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Items: 34

1.

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux.

Thomas DG, Doran AC, Fotakis P, Westerterp M, Antonson P, Jiang H, Jiang XC, Gustafsson JÅ, Tabas I, Tall AR.

Cell Rep. 2018 Dec 26;25(13):3774-3785.e4. doi: 10.1016/j.celrep.2018.11.100.

2.

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2).

Moore KJ, Koplev S, Fisher EA, Tabas I, Björkegren JLM, Doran AC, Kovacic JC.

J Am Coll Cardiol. 2018 Oct 30;72(18):2181-2197. doi: 10.1016/j.jacc.2018.08.2147. Review.

PMID:
30360827
3.

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.

Proto JD, Doran AC, Gusarova G, Yurdagul A Jr, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J, Tabas I.

Immunity. 2018 Oct 16;49(4):666-677.e6. doi: 10.1016/j.immuni.2018.07.015. Epub 2018 Oct 2.

PMID:
30291029
4.

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity.

Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I.

Sci Signal. 2018 Sep 25;11(549). pii: eaar3721. doi: 10.1126/scisignal.aar3721.

5.

The role of non-resolving inflammation in atherosclerosis.

Kasikara C, Doran AC, Cai B, Tabas I.

J Clin Invest. 2018 Jul 2;128(7):2713-2723. doi: 10.1172/JCI97950. Epub 2018 Jul 2. Review.

6.

Hypercholesterolemia induces T cell expansion in humanized immune mice.

Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G, D'Agati V, Winchester R, Sykes M, Yang YG, Tabas I.

J Clin Invest. 2018 Jun 1;128(6):2370-2375. doi: 10.1172/JCI97785. Epub 2018 Apr 30.

7.

Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models.

Feng B, Doran AC, Di L, West MA, Osgood SM, Mancuso JY, Shaffer CL, Tremaine L, Liras J.

J Pharm Sci. 2018 Aug;107(8):2225-2235. doi: 10.1016/j.xphs.2018.03.018. Epub 2018 Mar 30.

PMID:
29608887
8.

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis.

Yurdagul A Jr, Doran AC, Cai B, Fredman G, Tabas IA.

Front Cardiovasc Med. 2018 Jan 8;4:86. doi: 10.3389/fcvm.2017.00086. eCollection 2017. Review.

9.

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.

Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I.

J Clin Invest. 2017 Nov 1;127(11):4075-4089. doi: 10.1172/JCI94735. Epub 2017 Oct 3.

10.

Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.

Wager TT, Galatsis P, Chandrasekaran RY, Butler TW, Li J, Zhang L, Mente S, Subramanyam C, Liu S, Doran AC, Chang C, Fisher K, Grimwood S, Hedde JR, Marconi M, Schildknegt K.

ACS Chem Neurosci. 2017 Sep 20;8(9):1995-2004. doi: 10.1021/acschemneuro.7b00155. Epub 2017 Jun 30.

PMID:
28609096
11.

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis.

Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I.

J Clin Invest. 2017 Feb 1;127(2):564-568. doi: 10.1172/JCI90520. Epub 2017 Jan 9.

12.

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.

Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6526-31. doi: 10.1073/pnas.1524292113. Epub 2016 May 19.

13.

The Role of Lipids and Lipoproteins in Atherosclerosis.

Linton MRF, Yancey PG, Davies SS, Jerome WG, Linton EF, Song WL, Doran AC, Vickers KC.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
2019 Jan 3.

14.

Venous congestion, endothelial and neurohormonal activation in acute decompensated heart failure: cause or effect?

Colombo PC, Doran AC, Onat D, Wong KY, Ahmad M, Sabbah HN, Demmer RT.

Curr Heart Fail Rep. 2015 Jun;12(3):215-22. doi: 10.1007/s11897-015-0254-8. Review.

15.

Diphenhydramine has similar interspecies net active influx at the blood-brain barrier.

Shaffer CL, Osgood SM, Mancuso JY, Doran AC.

J Pharm Sci. 2014 May;103(5):1557-62. doi: 10.1002/jps.23927. Epub 2014 Mar 13.

PMID:
24633923
16.

Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice.

Lipinski MJ, Campbell KA, Duong SQ, Welch TJ, Garmey JC, Doran AC, Skaflen MD, Oldham SN, Kelly KA, McNamara CA.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2855-61. doi: 10.1161/ATVBAHA.112.300352. Epub 2012 Oct 4.

17.

An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.

Doran AC, Osgood SM, Mancuso JY, Shaffer CL.

Drug Metab Dispos. 2012 Nov;40(11):2162-73. doi: 10.1124/dmd.112.046391. Epub 2012 Aug 16.

PMID:
22899853
18.

Lymphocytes and the adventitial immune response in atherosclerosis.

Campbell KA, Lipinski MJ, Doran AC, Skaflen MD, Fuster V, McNamara CA.

Circ Res. 2012 Mar 16;110(6):889-900. doi: 10.1161/CIRCRESAHA.111.263186. Review.

19.

Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.

Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):317-24. doi: 10.1161/ATVBAHA.111.234856. Epub 2011 Nov 10.

20.

B-cell aortic homing and atheroprotection depend on Id3.

Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA.

Circ Res. 2012 Jan 6;110(1):e1-12. doi: 10.1161/CIRCRESAHA.111.256438. Epub 2011 Oct 27.

21.

Comparative analysis of the neurophysiological profile of group II metabotropic glutamate receptor activators and diazepam: effects on hippocampal and cortical EEG patterns in rats.

Siok CJ, Cogan SM, Shifflett LB, Doran AC, Kocsis B, Hajós M.

Neuropharmacology. 2012 Jan;62(1):226-36. doi: 10.1016/j.neuropharm.2011.07.011. Epub 2011 Jul 26.

PMID:
21791219
22.

1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.

Zhang L, Brodney MA, Candler J, Doran AC, Duplantier AJ, Efremov IV, Evrard E, Kraus K, Ganong AH, Haas JA, Hanks AN, Jenza K, Lazzaro JT, Maklad N, McCarthy SA, Qian W, Rogers BN, Rottas MD, Schmidt CJ, Siuciak JA, Tingley FD 3rd, Zhang AQ.

J Med Chem. 2011 Mar 24;54(6):1724-39. doi: 10.1021/jm101414h. Epub 2011 Mar 2.

PMID:
21366332
23.

Comment on "Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis".

Lipinski MJ, Perry HM, Doran AC, Oldham SN, McNamara CA.

J Immunol. 2011 Jan 1;186(1):4; author reply 6. doi: 10.4049/jimmunol.1090119. No abstract available.

24.

Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury.

Deliri H, Meller N, Kadakkal A, Malhotra R, Brewster J, Doran AC, Pei H, Oldham SN, Skaflen MD, Garmey JC, McNamara CA.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):110-6. doi: 10.1161/ATVBAHA.110.212068. Epub 2010 Oct 14.

PMID:
20947825
25.

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N.

Circ Res. 2010 Sep 17;107(6):737-46. doi: 10.1161/CIRCRESAHA.109.215715. Epub 2010 Jul 22.

26.

Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans.

Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA.

Circ Res. 2010 Apr 16;106(7):1303-11. doi: 10.1161/CIRCRESAHA.109.210294. Epub 2010 Feb 25.

27.

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.

Duplantier AJ, Efremov I, Candler J, Doran AC, Ganong AH, Haas JA, Hanks AN, Kraus KG, Lazzaro JT Jr, Lu J, Maklad N, McCarthy SA, O'Sullivan TJ, Rogers BN, Siuciak JA, Spracklin DK, Zhang L.

Bioorg Med Chem Lett. 2009 May 1;19(9):2524-9. doi: 10.1016/j.bmcl.2009.03.032. Epub 2009 Mar 14.

PMID:
19328692
28.

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.

Zhang L, Rogers BN, Duplantier AJ, McHardy SF, Efremov I, Berke H, Qian W, Zhang AQ, Maklad N, Candler J, Doran AC, Lazzaro JT Jr, Ganong AH.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5493-6. doi: 10.1016/j.bmcl.2008.09.026. Epub 2008 Sep 10.

PMID:
18812259
29.

The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin.

Doran AC, Meller N, Cutchins A, Deliri H, Slayton RP, Oldham SN, Kim JB, Keller SR, McNamara CA.

Circ Res. 2008 Sep 12;103(6):624-34. doi: 10.1161/CIRCRESAHA.108.175893. Epub 2008 Jul 31.

30.

Role of smooth muscle cells in the initiation and early progression of atherosclerosis.

Doran AC, Meller N, McNamara CA.

Arterioscler Thromb Vasc Biol. 2008 May;28(5):812-9. doi: 10.1161/ATVBAHA.107.159327. Epub 2008 Feb 14. Review.

31.

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J.

Drug Metab Dispos. 2006 Sep;34(9):1443-7. Epub 2006 Jun 7.

PMID:
16760229
32.

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J.

J Pharmacol Exp Ther. 2005 Jun;313(3):1254-62. Epub 2005 Mar 2.

PMID:
15743928
33.

Established theory of radiation-induced decay is not generalizable to Bolton-Hunter labeled peptides.

Doran AC, Wan YP, Kopin AS, Beinborn M.

Biochem Pharmacol. 2003 May 1;65(9):1515-20.

PMID:
12732364
34.

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