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Items: 1 to 50 of 66

1.

Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.

Penkert RR, Young NS, Surman SL, Sealy RE, Rosch J, Dormitzer PR, Settembre EC, Chandramouli S, Wong S, Hankins JS, Hurwitz JL.

Vaccine. 2017 Jun 22;35(29):3615-3620. doi: 10.1016/j.vaccine.2017.05.022. Epub 2017 May 26.

2.

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.

Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SC.

Nat Med. 2016 Dec;22(12):1465-1469. doi: 10.1038/nm.4223. Epub 2016 Nov 7.

3.

Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones.

Suphaphiphat P, Whittaker L, De Souza I, Daniels RS, Dormitzer PR, McCauley JW, Settembre EC.

Vaccine. 2016 Jul 12;34(32):3641-8. doi: 10.1016/j.vaccine.2016.05.031. Epub 2016 May 21.

4.

Trypsin pre-treatment corrects SRID over-estimation of immunologically active, pre-fusion HA caused by mixed immunoprecipitin rings.

Wen Y, Palladino G, Xie Y, Ferrari A, Ma X, Han L, Dormitzer PR, Settembre EC.

Vaccine. 2016 Jun 17;34(29):3388-95. doi: 10.1016/j.vaccine.2016.04.091. Epub 2016 May 4.

PMID:
27154389
5.

Infectious Diseases Society of America and Gain-of-Function Experiments With Pathogens Having Pandemic Potential.

Frank GM, Adalja A, Barbour A, Casadevall A, Dormitzer PR, Duchin J, Hayden FG, Hirsch MS, Hynes NA, Lipsitch M, Pavia AT, Relman DA.

J Infect Dis. 2016 May 1;213(9):1359-61. doi: 10.1093/infdis/jiv474. Epub 2015 Sep 27. No abstract available.

PMID:
26416656
6.

Conformationally selective biophysical assay for influenza vaccine potency determination.

Wen Y, Han L, Palladino G, Ferrari A, Xie Y, Carfi A, Dormitzer PR, Settembre EC.

Vaccine. 2015 Oct 5;33(41):5342-5349. doi: 10.1016/j.vaccine.2015.08.077. Epub 2015 Sep 6.

PMID:
26348403
7.

Self-amplifying mRNA vaccines.

Brito LA, Kommareddy S, Maione D, Uematsu Y, Giovani C, Berlanda Scorza F, Otten GR, Yu D, Mandl CW, Mason PW, Dormitzer PR, Ulmer JB, Geall AJ.

Adv Genet. 2015;89:179-233. doi: 10.1016/bs.adgen.2014.10.005. Epub 2014 Dec 4.

PMID:
25620012
8.

Maternal immunization: opportunities for scientific advancement.

Beigi RH, Fortner KB, Munoz FM, Roberts J, Gordon JL, Han HH, Glenn G, Dormitzer PR, Gu XX, Read JS, Edwards K, Patel SM, Swamy GK.

Clin Infect Dis. 2014 Dec 15;59 Suppl 7:S408-14. doi: 10.1093/cid/ciu708.

9.

A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes.

Swanson KA, Balabanis K, Xie Y, Aggarwal Y, Palomo C, Mas V, Metrick C, Yang H, Shaw CA, Melero JA, Dormitzer PR, Carfi A.

J Virol. 2014 Oct;88(20):11802-10. doi: 10.1128/JVI.01225-14. Epub 2014 Jul 30.

10.

A cationic nanoemulsion for the delivery of next-generation RNA vaccines.

Brito LA, Chan M, Shaw CA, Hekele A, Carsillo T, Schaefer M, Archer J, Seubert A, Otten GR, Beard CW, Dey AK, Lilja A, Valiante NM, Mason PW, Mandl CW, Barnett SW, Dormitzer PR, Ulmer JB, Singh M, O'Hagan DT, Geall AJ.

Mol Ther. 2014 Dec;22(12):2118-29. doi: 10.1038/mt.2014.133. Epub 2014 Jul 16.

11.

Rapid production of synthetic influenza vaccines.

Dormitzer PR.

Curr Top Microbiol Immunol. 2015;386:237-73. doi: 10.1007/82_2014_399. Review.

PMID:
24996863
12.

A cell culture-derived MF59-adjuvanted pandemic A/H7N9 vaccine is immunogenic in adults.

Bart SA, Hohenboken M, Della Cioppa G, Narasimhan V, Dormitzer PR, Kanesa-Thasan N.

Sci Transl Med. 2014 Apr 30;6(234):234ra55. doi: 10.1126/scitranslmed.3008761.

13.

Sendai virus-based RSV vaccine protects against RSV challenge in an in vivo maternal antibody model.

Jones BG, Sealy RE, Surman SL, Portner A, Russell CJ, Slobod KS, Dormitzer PR, DeVincenzo J, Hurwitz JL.

Vaccine. 2014 May 30;32(26):3264-73. doi: 10.1016/j.vaccine.2014.03.088. Epub 2014 Apr 14.

14.

Bringing influenza vaccines into the 21st century.

Settembre EC, Dormitzer PR, Rappuoli R.

Hum Vaccin Immunother. 2014;10(3):600-4. Epub 2013 Dec 30.

15.

Improving influenza virus backbones by including terminal regions of MDCK-adapted strains on hemagglutinin and neuraminidase gene segments.

Gomila RC, Suphaphiphat P, Judge C, Spencer T, Ferrari A, Wen Y, Palladino G, Dormitzer PR, Mason PW.

Vaccine. 2013 Oct 1;31(42):4736-43. doi: 10.1016/j.vaccine.2013.08.026. Epub 2013 Aug 20.

PMID:
23973324
16.

Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice.

Hekele A, Bertholet S, Archer J, Gibson DG, Palladino G, Brito LA, Otten GR, Brazzoli M, Buccato S, Bonci A, Casini D, Maione D, Qi ZQ, Gill JE, Caiazza NC, Urano J, Hubby B, Gao GF, Shu Y, De Gregorio E, Mandl CW, Mason PW, Settembre EC, Ulmer JB, Craig Venter J, Dormitzer PR, Rappuoli R, Geall AJ.

Emerg Microbes Infect. 2013 Aug;2(8):e52. doi: 10.1038/emi.2013.54. Epub 2013 Aug 14.

17.

Generation of a parvovirus B19 vaccine candidate.

Chandramouli S, Medina-Selby A, Coit D, Schaefer M, Spencer T, Brito LA, Zhang P, Otten G, Mandl CW, Mason PW, Dormitzer PR, Settembre EC.

Vaccine. 2013 Aug 20;31(37):3872-8. doi: 10.1016/j.vaccine.2013.06.062. Epub 2013 Jul 2.

PMID:
23827313
18.

The path to an RSV vaccine.

Shaw CA, Ciarlet M, Cooper BW, Dionigi L, Keith P, O'Brien KB, Rafie-Kolpin M, Dormitzer PR.

Curr Opin Virol. 2013 Jun;3(3):332-42. doi: 10.1016/j.coviro.2013.05.003. Epub 2013 May 30. Review.

PMID:
23727193
19.

Synthetic generation of influenza vaccine viruses for rapid response to pandemics.

Dormitzer PR, Suphaphiphat P, Gibson DG, Wentworth DE, Stockwell TB, Algire MA, Alperovich N, Barro M, Brown DM, Craig S, Dattilo BM, Denisova EA, De Souza I, Eickmann M, Dugan VG, Ferrari A, Gomila RC, Han L, Judge C, Mane S, Matrosovich M, Merryman C, Palladino G, Palmer GA, Spencer T, Strecker T, Trusheim H, Uhlendorff J, Wen Y, Yee AC, Zaveri J, Zhou B, Becker S, Donabedian A, Mason PW, Glass JI, Rappuoli R, Venter JC.

Sci Transl Med. 2013 May 15;5(185):185ra68. doi: 10.1126/scitranslmed.3006368.

20.

Strategic priorities for respiratory syncytial virus (RSV) vaccine development.

Anderson LJ, Dormitzer PR, Nokes DJ, Rappuoli R, Roca A, Graham BS.

Vaccine. 2013 Apr 18;31 Suppl 2:B209-15. doi: 10.1016/j.vaccine.2012.11.106. Review.

21.

Influenza subunit vaccine coated microneedle patches elicit comparable immune responses to intramuscular injection in guinea pigs.

Kommareddy S, Baudner BC, Bonificio A, Gallorini S, Palladino G, Determan AS, Dohmeier DM, Kroells KD, Sternjohn JR, Singh M, Dormitzer PR, Hansen KJ, O'Hagan DT.

Vaccine. 2013 Jul 25;31(34):3435-41. doi: 10.1016/j.vaccine.2013.01.050. Epub 2013 Feb 8.

PMID:
23398932
22.

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.

Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):264-9. doi: 10.1073/pnas.1218256109. Epub 2012 Nov 21.

23.

Structural vaccinology starts to deliver.

Dormitzer PR, Grandi G, Rappuoli R.

Nat Rev Microbiol. 2012 Dec;10(12):807-13. doi: 10.1038/nrmicro2893. Review.

PMID:
23154260
24.

The role of non-viral antigens in the cotton rat model of respiratory syncytial virus vaccine-enhanced disease.

Shaw CA, Galarneau JR, Bowenkamp KE, Swanson KA, Palmer GA, Palladino G, Markovits JE, Valiante NM, Dormitzer PR, Otten GR.

Vaccine. 2013 Jan 2;31(2):306-12. doi: 10.1016/j.vaccine.2012.11.006. Epub 2012 Nov 12.

PMID:
23153444
25.

Nonviral delivery of self-amplifying RNA vaccines.

Geall AJ, Verma A, Otten GR, Shaw CA, Hekele A, Banerjee K, Cu Y, Beard CW, Brito LA, Krucker T, O'Hagan DT, Singh M, Mason PW, Valiante NM, Dormitzer PR, Barnett SW, Rappuoli R, Ulmer JB, Mandl CW.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14604-9. doi: 10.1073/pnas.1209367109. Epub 2012 Aug 20.

26.

The epidemiology of respiratory syncytial virus lower respiratory tract infection on young children.

Cooper BW, Dormitzer PR, Ciarlet M.

Pediatr Infect Dis J. 2012 Aug;31(8):883; author reply 883-4. doi: 10.1097/INF.0b013e31825c11b6. No abstract available.

PMID:
22801098
27.

Influenza: options to improve pandemic preparation.

Rappuoli R, Dormitzer PR.

Science. 2012 Jun 22;336(6088):1531-3. doi: 10.1126/science.1221466.

PMID:
22723412
28.

New technologies for influenza vaccines.

Dormitzer PR, Tsai TF, Del Giudice G.

Hum Vaccin Immunother. 2012 Jan;8(1):45-58. doi: 10.4161/hv.8.1.18859. Epub 2012 Jan 1. Review.

PMID:
22251994
29.

Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry.

Aoki ST, Trask SD, Coulson BS, Greenberg HB, Dormitzer PR, Harrison SC.

J Virol. 2011 Oct;85(20):10509-17. doi: 10.1128/JVI.00234-11. Epub 2011 Aug 17.

30.

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

Whittle JR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14216-21. doi: 10.1073/pnas.1111497108. Epub 2011 Aug 8.

31.

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.

Swanson KA, Settembre EC, Shaw CA, Dey AK, Rappuoli R, Mandl CW, Dormitzer PR, Carfi A.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9619-24. doi: 10.1073/pnas.1106536108. Epub 2011 May 17.

32.

Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines.

Settembre EC, Dormitzer PR, Rappuoli R.

J Mol Cell Biol. 2011 Jun;3(3):144-6. doi: 10.1093/jmcb/mjq046. Epub 2011 Mar 23.

PMID:
21430014
33.

Influenza vaccine immunology.

Dormitzer PR, Galli G, Castellino F, Golding H, Khurana S, Del Giudice G, Rappuoli R.

Immunol Rev. 2011 Jan;239(1):167-77. doi: 10.1111/j.1600-065X.2010.00974.x. Review.

PMID:
21198671
34.

Atomic model of an infectious rotavirus particle.

Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC.

EMBO J. 2011 Jan 19;30(2):408-16. doi: 10.1038/emboj.2010.322. Epub 2010 Dec 14.

35.

2009 H1N1 swine flu: the 2010 perspective.

Bucher D, Tumpey T, Lowen A, Gill J, Shaw M, Matthews J, Galarza J, Arroyo JM, Dormitzer PR.

Ann N Y Acad Sci. 2010 Sep;1205 Suppl 1:E10-20. doi: 10.1111/j.1749-6632.2010.05739.x.

PMID:
20860673
36.

Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs.

Suphaphiphat P, Franti M, Hekele A, Lilja A, Spencer T, Settembre E, Palmer G, Crotta S, Tuccino AB, Keiner B, Trusheim H, Balabanis K, Sackal M, Rothfeder M, Mandl CW, Dormitzer PR, Mason PW.

Virol J. 2010 Jul 14;7:157. doi: 10.1186/1743-422X-7-157.

37.

Effect of mutations in VP5 hydrophobic loops on rotavirus cell entry.

Kim IS, Trask SD, Babyonyshev M, Dormitzer PR, Harrison SC.

J Virol. 2010 Jun;84(12):6200-7. doi: 10.1128/JVI.02461-09. Epub 2010 Apr 7.

38.

H1N1: can a pandemic cycle be broken?

Settembre EC, Dormitzer PR, Rappuoli R.

Sci Transl Med. 2010 Mar 24;2(24):24ps14. doi: 10.1126/scitranslmed.3000948.

PMID:
20375006
39.

Building an insurance against modern pandemics.

Rappuoli R, Medini D, Siena E, Budroni S, Dormitzer PR, Del Giudice G.

Curr Opin Investig Drugs. 2010 Feb;11(2):126-30.

PMID:
20112161
40.

Human RNA polymerase I-driven reverse genetics for influenza a virus in canine cells.

Suphaphiphat P, Keiner B, Trusheim H, Crotta S, Tuccino AB, Zhang P, Dormitzer PR, Mason PW, Franti M.

J Virol. 2010 Apr;84(7):3721-5. doi: 10.1128/JVI.01925-09. Epub 2010 Jan 13.

41.

Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice.

Dormitzer PR, Rappuoli R, Casini D, O'Hagan D, Runham C, Montomoli E, Baudner B, Donnelly Iii JJ, Lapini G, Wack A.

Version 2. PLoS Curr. 2009 Aug 31 [revised 2009 Jan 1];1:RRN1025.

42.

A rotavirus spike protein conformational intermediate binds lipid bilayers.

Trask SD, Kim IS, Harrison SC, Dormitzer PR.

J Virol. 2010 Feb;84(4):1764-70. doi: 10.1128/JVI.01682-09. Epub 2009 Dec 9.

43.

VP5* rearranges when rotavirus uncoats.

Yoder JD, Trask SD, Vo TP, Binka M, Feng N, Harrison SC, Greenberg HB, Dormitzer PR.

J Virol. 2009 Nov;83(21):11372-7. doi: 10.1128/JVI.01228-09. Epub 2009 Aug 19.

44.

Antibody affinity maturation and respiratory syncytial virus disease.

Shaw CA, Otten G, Wack A, Palmer GA, Mandl CW, Mbow ML, Valiante N, Dormitzer PR.

Nat Med. 2009 Jul;15(7):725; author reply 725-6. doi: 10.1038/nm0709-725a. No abstract available.

PMID:
19584854
45.

Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab.

Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PR.

Science. 2009 Jun 12;324(5933):1444-7. doi: 10.1126/science.1170481.

46.

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM.

Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10644-8. doi: 10.1073/pnas.0904024106. Epub 2009 Jun 1.

47.

Structure-based antigen design: a strategy for next generation vaccines.

Dormitzer PR, Ulmer JB, Rappuoli R.

Trends Biotechnol. 2008 Dec;26(12):659-67. doi: 10.1016/j.tibtech.2008.08.002. Epub 2008 Oct 30. Review.

PMID:
18977045
48.

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.

Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1867-72. doi: 10.1073/pnas.0711623105. Epub 2008 Jan 31.

49.

Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2.

Agrawal PB, Greenleaf RS, Tomczak KK, Lehtokari VL, Wallgren-Pettersson C, Wallefeld W, Laing NG, Darras BT, Maciver SK, Dormitzer PR, Beggs AH.

Am J Hum Genet. 2007 Jan;80(1):162-7. Epub 2006 Nov 14.

50.

Assembly of highly infectious rotavirus particles recoated with recombinant outer capsid proteins.

Trask SD, Dormitzer PR.

J Virol. 2006 Nov;80(22):11293-304. Epub 2006 Sep 13.

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