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Items: 1 to 50 of 79

1.

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis.

Beltrán E, Gerdes LA, Hansen J, Flierl-Hecht A, Krebs S, Blum H, Ertl-Wagner B, Barkhof F, Kümpfel T, Hohlfeld R, Dornmair K.

J Clin Invest. 2019 Sep 30. pii: 128475. doi: 10.1172/JCI128475. [Epub ahead of print]

2.

Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis.

Konjevic Sabolek M, Held K, Beltrán E, Niedl AG, Meinl E, Hohlfeld R, Lassmann H, Dornmair K.

Ann Clin Transl Neurol. 2019 Jul;6(7):1151-1164. doi: 10.1002/acn3.783. Epub 2019 Jun 14.

3.

Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer.

Penter L, Dietze K, Ritter J, Lammoglia Cobo MF, Garmshausen J, Aigner F, Bullinger L, Hackstein H, Wienzek-Lischka S, Blankenstein T, Hummel M, Dornmair K, Hansmann L.

Oncoimmunology. 2019 Mar 24;8(6):e1586409. doi: 10.1080/2162402X.2019.1586409. eCollection 2019.

4.

Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients.

Beltrán E, Nguyen XH, Quériault C, Barateau L, Dauvilliers Y, Dornmair K, Liblau RS.

J Autoimmun. 2019 Jun;100:1-6. doi: 10.1016/j.jaut.2019.03.010. Epub 2019 Apr 2.

PMID:
30948158
5.

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.

Spadaro M, Winklmeier S, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler FS, Gerdes LA, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Krishnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N, Meinl E.

Ann Neurol. 2018 Aug;84(2):315-328. doi: 10.1002/ana.25291. Epub 2018 Sep 9.

PMID:
30014603
6.

Sex bias in MHC I-associated shaping of the adaptive immune system.

Schneider-Hohendorf T, Görlich D, Savola P, Kelkka T, Mustjoki S, Gross CC, Owens GC, Klotz L, Dornmair K, Wiendl H, Schwab N.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2168-2173. doi: 10.1073/pnas.1716146115. Epub 2018 Feb 12.

7.

Unopposed IL-36 Activity Promotes Clonal CD4+ T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis.

Arakawa A, Vollmer S, Besgen P, Galinski A, Summer B, Kawakami Y, Wollenberg A, Dornmair K, Spannagl M, Ruzicka T, Thomas P, Prinz JC.

J Invest Dermatol. 2018 Jun;138(6):1338-1347. doi: 10.1016/j.jid.2017.12.024. Epub 2017 Dec 27.

8.

Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis.

Wasser B, Pramanik G, Hess M, Klein M, Luessi F, Dornmair K, Bopp T, Zipp F, Witsch E.

J Neuroimmune Pharmacol. 2016 Dec;11(4):721-732. Epub 2016 Jul 16.

PMID:
27423192
9.

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis.

Gerdes LA, Held K, Beltrán E, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R.

Ann Neurol. 2016 Aug;80(2):294-300. doi: 10.1002/ana.24715. Epub 2016 Jul 15.

10.

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7864-9. doi: 10.1073/pnas.1522730113. Epub 2016 Jun 20.

11.

Multiple sclerosis: Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor.

Rühl G, Niedl AG, Patronov A, Siewert K, Pinkert S, Kalemanov M, Friese MA, Attfield KE, Antes I, Hohlfeld R, Dornmair K.

Neurol Neuroimmunol Neuroinflamm. 2016 May 17;3(4):e241. doi: 10.1212/NXI.0000000000000241. eCollection 2016 Aug.

12.

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.

Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82. doi: 10.1073/pnas.1524924113. Epub 2016 May 9.

13.

CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.

Schneider-Hohendorf T, Mohan H, Bien CG, Breuer J, Becker A, Görlich D, Kuhlmann T, Widman G, Herich S, Elpers C, Melzer N, Dornmair K, Kurlemann G, Wiendl H, Schwab N.

Nat Commun. 2016 Apr 4;7:11153. doi: 10.1038/ncomms11153.

14.

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.

Hohlfeld R, Dornmair K, Meinl E, Wekerle H.

Lancet Neurol. 2016 Feb;15(2):198-209. doi: 10.1016/S1474-4422(15)00334-8. Epub 2015 Dec 24. Review.

PMID:
26724103
15.

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.

Hohlfeld R, Dornmair K, Meinl E, Wekerle H.

Lancet Neurol. 2016 Mar;15(3):317-31. doi: 10.1016/S1474-4422(15)00313-0. Epub 2015 Dec 24. Review. Erratum in: Lancet Neurol. 2016 Mar;15(3):241.

PMID:
26724102
16.

Melanocyte antigen triggers autoimmunity in human psoriasis.

Arakawa A, Siewert K, Stöhr J, Besgen P, Kim SM, Rühl G, Nickel J, Vollmer S, Thomas P, Krebs S, Pinkert S, Spannagl M, Held K, Kammerbauer C, Besch R, Dornmair K, Prinz JC.

J Exp Med. 2015 Dec 14;212(13):2203-12. doi: 10.1084/jem.20151093. Epub 2015 Nov 30.

17.

T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis.

Held K, Beltrán E, Moser M, Hohlfeld R, Dornmair K.

Hum Immunol. 2015 Sep;76(9):607-14. doi: 10.1016/j.humimm.2015.09.002. Epub 2015 Sep 14.

PMID:
26382249
18.

αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features.

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K.

Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107. eCollection 2015 Aug.

19.

Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype.

Pröbstel AK, Rudolf G, Dornmair K, Collongues N, Chanson JB, Sanderson NS, Lindberg RL, Kappos L, de Seze J, Derfuss T.

J Neuroinflammation. 2015 Mar 8;12:46. doi: 10.1186/s12974-015-0256-1.

20.

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation.

Beltrán E, Obermeier B, Moser M, Coret F, Simó-Castelló M, Boscá I, Pérez-Miralles F, Villar LM, Senel M, Tumani H, Hohlfeld R, Casanova B, Dornmair K.

Brain. 2014 Oct;137(Pt 10):2703-14. doi: 10.1093/brain/awu205. Epub 2014 Jul 23.

PMID:
25060097
21.

Quantifying activity: a new assay reveals T-cell signalling in tiny skin biopsy samples.

Dornmair K.

Exp Dermatol. 2014 Jun;23(6):389-90. doi: 10.1111/exd.12387.

PMID:
24665970
22.

Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.

Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E.

J Immunol. 2013 Oct 1;191(7):3594-604. doi: 10.4049/jimmunol.1301296. Epub 2013 Sep 6.

23.

Neurofascin as a target for autoantibodies in peripheral neuropathies.

Ng JK, Malotka J, Kawakami N, Derfuss T, Khademi M, Olsson T, Linington C, Odaka M, Tackenberg B, Prüss H, Schwab JM, Harms L, Harms H, Sommer C, Rasband MN, Eshed-Eisenbach Y, Peles E, Hohlfeld R, Yuki N, Dornmair K, Meinl E.

Neurology. 2012 Dec 4;79(23):2241-8. doi: 10.1212/WNL.0b013e31827689ad. Epub 2012 Oct 24.

24.

Analysis of the paired TCR α- and β-chains of single human T cells.

Kim SM, Bhonsle L, Besgen P, Nickel J, Backes A, Held K, Vollmer S, Dornmair K, Prinz JC.

PLoS One. 2012;7(5):e37338. doi: 10.1371/journal.pone.0037338. Epub 2012 May 23.

25.

Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis.

Bruder J, Siewert K, Obermeier B, Malotka J, Scheinert P, Kellermann J, Ueda T, Hohlfeld R, Dornmair K.

J Biol Chem. 2012 Jun 15;287(25):20986-95. doi: 10.1074/jbc.M112.356709. Epub 2012 May 1.

26.

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.

Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K.

Nat Med. 2012 May;18(5):824-8. doi: 10.1038/nm.2720.

PMID:
22484809
27.

What T-cell receptors can tell us about neurologic disease.

Hohlfeld R, Dornmair K.

Neurology. 2012 Feb 7;78(6):376-7. doi: 10.1212/WNL.0b013e318245d2f5. Epub 2012 Jan 11. No abstract available.

PMID:
22238413
28.

Clonal expansions of CD8⁺ T cells in latently HSV-1-infected human trigeminal ganglia.

Held K, Eiglmeier I, Himmelein S, Sinicina I, Brandt T, Theil D, Dornmair K, Derfuss T.

J Neurovirol. 2012 Feb;18(1):62-8. doi: 10.1007/s13365-011-0067-9. Epub 2011 Dec 14.

PMID:
22167486
29.

Inclusion body myositis: laser microdissection reveals differential up-regulation of IFN-γ signaling cascade in attacked versus nonattacked myofibers.

Ivanidze J, Hoffmann R, Lochmüller H, Engel AG, Hohlfeld R, Dornmair K.

Am J Pathol. 2011 Sep;179(3):1347-59. doi: 10.1016/j.ajpath.2011.05.055.

30.

Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.

Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E, Derfuss T.

Neurology. 2011 Aug 9;77(6):580-8. doi: 10.1212/WNL.0b013e318228c0b1. Epub 2011 Jul 27.

PMID:
21795651
31.

Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates.

Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T.

J Virol. 2011 Oct;85(19):9680-5. doi: 10.1128/JVI.00874-11. Epub 2011 Jul 27.

32.

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.

Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K.

J Neuroimmunol. 2011 Apr;233(1-2):245-8. doi: 10.1016/j.jneuroim.2011.01.010. Epub 2011 Feb 24.

33.

Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia.

Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A.

Blood Cancer J. 2011 Mar;1(3):e8. doi: 10.1038/bcj.2011.6. Epub 2011 Mar 4.

34.

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.

Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A.

Brain. 2010 Jul;133(Pt 7):1930-43. doi: 10.1093/brain/awq135. Epub 2010 Jun 2.

35.

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T.

J Immunol. 2009 Nov 1;183(9):5662-72. doi: 10.4049/jimmunol.0803762. Epub 2009 Oct 7.

36.

Novel approaches for identifying target antigens of autoreactive human B and T cells.

Dornmair K, Meinl E, Hohlfeld R.

Semin Immunopathol. 2009 Nov;31(4):467-77. doi: 10.1007/s00281-009-0179-y. Epub 2009 Sep 11. Review.

37.

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.

Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse AH, Potter BV.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83. doi: 10.1073/pnas.0809997106. Epub 2009 Jun 16.

38.

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis.

Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H.

Nat Med. 2009 Jun;15(6):626-32. doi: 10.1038/nm.1975.

PMID:
19483694
39.

Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue.

Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K.

Arch Neurol. 2009 May;66(5):655-8. doi: 10.1001/archneurol.2009.56.

PMID:
19433667
40.

CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery.

Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, Dornmair K, Wiendl H.

Brain. 2009 May;132(Pt 5):1236-46. doi: 10.1093/brain/awp003. Epub 2009 Jan 29.

PMID:
19179379
41.

The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons.

Deininger K, Eder M, Kramer ER, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12539-44. doi: 10.1073/pnas.0801174105. Epub 2008 Aug 22.

42.

B- and T-cell responses in multiple sclerosis: novel approaches offer new insights.

Hohlfeld R, Meinl E, Dornmair K.

J Neurol Sci. 2008 Nov 15;274(1-2):5-8. doi: 10.1016/j.jns.2008.07.006. Epub 2008 Aug 15. Review.

PMID:
18707694
43.

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis.

Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, Lottspeich F, Hohlfeld R, Dornmair K.

Nat Med. 2008 Jun;14(6):688-93. doi: 10.1038/nm1714. Epub 2008 May 18.

PMID:
18488038
44.

Revisiting the immunopathogenesis of the inflammatory myopathies.

Hohlfeld R, Dornmair K.

Neurology. 2007 Nov 20;69(21):1966-7. No abstract available.

PMID:
18025389
45.

Multiple sclerosis: T-cell receptor expression in distinct brain regions.

Junker A, Ivanidze J, Malotka J, Eiglmeier I, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K.

Brain. 2007 Nov;130(Pt 11):2789-99. Epub 2007 Sep 21.

PMID:
17890278
46.

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.

Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl H.

Mol Cell Neurosci. 2007 Nov;36(3):416-24. Epub 2007 Aug 15.

PMID:
17889554
47.

Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system.

Grundtner R, Dornmair K, Dahm R, Flügel A, Kawakami N, Zeitelhofer M, Schoderboeck L, Nosov M, Selzer E, Willheim M, Kiebler M, Wekerle H, Lassmann H, Bradl M.

Neurobiol Dis. 2007 Dec;28(3):261-75. Epub 2007 Aug 3.

PMID:
17889548
48.

Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.

Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus HG, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D.

Brain Pathol. 2007 Oct;17(4):389-98. Epub 2007 Sep 4.

PMID:
17784877
49.

Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.

Seitz S, Schneider CK, Malotka J, Nong X, Engel AG, Wekerle H, Hohlfeld R, Dornmair K.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12057-62. Epub 2006 Aug 1.

50.

Antigen recognition properties of a Vgamma1.3Vdelta2-T-cell receptor from a rare variant of polymyositis.

Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R.

J Neuroimmunol. 2004 Jul;152(1-2):168-75.

PMID:
15223249

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