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Items: 15


Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota.

Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L.

Cell Metab. 2018 Jun 5;27(6):1222-1235.e6. doi: 10.1016/j.cmet.2018.05.006.


HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.

Dorsett Y, Zhou Y, Tubbs AT, Chen BR, Purman C, Lee BS, George R, Bredemeyer AL, Zhao JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE, Sleckman BP.

Mol Cell. 2014 Dec 18;56(6):808-18. doi: 10.1016/j.molcel.2014.10.024. Epub 2014 Nov 26.


KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.

Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP.

Mol Cell Biol. 2014 Aug;34(15):2811-21. doi: 10.1128/MCB.00441-14. Epub 2014 May 19.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2022-7. doi: 10.1073/pnas.1013295108. Epub 2011 Jan 18.


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.

Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.


Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):187-92. doi: 10.1073/pnas.0908946107. Epub 2009 Dec 4.


Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.

Sernández IV, de Yébenes VG, Dorsett Y, Ramiro AR.

PLoS One. 2008;3(12):e3927. doi: 10.1371/journal.pone.0003927. Epub 2008 Dec 12.


AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.


MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.

Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC.

Immunity. 2008 May;28(5):630-8. doi: 10.1016/j.immuni.2008.04.002. Epub 2008 May 1.


A role for AID in chromosome translocations between c-myc and the IgH variable region.

Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, Nussenzweig MC.

J Exp Med. 2007 Sep 3;204(9):2225-32. Epub 2007 Aug 27. Erratum in: J Exp Med. 2007 Oct;204(10):2491.


Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T.

Mol Cell. 2004 Jul 23;15(2):185-97.


siRNAs: applications in functional genomics and potential as therapeutics.

Dorsett Y, Tuschl T.

Nat Rev Drug Discov. 2004 Apr;3(4):318-29. Review. No abstract available.


Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.

Meister G, Landthaler M, Dorsett Y, Tuschl T.

RNA. 2004 Mar;10(3):544-50.


Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.

Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC.

J Exp Med. 2001 Sep 17;194(6):769-79.

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