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Items: 41


Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.

Dorstyn L, Hackett-Jones E, Nikolic A, Norris MD, Lim Y, Toubia J, Haber M, Kumar S.

Cell Death Dis. 2019 Jan 22;10(2):56. doi: 10.1038/s41419-018-1296-0.


p53 accumulation following cytokinesis failure in the absence of caspase-2.

Lim Y, De Bellis D, Dorstyn L, Kumar S.

Cell Death Differ. 2018 Nov;25(11):2050-2052. doi: 10.1038/s41418-018-0161-0. Epub 2018 Aug 6. No abstract available.


New insights into apoptosome structure and function.

Dorstyn L, Akey CW, Kumar S.

Cell Death Differ. 2018 Jul;25(7):1194-1208. doi: 10.1038/s41418-017-0025-z. Epub 2018 May 15. Review.


Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.

Wilson CH, Nikolic A, Kentish SJ, Keller M, Hatzinikolas G, Dorstyn L, Page AJ, Kumar S.

Cell Death Dis. 2017 Oct 26;8(10):e3136. doi: 10.1038/cddis.2017.518.


Caspase-2-mediated cell death is required for deleting aneuploid cells.

Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S.

Oncogene. 2017 May 11;36(19):2704-2714. doi: 10.1038/onc.2016.423. Epub 2016 Dec 19.


Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.

Dawar S, Shahrin NH, Sladojevic N, D'Andrea RJ, Dorstyn L, Hiwase DK, Kumar S.

Cell Death Dis. 2016 Dec 1;7(12):e2509. doi: 10.1038/cddis.2016.406.


Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.

Wilson CH, Nikolic A, Kentish SJ, Shalini S, Hatzinikolas G, Page AJ, Dorstyn L, Kumar S.

Cell Death Discov. 2016 Feb 29;2:16009. doi: 10.1038/cddiscovery.2016.9. eCollection 2016.


Caspase-2 deficiency accelerates chemically induced liver cancer in mice.

Shalini S, Nikolic A, Wilson CH, Puccini J, Sladojevic N, Finnie J, Dorstyn L, Kumar S.

Cell Death Differ. 2016 Oct;23(10):1727-36. doi: 10.1038/cdd.2016.81. Epub 2016 Aug 12.


Fat, sex and caspase-2.

Wilson CH, Dorstyn L, Kumar S.

Cell Death Dis. 2016 Mar 3;7:e2125. doi: 10.1038/cddis.2016.40. No abstract available.


The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.

Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C.

Cell Death Differ. 2015 Nov;22(11):1803-11. doi: 10.1038/cdd.2015.31. Epub 2015 Apr 10.


Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

Wilson CH, Shalini S, Filipovska A, Richman TR, Davies S, Martin SD, McGee SL, Puccini J, Nikolic A, Dorstyn L, Kumar S.

Cell Death Dis. 2015 Jan 22;6:e1615. doi: 10.1038/cddis.2014.567.


Caspase-2 protects against oxidative stress in vivo.

Shalini S, Puccini J, Wilson CH, Finnie J, Dorstyn L, Kumar S.

Oncogene. 2015 Sep 17;34(38):4995-5002. doi: 10.1038/onc.2014.413. Epub 2014 Dec 22.


Old, new and emerging functions of caspases.

Shalini S, Dorstyn L, Dawar S, Kumar S.

Cell Death Differ. 2015 Apr;22(4):526-39. doi: 10.1038/cdd.2014.216. Epub 2014 Dec 19. Review.


An unexpected role for caspase-2 in neuroblastoma.

Dorstyn L, Puccini J, Nikolic A, Shalini S, Wilson CH, Norris MD, Haber M, Kumar S.

Cell Death Dis. 2014 Aug 21;5:e1383. doi: 10.1038/cddis.2014.342.


Caspase-2 protocols.

Dorstyn L, Kumar S.

Methods Mol Biol. 2014;1133:71-87. doi: 10.1007/978-1-4939-0357-3_4.


ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

Sandow JJ, Dorstyn L, O'Reilly LA, Tailler M, Kumar S, Strasser A, Ekert PG.

Cell Death Differ. 2014 Mar;21(3):475-80. doi: 10.1038/cdd.2013.168. Epub 2013 Nov 29.


Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19920-5. doi: 10.1073/pnas.1311947110. Epub 2013 Nov 18.


Caspase-2 as a tumour suppressor.

Puccini J, Dorstyn L, Kumar S.

Cell Death Differ. 2013 Sep;20(9):1133-9. doi: 10.1038/cdd.2013.87. Epub 2013 Jun 28. Review.


Genetic background and tumour susceptibility in mouse models.

Puccini J, Dorstyn L, Kumar S.

Cell Death Differ. 2013 Jul;20(7):964. doi: 10.1038/cdd.2013.35. Epub 2013 Apr 26. No abstract available.


Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.

Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1288-98. doi: 10.1038/cdd.2012.36. Epub 2012 Apr 13. Erratum in: Cell Death Differ. 2012 Aug;19(8):1411.


Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.

Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1370-80. doi: 10.1038/cdd.2012.13. Epub 2012 Feb 17.


Structure of the Drosophila apoptosome at 6.9 å resolution.

Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW.

Structure. 2011 Jan 12;19(1):128-40. doi: 10.1016/j.str.2010.10.009.


Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity.

Wati S, Rawlinson SM, Ivanov RA, Dorstyn L, Beard MR, Jans DA, Pitson SM, Burrell CJ, Li P, Carr JM.

J Gen Virol. 2011 Apr;92(Pt 4):807-18. doi: 10.1099/vir.0.028159-0. Epub 2010 Dec 9.


Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis.

Foot NJ, Leong YA, Dorstyn LE, Dalton HE, Ho K, Zhao L, Garrick MD, Yang B, Hiwase D, Kumar S.

Blood. 2011 Jan 13;117(2):638-46. doi: 10.1182/blood-2010-07-295287. Epub 2010 Oct 19.


Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.

Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15489-94. doi: 10.1073/pnas.0904880106. Epub 2009 Aug 25.


Analysing caspase activation and caspase activity in apoptotic cells.

Kumar S, Dorstyn L.

Methods Mol Biol. 2009;559:3-17. doi: 10.1007/978-1-60327-017-5_1.


A tumor suppressor function for caspase-2.

Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5336-41. doi: 10.1073/pnas.0811928106. Epub 2009 Mar 11.


Putative functions of caspase-2.

Dorstyn L, Kumar S.

F1000 Biol Rep. 2009 Dec 15;1:96. doi: 10.3410/B1-96.


Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.

Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.

Blood. 2008 Nov 15;112(10):4268-75. doi: 10.1182/blood-2008-04-150953. Epub 2008 Sep 5.


Caspase-2 is required for cell death induced by cytoskeletal disruption.

Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S.

Oncogene. 2008 May 29;27(24):3393-404. doi: 10.1038/sj.onc.1211005. Epub 2008 Jan 14.


A biochemical analysis of the activation of the Drosophila caspase DRONC.

Dorstyn L, Kumar S.

Cell Death Differ. 2008 Mar;15(3):461-70. Epub 2007 Dec 14.


Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.

Doumanis J, Dorstyn L, Kumar S.

Cell Death Differ. 2007 May;14(5):907-15. Epub 2007 Jan 5.


A cytochrome c-free fly apoptosome.

Dorstyn L, Kumar S.

Cell Death Differ. 2006 Jul;13(7):1049-51. Epub 2006 Apr 7. No abstract available.


The role of cytochrome c in caspase activation in Drosophila melanogaster cells.

Dorstyn L, Read S, Cakouros D, Huh JR, Hay BA, Kumar S.

J Cell Biol. 2002 Mar 18;156(6):1089-98. Epub 2002 Mar 18.


Characterization of the Drosophila caspase, DAMM.

Harvey NL, Daish T, Mills K, Dorstyn L, Quinn LM, Read SH, Richardson H, Kumar S.

J Biol Chem. 2001 Jul 6;276(27):25342-50. Epub 2001 May 3.


An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.

Quinn LM, Dorstyn L, Mills K, Colussi PA, Chen P, Coombe M, Abrams J, Kumar S, Richardson H.

J Biol Chem. 2000 Dec 22;275(51):40416-24.


DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7.

Dorstyn L, Read SH, Quinn LM, Richardson H, Kumar S.

J Biol Chem. 1999 Oct 22;274(43):30778-83. Erratum in: J Biol Chem 2000 May 19;275(20):15600.


DRONC, an ecdysone-inducible Drosophila caspase.

Dorstyn L, Colussi PA, Quinn LM, Richardson H, Kumar S.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4307-12.


Caspases in cell death.

Dorstyn L, Kinoshita M, Kumar S.

Results Probl Cell Differ. 1998;24:1-24. Review. No abstract available.


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