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Cathelicidins and the Onset of Labour.

Boeckel SRV, Hrabalkova L, Baker TL, MacPherson H, Frew L, Boyle AK, McHugh BJ, Wilson K, Norman JE, Dorin JR, Davidson DJ, Stock SJ.

Sci Rep. 2019 May 14;9(1):7356. doi: 10.1038/s41598-019-43766-7.


Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

McHugh BJ, Wang R, Li HN, Beaumont PE, Kells R, Stevens H, Young L, Rossi AG, Gray RD, Dorin JR, Gwyer Findlay EL, Brough D, Davidson DJ.

PLoS Pathog. 2019 Apr 12;15(4):e1007694. doi: 10.1371/journal.ppat.1007694. eCollection 2019 Apr.


Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor.

Sun CQ, Arnold RS, Hsieh CL, Dorin JR, Lian F, Li Z, Petros JA.

Cancer Biol Ther. 2019;20(6):774-786. doi: 10.1080/15384047.2018.1564564. Epub 2019 Mar 22.


Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA.

McGlasson SL, Semple F, MacPherson H, Gray M, Davidson DJ, Dorin JR.

Eur J Immunol. 2017 Apr;47(4):658-664. doi: 10.1002/eji.201646799. Epub 2017 Feb 14.


IL-1β-Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2.

Wang B, McHugh BJ, Qureshi A, Campopiano DJ, Clarke DJ, Fitzgerald JR, Dorin JR, Weller R, Davidson DJ.

J Invest Dermatol. 2017 Jan;137(1):95-105. doi: 10.1016/j.jid.2016.08.025. Epub 2016 Oct 1.


Correction: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Semple F, MacPherson H, Webb S, Kilanowski F, Lettice L, McGlasson SL, Wheeler AP, Chen V, Millhauser GL, Melrose L, Davidson DJ, Dorin JR.

PLoS Genet. 2016 Jan 8;12(1):e1005801. doi: 10.1371/journal.pgen.1005801. eCollection 2016 Jan.


Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.

Semple F, MacPherson H, Webb S, Kilanowski F, Lettice L, McGlasson SL, Wheeler AP, Chen V, Millhauser GL, Melrose L, Davidson DJ, Dorin JR.

PLoS Genet. 2015 Dec 8;11(12):e1005673. doi: 10.1371/journal.pgen.1005673. eCollection 2015 Dec. Erratum in: PLoS Genet. 2016 Jan;12(1):e1005801.


Novel phenotype of mouse spermatozoa following deletion of nine β-defensin genes.

Dorin JR.

Asian J Androl. 2015 Sep-Oct;17(5):716-9. doi: 10.4103/1008-682X.159712. Review.


Importance of β-defensins in sperm function.

Dorin JR, Barratt CL.

Mol Hum Reprod. 2014 Sep;20(9):821-6. doi: 10.1093/molehr/gau050. Epub 2014 Jul 9. Review.


Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

Zhou YS, Webb S, Lettice L, Tardif S, Kilanowski F, Tyrrell C, Macpherson H, Semple F, Tennant P, Baker T, Hart A, Devenney P, Perry P, Davey T, Barran P, Barratt CL, Dorin JR.

PLoS Genet. 2013 Oct;9(10):e1003826. doi: 10.1371/journal.pgen.1003826. Epub 2013 Oct 24.


Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP.

Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10.


β-Defensins: multifunctional modulators of infection, inflammation and more?

Semple F, Dorin JR.

J Innate Immun. 2012;4(4):337-48. doi: 10.1159/000336619. Epub 2012 Mar 21. Review.


Rare corneal clones in mice suggest an age-related decrease of stem cell activity and support the limbal epithelial stem cell hypothesis.

Douvaras P, Webb S, Whitaker DA, Dorà N, Hill RE, Dorin JR, West JD.

Stem Cell Res. 2012 Jan;8(1):109-19. doi: 10.1016/j.scr.2011.08.007. Epub 2011 Sep 5.


Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.

Semple F, MacPherson H, Webb S, Cox SL, Mallin LJ, Tyrrell C, Grimes GR, Semple CA, Nix MA, Millhauser GL, Dorin JR.

Eur J Immunol. 2011 Nov;41(11):3291-300. doi: 10.1002/eji.201141648. Epub 2011 Sep 6.


Synthesis of cyclic peptides through an intramolecular amide bond rearrangement.

Macmillan D, De Cecco M, Reynolds NL, Santos LF, Barran PE, Dorin JR.

Chembiochem. 2011 Sep 19;12(14):2133-6. doi: 10.1002/cbic.201100364. Epub 2011 Aug 1. No abstract available.


Peptide fragments of a beta-defensin derivative with potent bactericidal activity.

Reynolds NL, De Cecco M, Taylor K, Stanton C, Kilanowski F, Kalapothakis J, Seo E, Uhrin D, Campopiano D, Govan J, Macmillan D, Barran P, Dorin JR.

Antimicrob Agents Chemother. 2010 May;54(5):1922-9. doi: 10.1128/AAC.01568-09. Epub 2010 Feb 22.


Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo.

Semple F, Webb S, Li HN, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ, Dorin JR.

Eur J Immunol. 2010 Apr;40(4):1073-8. doi: 10.1002/eji.200940041.


Conformational preferences of linear beta-defensins are revealed by ion mobility-mass spectrometry.

De Cecco M, Seo ES, Clarke DJ, McCullough BJ, Taylor K, Macmillan D, Dorin JR, Campopiano DJ, Barran PE.

J Phys Chem B. 2010 Feb 18;114(6):2312-8. doi: 10.1021/jp9111662.


Isoleucine/leucine2 is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6.

Tyrrell C, De Cecco M, Reynolds NL, Kilanowski F, Campopiano D, Barran P, Macmillan D, Dorin JR.

Mol Immunol. 2010 Mar;47(6):1378-82. doi: 10.1016/j.molimm.2009.11.025.


Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin.

Kang J, Reynolds NL, Tyrrell C, Dorin JR, Macmillan D.

Org Biomol Chem. 2009 Dec 7;7(23):4918-23. doi: 10.1039/b913886b. Epub 2009 Sep 24.


Efficient production of human beta-defensin 2 (HBD2) in Escherichia coli.

Vargues T, Morrison GJ, Seo ES, Clarke DJ, Fielder HL, Bennani J, Pathania U, Kilanowski F, Dorin JR, Govan JR, Mackay CL, Uhrín D, Campopiano DJ.

Protein Pept Lett. 2009;16(6):668-76.


mc1r Pathway regulation of zebrafish melanosome dispersion.

Richardson J, Lundegaard PR, Reynolds NL, Dorin JR, Porteous DJ, Jackson IJ, Patton EE.

Zebrafish. 2008 Dec;5(4):289-95. doi: 10.1089/zeb.2008.0541.


Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.

Taylor K, Clarke DJ, McCullough B, Chin W, Seo E, Yang D, Oppenheim J, Uhrin D, Govan JR, Campopiano DJ, MacMillan D, Barran P, Dorin JR.

J Biol Chem. 2008 Mar 14;283(11):6631-9. doi: 10.1074/jbc.M709238200. Epub 2008 Jan 7.


Genetics. Beta-defensin repertoire expands.

Dorin JR, Jackson IJ.

Science. 2007 Nov 30;318(5855):1395. No abstract available.


Structure-activity relationships in beta-defensin peptides.

Taylor K, Barran PE, Dorin JR.

Biopolymers. 2008;90(1):1-7. Review.


Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens.

Taylor K, McCullough B, Clarke DJ, Langley RJ, Pechenick T, Hill A, Campopiano DJ, Barran PE, Dorin JR, Govan JR.

Antimicrob Agents Chemother. 2007 May;51(5):1719-24. Epub 2007 Mar 12.


Following damage, the majority of bone marrow-derived airway cells express an epithelial marker.

MacPherson H, Keir PA, Edwards CJ, Webb S, Dorin JR.

Respir Res. 2006 Dec 19;7:145.


The changing of the guard: Molecular diversity and rapid evolution of beta-defensins.

Semple CA, Gautier P, Taylor K, Dorin JR.

Mol Divers. 2006 Nov;10(4):575-84. Review.


Beta-defensin evolution: selection complexity and clues for residues of functional importance.

Semple CA, Taylor K, Eastwood H, Barran PE, Dorin JR.

Biochem Soc Trans. 2006 Apr;34(Pt 2):257-62. Review.


Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.

McMichael JW, Maxwell AI, Hayashi K, Taylor K, Wallace WA, Govan JR, Dorin JR, Sallenave JM.

Infect Immun. 2005 Jun;73(6):3609-17.


The complexity of selection at the major primate beta-defensin locus.

Semple CA, Maxwell A, Gautier P, Kilanowski FM, Eastwood H, Barran PE, Dorin JR.

BMC Evol Biol. 2005 May 18;5:32.


Murine epithelial cells: isolation and culture.

Davidson DJ, Gray MA, Kilanowski FM, Tarran R, Randell SH, Sheppard DN, Argent BE, Dorin JR.

J Cyst Fibros. 2004 Aug;3 Suppl 2:59-62. Review.


Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity.

Campopiano DJ, Clarke DJ, Polfer NC, Barran PE, Langley RJ, Govan JR, Maxwell A, Dorin JR.

J Biol Chem. 2004 Nov 19;279(47):48671-9. Epub 2004 Aug 17.


Instability of the insertional mutation in CftrTgH(neoim)Hgu cystic fibrosis mouse model.

Charizopoulou N, Jansen S, Dorsch M, Stanke F, Dorin JR, Hedrich HJ, Tümmler B.

BMC Genet. 2004 Apr 21;5:6.


The CF mouse: an important tool for studying cystic fibrosis.

Davidson DJ, Dorin JR.

Expert Rev Mol Med. 2001 Mar 12;2001:1-27. doi: 10.1017/S1462399401002551. No abstract available.


Rapid sequence divergence in mammalian beta-defensins by adaptive evolution.

Maxwell AI, Morrison GM, Dorin JR.

Mol Immunol. 2003 Nov;40(7):413-21. Review.


Duplication and selection in the evolution of primate beta-defensin genes.

Semple CA, Rolfe M, Dorin JR.

Genome Biol. 2003;4(5):R31. Epub 2003 Apr 17.


Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.

Morrison GM, Semple CA, Kilanowski FM, Hill RE, Dorin JR.

Mol Biol Evol. 2003 Mar;20(3):460-70.


Residual cftr expression varies with age in cftr(tm1Hgu) cystic fibrosis mice: impact on morphology and physiology.

Larbig M, Jansen S, Dorsch M, Bernhard W, Bellmann B, Dorin JR, Porteous DJ, Von Der Hardt H, Steinmetz I, Hedrich HJ, Tuemmler B, Tschernig T.

Pathobiology. 2002-2003;70(2):89-97.


Identification and characterization of a novel murine beta-defensin-related gene.

Morrison GM, Rolfe M, Kilanowski FM, Cross SH, Dorin JR.

Mamm Genome. 2002 Aug;13(8):445-51. Erratum in: Mamm Genome. 2002 Oct;13(10):603.


The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.

Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH.

Cell. 2002 May 17;109(4):497-508.


The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.

Dickinson P, Smith SN, Webb S, Kilanowski FM, Campbell IJ, Taylor MS, Porteous DJ, Willemsen R, de Jonge HR, Farley R, Alton EW, Dorin JR.

Hum Mol Genet. 2002 Feb 1;11(3):243-51.


Evidence for stem-cell niches in the tracheal epithelium.

Borthwick DW, Shahbazian M, Krantz QT, Dorin JR, Randell SH.

Am J Respir Cell Mol Biol. 2001 Jun;24(6):662-70.


A primary culture model of differentiated murine tracheal epithelium.

Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR.

Am J Physiol Lung Cell Mol Physiol. 2000 Oct;279(4):L766-78.


Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting.

Dickinson P, Kimber WL, Kilanowski FM, Webb S, Stevenson BJ, Porteous DJ, Dorin JR.

Transgenic Res. 2000 Feb;9(1):55-66.


A mouse model of intestinal stem cell function and regeneration.

Slorach EM, Campbell FC, Dorin JR.

J Cell Sci. 1999 Sep;112 Pt 18:3029-38.


Murine submucosal glands are clonally derived and show a cystic fibrosis gene-dependent distribution pattern.

Borthwick DW, West JD, Keighren MA, Flockhart JH, Innes BA, Dorin JR.

Am J Respir Cell Mol Biol. 1999 Jun;20(6):1181-9.


A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.

Morrison GM, Davidson DJ, Dorin JR.

FEBS Lett. 1999 Jan 8;442(1):112-6.

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