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Items: 1 to 50 of 247

1.

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments.

von Berg L, Stern D, Weisemann J, Rummel A, Dorner MB, Dorner BG.

Toxins (Basel). 2019 Oct 11;11(10). pii: E588. doi: 10.3390/toxins11100588.

2.

Application of Network Analysis to Flow Systems with Alternating Wave Channels: Part A (Pressure Flows).

Marschik C, Dörner M, Roland W, Miethlinger J, Schöppner V, Steinbichler G.

Polymers (Basel). 2019 Sep 12;11(9). pii: E1488. doi: 10.3390/polym11091488.

3.

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.

Evripioti AA, Ortega-Prieto AM, Skelton JK, Bazot Q, Dorner M.

Philos Trans R Soc Lond B Biol Sci. 2019 May 27;374(1773):20180292. doi: 10.1098/rstb.2018.0292.

4.

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology.

von Berg L, Stern D, Pauly D, Mahrhold S, Weisemann J, Jentsch L, Hansbauer EM, Müller C, Avondet MA, Rummel A, Dorner MB, Dorner BG.

Sci Rep. 2019 Apr 2;9(1):5531. doi: 10.1038/s41598-019-41722-z.

5.

Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.

Skelton JK, Ortega-Prieto AM, Kaye S, Jimenez-Guardeño JM, Turner J, Malim MH, Towers GJ, Dorner M.

J Virol. 2019 May 15;93(11). pii: e02123-18. doi: 10.1128/JVI.02123-18. Print 2019 Jun 1.

6.

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection.

Ortega-Prieto AM, Skelton JK, Cherry C, Briones-Orta MA, Hateley CA, Dorner M.

J Vis Exp. 2019 Feb 19;(144). doi: 10.3791/58333.

7.

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.

Mazzon M, Ortega-Prieto AM, Imrie D, Luft C, Hess L, Czieso S, Grove J, Skelton JK, Farleigh L, Bugert JJ, Wright E, Temperton N, Angell R, Oxenford S, Jacobs M, Ketteler R, Dorner M, Marsh M.

Viruses. 2019 Feb 20;11(2). pii: E176. doi: 10.3390/v11020176.

8.

In Vivo Model Systems for Hepatitis B Virus Research.

Ortega-Prieto AM, Cherry C, Gunn H, Dorner M.

ACS Infect Dis. 2019 May 10;5(5):688-702. doi: 10.1021/acsinfecdis.8b00223. Epub 2019 Jan 8.

9.

Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: results from a prospective observational cohort study.

Kotterba S, Neusser T, Norenberg C, Bussfeld P, Glaser T, Dörner M, Schürks M.

BMC Neurol. 2018 Aug 24;18(1):123. doi: 10.1186/s12883-018-1113-5.

10.

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Sikorra S, Skiba M, Dorner MB, Weisemann J, Weil M, Valdezate S, Davletov B, Rummel A, Dorner BG, Binz T.

Toxins (Basel). 2018 Aug 1;10(8). pii: E311. doi: 10.3390/toxins10080311.

11.

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Stern D, Weisemann J, Le Blanc A, von Berg L, Mahrhold S, Piesker J, Laue M, Luppa PB, Dorner MB, Dorner BG, Rummel A.

PLoS Pathog. 2018 May 2;14(5):e1007048. doi: 10.1371/journal.ppat.1007048. eCollection 2018 May.

12.

Erratum to "Investigation of Clostridium botulinum group III's mobilome content" [Anaerobe 49 (2018) 71-77].

Woudstra C, Le Maréchal C, Souillard R, Anniballi F, Auricchio B, Bano L, Bayon-Auboyer MH, Koene M, Mermoud I, Brito RB, Lobato FCF, Silva ROS, Dorner MB, Fach P.

Anaerobe. 2019 Jun;57:117. doi: 10.1016/j.anaerobe.2018.04.008. Epub 2018 Apr 18. No abstract available.

PMID:
29678457
13.

A Hitchhiker's guide to humanized mice: new pathways to studying viral infections.

Skelton JK, Ortega-Prieto AM, Dorner M.

Immunology. 2018 May;154(1):50-61. doi: 10.1111/imm.12906. Epub 2018 Mar 9. Review.

14.

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.

Ortega-Prieto AM, Skelton JK, Wai SN, Large E, Lussignol M, Vizcay-Barrena G, Hughes D, Fleck RA, Thursz M, Catanese MT, Dorner M.

Nat Commun. 2018 Feb 14;9(1):682. doi: 10.1038/s41467-018-02969-8.

15.

Modeling Unique Patients in Humanized Mice: Toward a Curative Strategy for HIV.

Dorner M, de Jong YP.

Mol Ther. 2018 Feb 7;26(2):329-330. doi: 10.1016/j.ymthe.2018.01.003. No abstract available.

16.

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.

Reynolds CJ, Suleyman OM, Ortega-Prieto AM, Skelton JK, Bonnesoeur P, Blohm A, Carregaro V, Silva JS, James EA, Maillère B, Dorner M, Boyton RJ, Altmann DM.

Sci Rep. 2018 Jan 12;8(1):672. doi: 10.1038/s41598-017-18781-1.

17.

Unusual Outbreak of Fatal Clostridiosis in a Group of Captive Brown Pelicans ( Pelecanus occidentalis).

Lueders I, Ludwig C, Kasberg J, Baums CG, Klimke K, Dorner MB, Ströse D, Schmidt V.

J Avian Med Surg. 2017 Dec;31(4):359-363. doi: 10.1647/2016-237.

PMID:
29327957
18.

Investigation of Clostridium botulinum group III's mobilome content.

Woudstra C, Le Maréchal C, Souillard R, Anniballi F, Auricchio B, Bano L, Bayon-Auboyer MH, Koene M, Mermoud I, Brito RB, Lobato FCF, Silva ROS, Dorner MB, Fach P.

Anaerobe. 2018 Feb;49:71-77. doi: 10.1016/j.anaerobe.2017.12.009. Epub 2017 Dec 26. Erratum in: Anaerobe. 2018 Apr 18;:.

PMID:
29287670
19.

Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.

Ortega-Prieto AM, Dorner M.

Vaccines (Basel). 2017 Sep 1;5(3). pii: E24. doi: 10.3390/vaccines5030024. Review.

20.

Reoccurrence of botulinum neurotoxin subtype A3 inducing food-borne botulism, Slovakia, 2015.

Mad'arová L, Dorner BG, Schaade L, Donáth V, Avdičová M, Fatkulinová M, Strhársky J, Sedliačiková I, Klement C, Dorner MB.

Euro Surveill. 2017 Aug 10;22(32). pii: 30591. doi: 10.2807/1560-7917.ES.2017.22.32.30591.

21.

Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo.

Koutsoudakis G, Paris de León A, Herrera C, Dorner M, Pérez-Vilaró G, Lyonnais S, Grijalvo S, Eritja R, Meyerhans A, Mirambeau G, Díez J.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02354-16. doi: 10.1128/AAC.02354-16. Print 2017 May.

22.

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation.

von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A.

MBio. 2016 Nov 8;7(6). pii: e01915-16. doi: 10.1128/mBio.01915-16.

23.

A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease.

McDonald JU, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, Dorner M, Wright VJ, Levin M, Martinon-Torres F, Herberg JA, Tregoning JS.

mSystems. 2016 Jun 28;1(3). pii: e00051-16. eCollection 2016 May-Jun.

24.

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry.

Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG.

Analyst. 2016 Sep 21;141(18):5281-97. doi: 10.1039/c6an00693k. Epub 2016 Jun 29.

PMID:
27353114
25.

Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells.

Billerbeck E, Mommersteeg MC, Shlomai A, Xiao JW, Andrus L, Bhatta A, Vercauteren K, Michailidis E, Dorner M, Krishnan A, Charlton MR, Chiriboga L, Rice CM, de Jong YP.

J Hepatol. 2016 Aug;65(2):334-43. doi: 10.1016/j.jhep.2016.04.022. Epub 2016 May 2.

26.

Development of a Genus-Specific Antigen Capture ELISA for Orthopoxviruses - Target Selection and Optimized Screening.

Stern D, Pauly D, Zydek M, Miller L, Piesker J, Laue M, Lisdat F, Dorner MB, Dorner BG, Nitsche A.

PLoS One. 2016 Mar 1;11(3):e0150110. doi: 10.1371/journal.pone.0150110. eCollection 2016.

27.

Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis.

Lussignol M, Kopp M, Molloy K, Vizcay-Barrena G, Fleck RA, Dorner M, Bell KL, Chait BT, Rice CM, Catanese MT.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2484-9. doi: 10.1073/pnas.1518934113. Epub 2016 Feb 16.

28.

The expanding toolbox for hepatitis C virus research.

Ortega-Prieto AM, Dorner M.

J Viral Hepat. 2016 May;23(5):320-9. doi: 10.1111/jvh.12500. Epub 2016 Jan 13. Review.

PMID:
26762605
29.

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

Weisemann J, Krez N, Fiebig U, Worbs S, Skiba M, Endermann T, Dorner MB, Bergström T, Muñoz A, Zegers I, Müller C, Jenkinson SP, Avondet MA, Delbrassinne L, Denayer S, Zeleny R, Schimmel H, Åstot C, Dorner BG, Rummel A.

Toxins (Basel). 2015 Nov 26;7(12):5035-54. doi: 10.3390/toxins7124861.

30.

Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples.

Simon S, Fiebig U, Liu Y, Tierney R, Dano J, Worbs S, Endermann T, Nevers MC, Volland H, Sesardic D, Dorner MB.

Toxins (Basel). 2015 Nov 26;7(12):5011-34. doi: 10.3390/toxins7124860.

31.

Simultaneous differentiation and quantification of ricin and agglutinin by an antibody-sandwich surface plasmon resonance sensor.

Stern D, Pauly D, Zydek M, Müller C, Avondet MA, Worbs S, Lisdat F, Dorner MB, Dorner BG.

Biosens Bioelectron. 2016 Apr 15;78:111-117. doi: 10.1016/j.bios.2015.11.020. Epub 2015 Nov 11.

PMID:
26599480
32.

Comparison of intrinsic dynamics of cytochrome p450 proteins using normal mode analysis.

Dorner ME, McMunn RD, Bartholow TG, Calhoon BE, Conlon MR, Dulli JM, Fehling SC, Fisher CR, Hodgson SW, Keenan SW, Kruger AN, Mabin JW, Mazula DL, Monte CA, Olthafer A, Sexton AE, Soderholm BR, Strom AM, Hati S.

Protein Sci. 2015 Sep;24(9):1495-507. doi: 10.1002/pro.2737. Epub 2015 Jul 16.

33.

Advances in experimental systems to study hepatitis C virus in vitro and in vivo.

Catanese MT, Dorner M.

Virology. 2015 May;479-480:221-33. doi: 10.1016/j.virol.2015.03.014. Epub 2015 Apr 4. Review.

34.

Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.

Kull S, Schulz KM, Weisemann J, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG.

PLoS One. 2015 Feb 6;10(2):e0116381. doi: 10.1371/journal.pone.0116381. eCollection 2015.

35.

Molecular gene profiling of Clostridium botulinum group III and its detection in naturally contaminated samples originating from various European countries.

Woudstra C, Le Maréchal C, Souillard R, Bayon-Auboyer MH, Anniballi F, Auricchio B, De Medici D, Bano L, Koene M, Sansonetti MH, Desoutter D, Hansbauer EM, Dorner MB, Dorner BG, Fach P.

Appl Environ Microbiol. 2015 Apr;81(7):2495-505. doi: 10.1128/AEM.03915-14. Epub 2015 Jan 30.

36.

Infant botulism: is there an association with thiamine deficiency?

Ringe H, Schuelke M, Weber S, Dorner BG, Kirchner S, Dorner MB.

Pediatrics. 2014 Nov;134(5):e1436-40. doi: 10.1542/peds.2013-3378. Epub 2014 Oct 13.

37.

Broadly neutralizing antibodies abrogate established hepatitis C virus infection.

de Jong YP, Dorner M, Mommersteeg MC, Xiao JW, Balazs AB, Robbins JB, Winer BY, Gerges S, Vega K, Labitt RN, Donovan BM, Giang E, Krishnan A, Chiriboga L, Charlton MR, Burton DR, Baltimore D, Law M, Rice CM, Ploss A.

Sci Transl Med. 2014 Sep 17;6(254):254ra129. doi: 10.1126/scitranslmed.3009512.

38.

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.

Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R.

Science. 2014 Jun 20;344(6190):1405-10. doi: 10.1126/science.1253823.

39.

Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice.

Billerbeck E, Labitt RN, Vega K, Frias-Staheli N, Dorner M, Xiao JW, Rice CM, Ploss A.

Immunology. 2014 Oct;143(2):202-18. doi: 10.1111/imm.12304.

40.

Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness.

Sheahan T, Imanaka N, Marukian S, Dorner M, Liu P, Ploss A, Rice CM.

Cell Host Microbe. 2014 Feb 12;15(2):190-202. doi: 10.1016/j.chom.2014.01.007.

41.

Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing.

Frias-Staheli N, Dorner M, Marukian S, Billerbeck E, Labitt RN, Rice CM, Ploss A.

J Virol. 2014 Feb;88(4):2205-18. doi: 10.1128/JVI.03085-13. Epub 2013 Dec 11.

42.

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.

Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16538-43. doi: 10.1073/pnas.1315295110. Epub 2013 Sep 16.

43.

Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity.

Stevens GB, Silver DA, Zgaga-Griesz A, Bessler WG, Vashist SK, Patel P, Achazi K, Strotmeier J, Worbs S, Dorner MB, Dorner BG, Pauly D, Rummel A, Urban GA, Krueger M.

Analyst. 2013 Oct 21;138(20):6154-62. doi: 10.1039/c3an00525a.

PMID:
23971072
44.

Completion of the entire hepatitis C virus life cycle in genetically humanized mice.

Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A.

Nature. 2013 Sep 12;501(7466):237-41. doi: 10.1038/nature12427. Epub 2013 Jul 31.

45.

Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines.

Vogt A, Scull MA, Friling T, Horwitz JA, Donovan BM, Dorner M, Gerold G, Labitt RN, Rice CM, Ploss A.

Virology. 2013 Sep;444(1-2):1-11. doi: 10.1016/j.virol.2013.05.036. Epub 2013 Jun 16.

46.

Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission.

Catanese MT, Loureiro J, Jones CT, Dorner M, von Hahn T, Rice CM.

J Virol. 2013 Aug;87(15):8282-93. doi: 10.1128/JVI.01102-13. Epub 2013 May 22.

47.

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC.

Nat Med. 2013 Jun;19(6):730-8. doi: 10.1038/nm.3197. Epub 2013 May 19.

48.

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases.

Bernasconi M, Ueda S, Krukowski P, Bornhauser BC, Ladell K, Dorner M, Sigrist JA, Campidelli C, Aslandogmus R, Alessi D, Berger C, Pileri SA, Speck RF, Nadal D.

Int J Cancer. 2013 Nov 15;133(10):2341-50. doi: 10.1002/ijc.28239. Epub 2013 May 29.

49.

Necrotizing endometritis and isolation of an alpha-toxin producing strain of Clostridium septicum in a wild sooty mangabey from Côte d'Ivoire.

Kirchner S, Mätz-Rensing K, Dorner MB, Leendertz FH, Dorner BG, Leendertz SA.

J Med Primatol. 2013 Aug;42(4):220-4. doi: 10.1111/jmp.12047. Epub 2013 Apr 26.

PMID:
23617545
50.

Expression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein.

Horwitz JA, Dorner M, Friling T, Donovan BM, Vogt A, Loureiro J, Oh T, Rice CM, Ploss A.

Virology. 2013 Apr 25;439(1):23-33. doi: 10.1016/j.virol.2013.01.019. Epub 2013 Feb 26.

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