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Age-associated cholesterol reduction triggers brain insulin resistance by facilitating ligand-independent receptor activation and pathway desensitization.

Martín-Segura A, Ahmed T, Casadomé-Perales Á, Palomares-Perez I, Palomer E, Kerstens A, Munck S, Balschun D, Dotti CG.

Aging Cell. 2019 Jun;18(3):e12932. doi: 10.1111/acel.12932. Epub 2019 Mar 18.


Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice.

Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B.

J Alzheimers Dis. 2018;66(2):801-809. doi: 10.3233/JAD-180410.


High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG.

Neurobiol Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001. Epub 2018 Feb 7.


Could blocking the formation of amyloid channels rescue Alzheimer's phenotype?

Guix FX, Dotti CG.

EMBO Mol Med. 2018 Jan;10(1):7-9. doi: 10.15252/emmm.201708491. No abstract available.


E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion.

Benvegnù S, Wahle T, Dotti CG.

Oncotarget. 2017 Aug 10;8(52):89439-89450. doi: 10.18632/oncotarget.20143. eCollection 2017 Oct 27.


Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Oct 24;12(10):e0187179. doi: 10.1371/journal.pone.0187179. eCollection 2017.


Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Jul 7;12(7):e0178016. doi: 10.1371/journal.pone.0178016. eCollection 2017.


Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.

Benvegnù S, Mateo MI, Palomer E, Jurado-Arjona J, Dotti CG.

Mol Cell. 2017 May 4;66(3):358-372.e7. doi: 10.1016/j.molcel.2017.04.005.


Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production.

Colié S, Sarroca S, Palenzuela R, Garcia I, Matheu A, Corpas R, Dotti CG, Esteban JA, Sanfeliu C, Nebreda AR.

Sci Rep. 2017 Mar 31;7:45306. doi: 10.1038/srep45306.


Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG.

PLoS One. 2017 Feb 16;12(2):e0171968. doi: 10.1371/journal.pone.0171968. eCollection 2017. Erratum in: PLoS One. 2017 Jul 7;12 (7):e0178016. PLoS One. 2017 Oct 24;12 (10 ):e0187179.


Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons.

Palomer E, Martín-Segura A, Baliyan S, Ahmed T, Balschun D, Venero C, Martin MG, Dotti CG.

Cell Rep. 2016 Sep 13;16(11):2889-2900. doi: 10.1016/j.celrep.2016.08.028.


Genes Related to Fatty Acid β-Oxidation Play a Role in the Functional Decline of the Drosophila Brain with Age.

Laranjeira A, Schulz J, Dotti CG.

PLoS One. 2016 Aug 12;11(8):e0161143. doi: 10.1371/journal.pone.0161143. eCollection 2016.


Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons.

Ungureanu AA, Benilova I, Krylychkina O, Braeken D, De Strooper B, Van Haesendonck C, Dotti CG, Bartic C.

Sci Rep. 2016 May 13;6:25841. doi: 10.1038/srep25841.


Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.

Palomer E, Carretero J, Benvegnù S, Dotti CG, Martin MG.

Nat Commun. 2016 Mar 24;7:11081. doi: 10.1038/ncomms11081.


PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA.

Nat Neurosci. 2016 Mar;19(3):443-53. doi: 10.1038/nn.4225. Epub 2016 Jan 18.


Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.

Hernández-Jiménez M, Martínez-López D, Gabandé-Rodríguez E, Martín-Segura A, Lizasoain I, Ledesma MD, Dotti CG, Moro MA.

Stroke. 2016 Jan;47(1):206-13. doi: 10.1161/STROKEAHA.115.010810. Epub 2015 Dec 1.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery.

Brachet A, Norwood S, Brouwers JF, Palomer E, Helms JB, Dotti CG, Esteban JA.

J Cell Biol. 2015 Mar 16;208(6):791-806. doi: 10.1083/jcb.201407122. Epub 2015 Mar 9.


Glial β-oxidation regulates Drosophila energy metabolism.

Schulz JG, Laranjeira A, Van Huffel L, Gärtner A, Vilain S, Bastianen J, Van Veldhoven PP, Dotti CG.

Sci Rep. 2015 Jan 15;5:7805. doi: 10.1038/srep07805.


Cadherins as regulators of neuronal polarity.

Gärtner A, Fornasiero EF, Dotti CG.

Cell Adh Migr. 2015;9(3):175-82. doi: 10.4161/19336918.2014.983808. Epub 2014 Nov 14. Review.


FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.

La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C.

Nat Neurosci. 2014 Dec;17(12):1693-700. doi: 10.1038/nn.3870. Epub 2014 Nov 17.


Improvement of biochemical and behavioral defects in the Niemann-Pick type A mouse by intraventricular infusion of MARCKS.

Trovò L, Stroobants S, D'Hooge R, Ledesma MD, Dotti CG.

Neurobiol Dis. 2015 Jan;73:319-26. doi: 10.1016/j.nbd.2014.09.008. Epub 2014 Sep 22.


Cholesterol in brain disease: sometimes determinant and frequently implicated.

Martín MG, Pfrieger F, Dotti CG.

EMBO Rep. 2014 Oct;15(10):1036-52. doi: 10.15252/embr.201439225. Epub 2014 Sep 15. Review.


Lipid dynamics at dendritic spines.

Dotti CG, Esteban JA, Ledesma MD.

Front Neuroanat. 2014 Aug 8;8:76. doi: 10.3389/fnana.2014.00076. eCollection 2014. Review.


Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons.

Gärtner A, Fornasiero EF, Valtorta F, Dotti CG.

J Cell Sci. 2014 Oct 15;127(Pt 20):4409-19. doi: 10.1242/jcs.149815. Epub 2014 Aug 15.


Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents.

Martin MG, Ahmed T, Korovaichuk A, Venero C, Menchón SA, Salas I, Munck S, Herreras O, Balschun D, Dotti CG.

EMBO Mol Med. 2014 Jul;6(7):902-17. doi: 10.15252/emmm.201303711.


The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways.

Berto GE, Iobbi C, Camera P, Scarpa E, Iampietro C, Bianchi F, Gai M, Sgrò F, Cristofani F, Gärtner A, Dotti CG, Di Cunto F.

PLoS One. 2014 Apr 2;9(4):e93721. doi: 10.1371/journal.pone.0093721. eCollection 2014.


Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.

Kappagantula S, Andrews MR, Cheah M, Abad-Rodriguez J, Dotti CG, Fawcett JW.

J Neurosci. 2014 Feb 12;34(7):2477-92. doi: 10.1523/JNEUROSCI.4432-13.2014.


High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.

Gabandé-Rodríguez E, Boya P, Labrador V, Dotti CG, Ledesma MD.

Cell Death Differ. 2014 Jun;21(6):864-75. doi: 10.1038/cdd.2014.4. Epub 2014 Jan 31.


Prion protein accumulation in lipid rafts of mouse aging brain.

Agostini F, Dotti CG, Pérez-Cañamás A, Ledesma MD, Benetti F, Legname G.

PLoS One. 2013 Sep 10;8(9):e74244. doi: 10.1371/journal.pone.0074244. eCollection 2013.


Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B.

Iannilli F, Zalfa F, Gartner A, Bagni C, Dotti CG.

PLoS One. 2013 Jun 18;8(6):e66602. doi: 10.1371/journal.pone.0066602. Print 2013.


Substrate topography determines neuronal polarization and growth in vitro.

Micholt L, Gärtner A, Prodanov D, Braeken D, Dotti CG, Bartic C.

PLoS One. 2013 Jun 13;8(6):e66170. doi: 10.1371/journal.pone.0066170. Print 2013.


Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG.

Nat Neurosci. 2013 Apr;16(4):449-55. doi: 10.1038/nn.3342. Epub 2013 Feb 24.


APLP2 regulates neuronal stem cell differentiation during cortical development.

Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B, Gärtner A.

J Cell Sci. 2013 Mar 1;126(Pt 5):1268-77. doi: 10.1242/jcs.122440. Epub 2013 Jan 23.


Neuronal polarity: demarcation, growth and commitment.

Cáceres A, Ye B, Dotti CG.

Curr Opin Cell Biol. 2012 Aug;24(4):547-53. doi: 10.1016/ Epub 2012 Jun 20. Review.


N-cadherin: a new player in neuronal polarity.

Gärtner A, Fornasiero EF, Dotti CG.

Cell Cycle. 2012 Jun 15;11(12):2223-4. doi: 10.4161/cc.20797. Epub 2012 Jun 15. No abstract available.


Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons.

Totaro A, Tavano S, Filosa G, Gärtner A, Pennucci R, Santambrogio P, Bachi A, Dotti CG, de Curtis I.

Biol Cell. 2012 Sep;104(9):533-52. doi: 10.1111/boc.201100060. Epub 2012 Jun 22.


Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B.

EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2.


N-cadherin specifies first asymmetry in developing neurons.

Gärtner A, Fornasiero EF, Munck S, Vennekens K, Seuntjens E, Huttner WB, Valtorta F, Dotti CG.

EMBO J. 2012 Apr 18;31(8):1893-903. doi: 10.1038/emboj.2012.41. Epub 2012 Feb 21.


APM_GUI: analyzing particle movement on the cell membrane and determining confinement.

Menchón SA, Martín MG, Dotti CG.

BMC Biophys. 2012 Feb 20;5:4. doi: 10.1186/2046-1682-5-4.


Cholesterol loss during glutamate-mediated excitotoxicity.

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG.

EMBO J. 2012 Apr 4;31(7):1764-73. doi: 10.1038/emboj.2012.31. Epub 2012 Feb 17.


Peripheral cholesterol, metabolic disorders and Alzheimer's disease.

Ledesma MD, Dotti CG.

Front Biosci (Elite Ed). 2012 Jan 1;4:181-94. Review.


Lipid changes in the aged brain: effect on synaptic function and neuronal survival.

Ledesma MD, Martin MG, Dotti CG.

Prog Lipid Res. 2012 Jan;51(1):23-35. doi: 10.1016/j.plipres.2011.11.004. Epub 2011 Nov 28. Review.


Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T.

J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.


Cytokinesis remnants define first neuronal asymmetry in vivo.

Pollarolo G, Schulz JG, Munck S, Dotti CG.

Nat Neurosci. 2011 Nov 13;14(12):1525-33. doi: 10.1038/nn.2976.


Alterations in phosphatidylethanolamine levels affect the generation of Aβ.

Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T.

Aging Cell. 2012 Feb;11(1):63-72. doi: 10.1111/j.1474-9726.2011.00760.x. Epub 2011 Nov 28.


Neuronal (bi)polarity as a self-organized process enhanced by growing membrane.

Menchón SA, Gärtner A, Román P, Dotti CG.

PLoS One. 2011;6(9):e24190. doi: 10.1371/journal.pone.0024190. Epub 2011 Sep 14.


The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides.

Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, LaFerla FM, Taraglio S, Dotti CG, Di Cunto F.

PLoS One. 2011;6(7):e22370. doi: 10.1371/journal.pone.0022370. Epub 2011 Jul 28.


Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis.

Trovò L, Van Veldhoven PP, Martín MG, Dotti CG.

J Cell Sci. 2011 Apr 15;124(Pt 8):1308-15. doi: 10.1242/jcs.078766.


Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.

Sodero AO, Trovò L, Iannilli F, Van Veldhoven P, Dotti CG, Martin MG.

J Neurochem. 2011 Mar;116(5):747-55. doi: 10.1111/j.1471-4159.2010.07079.x. Epub 2011 Jan 7. Review.

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