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Items: 50

1.

An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric and autoinhibited and provides a model for activation.

Moon TM, Sheehe JL, Nukareddy P, Nausch LW, Wohlfahrt J, Matthews DE, Blumenthal DK, Dostmann WR.

J Biol Chem. 2018 May 25;293(21):7916-7929. doi: 10.1074/jbc.RA117.000647. Epub 2018 Mar 30.

PMID:
29602907
2.

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Moon TM, Tykocki NR, Sheehe JL, Osborne BW, Tegge W, Brayden JE, Dostmann WR.

Chem Biol. 2015 Dec 17;22(12):1653-61. doi: 10.1016/j.chembiol.2015.11.005.

3.

Altered cGMP dynamics at the plasma membrane contribute to diarrhea in ulcerative colitis.

Arora K, Sinha C, Zhang W, Moon CS, Ren A, Yarlagadda S, Dostmann WR, Adebiyi A, Haberman Y, Denson LA, Wang X, Naren AP.

Am J Pathol. 2015 Oct;185(10):2790-804. doi: 10.1016/j.ajpath.2015.06.007. Epub 2015 Aug 8.

4.

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA.

Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.

5.

Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells.

Held KF, Dostmann WR.

Methods Mol Biol. 2013;1020:131-45. doi: 10.1007/978-1-62703-459-3_8.

6.

The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase.

Moon TM, Osborne BW, Dostmann WR.

Biochim Biophys Acta. 2013 Jul;1834(7):1346-51. doi: 10.1016/j.bbapap.2013.02.009. Epub 2013 Feb 13. Review.

7.

Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle.

Held KF, Dostmann WR.

Front Pharmacol. 2012 Jul 12;3:130. doi: 10.3389/fphar.2012.00130. eCollection 2012.

8.

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C.

Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20.

9.

Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.

Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL Jr, Kornev AP, Taylor SS, Dostmann WR.

Structure. 2011 Sep 7;19(9):1317-27. doi: 10.1016/j.str.2011.06.012.

10.

Direct modulation of the protein kinase A catalytic subunit α by growth factor receptor tyrosine kinases.

Caldwell GB, Howe AK, Nickl CK, Dostmann WR, Ballif BA, Deming PB.

J Cell Biochem. 2012 Jan;113(1):39-48. doi: 10.1002/jcb.23325.

11.

Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors.

Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, Vernon J, Garthwaite J.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22060-5. doi: 10.1073/pnas.1013147107. Epub 2010 Dec 6.

12.

Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha).

Lavogina D, Nickl CK, Enkvist E, Raidaru G, Lust M, Vaasa A, Uri A, Dostmann WR.

Biochim Biophys Acta. 2010 Sep;1804(9):1857-68. doi: 10.1016/j.bbapap.2010.04.007. Epub 2010 Apr 18.

13.

(D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha.

Nickl CK, Raidas SK, Zhao H, Sausbier M, Ruth P, Tegge W, Brayden JE, Dostmann WR.

Biochim Biophys Acta. 2010 Mar;1804(3):524-32. doi: 10.1016/j.bbapap.2009.12.004. Epub 2009 Dec 16.

14.

cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake.

Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD.

Mol Brain. 2009 Aug 5;2:26. doi: 10.1186/1756-6606-2-26.

15.

Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.

Pinkse MW, Rijkers DT, Dostmann WR, Heck AJ.

J Biol Chem. 2009 Jun 12;284(24):16354-68. doi: 10.1074/jbc.M808521200. Epub 2009 Apr 15.

16.

Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors.

Nausch LW, Ledoux J, Bonev AD, Nelson MT, Dostmann WR.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):365-70. doi: 10.1073/pnas.0710387105. Epub 2007 Dec 28.

17.

The hinge region operates as a stability switch in cGMP-dependent protein kinase I alpha.

Scholten A, Fuss H, Heck AJ, Dostmann WR.

FEBS J. 2007 May;274(9):2274-86. Epub 2007 Apr 2.

18.

Nitric oxide-evoked transient kinetics of cyclic GMP in vascular smooth muscle cells.

Cawley SM, Sawyer CL, Brunelle KF, van der Vliet A, Dostmann WR.

Cell Signal. 2007 May;19(5):1023-33. Epub 2006 Nov 28.

PMID:
17207606
19.

Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9.

Bove PF, Wesley UV, Greul AK, Hristova M, Dostmann WR, van der Vliet A.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):138-46. Epub 2006 Sep 15.

20.

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M.

Circ Res. 2006 Feb 3;98(2):226-34. Epub 2005 Dec 15.

PMID:
16357307
21.

A role for cyclic-GMP dependent protein kinase in anoikis.

Hou Y, Wong E, Martin J, Schoenlein PV, Dostmann WR, Browning DD.

Cell Signal. 2006 Jun;18(6):882-8. Epub 2005 Aug 31.

PMID:
16139477
22.

Poly-L-proline type II peptide mimics as probes of the active site occupancy requirements of cGMP-dependent protein kinase.

Zhang R, Nickl CK, Mamai A, Flemer S, Natarajan A, Dostmann WR, Madalengoitia JS.

J Pept Res. 2005 Oct;66(4):151-9.

PMID:
16138853
23.

Cygnets: in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP.

Honda A, Sawyer CL, Cawley SM, Dostmann WR.

Methods Mol Biol. 2005;307:27-43.

PMID:
15988053
24.

Inhibition of cGMP-dependent protein kinase reverses phenotypic modulation of vascular smooth muscle cells.

Dey NB, Foley KF, Lincoln TM, Dostmann WR.

J Cardiovasc Pharmacol. 2005 May;45(5):404-13.

PMID:
15821435
25.

Culture conditions influence uptake and intracellular localization of the membrane permeable cGMP-dependent protein kinase inhibitor DT-2.

Foley KF, De Frutos S, Laskovski KE, Tegge W, Dostmann WR.

Front Biosci. 2005 May 1;10:1302-12.

PMID:
15769626
26.

Membrane-permeable cygnets: rapid cellular internalization of fluorescent cGMP-indicators.

Honda A, Moosmeier MA, Dostmann WR.

Front Biosci. 2005 May 1;10:1290-301.

PMID:
15769625
27.

p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.

Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD.

J Biol Chem. 2005 Apr 22;280(16):15649-58. Epub 2005 Feb 22.

28.

Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.

Krieg T, Philipp S, Cui L, Dostmann WR, Downey JM, Cohen MV.

Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1976-81. Epub 2004 Dec 9.

29.

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.

Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA.

Circ Res. 2005 Jan 7;96(1):100-9. Epub 2004 Dec 2.

PMID:
15576651
30.

Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation.

Taylor MS, Okwuchukwuasanya C, Nickl CK, Tegge W, Brayden JE, Dostmann WR.

Mol Pharmacol. 2004 May;65(5):1111-9.

31.

Cygnets: spatial and temporal analysis of intracellular cGMP.

Sawyer CL, Honda A, Dostmann WR.

Proc West Pharmacol Soc. 2003;46:28-31. No abstract available.

PMID:
14699878
32.

Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Ialpha.

Dostmann WR, Tegge W, Frank R, Nickl CK, Taylor MS, Brayden JE.

Pharmacol Ther. 2002 Feb-Mar;93(2-3):203-15. Review.

PMID:
12191612
33.

Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator.

Honda A, Adams SR, Sawyer CL, Lev-Ram V, Tsien RY, Dostmann WR.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2437-42.

34.

Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation.

Dostmann WR, Taylor MS, Nickl CK, Brayden JE, Frank R, Tegge WJ.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14772-7.

35.

Delineation of selective cyclic GMP-dependent protein kinase Ialpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper.

Dostmann WR, Nickl C, Thiel S, Tsigelny I, Frank R, Tegge WJ.

Pharmacol Ther. 1999 May-Jun;82(2-3):373-87.

PMID:
10454213
36.

Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Ialpha.

Ruth P, Pfeifer A, Kamm S, Klatt P, Dostmann WR, Hofmann F.

J Biol Chem. 1997 Apr 18;272(16):10522-8.

39.

Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase.

Herberg FW, Taylor SS, Dostmann WR.

Biochemistry. 1996 Mar 5;35(9):2934-42.

PMID:
8608131
41.

Expression of a chimeric, cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I alpha.

Wild N, Herberg FW, Hofmann F, Dostmann WR.

FEBS Lett. 1995 Nov 6;374(3):356-62.

42.
43.

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.

Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI.

Science. 1995 Aug 11;269(5225):807-13.

PMID:
7638597
44.

Ala335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I.

Zorn M, Fladmark KE, Ogreid D, Jastorff B, Døskeland SO, Dostmann WR.

FEBS Lett. 1995 Apr 10;362(3):291-4.

45.
46.

Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase.

Su Y, Taylor SS, Dostmann WR, Xuong NH, Varughese KI.

J Mol Biol. 1993 Apr 5;230(3):1091-3.

PMID:
8478923
48.

Unfolding of the regulatory subunit of cAMP-dependent protein kinase I.

León DA, Dostmann WR, Taylor SS.

Biochemistry. 1991 Mar 26;30(12):3035-40.

PMID:
1848784
50.

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

Dostmann WR, Taylor SS, Genieser HG, Jastorff B, Døskeland SO, Ogreid D.

J Biol Chem. 1990 Jun 25;265(18):10484-91.

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