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Items: 12


Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.

Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer SL, Cullen JJ, Buettner GR.

Mol Cancer Res. 2019 Oct;17(10):2102-2114. doi: 10.1158/1541-7786.MCR-19-0381. Epub 2019 Jul 23.


2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice.

Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR.

Sci Rep. 2019 Apr 24;9(1):6514. doi: 10.1038/s41598-019-42760-3.


Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.

Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski T.

Mol Pharmacol. 2018 Aug;94(2):876-884. doi: 10.1124/mol.118.112144. Epub 2018 May 11.


Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

Erudaitius D, Mantooth J, Huang A, Soliman J, Doskey CM, Buettner GR, Rodgers VGJ.

Free Radic Biol Med. 2018 May 20;120:356-367. doi: 10.1016/j.freeradbiomed.2018.03.044. Epub 2018 Mar 27.


Pharmacologic ascorbate (P-AscH-) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.

Wilkes JG, O'Leary BR, Du J, Klinger AR, Sibenaller ZA, Doskey CM, Gibson-Corley KN, Alexander MS, Tsai S, Buettner GR, Cullen JJ.

Clin Exp Metastasis. 2018 Feb;35(1-2):37-51. doi: 10.1007/s10585-018-9876-z. Epub 2018 Feb 2.


Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy.

Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR.

Redox Biol. 2016 Dec;10:274-284. doi: 10.1016/j.redox.2016.10.010. Epub 2016 Oct 28.


Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

Doskey CM, van 't Erve TJ, Wagner BA, Buettner GR.

PLoS One. 2015 Jul 14;10(7):e0132572. doi: 10.1371/journal.pone.0132572. eCollection 2015.


Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Du J, Cieslak JA 3rd, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, Spitz DR, Buettner GR, Cullen JJ.

Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16.


Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

Cieslak JA, Strother RK, Rawal M, Du J, Doskey CM, Schroeder SR, Button A, Wagner BA, Buettner GR, Cullen JJ.

Free Radic Biol Med. 2015 Jun;83:227-37. doi: 10.1016/j.freeradbiomed.2015.02.018. Epub 2015 Feb 26.


Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Xiao W, Sarsour EH, Wagner BA, Doskey CM, Buettner GR, Domann FE, Goswami PC.

Arch Toxicol. 2016 Feb;90(2):319-32. doi: 10.1007/s00204-014-1407-3. Epub 2014 Nov 23.


Forkhead box M1 regulates quiescence-associated radioresistance of human head and neck squamous carcinoma cells.

Eckers JC, Kalen AL, Sarsour EH, Tompkins VS, Janz S, Son JM, Doskey CM, Buettner GR, Goswami PC.

Radiat Res. 2014 Oct;182(4):420-9. doi: 10.1667/RR13726.1. Epub 2014 Sep 17.


Heritability of glutathione and related metabolites in stored red blood cells.

van 't Erve TJ, Doskey CM, Wagner BA, Hess JR, Darbro BW, Ryckman KK, Murray JC, Raife TJ, Buettner GR.

Free Radic Biol Med. 2014 Nov;76:107-13. doi: 10.1016/j.freeradbiomed.2014.07.040. Epub 2014 Aug 7.

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