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Items: 40


The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C.

Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3.


Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.


COPs and POPs Patrol Inflammasome Activation.

Indramohan M, Stehlik C, Dorfleutner A.

J Mol Biol. 2018 Jan 19;430(2):153-173. doi: 10.1016/j.jmb.2017.10.004. Epub 2017 Oct 10. Review.


In vivo Analysis of Neutrophil Infiltration during LPS-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1945. doi: 10.21769/BioProtoc.1945.


The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.


ASC-particle-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1944. doi: 10.21769/BioProtoc.1944.


SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.

Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM.

Autophagy. 2017 Feb;13(2):285-301. doi: 10.1080/15548627.2016.1261238. Epub 2016 Dec 8.


The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C.

Cell Mol Immunol. 2017 Jan;14(1):127-142. doi: 10.1038/cmi.2016.35. Epub 2016 Aug 15.


A dRAStic RHOAdblock of Pyrin inflammasome activation.

Dorfleutner A, Stehlik C.

Nat Immunol. 2016 Jul 19;17(8):900-2. doi: 10.1038/ni.3511. No abstract available.


Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking.

Khare S, Radian AD, Dorfleutner A, Stehlik C.

Methods Mol Biol. 2016;1417:131-43. doi: 10.1007/978-1-4939-3566-6_8.


Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.


The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.


ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides.

Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C.

Mol Immunol. 2015 Oct;67(2 Pt B):294-302. doi: 10.1016/j.molimm.2015.06.013. Epub 2015 Jul 2.


Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.


An updated view on the structure and function of PYRIN domains.

Chu LH, Gangopadhyay A, Dorfleutner A, Stehlik C.

Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.


The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.


An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.

Ratsimandresy RA, Dorfleutner A, Stehlik C.

Front Immunol. 2013 Dec 9;4:440. doi: 10.3389/fimmu.2013.00440. Review.


NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.

Radian AD, de Almeida L, Dorfleutner A, Stehlik C.

Microbes Infect. 2013 Jul-Aug;15(8-9):630-9. doi: 10.1016/j.micinf.2013.04.001. Epub 2013 Apr 22. Review.


Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.

Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM.

Arthritis Rheum. 2012 Nov;64(11):3638-48. doi: 10.1002/art.34610.


SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis.

Shi B, Huang Q, Tak PP, Vervoordeldonk MJ, Huang CC, Dorfleutner A, Stehlik C, Pope RM.

Ann Rheum Dis. 2012 Aug;71(8):1411-7. doi: 10.1136/annrheumdis-2011-200899. Epub 2012 Apr 20.


An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.

Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C.

Immunity. 2012 Mar 23;36(3):464-76. doi: 10.1016/j.immuni.2012.02.001. Epub 2012 Feb 21.


Inflammasomes and their activation.

Khare S, Luc N, Dorfleutner A, Stehlik C.

Crit Rev Immunol. 2010;30(5):463-87. Review.


Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.

Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C.

J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23.


IL-17 induces monocyte migration in rheumatoid arthritis.

Shahrara S, Pickens SR, Dorfleutner A, Pope RM.

J Immunol. 2009 Mar 15;182(6):3884-91. doi: 10.4049/jimmunol.0802246.


Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.

Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C.

J Immunol. 2009 Mar 1;182(5):3173-82. doi: 10.4049/jimmunol.0802367.


Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.

Dorfleutner A, Cho Y, Vincent D, Cunnick J, Lin H, Weed SA, Stehlik C, Flynn DC.

J Cell Sci. 2008 Jul 15;121(Pt 14):2394-405. doi: 10.1242/jcs.026187. Epub 2008 Jun 24.


COPs and POPs: modulators of inflammasome activity.

Stehlik C, Dorfleutner A.

J Immunol. 2007 Dec 15;179(12):7993-8. Review.


AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts.

Zhang J, Park SI, Artime MC, Summy JM, Shah AN, Bomser JA, Dorfleutner A, Flynn DC, Gallick GE.

J Clin Invest. 2007 Oct;117(10):2962-73.


A Shope Fibroma virus PYRIN-only protein modulates the host immune response.

Dorfleutner A, Talbott SJ, Bryan NB, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C.

Virus Genes. 2007 Dec;35(3):685-94. Epub 2007 Aug 4.


AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.

Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC.

J Cell Physiol. 2007 Dec;213(3):740-9.


Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.

Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C.

Infect Immun. 2007 Mar;75(3):1484-92. Epub 2006 Dec 18.


Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.

Helfer B, Boswell BC, Finlay D, Cipres A, Vuori K, Bong Kang T, Wallach D, Dorfleutner A, Lahti JM, Flynn DC, Frisch SM.

Cancer Res. 2006 Apr 15;66(8):4273-8.


HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.

Kroismayr R, Baranyi U, Stehlik C, Dorfleutner A, Binder BR, Lipp J.

J Cell Sci. 2004 Sep 15;117(Pt 20):4749-56. Epub 2004 Aug 25.


Cross-talk of integrin alpha3beta1 and tissue factor in cell migration.

Dorfleutner A, Hintermann E, Tarui T, Takada Y, Ruf W.

Mol Biol Cell. 2004 Oct;15(10):4416-25. Epub 2004 Jul 14.


VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells.

Stehlik C, Kroismayr R, Dorfleutner A, Binder BR, Lipp J.

FEBS Lett. 2004 Jul 2;569(1-3):149-55.


Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.

Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W.

Nat Med. 2004 May;10(5):502-9. Epub 2004 Apr 18.


Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.

Stehlik C, Lee SH, Dorfleutner A, Stassinopoulos A, Sagara J, Reed JC.

J Immunol. 2003 Dec 1;171(11):6154-63.


Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation.

Dorfleutner A, Ruf W.

Blood. 2003 Dec 1;102(12):3998-4005. Epub 2003 Aug 14.


Specificity of coagulation factor signaling.

Ruf W, Dorfleutner A, Riewald M.

J Thromb Haemost. 2003 Jul;1(7):1495-503. Review.


The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways.

Stehlik C, Fiorentino L, Dorfleutner A, Bruey JM, Ariza EM, Sagara J, Reed JC.

J Exp Med. 2002 Dec 16;196(12):1605-15.

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