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Items: 1 to 50 of 76

1.

Recurrent Subcutaneous Teratoma in an Adult Red-crowned Amazon Parrot (Amazona viridigenalis).

Lauer S, Pinkerton ME, Mans C, Doss GA.

J Avian Med Surg. 2019 Mar 1;33(1):59-64. doi: 10.1647/2017-331.

PMID:
31124613
2.

Effects of Midazolam and Midazolam-Butorphanol on Gastrointestinal Transit Time and Motility in Cockatiels (Nymphicus hollandicus).

Martel A, Mans C, Doss GA, Williams JM.

J Avian Med Surg. 2018 Dec 1;32(4):286-293. doi: 10.1647/2017-266.

PMID:
31112641
3.

Assessment of sedation after intranasal administration of midazolam and midazolam-butorphanol in cockatiels (Nymphicus hollandicus).

Doss GA, Fink DM, Mans C.

Am J Vet Res. 2018 Dec;79(12):1246-1252. doi: 10.2460/ajvr.79.12.1246.

PMID:
30457900
4.

Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius).

Fink DM, Doss GA, Sladky KK, Mans C.

J Am Vet Med Assoc. 2018 Nov 1;253(9):1146-1150. doi: 10.2460/javma.253.9.1146.

PMID:
30311528
5.

Effect of injection site on alfaxalone-induced sedation in ball pythons (Python regius).

Yaw TJ, Mans C, Johnson SM, Doss GA, Sladky KK.

J Small Anim Pract. 2018 Dec;59(12):747-751. doi: 10.1111/jsap.12918. Epub 2018 Aug 30.

PMID:
30160303
6.

Diagnosis and management of inflammatory bowel disease in a harpy eagle (Harpia harpyja) with suspected fenbendazole toxicosis.

Doss GA, Mans C, Johnson L, Pinkerton ME, Hardie RJ, Sladky KK.

J Am Vet Med Assoc. 2018 Feb 1;252(3):336-342. doi: 10.2460/javma.252.3.336.

PMID:
29346050
7.

Contrast fluoroscopic evaluation of gastrointestinal transit times with and without the use of falconry hoods in red-tailed hawks (Buteo jamaicensis).

Doss GA, Williams JM, Mans C.

J Am Vet Med Assoc. 2017 Nov 1;251(9):1064-1069. doi: 10.2460/javma.251.9.1064.

PMID:
29035663
8.

PHARMACOKINETICS OF PIROXICAM IN CRANES (FAMILY GRUIDAE).

Keiper NL, Cox SK, Doss GA, Elsmo B, Franzen-Klein D, Hartup BK.

J Zoo Wildl Med. 2017 Sep;48(3):886-890. doi: 10.1638/2016-0182.1.

PMID:
28920805
9.

Comparison of subcutaneous dexmedetomidine-midazolam versus alfaxalone-midazolam sedation in leopard geckos (Eublepharis macularius).

Doss GA, Fink DM, Sladky KK, Mans C.

Vet Anaesth Analg. 2017 Sep;44(5):1175-1183. doi: 10.1016/j.vaa.2017.03.007. Epub 2017 Apr 24.

PMID:
28882371
10.

Vertebral heart size in chinchillas (Chinchilla lanigera) usingradiography and CT.

Doss GA, Mans C, Hoey S, Di Girolamo N, Stepien RL, Waller KR 3rd.

J Small Anim Pract. 2017 Dec;58(12):714-719. doi: 10.1111/jsap.12715. Epub 2017 Aug 21.

PMID:
28833200
11.

Determination of Gastrointestinal Transit Times in Barred Owls ( Strix varia ) by Contrast Fluoroscopy.

Doss GA, Williams JM, Mans C.

J Avian Med Surg. 2017 Jun;31(2):123-127. doi: 10.1647/2016-182.

PMID:
28644080
12.

The Effect of Manual Restraint on Physiological Parameters in Barred Owls ( Strix varia ).

Doss GA, Mans C.

J Avian Med Surg. 2017 Mar;31(1):1-5. doi: 10.1647/2016-167.

PMID:
28358611
13.

Echocardiographic effects of dexmedetomidine-ketamine in chinchillas ( Chinchilla lanigera).

Doss GA, Mans C, Stepien RL.

Lab Anim. 2017 Feb;51(1):89-92. doi: 10.1177/0023677216658079. Epub 2016 Jul 9.

PMID:
27368710
14.

Changes in Physiologic Parameters and Effects of Hooding in Red-tailed Hawks ( Buteo jamaicensis ) During Manual Restraint.

Doss GA, Mans C.

J Avian Med Surg. 2016 Jun;30(2):127-32. doi: 10.1647/2015-096.

PMID:
27315379
15.

Urinalysis in chinchillas (Chinchilla lanigera).

Doss GA, Mans C, Houseright RA, Webb JL.

J Am Vet Med Assoc. 2016 Apr 15;248(8):901-7. doi: 10.2460/javma.248.8.901.

PMID:
27031416
16.

Angiofibroma in a cockatiel (Nymphicus hollandicus).

Doss GA, Miller JL, Steinberg H, Mans C.

J Comp Pathol. 2015 Feb-Apr;152(2-3):274-7. doi: 10.1016/j.jcpa.2014.12.015. Epub 2015 Feb 26.

PMID:
25728811
17.

Evaluation of metomidate hydrochloride as an anesthetic in leopard frogs (Rana pipiens).

Doss GA, Nevarez JG, Fowlkes N, da Cunha AF.

J Zoo Wildl Med. 2014 Mar;45(1):53-9.

PMID:
24712162
18.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, Samuel K, Hora DF, Kumar S, Madeira M, Eng W, Hargreaves R, Purcell M, Gantert L, Cook J, DeVita RJ, Mills SG.

J Med Chem. 2013 Jul 25;56(14):5940-8. doi: 10.1021/jm400751p. Epub 2013 Jul 9.

PMID:
23808489
19.
20.

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.

Morriello GJ, Wendt HR, Bansal A, Di Salvo J, Feighner S, He J, Hurley AL, Hreniuk DL, Salituro GM, Reddy MV, Galloway SM, McGettigan KK, Laws G, McKnight C, Doss GA, Tsou NN, Black RM, Morris J, Ball RG, Sanfiz AT, Streckfuss E, Struthers M, Edmondson SD.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1865-70. doi: 10.1016/j.bmcl.2010.12.087. Epub 2010 Dec 25.

PMID:
21353541
21.

In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys.

Reddy VB, Doss GA, Karanam BV, Samuel K, Lanza TJ Jr, Lin LS, Yu NX, Zhang AS, Raab CE, Stearns RA, Kumar S.

Xenobiotica. 2010 Sep;40(9):650-62. doi: 10.3109/00498254.2010.501117.

PMID:
20608842
22.

Glutathione S-transferase catalyzed desulfonylation of a sulfonylfuropyridine.

Bateman TJ, Debenham JS, Madsen-Duggan C, Toupence RB, Walsh TF, Truong Q, Bradley SA, Doss GA, Kumar S, Reddy VB.

Drug Metab Dispos. 2010 Jan;38(1):108-14. doi: 10.1124/dmd.109.029801.

PMID:
19797605
23.

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

Jiang J, Bunda JL, Doss GA, Chicchi GG, Kurtz MM, Tsao KL, Tong X, Zheng S, Upthagrove A, Samuel K, Tschirret-Guth R, Kumar S, Wheeldon A, Carlson EJ, Hargreaves R, Burns D, Hamill T, Ryan C, Krause SM, Eng W, DeVita RJ, Mills SG.

J Med Chem. 2009 May 14;52(9):3039-46. doi: 10.1021/jm8016514.

PMID:
19354254
24.

Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.

Chu XY, Liang Y, Cai X, Cuevas-Licea K, Rippley RK, Kassahun K, Shou M, Braun MP, Doss GA, Anari MR, Evers R.

Pharm Res. 2009 Feb;26(2):459-68. doi: 10.1007/s11095-008-9799-5. Epub 2008 Dec 11.

PMID:
19082692
25.

Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.

Lin LS, Ha S, Ball RG, Tsou NN, Castonguay LA, Doss GA, Fong TM, Shen CP, Xiao JC, Goulet MT, Hagmann WK.

J Med Chem. 2008 Apr 10;51(7):2108-14. doi: 10.1021/jm7014974. Epub 2008 Mar 12.

PMID:
18333607
26.

Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.

Pasternak A, Goble SD, Doss GA, Tsou NN, Butora G, Vicario PP, Ayala JM, Struthers M, Demartino JA, Mills SG, Yang L.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1374-7. doi: 10.1016/j.bmcl.2008.01.016. Epub 2008 Jan 9.

PMID:
18215519
27.

Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes.

Zhu B, Bush D, Doss GA, Vincent S, Franklin RB, Xu S.

Drug Metab Dispos. 2008 Feb;36(2):331-8. Epub 2007 Nov 12.

PMID:
17998299
28.

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W.

Drug Metab Dispos. 2008 Feb;36(2):469-73. Epub 2007 Nov 12.

PMID:
17998295
29.

Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.

Biftu T, Scapin G, Singh S, Feng D, Becker JW, Eiermann G, He H, Lyons K, Patel S, Petrov A, Sinha-Roy R, Zhang B, Wu J, Zhang X, Doss GA, Thornberry NA, Weber AE.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. Epub 2007 Apr 2.

PMID:
17433672
30.

Addressing metabolic activation as an integral component of drug design.

Doss GA, Baillie TA.

Drug Metab Rev. 2006;38(4):641-9. Review.

PMID:
17145693
31.

Highly constrained bicyclic VLA-4 antagonists.

Chang LL, Truong Q, Doss GA, MacCoss M, Lyons K, McCauley E, Mumford R, Forrest G, Vincent S, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):597-601. Epub 2006 Nov 7.

PMID:
17118652
32.

Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.

Anari MR, Creighton MD, Ngui JS, Tschirret-Guth RA, Teffera Y, Doss GA, Tang W, Yu NX, Ciccotto SL, Hobra DF Jr, Coleman JB, Vincent SH, Evans DC.

Drug Metab Dispos. 2006 Aug;34(8):1367-75. Epub 2006 May 12.

PMID:
16698892
33.

Short synthesis of octosyl nucleosides.

Knapp S, Thakur VV, Madduru MR, Malolanarasimhan K, Morriello GJ, Doss GA.

Org Lett. 2006 Mar 30;8(7):1335-7.

PMID:
16562885
34.

Metabolic activation of a pentafluorophenylethylamine derivative: formation of glutathione conjugates in vitro in the rat.

Shang J, Xu S, Teffera Y, Doss GA, Stearns RA, Edmonson S, Beconi MG.

Xenobiotica. 2005 Jul;35(7):697-713.

PMID:
16316929
35.

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.

Debenham JS, Madsen-Duggan CB, Walsh TF, Wang J, Tong X, Doss GA, Lao J, Fong TM, Schaeffer MT, Xiao JC, Huang CR, Shen CP, Feng Y, Marsh DJ, Stribling DS, Shearman LP, Strack AM, MacIntyre DE, Van der Ploeg LH, Goulet MT.

Bioorg Med Chem Lett. 2006 Feb;16(3):681-5. Epub 2005 Nov 2.

PMID:
16263284
36.

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.

Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.

Drug Metab Dispos. 2006 Jan;34(1):145-51. Epub 2005 Oct 26.

PMID:
16251255
37.

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS.

Chem Res Toxicol. 2005 Sep;18(9):1427-37.

PMID:
16167835
38.

Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.

Ashton WT, Sisco RM, Dong H, Lyons KA, He H, Doss GA, Leiting B, Patel RA, Wu JK, Marsilio F, Thornberry NA, Weber AE.

Bioorg Med Chem Lett. 2005 May 2;15(9):2253-8.

PMID:
15837304
39.

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W.

Chem Res Toxicol. 2005 Apr;18(4):675-85.

PMID:
15833027
40.

2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists.

Palucki BL, Park MK, Nargund RP, Tang R, MacNeil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, Van der Ploeg LH, Patchett AA.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):1993-6.

PMID:
15808454
41.

Identification of a new source of interference leached from polypropylene tubes in mass-selective analysis.

Xia YQ, Patel S, Bakhtiar R, Franklin RB, Doss GA.

J Am Soc Mass Spectrom. 2005 Mar;16(3):417-21. Erratum in: J Am Soc Mass Spectrom. 2005 May;16(5):802.

42.

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA.

Chem Res Toxicol. 2005 Feb;18(2):271-6.

PMID:
15720132
43.

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.

Plummer CW, Finke PE, Mills SG, Wang J, Tong X, Doss GA, Fong TM, Lao JZ, Schaeffer MT, Chen J, Shen CP, Stribling DS, Shearman LP, Strack AM, Van der Ploeg LH.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1441-6.

PMID:
15713403
44.

Estrogen receptor ligands. 12. Synthesis of the major metabolites of an ERalpha-selective, dihydrobenzoxathiin antagonist for osteoporosis.

Kim S, Wu JY, Zhang Z, Tang W, Doss GA, Dean BJ, Dininno F, Hammond ML.

Org Lett. 2005 Feb 3;7(3):411-4.

PMID:
15673252
45.

Potent Kv1.3 inhibitors from correolide-modification of the C18 position.

Bao J, Miao S, Kayser F, Kotliar AJ, Baker RK, Doss GA, Felix JP, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Garcia ML, Ha SN, Castonguay L, Koo GC, Shah K, Springer MS, Staruch MJ, Parsons WH, Rupprecht KM.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51.

PMID:
15603971
46.

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist.

Palucki BL, Park MK, Nargund RP, Ye Z, Sebhat IK, Pollard PG, Kalyani RN, Tang R, Macneil T, Weinberg DH, Vongs A, Rosenblum CI, Doss GA, Miller RR, Stearns RA, Peng Q, Tamvakopoulos C, McGowan E, Martin WJ, Metzger JM, Shepherd CA, Strack AM, Macintyre DE, Van der Ploeg LH, Patchett AA.

Bioorg Med Chem Lett. 2005 Jan 3;15(1):171-5.

PMID:
15582434
48.

Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys.

Dean B, Chang S, Doss GA, King C, Thomas PE.

Arch Biochem Biophys. 2004 Sep 15;429(2):244-51.

PMID:
15313229
50.

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.

Ashton WT, Dong H, Sisco RM, Doss GA, Leiting B, Patel RA, Wu JK, Marsilio F, Thornberry NA, Weber AE.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):859-63.

PMID:
15012982

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