Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 48

1.

Host conditioning and rejection monitoring in hepatocyte transplantation in humans.

Soltys KA, Setoyama K, Tafaleng EN, Soto Gutiérrez A, Fong J, Fukumitsu K, Nishikawa T, Nagaya M, Sada R, Haberman K, Gramignoli R, Dorko K, Tahan V, Dreyzin A, Baskin K, Crowley JJ, Quader MA, Deutsch M, Ashokkumar C, Shneider BL, Squires RH, Ranganathan S, Reyes-Mugica M, Dobrowolski SF, Mazariegos G, Elango R, Stolz DB, Strom SC, Vockley G, Roy-Chowdhury J, Cascalho M, Guha C, Sindhi R, Platt JL, Fox IJ.

J Hepatol. 2017 May;66(5):987-1000. doi: 10.1016/j.jhep.2016.12.017. Epub 2016 Dec 24.

2.

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.

Giebel NL, Shadley JD, McCarver DG, Dorko K, Gramignoli R, Strom SC, Yan K, Simpson PM, Hines RN.

Drug Metab Dispos. 2016 Jul;44(7):1027-37. doi: 10.1124/dmd.116.069344. Epub 2016 Feb 26.

3.

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.

Hansel MC, Davila JC, Vosough M, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Strom SC.

Curr Protoc Toxicol. 2016 Feb 1;67:14.13.1-14.13.27. doi: 10.1002/0471140856.tx1413s67. Review.

4.

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.

Wang S, Ni HM, Dorko K, Kumer SC, Schmitt TM, Nawabi A, Komatsu M, Huang H, Ding WX.

Oncotarget. 2016 Apr 5;7(14):17681-98. doi: 10.18632/oncotarget.6893.

5.

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.

J Clin Transl Res. 2015;1(2):100-106. Epub 2015 Sep 30.

6.

Liver-Regenerative Transplantation: Regrow and Reset.

Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Handa K, Matsubara K, Fukumitsu K, Dorko K, Presnell SC, Yagi H, Soto-Gutierrez A.

Am J Transplant. 2016 Jun;16(6):1688-96. doi: 10.1111/ajt.13678. Epub 2016 Feb 18. Review.

7.

The proteome of methylmalonic acidemia (MMA): the elucidation of altered pathways in patient livers.

Caterino M, Chandler RJ, Sloan JL, Dorko K, Cusmano-Ozog K, Ingenito L, Strom SC, Imperlini E, Scolamiero E, Venditti CP, Ruoppolo M.

Mol Biosyst. 2016 Feb;12(2):566-74. doi: 10.1039/c5mb00736d.

8.

Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression.

Li Z, Zhao J, Tikhanovich I, Kuravi S, Helzberg J, Dorko K, Roberts B, Kumer S, Weinman SA.

Cell Death Differ. 2016 Apr;23(4):583-95. doi: 10.1038/cdd.2015.125. Epub 2015 Oct 16.

9.

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.

Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):213-22. doi: 10.1016/j.taap.2015.09.022. Epub 2015 Sep 30.

10.

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity.

Xie Y, Woolbright BL, Kos M, McGill MR, Dorko K, Kumer SC, Schmitt TM, Jaeschke H.

J Clin Transl Res. 2015 Sep 30;1(2):1-7. eCollection 2015 Sep 30.

11.

Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling.

Tikhanovich I, Kuravi S, Artigues A, Villar MT, Dorko K, Nawabi A, Roberts B, Weinman SA.

J Biol Chem. 2015 Sep 4;290(36):22236-49. doi: 10.1074/jbc.M115.653543. Epub 2015 Jul 28.

12.

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H.

Toxicol Appl Pharmacol. 2015 Mar 15;283(3):168-77. doi: 10.1016/j.taap.2015.01.015. Epub 2015 Jan 28.

13.

Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.

Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P.

J Biol Chem. 2015 Mar 20;290(12):7871-86. doi: 10.1074/jbc.M114.605386. Epub 2015 Jan 26.

14.

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.

Hansel MC, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W, Davila J, Strom SC.

Curr Protoc Toxicol. 2014 Nov 6;62:14.12.1-23. doi: 10.1002/0471140856.tx1412s62.

15.

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H.

Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274. doi: 10.1016/j.taap.2014.05.010. Epub 2014 Jun 3.

16.

Rapid and sensitive assessment of human hepatocyte functions.

Gramignoli R, Tahan V, Dorko K, Venkataramanan R, Fox IJ, Ellis EC, Vosough M, Strom SC.

Cell Transplant. 2014;23(12):1545-56. doi: 10.3727/096368914X680064. Epub 2014 Apr 4.

PMID:
24702711
17.

Bedaquiline metabolism: enzymes and novel metabolites.

Liu K, Li F, Lu J, Liu S, Dorko K, Xie W, Ma X.

Drug Metab Dispos. 2014 May;42(5):863-6. doi: 10.1124/dmd.113.056119. Epub 2014 Feb 10.

18.

Hypothermic storage of human hepatocytes for transplantation.

Gramignoli R, Dorko K, Tahan V, Skvorak KJ, Ellis E, Jorns C, Ericzon BG, Fox IJ, Strom SC.

Cell Transplant. 2014;23(9):1143-51. doi: 10.3727/096368913X668627.

PMID:
23768881
19.

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan R, Ellis EC, Jorns C, Ericzon BG, Rosenborg S, Kuiper R, Soltys KA, Mazariegos GV, Fox IJ, Wilson EM, Grompe M, Strom SC.

Stem Cell Res. 2013 Jul;11(1):563-73. doi: 10.1016/j.scr.2013.03.002. Epub 2013 Mar 27.

20.

Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice.

Skvorak KJ, Dorko K, Marongiu F, Tahan V, Hansel MC, Gramignoli R, Arning E, Bottiglieri T, Gibson KM, Strom SC.

Mol Genet Metab. 2013 Jun;109(2):132-8. doi: 10.1016/j.ymgme.2013.02.011. Epub 2013 Feb 26.

PMID:
23566440
21.

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions.

Hansel MC, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, Tahan V, Lee BR, Tafaleng E, Guzman-Lepe J, Soto-Gutierrez A, Fox IJ, Strom SC.

Cell Transplant. 2014 Jan;23(1):27-38. doi: 10.3727/096368912X662453. Epub 2013 Feb 4.

22.

Placental stem cell correction of murine intermediate maple syrup urine disease.

Skvorak KJ, Dorko K, Marongiu F, Tahan V, Hansel MC, Gramignoli R, Gibson KM, Strom SC.

Hepatology. 2013 Mar;57(3):1017-23. doi: 10.1002/hep.26150. Epub 2013 Feb 15.

23.

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes.

Sharma S, Ellis EC, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison DR, Caritis SN, Hines RN, Venkataramanan R, Strom SC.

Drug Metab Dispos. 2013 Feb;41(2):296-304. doi: 10.1124/dmd.112.044891. Epub 2012 Nov 5.

24.

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation.

Gramignoli R, Green ML, Tahan V, Dorko K, Skvorak KJ, Marongiu F, Zao W, Venkataramanan R, Ellis EC, Geller D, Breite AG, Dwulet FE, McCarthy RC, Strom SC.

Cell Transplant. 2012;21(6):1245-60. doi: 10.3727/096368911X600939. Epub 2011 Nov 11.

PMID:
22080793
25.

Hepatic differentiation of amniotic epithelial cells.

Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade AR, Paola Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro TL, Tahan V, Skvorak KJ, Ellis EC, Badylak SF, Davila JC, Hines R, Laconi E, Strom SC.

Hepatology. 2011 May;53(5):1719-29. doi: 10.1002/hep.24255.

26.

The second extracellular loop dictates Occludin-mediated HCV entry.

Liu S, Kuo W, Yang W, Liu W, Gibson GA, Dorko K, Watkins SC, Strom SC, Wang T.

Virology. 2010 Nov 10;407(1):160-70. doi: 10.1016/j.virol.2010.08.009. Epub 2010 Sep 6.

27.

Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats.

Tahan G, Gramignoli R, Marongiu F, Aktolga S, Cetinkaya A, Tahan V, Dorko K.

Dig Dis Sci. 2011 Mar;56(3):715-20. doi: 10.1007/s10620-010-1364-5. Epub 2010 Jul 30.

PMID:
20676767
28.

Isolation of amniotic mesenchymal stem cells.

Marongiu F, Gramignoli R, Sun Q, Tahan V, Miki T, Dorko K, Ellis E, Strom SC.

Curr Protoc Stem Cell Biol. 2010 Mar;Chapter 1:Unit 1E.5. doi: 10.1002/9780470151808.sc01e05s12.

PMID:
20200854
29.

Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes.

Sharma S, Ellis EC, Dorko K, Zhang S, Mattison DR, Caritis SN, Venkataramanan R, Strom SC.

Drug Metab Dispos. 2010 May;38(5):723-7. doi: 10.1124/dmd.109.029918. Epub 2010 Jan 22.

30.

Isolation of amniotic epithelial stem cells.

Miki T, Marongiu F, Dorko K, Ellis EC, Strom SC.

Curr Protoc Stem Cell Biol. 2010 Jan;Chapter 1:Unit 1E.3. doi: 10.1002/9780470151808.sc01e03s12.

PMID:
20049689
31.

Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels.

Sellaro TL, Ranade A, Faulk DM, McCabe GP, Dorko K, Badylak SF, Strom SC.

Tissue Eng Part A. 2010 Mar;16(3):1075-82. doi: 10.1089/ten.TEA.2008.0587.

32.

Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease.

Skvorak KJ, Paul HS, Dorko K, Marongiu F, Ellis E, Chace D, Ferguson C, Gibson KM, Homanics GE, Strom SC.

Mol Ther. 2009 Jul;17(7):1266-73. doi: 10.1038/mt.2009.99. Epub 2009 May 12.

33.

Production of hepatocyte-like cells from human amnion.

Miki T, Marongiu F, Ellis EC, Dorko K, Mitamura K, Ranade A, Gramignoli R, Davila J, Strom SC.

Methods Mol Biol. 2009;481:155-68. doi: 10.1007/978-1-59745-201-4_13. Review.

PMID:
19096803
34.

Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes.

Chandler RJ, Tsai MS, Dorko K, Sloan J, Korson M, Freeman R, Strom S, Venditti CP.

BMC Med Genet. 2007 Apr 30;8:24.

35.

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand.

Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR, Strom SC.

Nat Med. 2000 May;6(5):564-7.

PMID:
10802713
36.

Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.

Jo M, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC.

J Biol Chem. 2000 Mar 24;275(12):8806-11.

37.

Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes.

Ramachandran V, Kostrubsky VE, Komoroski BJ, Zhang S, Dorko K, Esplen JE, Strom SC, Venkataramanan R.

Drug Metab Dispos. 1999 Oct;27(10):1194-9.

PMID:
10497147
38.

CD14 expression and production by human hepatocytes.

Su GL, Dorko K, Strom SC, Nüssler AK, Wang SC.

J Hepatol. 1999 Sep;31(3):435-42.

PMID:
10488701
39.

Isolation and characterization of a human hepatic epithelial-like cell line (AKN-1) from a normal liver.

Nussler AK, Vergani G, Gollin SM, Dorko K, Morris SM Jr, Demetris AJ, Nomoto M, Beger HG, Strom SC.

In Vitro Cell Dev Biol Anim. 1999 Apr;35(4):190-7.

PMID:
10478798
40.

The use of human hepatocyte cultures to study the induction of cytochrome P-450.

Kostrubsky VE, Ramachandran V, Venkataramanan R, Dorko K, Esplen JE, Zhang S, Sinclair JF, Wrighton SA, Strom SC.

Drug Metab Dispos. 1999 Aug;27(8):887-94.

PMID:
10421615
41.

Epidermal growth factor- and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes.

Runge DM, Runge D, Dorko K, Pisarov LA, Leckel K, Kostrubsky VE, Thomas D, Strom SC, Michalopoulos GK.

J Hepatol. 1999 Feb;30(2):265-74.

PMID:
10068107
42.

Primary human hepatocyte culture for the study of HCV.

O' Connell JF, Cox S, Buontempo P, Skelton A, Pisarov LA, Dorko K, Strom SC.

Methods Mol Med. 1999;19:495-500. doi: 10.1385/0-89603-521-2:495.

PMID:
21374391
43.

Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation.

Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, Dorko K, Sauter BV, Strom SC.

N Engl J Med. 1998 May 14;338(20):1422-6. No abstract available.

44.

Transplantation of human hepatocytes.

Strom SC, Fisher RA, Rubinstein WS, Barranger JA, Towbin RB, Charron M, Mieles L, Pisarov LA, Dorko K, Thompson MT, Reyes J.

Transplant Proc. 1997 Jun;29(4):2103-6. No abstract available.

PMID:
9193547
45.

Effects of hepatocellular mitogens on cytokine-induced nitric oxide synthesis in human hepatocytes.

Liu ZZ, Cui S, Billiar TR, Dorko K, Halfter W, Geller DA, Michalopoulos G, Beger HG, Albina J, Nussler AK.

J Leukoc Biol. 1996 Sep;60(3):382-8.

PMID:
8830795
46.

Use of human hepatocytes to study P450 gene induction.

Strom SC, Pisarov LA, Dorko K, Thompson MT, Schuetz JD, Schuetz EG.

Methods Enzymol. 1996;272:388-401. No abstract available.

PMID:
8791798
47.

Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes.

Nussler AK, Di Silvio M, Liu ZZ, Geller DA, Freeswick P, Dorko K, Bartoli F, Billiar TR.

Hepatology. 1995 Jun;21(6):1552-60.

PMID:
7539395
48.

A new technique for isolating and culturing human hepatocytes from whole or split livers not used for transplantation.

Dorko K, Freeswick PD, Bartoli F, Cicalese L, Bardsley BA, Tzakis A, Nussler AK.

Cell Transplant. 1994 Sep-Oct;3(5):387-95.

PMID:
7827776

Supplemental Content

Support Center