep.2017.08.048.


Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?

Özdemir BC, Dotto GP.

Trends Cancer. 2017 Mar;3(3):181-197. doi: 10.1016/j.trecan.2017.02.002. Epub 2017 Mar 6. Review.


Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.

Kim DE, Procopio MG, Ghosh S, Jo SH, Goruppi S, Magliozzi F, Bordignon P, Neel V, Angelino P, Dotto GP.

J Exp Med. 2017 Aug 7;214(8):2349-2368. doi: 10.1084/jem.20170724. Epub 2017 Jul 6.


CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma.

Dziunycz PJ, Neu J, Lefort K, Djerbi N, Freiberger SN, Iotzova-Weiss G, French LE, Dotto GP, Hofbauer GF.

PLoS One. 2017 Apr 14;12(4):e0173000. doi: 10.1371/journal.pone.0173000. eCollection 2017.


RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress.

Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW.

Curr Biol. 2016 Aug 22;26(16):2221-2222. doi: 10.1016/j.cub.2016.07.072. No abstract available.


PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation.

Jo SH, Kim DE, Clocchiatti A, Dotto GP.

Oncotarget. 2016 Sep 13;7(37):58717-58727. doi: 10.18632/oncotarget.11227.


Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer.

Lefort K, Ostano P, Mello-Grand M, Calpini V, Scatolini M, Farsetti A, Dotto GP, Chiorino G.

Oncotarget. 2016 Jul 26;7(30):48011-48026. doi: 10.18632/oncotarget.10333.


Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

Dotto GP, Rustgi AK.

Cancer Cell. 2016 May 9;29(5):622-637. doi: 10.1016/j.ccell.2016.04.004. Review.


Negative control of CSL gene transcription by stress/DNA damage response and p53.

Menietti E, Xu X, Ostano P, Joseph JM, Lefort K, Dotto GP.

Cell Cycle. 2016 Jul 2;15(13):1767-78. doi: 10.1080/15384101.2016.1186317. Epub 2016 May 10.


Sexual dimorphism in cancer.

Clocchiatti A, Cora E, Zhang Y, Dotto GP.

Nat Rev Cancer. 2016 May;16(5):330-9. doi: 10.1038/nrc.2016.30. Epub 2016 Apr 15. Review.


CSL-p53: From senescence to CAF activation.

Procopio MG, Laszlo C, Dotto GP.

Cell Cycle. 2016;15(4):485-6. doi: 10.1080/15384101.2015.1130091. Epub 2016 Jan 6. No abstract available.


Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3242. No abstract available.


Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Sep;17(9):1193-204. doi: 10.1038/ncb3228. Epub 2015 Aug 24. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370.


A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes.

Kurinna S, Schäfer M, Ostano P, Karouzakis E, Chiorino G, Bloch W, Bachmann A, Gay S, Garrod D, Lefort K, Dotto GP, Beer HD, Werner S.

Nat Commun. 2014 Oct 6;5:5099. doi: 10.1038/ncomms6099.


Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer.

Brooks YS, Ostano P, Jo SH, Dai J, Getsios S, Dziunycz P, Hofbauer GF, Cerveny K, Chiorino G, Lefort K, Dotto GP.

J Clin Invest. 2014 May;124(5):2260-76. doi: 10.1172/JCI72718. Epub 2014 Apr 17.


Multifocal epithelial tumors and field cancerization: stroma as a primary determinant.

Dotto GP.

J Clin Invest. 2014 Apr;124(4):1446-53. doi: 10.1172/JCI72589. Epub 2014 Apr 1. Review.


miR-34a/SIRT6 in squamous differentiation and cancer.

Dotto GP, Karine L.

Cell Cycle. 2014;13(7):1055-6. doi: 10.4161/cc.28378. Epub 2014 Feb 28. No abstract available.


Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.

Zhu Z, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A.

Cancer Res. 2014 Apr 1;74(7):2082-93. doi: 10.1158/0008-5472.CAN-12-0452. Epub 2014 Feb 13.


The oncogene ATF3 is potentiated by cyclosporine A and ultraviolet light A.

Dziunycz PJ, Lefort K, Wu X, Freiberger SN, Neu J, Djerbi N, Iotzowa-Weiss G, French LE, Dotto GP, Hofbauer GFL.

J Invest Dermatol. 2014 Jul;134(7):1998-2004. doi: 10.1038/jid.2014.77. Epub 2014 Feb 7.


Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.

Goruppi S, Dotto GP.

Trends Cell Biol. 2013 Dec;23(12):593-602. doi: 10.1016/j.tcb.2013.08.006. Epub 2013 Sep 25. Review.


The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1.

Dai J, Brooks Y, Lefort K, Getsios S, Dotto GP.

PLoS One. 2013 Jul 29;8(7):e70392. doi: 10.1371/journal.pone.0070392. Print 2013.


A miR-34a-SIRT6 axis in the squamous cell differentiation network.

Lefort K, Brooks Y, Ostano P, Cario-André M, Calpini V, Guinea-Viniegra J, Albinger-Hegyi A, Hoetzenecker W, Kolfschoten I, Wagner EF, Werner S, Dotto GP.

EMBO J. 2013 Aug 14;32(16):2248-63. doi: 10.1038/emboj.2013.156. Epub 2013 Jul 16.


Gene profiling analysis of the early effects of ablative fractional carbon dioxide laser treatment on human skin.

Kim JE, Won CH, Bak H, Kositratna G, Manstein D, Dotto GP, Chang SE.

Dermatol Surg. 2013 Jul;39(7):1033-43. doi: 10.1111/dsu.12170. Epub 2013 Mar 14.


Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.

Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP.

Cell. 2012 Jun 8;149(6):1207-20. doi: 10.1016/j.cell.2012.03.048.


p21 as a transcriptional co-repressor of S-phase and mitotic control genes.

Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J.

PLoS One. 2012;7(5):e37759. doi: 10.1371/journal.pone.0037759. Epub 2012 May 25.


p63 and FGFR: when development meets proliferation.

Dotto GP.

EMBO Mol Med. 2012 Mar;4(3):165-7. doi: 10.1002/emmm.201200202. Epub 2012 Feb 13. No abstract available.


IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.

Restivo G, Nguyen BC, Dziunycz P, Ristorcelli E, Ryan RJ, Özuysal ÖY, Di Piazza M, Radtke F, Dixon MJ, Hofbauer GF, Lefort K, Dotto GP.

EMBO J. 2011 Nov 16;30(22):4571-85. doi: 10.1038/emboj.2011.325.


p63 and epithelial metaplasia: a gutsy choice.

Lefort K, Dotto GP.

Cell. 2011 Jun 24;145(7):1003-5. doi: 10.1016/j.cell.2011.06.008.


Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis.

Dotto GP.

Cancer Res. 2011 Mar 15;71(6):2029-33. doi: 10.1158/0008-5472.CAN-10-3750. Review.


Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.

Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP.

Genes Dev. 2010 Jul 15;24(14):1519-32. doi: 10.1101/gad.1886910.


The p63 target HBP1 is required for skin differentiation and stratification.

Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R.

Cell Death Differ. 2010 Dec;17(12):1896-907. doi: 10.1038/cdd.2010.59. Epub 2010 Jun 4.


Opposing roles for calcineurin and ATF3 in squamous skin cancer.

Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, Hofbauer GF, Dotto GP.

Nature. 2010 May 20;465(7296):368-72. doi: 10.1038/nature08996.


Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes.

Lambertini C, Pantano S, Dotto GP.

PLoS One. 2010 Apr 28;5(4):e10369. doi: 10.1371/journal.pone.0010369.


Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

Thomason HA, Zhou H, Kouwenhoven EN, Dotto GP, Restivo G, Nguyen BC, Little H, Dixon MJ, van Bokhoven H, Dixon J.

J Clin Invest. 2010 May;120(5):1561-9. doi: 10.1172/JCI40266. Epub 2010 Apr 26.


An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells.

Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, Choi I, Otu HH, Shin JW, Dotto GP, Koh CJ, Detmar M, Hong YK.

Blood. 2010 Jul 8;116(1):140-50. doi: 10.1182/blood-2009-11-252270. Epub 2010 Mar 29.


Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.

Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB.

J Clin Invest. 2010 Feb;120(2):446-56. doi: 10.1172/JCI36478. Epub 2010 Jan 11.


A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Ostano P, Dummer R, Brissette JL, Dotto GP.

J Clin Invest. 2009 Oct;119(10):3127-37. doi: 10.1172/JCI38543. Erratum in: J Clin Invest. 2010 Feb;120(2):6455. Pazin, Mike [corrected to Pazin, Michael J].


Crosstalk of Notch with p53 and p63 in cancer growth control.

Dotto GP.

Nat Rev Cancer. 2009 Aug;9(8):587-95. doi: 10.1038/nrc2675. Epub 2009 Jul 16. Review.


Impact of normalization on miRNA microarray expression profiling.

Pradervand S, Weber J, Thomas J, Bueno M, Wirapati P, Lefort K, Dotto GP, Harshman K.

RNA. 2009 Mar;15(3):493-501. doi: 10.1261/rna.1295509. Epub 2009 Jan 28.

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